NADK catalyzes the transfer of a phosphate group from ATP to NAD to generate NADP, which in its reduced form acts as an electron donor for biosynthetic reactions (Lerner et al., 2001 [PubMed 11594753]).[supplied by OMIM, Mar 2008] See more...

Aliases for NADK Gene

Aliases for NADK Gene

  • NAD Kinase 2 3 4 5
  • Poly(P)/ATP NAD Kinase 3 4
  • EC 2.7.1.23 4 51
  • DJ283E3.1 3
  • FLJ13052 2
  • EC 2.7.1 51
  • NADK 5

External Ids for NADK Gene

Previous GeneCards Identifiers for NADK Gene

  • GC01M001715
  • GC01M000958
  • GC01M001682

Summaries for NADK Gene

Entrez Gene Summary for NADK Gene

  • NADK catalyzes the transfer of a phosphate group from ATP to NAD to generate NADP, which in its reduced form acts as an electron donor for biosynthetic reactions (Lerner et al., 2001 [PubMed 11594753]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NADK Gene

NADK (NAD Kinase) is a Protein Coding gene. Diseases associated with NADK include Mycobacterium Tuberculosis 1. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and NAD metabolism. Gene Ontology (GO) annotations related to this gene include NAD+ kinase activity.

Gene Wiki entry for NADK Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NADK Gene

Genomics for NADK Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NADK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NADK on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NADK

Top Transcription factor binding sites by QIAGEN in the NADK gene promoter:
  • ARP-1
  • Egr-2
  • Egr-3
  • Evi-1
  • HOXA9
  • HSF2
  • Meis-1
  • Sox5
  • USF-1
  • USF1

Genomic Locations for NADK Gene

Genomic Locations for NADK Gene
chr1:1,751,232-1,780,509
(GRCh38/hg38)
Size:
29,278 bases
Orientation:
Minus strand
chr1:1,682,671-1,711,896
(GRCh37/hg19)
Size:
29,226 bases
Orientation:
Minus strand

Genomic View for NADK Gene

Genes around NADK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NADK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NADK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NADK Gene

Proteins for NADK Gene

  • Protein details for NADK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95544-NADK_HUMAN
    Recommended name:
    NAD kinase
    Protein Accession:
    O95544
    Secondary Accessions:
    • A6NNN3
    • A8K296
    • B7Z434
    • F5GXR5
    • Q5QPS4
    • Q9H2P2
    • Q9H931

    Protein attributes for NADK Gene

    Size:
    446 amino acids
    Molecular mass:
    49228 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NADK Gene

    Alternative splice isoforms for NADK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NADK Gene

Selected DME Specific Peptides for NADK Gene

O95544:
  • ICPHSLSFRP
  • STPTGSTAY
  • IVSTPTGST
  • GGDGTLL
  • PTGSTAY
  • PICPHSL

Post-translational modifications for NADK Gene

  • Ubiquitination at Lys57
  • Modification sites at PhosphoSitePlus

Domains & Families for NADK Gene

Gene Families for NADK Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NADK Gene

Suggested Antigen Peptide Sequences for NADK Gene

GenScript: Design optimal peptide antigens:
  • Poly(P)/ATP NAD kinase (NADK_HUMAN)
  • FLJ13052 protein (Q6PJ22_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95544

UniProtKB/Swiss-Prot:

NADK_HUMAN :
  • Belongs to the NAD kinase family.
Family:
  • Belongs to the NAD kinase family.
genes like me logo Genes that share domains with NADK: view

Function for NADK Gene

Molecular function for NADK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + NAD(+) = ADP + H(+) + NADP(+); Xref=Rhea:RHEA:18629, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57540, ChEBI:CHEBI:58349, ChEBI:CHEBI:456216; EC=2.7.1.23; Evidence={ECO:0000269|PubMed:11594753};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=3.3 mM for ATP {ECO:0000269|PubMed:11594753}; KM=0.54 mM for NAD {ECO:0000269|PubMed:11594753}; Vmax=6.7 umol/min/mg enzyme {ECO:0000269|PubMed:11594753}; pH dependence: Optimum pH is 7.5. {ECO:0000269|PubMed:11594753}; Temperature dependence: Optimum temperature is 55 degrees Celsius. {ECO:0000269|PubMed:11594753};

