Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008] See more...

Aliases for NABP1 Gene

Aliases for NABP1 Gene

  • Nucleic Acid Binding Protein 1 2 3 5
  • Sensor Of Single-Strand DNA Complex Subunit B2 2 3 4
  • Single-Stranded DNA-Binding Protein 2 2 3 4
  • Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 2A 3 4
  • Oligonucleotide/Oligosaccharide-Binding Fold Containing 2A 2 3
  • Sensor Of SsDNA Subunit B2 3 4
  • SOSS Complex Subunit B2 3 4
  • SOSS-B2 3 4
  • OBFC2A 3 4
  • SSB2 3 4
  • Nucleic Acid-Binding Protein 1 4
  • HSSB2 4

External Ids for NABP1 Gene

Previous HGNC Symbols for NABP1 Gene

  • OBFC2A

Previous GeneCards Identifiers for NABP1 Gene

  • GC02P192543

Summaries for NABP1 Gene

Entrez Gene Summary for NABP1 Gene

  • Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]

GeneCards Summary for NABP1 Gene

NABP1 (Nucleic Acid Binding Protein 1) is a Protein Coding gene. Diseases associated with NABP1 include Acute Promyelocytic Leukemia and Cholestasis, Intrahepatic, Of Pregnancy 3. Among its related pathways are Gene Expression and Formation of HIV-1 elongation complex containing HIV-1 Tat. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and single-stranded DNA binding. An important paralog of this gene is NABP2.

UniProtKB/Swiss-Prot Summary for NABP1 Gene

  • Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

Additional gene information for NABP1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NABP1 Gene

Genomics for NABP1 Gene

GeneHancer (GH) Regulatory Elements for NABP1 Gene

Promoters and enhancers for NABP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J191674 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 535.6 +1.0 975 8.4 HNRNPK ZBTB40 SIN3A NRF1 POLR2G SP1 GTF2E2 PHF8 FOS ZNF10 NABP1 lnc-CAVIN2-2 CAVIN2 ENSG00000233766 ENSG00000274845
GH02J191655 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 500.4 -20.9 -20867 3.6 JUND NR2F2 FOS CEBPB ZBTB33 MAFK STAT3 EP300 RFX5 CEBPG NABP1 lnc-CAVIN2-3 lnc-CAVIN2-2
GH02J191617 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 44.1 -56.0 -55968 11 ZNF217 SP1 JUND FOS EP300 TCF7 RELA MEF2C TRIM22 TEAD1 NABP1 STAT4 lnc-NABP1-2 lnc-CAVIN2-3
GH02J191611 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 25.8 -65.5 -65514 1.9 JUND FOS EP300 RCOR1 NFYB BCL11A FOSL2 MAFK IRF4 IKZF1 NABP1 lnc-NABP1-2 RF00017-3388
GH02J191570 Enhancer 1.1 FANTOM5 ENCODE 24.8 -106.4 -106353 1.6 CTCF AFF1 REST TOE1 RAD21 TRIM22 TAF9B HDAC3 NCOR1 RELA NABP1 RF00017-3388 lnc-NABP1-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NABP1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NABP1

Genomic Locations for NABP1 Gene

Genomic Locations for NABP1 Gene
chr2:191,678,068-191,696,664
(GRCh38/hg38)
Size:
18,597 bases
Orientation:
Plus strand
chr2:192,542,794-192,561,385
(GRCh37/hg19)
Size:
18,592 bases
Orientation:
Plus strand

Genomic View for NABP1 Gene

Genes around NABP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NABP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NABP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NABP1 Gene

Proteins for NABP1 Gene

  • Protein details for NABP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AH0-SOSB2_HUMAN
    Recommended name:
    SOSS complex subunit B2
    Protein Accession:
    Q96AH0
    Secondary Accessions:
    • Q658Y8
    • Q9H5X6

    Protein attributes for NABP1 Gene

    Size:
    204 amino acids
    Molecular mass:
    22423 Da
    Quaternary structure:
    • Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1.

    Alternative splice isoforms for NABP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NABP1 Gene

Post-translational modifications for NABP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NABP1 Gene

Domains & Families for NABP1 Gene

Gene Families for NABP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NABP1 Gene

Blocks:
  • C2 domain
  • OB-fold nucleic acid binding domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NABP1 Gene

GenScript: Design optimal peptide antigens:
  • Single-stranded DNA-binding protein 2 (SOSB2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96AH0

UniProtKB/Swiss-Prot:

SOSB2_HUMAN :
  • Belongs to the SOSS-B family. SOSS-B2 subfamily.
Family:
  • Belongs to the SOSS-B family. SOSS-B2 subfamily.
genes like me logo Genes that share domains with NABP1: view

Function for NABP1 Gene

Molecular function for NABP1 Gene

UniProtKB/Swiss-Prot Function:
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

Phenotypes From GWAS Catalog for NABP1 Gene

Gene Ontology (GO) - Molecular Function for NABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA 21873635
GO:0003697 single-stranded DNA binding ISS,IEA --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 19683501
genes like me logo Genes that share ontologies with NABP1: view
genes like me logo Genes that share phenotypes with NABP1: view

