NACA2 Gene (Protein Coding)

Nascent Polypeptide Associated Complex Subunit Alpha 2

GC17M061590
GIFtS:
34
See more...

Aliases for NACA2 Gene

Aliases for NACA2 Gene

  • Nascent Polypeptide Associated Complex Subunit Alpha 2 2 3 5
  • Nascent Polypeptide-Associated Complex Subunit Alpha-2 3 4
  • Alpha-NAC Protein 2 3
  • NACAL 3 4
  • Nascent-Polypeptide-Associated Complex Alpha Polypeptide-Like 2
  • IgE Autoantigen Alpha-Nascent Polypeptide-Associated Complex 3
  • Nascent Polypeptide-Associated Complex, Alpha Polypeptide, 2 3
  • Nascent Polypeptide-Associated Complex Subunit Alpha-Like 4
  • Nascent Polypeptide Associated Complex Alpha Subunit 2 3
  • Hom S 2.01 Protein 3
  • Alpha-NAC-Like 4
  • NAC-Alpha-Like 4
  • Hom S 2.01 4
  • MGC71999 2
  • NACA2 5
  • ANAC 3

External Ids for NACA2 Gene

Previous HGNC Symbols for NACA2 Gene

  • NACAL

Previous GeneCards Identifiers for NACA2 Gene

  • GC17M057025
  • GC17M059668
  • GC17M055034

Summaries for NACA2 Gene

GeneCards Summary for NACA2 Gene

NACA2 (Nascent Polypeptide Associated Complex Subunit Alpha 2) is a Protein Coding gene. Diseases associated with NACA2 include Scleral Staphyloma and Melon Allergy. An important paralog of this gene is NACA.

UniProtKB/Swiss-Prot Summary for NACA2 Gene

  • Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).

Additional gene information for NACA2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NACA2 Gene

Genomics for NACA2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for NACA2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NACA2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NACA2

Top Transcription factor binding sites by QIAGEN in the NACA2 gene promoter:
  • AP-1
  • AREB6
  • c-Fos
  • c-Jun
  • E47
  • FosB
  • Fra-1
  • p53
  • SRF
  • SRF (504 AA)

Genomic Locations for NACA2 Gene

Genomic Locations for NACA2 Gene
chr17:61,590,421-61,591,219
(GRCh38/hg38)
Size:
799 bases
Orientation:
Minus strand
chr17:59,667,794-59,668,563
(GRCh37/hg19)
Size:
770 bases
Orientation:
Minus strand

Genomic View for NACA2 Gene

Genes around NACA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NACA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NACA2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NACA2 Gene

Proteins for NACA2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NACA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H009-NACA2_HUMAN
    Recommended name:
    Nascent polypeptide-associated complex subunit alpha-2
    Protein Accession:
    Q9H009
    Secondary Accessions:
    • Q2VIR9

    Protein attributes for NACA2 Gene

    Size:
    215 amino acids
    Molecular mass:
    23223 Da
    Quaternary structure:
    • Part of the nascent polypeptide-associated complex (NAC), consisting of NACA and BTF3. NAC associates with ribosomes through the BTF3 subunit. Both subunits can contact nascent polypeptide chains (By similarity).
    Miscellaneous:
    • NACAL arose from a recent (40-63 million-year-old), anthropoid primate-specific retroduplication of NACA.

neXtProt entry for NACA2 Gene

Protein Expression for NACA2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NACA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NACA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NACA2 Gene

Domains & Families for NACA2 Gene

Gene Families for NACA2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NACA2 Gene

InterPro:
Blocks:
  • Ubiquitin-associated domain
ProtoNet:

Suggested Antigen Peptide Sequences for NACA2 Gene

GenScript: Design optimal peptide antigens:
  • Nascent polypeptide-associated complex subunit alpha-like (NACA2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H009

UniProtKB/Swiss-Prot:

NACA2_HUMAN :
  • Belongs to the NAC-alpha family.
Family:
  • Belongs to the NAC-alpha family.
genes like me logo Genes that share domains with NACA2: view

Function for NACA2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for NACA2 Gene

UniProtKB/Swiss-Prot Function:
Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).

