NADK catalyzes the transfer of a phosphate group from ATP to NAD to generate NADP, which in its reduced form acts as an electron donor for biosynthetic reactions (Lerner et al., 2001 [PubMed 11594753]).[supplied by OMIM, Mar 2008] See more...

Aliases for NADK Gene

Aliases for NADK Gene

  • NAD Kinase 2 3 4 5
  • Poly(P)/ATP NAD Kinase 3 4
  • EC 2.7.1.23 4 54
  • DJ283E3.1 3
  • EC 2.7.1 54

External Ids for NADK Gene

Previous GeneCards Identifiers for NADK Gene

  • GC01M001715
  • GC01M000958
  • GC01M001682

Summaries for NADK Gene

Entrez Gene Summary for NADK Gene

  • NADK catalyzes the transfer of a phosphate group from ATP to NAD to generate NADP, which in its reduced form acts as an electron donor for biosynthetic reactions (Lerner et al., 2001 [PubMed 11594753]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NADK Gene

NADK (NAD Kinase) is a Protein Coding gene. Among its related pathways are NAD metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include NAD+ kinase activity.

Gene Wiki entry for NADK Gene

Additional gene information for NADK Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NADK Gene

Genomics for NADK Gene

GeneHancer (GH) Regulatory Elements for NADK Gene

Promoters and enhancers for NADK Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J001775 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 801.8 +1.0 988 8.6 ZNF785 ZNF24 ZBTB40 SP1 CTCF FOXA1 SMARCE1 RBPJ POLR2A USF2 NADK lnc-NADK-1 CCNL2 ENSG00000269737 ATAD3B CDK11A INTS11 SDF4 ENSG00000230092 ENSG00000240731
GH01J001343 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.7 +427.5 427527 19.2 ZNF24 ZBTB40 CTCF ZBTB6 RBPJ SMARCE1 POLR2A NR2F1 NR2F6 CREB1 MXRA8 DVL1 HSALNG0000137 NONHSAG000093.2 UBE2J2 ENSG00000230092 INTS11 ATAD3B ENSG00000237094 CDK11A
GH01J001019 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.6 +759.8 759793 3.4 ZNF785 CTCF SMARCE1 POLR2A CC2D1A ELF1 L3MBTL2 DACH1 ZNF121 ZNF148 AGRN ENSG00000272512 NADK C1orf159 ENSG00000239906 ENSG00000241860 ENSG00000237094 LINC01786 CDK11B LINC01409
GH01J001373 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 14.7 +405.4 405391 3.9 GTF3C2 ZNF785 SIN3A ZNF24 SP1 ZBTB40 CTCF SIX5 ZBTB6 MLX AURKAIP1 lnc-CCNL2-4 lnc-TAS1R3-3 ENSG00000230092 CDK11A ENSG00000269737 ATAD3B CCNL2 SDF4 ENSG00000237094
GH01J001229 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 14.6 +548.8 548839 4.3 SP1 ZBTB40 CTCF SREBF1 SIX5 ZBTB6 POLR2A USF2 FOS CREB1 SDF4 B3GALT6 lnc-C1QTNF12-2 ENSG00000230092 ENSG00000269737 INTS11 CCNL2 CDK11A ATAD3B ENSG00000240731
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NADK on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NADK gene promoter:
  • ARP-1
  • Egr-2
  • Egr-3
  • Evi-1
  • HOXA9
  • HSF2
  • Meis-1
  • Sox5
  • USF-1
  • USF1

Genomic Locations for NADK Gene

Genomic Locations for NADK Gene
chr1:1,751,232-1,780,514
(GRCh38/hg38)
Size:
29,283 bases
Orientation:
Minus strand
chr1:1,682,671-1,711,896
(GRCh37/hg19)
Size:
29,226 bases
Orientation:
Minus strand

Genomic View for NADK Gene

Genes around NADK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NADK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NADK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NADK Gene

Proteins for NADK Gene

  • Protein details for NADK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95544-NADK_HUMAN
    Recommended name:
    NAD kinase
    Protein Accession:
    O95544
    Secondary Accessions:
    • A6NNN3
    • A8K296
    • B7Z434
    • F5GXR5
    • Q5QPS4
    • Q9H2P2
    • Q9H931

    Protein attributes for NADK Gene

    Size:
    446 amino acids
    Molecular mass:
    49228 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NADK Gene