Enzyme Numbers (IUBMB) for NADK Gene

Phenotypes From GWAS Catalog for NADK Gene

Gene Ontology (GO) - Molecular Function for NADK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003951 NAD+ kinase activity IEA,IDA 11594753
GO:0005515 protein binding IPI 15161933
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with NADK: view
genes like me logo Genes that share phenotypes with NADK: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NADK

CRISPR Products

miRNA for NADK Gene

miRTarBase miRNAs that target NADK

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NADK

Clone Products

  • Addgene plasmids for NADK

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NADK Gene

Localization for NADK Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NADK gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NADK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS 11594753
genes like me logo Genes that share ontologies with NADK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NADK Gene

Pathways & Interactions for NADK Gene

genes like me logo Genes that share pathways with NADK: view

Pathways by source for NADK Gene

1 GeneGo (Thomson Reuters) pathway for NADK Gene
  • NAD metabolism

Gene Ontology (GO) - Biological Process for NADK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006741 NADP biosynthetic process IEA,IBA 21873635
GO:0016310 phosphorylation IEA,NAS 11594753
GO:0019674 NAD metabolic process IEA,TAS --
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA --
GO:0046034 ATP metabolic process NAS 11594753
genes like me logo Genes that share ontologies with NADK: view

No data available for SIGNOR curated interactions for NADK Gene

Drugs & Compounds for NADK Gene

(6) Drugs for NADK Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Approved Nutra 0
NAD Experimental Pharma Agonist, Full agonist, Activator 0
NADP Experimental Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(3) Additional Compounds for NADK Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
genes like me logo Genes that share compounds with NADK: view

Transcripts for NADK Gene

mRNA/cDNA for NADK Gene

6 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NADK

Clone Products

  • Addgene plasmids for NADK

Alternative Splicing Database (ASD) splice patterns (SP) for NADK Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b · 14c ^ 15 ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: -
SP4: - -
SP5:
SP6: - - - - - - - - - -
SP7: - - - -
SP8: - - - - - - - - -
SP9: - - - - -
SP10: - - - -
SP11: - - -
SP12: - - - - -
SP13:
SP14: -
SP15:
SP16:

ExUns: 16a · 16b ^ 17a · 17b · 17c · 17d ^ 18a · 18b ^ 19 ^ 20a · 20b
SP1: - -
SP2: - -
SP3: - -
SP4: -
SP5: - - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for NADK Gene

GeneLoc Exon Structure for
NADK

Expression for NADK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NADK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NADK Gene

This gene is overexpressed in Whole Blood (x9.0).

Protein differential expression in normal tissues from HIPED for NADK Gene

This gene is overexpressed in Monocytes (23.2), Blymphocyte (11.0), and Peripheral blood mononuclear cells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NADK Gene



Protein tissue co-expression partners for NADK Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NADK

SOURCE GeneReport for Unigene cluster for NADK Gene:

Hs.654792

mRNA Expression by UniProt/SwissProt for NADK Gene:

O95544-NADK_HUMAN
Tissue specificity: Widely expressed but not detected in skeletal muscle.

