Aliases for NADSYN1 Gene
External Ids for NADSYN1 Gene
Previous GeneCards Identifiers for NADSYN1 Gene
Nicotinamide adenine dinucleotide (NAD) is a coenzyme in metabolic redox reactions, a precursor for several cell signaling molecules, and a substrate for protein posttranslational modifications. NAD synthetase (EC 184.108.40.206) catalyzes the final step in the biosynthesis of NAD from nicotinic acid adenine dinucleotide (NaAD).[supplied by OMIM, Apr 2004]
GeneCards Summary for NADSYN1 Gene
NADSYN1 (NAD Synthetase 1) is a Protein Coding gene. Diseases associated with NADSYN1 include Smith-Lemli-Opitz Syndrome and Superficial Keratitis. Among its related pathways are NAD metabolism and Metabolism of water-soluble vitamins and cofactors. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds and NAD+ synthase (glutamine-hydrolyzing) activity.
UniProtKB/Swiss-Prot Summary for NADSYN1 Gene
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD (PubMed:12547821). Uses L-glutamine as a nitrogen source (PubMed:12547821).