    Alternative splice isoforms for NADK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NADK Gene

Selected DME Specific Peptides for NADK Gene

O95544:
  • ICPHSLSFRP
  • STPTGSTAY
  • IVSTPTGST
  • GGDGTLL
  • PTGSTAY
  • PICPHSL

Post-translational modifications for NADK Gene

  • Ubiquitination at Lys57
  • Modification sites at PhosphoSitePlus

Domains & Families for NADK Gene

Gene Families for NADK Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NADK Gene

Suggested Antigen Peptide Sequences for NADK Gene

GenScript: Design optimal peptide antigens:
  • Poly(P)/ATP NAD kinase (NADK_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95544

UniProtKB/Swiss-Prot:

NADK_HUMAN :
  • Belongs to the NAD kinase family.
Family:
  • Belongs to the NAD kinase family.
genes like me logo Genes that share domains with NADK: view

Function for NADK Gene

Molecular function for NADK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + NAD(+) = ADP + H(+) + NADP(+); Xref=Rhea:RHEA:18629, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57540, ChEBI:CHEBI:58349, ChEBI:CHEBI:456216; EC=2.7.1.23; Evidence=. ;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=3.3 mM for ATP {ECO:0000269 PubMed:11594753}; KM=0.54 mM for NAD {ECO:0000269 PubMed:11594753}; Vmax=6.7 umol/min/mg enzyme {ECO:0000269 PubMed:11594753}; pH dependence: Optimum pH is 7.5. {ECO:0000269 PubMed:11594753}; Temperature dependence: Optimum temperature is 55 degrees Celsius. {ECO:0000269 PubMed:11594753};

Enzyme Numbers (IUBMB) for NADK Gene

Phenotypes From GWAS Catalog for NADK Gene

Gene Ontology (GO) - Molecular Function for NADK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003951 NAD+ kinase activity IDA,IEA 11594753
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with NADK: view
genes like me logo Genes that share phenotypes with NADK: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NADK

CRISPR Products

miRNA for NADK Gene

miRTarBase miRNAs that target NADK

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NADK

Clone Products

  • Addgene plasmids for NADK

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NADK Gene

Localization for NADK Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NADK gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NADK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS 11594753
genes like me logo Genes that share ontologies with NADK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NADK Gene

Pathways & Interactions for NADK Gene

genes like me logo Genes that share pathways with NADK: view

Pathways by source for NADK Gene

1 GeneGo (Thomson Reuters) pathway for NADK Gene

Gene Ontology (GO) - Biological Process for NADK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006741 NADP biosynthetic process IEA,IBA 21873635
GO:0016310 phosphorylation NAS,IEA 11594753
GO:0019674 NAD metabolic process TAS,IEA --
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA --
GO:0046034 ATP metabolic process NAS 11594753
genes like me logo Genes that share ontologies with NADK: view

No data available for SIGNOR curated interactions for NADK Gene

Drugs & Compounds for NADK Gene

(4) Drugs for NADK Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Approved Nutra 0
NAD Experimental Pharma Full agonist, Agonist, Activator 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(5) Additional Compounds for NADK Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
NADP
  • beta-Nicotinamide adenine dinucleotide phosphate
  • NADP+
  • Nicotinamide adenine dinucleotide phosphate
  • Oxidized nicotinamide-adenine dinucleotide phosphate
  • TPN
53-59-8
genes like me logo Genes that share compounds with NADK: view

Transcripts for NADK Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NADK

Clone Products

  • Addgene plasmids for NADK

Alternative Splicing Database (ASD) splice patterns (SP) for NADK Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b · 14c ^ 15 ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: -
SP4: - -
SP5:
SP6: - - - - - - - - - -
SP7: - - - -
SP8: - - - - - - - - -
SP9: - - - - -
SP10: - - - -
SP11: - - -
SP12: - - - - -
SP13:
SP14: -
SP15:
SP16:

ExUns: 16a · 16b ^ 17a · 17b · 17c · 17d ^ 18a · 18b ^ 19 ^ 20a · 20b
SP1: - -
SP2: - -
SP3: - -
SP4: -
SP5: - - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for NADK Gene

GeneLoc Exon Structure for
NADK
ECgene alternative splicing isoforms for
NADK

Expression for NADK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NADK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NADK Gene

This gene is overexpressed in Whole Blood (x9.0).