Evidence on tissue expression from TISSUES for NADK Gene

  • Nervous system(4.7)
  • Liver(4.4)
  • Lung(2.5)
  • Bone marrow(2.2)
  • Blood(2.2)
  • Skin(2.2)
  • Intestine(2.2)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with NADK: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NADK Gene

Orthologs for NADK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NADK Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NADK 30 31
  • 99.39 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NADK 30 31
  • 86.77 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NADK 30 31
  • 86.18 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nadk 30
  • 86.16 (n)
Mouse
(Mus musculus)
Mammalia Nadk 30 17 31
  • 86.08 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NADK 31
  • 79 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia NADK 31
  • 69 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NADK 30 31
  • 75.29 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NADK 31
  • 83 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nadk 30
  • 72.81 (n)
Zebrafish
(Danio rerio)
Actinopterygii nadka 30 31 31
  • 70.22 (n)
OneToMany
nadkb 31
  • 60 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG33156 30 31
  • 61.5 (n)
OneToMany
CG6145 31
  • 42 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011122 30
  • 46.02 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YEF1 31
  • 29 (a)
OneToMany
UTR1 31 33 33
  • 25 (a)
OneToMany
Rice
(Oryza sativa)
Liliopsida Os.17282 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 52 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC3H5.11 30
  • 46.62 (n)
Species where no ortholog for NADK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NADK Gene

ENSEMBL:
Gene Tree for NADK (if available)
TreeFam:
Gene Tree for NADK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NADK: view image

Paralogs for NADK Gene

(1) SIMAP similar genes for NADK Gene using alignment to 6 proteins:

  • NADK_HUMAN
  • J3KSP9_HUMAN
  • J3KTI3_HUMAN
  • J3QR86_HUMAN
  • J3QRC0_HUMAN
  • Q5QPS5_HUMAN
genes like me logo Genes that share paralogs with NADK: view

No data available for Paralogs for NADK Gene

Variants for NADK Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NADK Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
716793 Benign: not provided 1,759,182(-) G/A MISSENSE_VARIANT,INTRON_VARIANT
716794 Benign: not provided 1,759,828(-) G/A MISSENSE_VARIANT,INTRON_VARIANT
752339 Likely Benign: not provided 1,759,226(-) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT
762412 Likely Benign: not provided 1,754,135(-) G/A SYNONYMOUS_VARIANT
791769 Benign: not provided 1,757,140(-) C/A MISSENSE_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for NADK Gene

Structural Variations from Database of Genomic Variants (DGV) for NADK Gene

Variant ID Type Subtype PubMed ID
dgv10n100 CNV gain 25217958
dgv3e212 CNV loss 25503493
dgv42n54 CNV loss 21841781
dgv4e212 CNV gain 25503493
dgv5e212 CNV gain 25503493
dgv5n111 CNV deletion 26073780
dgv9n100 CNV loss 25217958
esv2758913 CNV gain+loss 17122850
esv2760410 CNV gain+loss 21179565
esv27786 CNV gain 19812545
nsv1003545 CNV gain+loss 25217958
nsv1011683 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1160797 CNV duplication 26073780
nsv1160925 CNV deletion 26073780
nsv1160926 CNV duplication 26073780
nsv436343 CNV deletion 17901297
nsv482937 CNV loss 15286789
nsv545030 CNV gain 21841781
nsv545031 CNV gain 21841781
nsv545041 CNV loss 21841781
nsv834091 CNV loss 17160897
nsv945749 CNV duplication 23825009
nsv950521 CNV deletion 24416366

Variation tolerance for NADK Gene

Residual Variation Intolerance Score: 57.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NADK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NADK

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NADK Gene

Disorders for NADK Gene

MalaCards: The human disease database

(1) MalaCards diseases for NADK Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
mycobacterium tuberculosis 1
  • mycobacterium tuberculosis, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards
Search NADK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NADK

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with NADK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NADK Gene

Publications for NADK Gene

  1. Structural and functional characterization of human NAD kinase. (PMID: 11594753) Lerner F … Ziegler M (Biochemical and biophysical research communications 2001) 2 3 4 23
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. NAD kinase levels control the NADPH concentration in human cells. (PMID: 17855339) Pollak N … Ziegler M (The Journal of biological chemistry 2007) 3 23
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for NADK Gene

Sources for NADK Gene