Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008] See more...

Aliases for NABP2 Gene

Aliases for NABP2 Gene

  • Nucleic Acid Binding Protein 2 2 3 5
  • Sensor Of Single-Strand DNA Complex Subunit B1 2 3 4
  • SOSS-B1 2 3 4
  • HSSB1 2 3 4
  • SSB1 2 3 4
  • Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 2B 3 4
  • Oligonucleotide/Oligosaccharide-Binding Fold Containing 2B 2 3
  • Single-Stranded DNA-Binding Protein 1 3 4
  • Single Strand DNA-Binding Protein 1 2 3
  • Sensor Of SsDNA Subunit B1 3 4
  • SOSS Complex Subunit B1 3 4
  • OBFC2B 3 4
  • Nucleic Acid-Binding Protein 2 4
  • MGC2731 2
  • LP3587 3
  • NABP2 5

External Ids for NABP2 Gene

Previous HGNC Symbols for NABP2 Gene

  • OBFC2B

Previous GeneCards Identifiers for NABP2 Gene

  • GC12P056616

Summaries for NABP2 Gene

Entrez Gene Summary for NABP2 Gene

  • Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]

GeneCards Summary for NABP2 Gene

NABP2 (Nucleic Acid Binding Protein 2) is a Protein Coding gene. Diseases associated with NABP2 include Brachydactyly, Type E1. Among its related pathways are Gene Expression and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and single-stranded DNA binding. An important paralog of this gene is NABP1.

UniProtKB/Swiss-Prot Summary for NABP2 Gene

  • Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

Additional gene information for NABP2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NABP2 Gene

Genomics for NABP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NABP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NABP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NABP2

Genomic Locations for NABP2 Gene

Genomic Locations for NABP2 Gene
chr12:56,222,012-56,229,858
(GRCh38/hg38)
Size:
7,847 bases
Orientation:
Plus strand
chr12:56,615,799-56,623,638
(GRCh37/hg19)
Size:
7,840 bases
Orientation:
Plus strand

Genomic View for NABP2 Gene

Genes around NABP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NABP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NABP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NABP2 Gene

Proteins for NABP2 Gene

  • Protein details for NABP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ15-SOSB1_HUMAN
    Recommended name:
    SOSS complex subunit B1
    Protein Accession:
    Q9BQ15
    Secondary Accessions:
    • A6NDF8
    • Q6XYC8

    Protein attributes for NABP2 Gene

    Size:
    211 amino acids
    Molecular mass:
    22338 Da
    Quaternary structure:
    • Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1. Directly interacts with ATM, SOSS-A/INTS3 and RAD51. Interacts with INTS7.
    SequenceCaution:
    • Sequence=AAP34465.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NABP2 Gene

    Alternative splice isoforms for NABP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NABP2 Gene

Post-translational modifications for NABP2 Gene

  • Phosphorylated by ATM in response to DNA damage. Phosphorylation prevents degradation by the proteasome, hence stabilization of the protein and accumulation within cells.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NABP2 Gene

Domains & Families for NABP2 Gene

Gene Families for NABP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NABP2 Gene

InterPro:
Blocks:
  • OB-fold nucleic acid binding domain
ProtoNet:

Suggested Antigen Peptide Sequences for NABP2 Gene

GenScript: Design optimal peptide antigens:
  • Single-stranded DNA-binding protein 1 (SOSB1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BQ15

UniProtKB/Swiss-Prot:

SOSB1_HUMAN :
  • Belongs to the SOSS-B family. SOSS-B1 subfamily.
Family:
  • Belongs to the SOSS-B family. SOSS-B1 subfamily.
genes like me logo Genes that share domains with NABP2: view

Function for NABP2 Gene

Molecular function for NABP2 Gene

UniProtKB/Swiss-Prot Function:
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

Phenotypes From GWAS Catalog for NABP2 Gene

Gene Ontology (GO) - Molecular Function for NABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IBA 21873635
GO:0003697 single-stranded DNA binding IDA 18449195
GO:0005515 protein binding IPI 18449195
GO:0061730 NOT C-rich strand telomeric DNA binding IDA 25589350
genes like me logo Genes that share ontologies with NABP2: view
genes like me logo Genes that share phenotypes with NABP2: view

Animal Models for NABP2 Gene

MGI Knock Outs for NABP2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NABP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NABP2 Gene

Localization for NABP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NABP2 Gene