Human Phenotype Ontology for NABP1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NABP1 Gene

MGI Knock Outs for NABP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NABP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NABP1 Gene

Localization for NABP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NABP1 Gene

Nucleus. Note=Localizes to nuclear foci following DNA damage.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NABP1 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region ISS,IEA --
GO:0005634 nucleus IDA,IEA 19683501
GO:0005654 nucleoplasm IDA,TAS --
GO:0005829 cytosol IDA --
GO:0070876 SOSS complex IDA,IBA 18449195
genes like me logo Genes that share ontologies with NABP1: view

Pathways & Interactions for NABP1 Gene

genes like me logo Genes that share pathways with NABP1: view

Pathways by source for NABP1 Gene

2 Reactome pathways for NABP1 Gene

Gene Ontology (GO) - Biological Process for NABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IMP 19605351
GO:0006281 DNA repair IMP 19683501
GO:0006974 cellular response to DNA damage stimulus IMP 19683501
GO:0007093 mitotic cell cycle checkpoint IMP,IBA 19683501
GO:0010212 response to ionizing radiation IBA,IMP 19605351
genes like me logo Genes that share ontologies with NABP1: view

No data available for SIGNOR curated interactions for NABP1 Gene

Drugs & Compounds for NABP1 Gene

No Compound Related Data Available

Transcripts for NABP1 Gene

mRNA/cDNA for NABP1 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NABP1

Alternative Splicing Database (ASD) splice patterns (SP) for NABP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f
SP1: - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - -
SP9: -
SP10: - - - - -
SP11:
SP12: -

Relevant External Links for NABP1 Gene

GeneLoc Exon Structure for
NABP1

Expression for NABP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NABP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NABP1 Gene

This gene is overexpressed in Whole Blood (x7.0) and Spleen (x4.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NABP1

SOURCE GeneReport for Unigene cluster for NABP1 Gene:

Hs.591610

Evidence on tissue expression from TISSUES for NABP1 Gene

  • Intestine(4.3)
  • Bone marrow(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for NABP1 Gene

Germ Layers:
  • mesoderm
Systems:
  • immune
  • lymphatic
Regions:
General:
  • blood
  • bone marrow
  • white blood cell
genes like me logo Genes that share expression patterns with NABP1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for NABP1 Gene

Orthologs for NABP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NABP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OBFC2A 31 30
  • 99.84 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NABP1 31 30
  • 91.83 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nabp1 17 31 30
  • 88.72 (n)
rat
(Rattus norvegicus)
Mammalia Nabp1 30
  • 87.88 (n)
oppossum
(Monodelphis domestica)
Mammalia NABP1 31
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NABP1 31
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NABP1 31
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves OBFC2A 30
  • 74.3 (n)
NABP1 31
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 69 (a)
OneToMany
-- 31
  • 52 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii nabp1a 31 30
  • 65.18 (n)
OneToMany
nabp1b 31
  • 52 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2385 30
fruit fly
(Drosophila melanogaster)
Insecta CG5181 31
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C06G3.8 31
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 50 (a)
OneToMany
Species where no ortholog for NABP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NABP1 Gene

ENSEMBL:
Gene Tree for NABP1 (if available)
TreeFam:
Gene Tree for NABP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NABP1: view image

Paralogs for NABP1 Gene

Paralogs for NABP1 Gene

(1) SIMAP similar genes for NABP1 Gene using alignment to 3 proteins:

  • SOSB2_HUMAN
  • F8WAF5_HUMAN
  • H7C0W4_HUMAN
genes like me logo Genes that share paralogs with NABP1: view

Variants for NABP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NABP1 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs12612256 - p.Thr154Ser

Additional dbSNP identifiers (rs#s) for NABP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NABP1 Gene

Variant ID Type Subtype PubMed ID
nsv834494 CNV gain 17160897

Variation tolerance for NABP1 Gene

Residual Variation Intolerance Score: 40.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NABP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NABP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NABP1 Gene

Disorders for NABP1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NABP1 Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
acute promyelocytic leukemia
  • apl
cholestasis, intrahepatic, of pregnancy 3
  • icp3
acute stress disorder
  • traumatic stress disorder
- elite association - COSMIC cancer census association via MalaCards
Search NABP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NABP1

genes like me logo Genes that share disorders with NABP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NABP1 Gene

Publications for NABP1 Gene

  1. HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. (PMID: 19605351) Li Y … Wang W (The Journal of biological chemistry 2009) 3 4 54
  2. SOSS complexes participate in the maintenance of genomic stability. (PMID: 19683501) Huang J … Chen J (Molecular cell 2009) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. DIRC3 and near NABP1 genetic polymorphisms are associated laryngeal squamous cell carcinoma patient survival. (PMID: 27793000) Shen Z … Shao Y (Oncotarget 2016) 3 54
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 54

Products for NABP1 Gene

Sources for NABP1 Gene