Phenotypes From GWAS Catalog for NACA2 Gene

Gene Ontology (GO) - Molecular Function for NACA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051082 unfolded protein binding IBA 21873635
genes like me logo Genes that share ontologies with NACA2: view
genes like me logo Genes that share phenotypes with NACA2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NACA2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NACA2 Gene

Localization for NACA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NACA2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NACA2 gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NACA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA,IBA 21873635
GO:0005854 nascent polypeptide-associated complex IEA --
genes like me logo Genes that share ontologies with NACA2: view

Pathways & Interactions for NACA2 Gene

PathCards logo

SuperPathways for NACA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NACA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006612 protein targeting to membrane IBA 21873635
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with NACA2: view

No data available for Pathways by source and SIGNOR curated interactions for NACA2 Gene

Drugs & Compounds for NACA2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for NACA2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for NACA2 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NACA2

Alternative Splicing Database (ASD) splice patterns (SP) for NACA2 Gene

No ASD Table

Relevant External Links for NACA2 Gene

GeneLoc Exon Structure for
NACA2

Expression for NACA2 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NACA2 Gene

mRNA expression in normal human tissues for NACA2 Gene
mRNA expression by GTEx for NACA2 GenemRNA expression by BioGPS for NACA2 Gene

mRNA differential expression in normal tissues according to GTEx for NACA2 Gene

This gene is overexpressed in Testis (x45.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NACA2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NACA2

SOURCE GeneReport for Unigene cluster for NACA2 Gene:

Hs.591178

mRNA Expression by UniProt/SwissProt for NACA2 Gene:

Q9H009-NACA2_HUMAN
Tissue specificity: Expressed specifically in testis and skeletal muscle.
genes like me logo Genes that share expression patterns with NACA2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NACA2 Gene

Orthologs for NACA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NACA2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia NACA2 30 31
  • 98.91 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia NACA 31
  • 89 (a)
 OneToMany
Dog
(Canis familiaris)
 Mammalia -- 31
  • 81 (a)
 ManyToMany
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 24 (a)
 OneToMany
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 12 (a)
 OneToMany
Mouse
(Mus musculus)
 Mammalia Naca 31
  • 8 (a)
 OneToMany
Chicken
(Gallus gallus)
 Aves -- 31
  • 81 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 85 (a)
 OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia naca.2 30
  • 76.95 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta Nacalpha 31
  • 53 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea Y65B4BR.5 30
  • 59.26 (n)
icd-2 31
  • 51 (a)
 OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes EGD2 31
  • 33 (a)
 OneToMany
Rice
(Oryza sativa)
 Liliopsida Os01g0698900 30
  • 59.18 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.1556 31
  • 71 (a)
 OneToMany
Species where no ortholog for NACA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for NACA2 Gene

ENSEMBL:
Gene Tree for NACA2 (if available)
TreeFam:
Gene Tree for NACA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NACA2: view image

Paralogs for NACA2 Gene

Paralogs for NACA2 Gene

(3) SIMAP similar genes for NACA2 Gene using alignment to 1 proteins:

  • NACA2_HUMAN

Pseudogenes.org Pseudogenes for NACA2 Gene

genes like me logo Genes that share paralogs with NACA2: view

Variants for NACA2 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NACA2 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs17531723 - p.Val64Ile

Additional dbSNP identifiers (rs#s) for NACA2 Gene

Variation tolerance for NACA2 Gene

Residual Variation Intolerance Score: 82.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.72; 96.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NACA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NACA2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NACA2 Gene

Disorders for NACA2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for NACA2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
scleral staphyloma
  • scleral ectasia
melon allergy
  • cucumis melo fruit allergy
laryngeal tuberculosis
  • tuberculosis, laryngeal
peach allergy
  • prunus persica fruit allergy
- elite association - COSMIC cancer census association via MalaCards
Search NACA2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NACA2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with NACA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NACA2 Gene

Publications for NACA2 Gene

  1. Characterization of a novel isoform of alpha-nascent polypeptide-associated complex as IgE-defined autoantigen. (PMID: 12406326) Mossabeb R … Valenta R (The Journal of investigative dermatology 2002) 2 3 4
  2. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J … Grant SF (BMC medical genetics 2010) 3 41
  3. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 41
  4. Emergence of young human genes after a burst of retroposition in primates. (PMID: 16201836) Marques AC … Kaessmann H (PLoS biology 2005) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

ExternalLinks

View latest publications for NACA2 gene in Mastermind

Products for NACA2 Gene

Sources for NACA2 Gene