Aliases for NACA Gene
External Ids for NACA Gene
Previous GeneCards Identifiers for NACA Gene
This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of this gene on different chromosomes. [provided by RefSeq, Feb 2016]
GeneCards Summary for NACA Gene
NACA (Nascent Polypeptide Associated Complex Subunit Alpha) is a Protein Coding gene. Diseases associated with NACA include Skeletal Muscle Neoplasm and Juvenile Myelomonocytic Leukemia. Among its related pathways are ERK Signaling and Parathyroid hormone synthesis, secretion and action. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and TBP-class protein binding. An important paralog of this gene is NACAD.
UniProtKB/Swiss-Prot Summary for NACA Gene
Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity).
Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.