Aliases for NAE1 Gene
External Ids for NAE1 Gene
Previous HGNC Symbols for NAE1 Gene
Previous GeneCards Identifiers for NAE1 Gene
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for NAE1 Gene
NAE1 (NEDD8 Activating Enzyme E1 Subunit 1) is a Protein Coding gene. Diseases associated with NAE1 include Alzheimer Disease. Among its related pathways are Parkinson disease and Alzheimers Disease. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and NEDD8 activating enzyme activity. An important paralog of this gene is UBA1.
UniProtKB/Swiss-Prot Summary for NAE1 Gene
Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.