Nucleus. Note=Localizes to nuclear foci following DNA damage. Foci formation is not cell-cycle dependent. Partial colocalization with RAD51 after ionizing radiation treatment.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NABP2 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 1
mitochondrion 1
plasma membrane 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region IBA,IDA 25589350
GO:0005634 nucleus IEA,IDA 18449195
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol IDA --
GO:0070876 SOSS complex IBA,IDA 18449195
genes like me logo Genes that share ontologies with NABP2: view

Pathways & Interactions for NABP2 Gene

genes like me logo Genes that share pathways with NABP2: view

Pathways by source for NABP2 Gene

2 BioSystems pathways for NABP2 Gene
2 Reactome pathways for NABP2 Gene

Gene Ontology (GO) - Biological Process for NABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IBA,IMP 19605351
GO:0006281 DNA repair ISS --
GO:0006974 cellular response to DNA damage stimulus IMP 18449195
GO:0007093 mitotic cell cycle checkpoint IBA,IMP 19683501
GO:0010212 response to ionizing radiation IBA,IMP 19605351
genes like me logo Genes that share ontologies with NABP2: view

No data available for SIGNOR curated interactions for NABP2 Gene

Drugs & Compounds for NABP2 Gene

No Compound Related Data Available

Transcripts for NABP2 Gene

mRNA/cDNA for NABP2 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NABP2

Alternative Splicing Database (ASD) splice patterns (SP) for NABP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2: -
SP3:
SP4: - - - -
SP5:
SP6: - - - - -

Relevant External Links for NABP2 Gene

GeneLoc Exon Structure for
NABP2

Expression for NABP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NABP2 Gene

Protein differential expression in normal tissues from HIPED for NABP2 Gene

This gene is overexpressed in Fetal testis (31.7), Lymph node (26.4), and Fetal heart (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NABP2 Gene



Protein tissue co-expression partners for NABP2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NABP2

SOURCE GeneReport for Unigene cluster for NABP2 Gene:

Hs.240170

Evidence on tissue expression from TISSUES for NABP2 Gene

  • Skin(4.3)
  • Lung(4.2)
  • Muscle(2.2)
  • Nervous system(2.2)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with NABP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NABP2 Gene

Orthologs for NABP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NABP2 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia NABP2 30 31
  • 92.58 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NABP2 30 31
  • 92.26 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nabp2 30
  • 87.99 (n)
Mouse
(Mus musculus)
Mammalia Nabp2 30 17 31
  • 87.52 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NABP2 31
  • 74 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nabp2 30
  • 68.47 (n)
Str.11818 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.15476 30
Zebrafish
(Danio rerio)
Actinopterygii LOC101882738 30
  • 67.35 (n)
NABP2 31
  • 63 (a)
OneToOne
wufc60e10 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG5181 31
  • 38 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea C06G3.8 31
  • 35 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 50 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.4773 30
Species where no ortholog for NABP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for NABP2 Gene

ENSEMBL:
Gene Tree for NABP2 (if available)
TreeFam:
Gene Tree for NABP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NABP2: view image

Paralogs for NABP2 Gene

Paralogs for NABP2 Gene

(1) SIMAP similar genes for NABP2 Gene using alignment to 3 proteins:

  • SOSB1_HUMAN
  • C9JMP5_HUMAN
  • C9JT95_HUMAN

Pseudogenes.org Pseudogenes for NABP2 Gene

genes like me logo Genes that share paralogs with NABP2: view

Variants for NABP2 Gene

Additional dbSNP identifiers (rs#s) for NABP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for NABP2 Gene

Variant ID Type Subtype PubMed ID
nsv1051961 CNV gain 25217958
nsv482992 CNV gain+loss 15286789
nsv952186 CNV deletion 24416366

Variation tolerance for NABP2 Gene

Residual Variation Intolerance Score: 31.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NABP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NABP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NABP2 Gene

Disorders for NABP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NABP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
brachydactyly, type e1
  • bde1
- elite association - COSMIC cancer census association via MalaCards
Search NABP2 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with NABP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NABP2 Gene

Publications for NABP2 Gene

  1. A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling. (PMID: 21659603) Cotta-Ramusino C … Elledge SJ (Science (New York, N.Y.) 2011) 3 4
  2. SOSS complexes participate in the maintenance of genomic stability. (PMID: 19683501) Huang J … Chen J (Molecular cell 2009) 3 4
  3. HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. (PMID: 19605351) Li Y … Wang W (The Journal of biological chemistry 2009) 3 4
  4. Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. (PMID: 18449195) Richard DJ … Khanna KK (Nature 2008) 3 4
  5. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3

Products for NABP2 Gene

Sources for NABP2 Gene