Protein differential expression in normal tissues from HIPED for NADK Gene

This gene is overexpressed in Monocytes (23.2), Blymphocyte (11.0), and Peripheral blood mononuclear cells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NADK Gene



Protein tissue co-expression partners for NADK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NADK Gene:

NADK

SOURCE GeneReport for Unigene cluster for NADK Gene:

Hs.654792

mRNA Expression by UniProt/SwissProt for NADK Gene:

O95544-NADK_HUMAN
Tissue specificity: Widely expressed but not detected in skeletal muscle.

Evidence on tissue expression from TISSUES for NADK Gene

  • Nervous system(4.7)
  • Liver(4.4)
  • Lung(2.5)
genes like me logo Genes that share expression patterns with NADK: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NADK Gene

Orthologs for NADK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NADK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NADK 33 32
  • 99.39 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NADK 33 32
  • 86.77 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NADK 33 32
  • 86.18 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nadk 32
  • 86.16 (n)
mouse
(Mus musculus)
Mammalia Nadk 17 33 32
  • 86.08 (n)
oppossum
(Monodelphis domestica)
Mammalia NADK 33
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NADK 33
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves NADK 33 32
  • 75.29 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NADK 33
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nadk 32
  • 72.81 (n)
zebrafish
(Danio rerio)
Actinopterygii nadka 33 33 32
  • 70.22 (n)
OneToMany
nadkb 33
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG33156 33 32
  • 61.5 (n)
OneToMany
CG6145 33
  • 42 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011122 32
  • 46.02 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YEF1 33
  • 29 (a)
OneToMany
UTR1 35 33
  • 25 (a)
rice
(Oryza sativa)
Liliopsida Os.17282 32
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 52 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC3H5.11 32
  • 46.62 (n)
Species where no ortholog for NADK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NADK Gene

ENSEMBL:
Gene Tree for NADK (if available)
TreeFam:
Gene Tree for NADK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NADK: view image

Paralogs for NADK Gene

(1) SIMAP similar genes for NADK Gene using alignment to 6 proteins:

  • NADK_HUMAN
  • J3KSP9_HUMAN
  • J3KTI3_HUMAN
  • J3QR86_HUMAN
  • J3QRC0_HUMAN
  • Q5QPS5_HUMAN
genes like me logo Genes that share paralogs with NADK: view

No data available for Paralogs for NADK Gene

Variants for NADK Gene

Sequence variations from dbSNP and Humsavar for NADK Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000157898 -- 1,774,164(-) TATATATATA/TATATATA/TATATATATATA genic_upstream_transcript_variant, intron_variant
rs1000297994 -- 1,758,792(-) G/ genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000335089 -- 1,776,271(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000388683 -- 1,766,959(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000417048 -- 1,774,293(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NADK Gene

Variant ID Type Subtype PubMed ID
dgv10n100 CNV gain 25217958
dgv3e212 CNV loss 25503493
dgv42n54 CNV loss 21841781
dgv4e212 CNV gain 25503493
dgv5e212 CNV gain 25503493
dgv5n111 CNV deletion 26073780
dgv9n100 CNV loss 25217958
esv2758913 CNV gain+loss 17122850
esv2760410 CNV gain+loss 21179565
esv27786 CNV gain 19812545
nsv1003545 CNV gain+loss 25217958
nsv1011683 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1160797 CNV duplication 26073780
nsv1160925 CNV deletion 26073780
nsv1160926 CNV duplication 26073780
nsv436343 CNV deletion 17901297
nsv482937 CNV loss 15286789
nsv545030 CNV gain 21841781
nsv545031 CNV gain 21841781
nsv545041 CNV loss 21841781
nsv834091 CNV loss 17160897
nsv945749 CNV duplication 23825009
nsv950521 CNV deletion 24416366

Variation tolerance for NADK Gene

Residual Variation Intolerance Score: 57.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NADK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NADK

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NADK Gene

Disorders for NADK Gene

Additional Disease Information for NADK

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NADK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NADK Gene

Publications for NADK Gene

  1. Structural and functional characterization of human NAD kinase. (PMID: 11594753) Lerner F … Ziegler M (Biochemical and biophysical research communications 2001) 2 3 4 23 56
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  3. NAD kinase levels control the NADPH concentration in human cells. (PMID: 17855339) Pollak N … Ziegler M (The Journal of biological chemistry 2007) 3 23 56
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56

Products for NADK Gene

Sources for NADK Gene