NAB1 Gene (Protein Coding)

NGFI-A Binding Protein 1

GC02P190646
GIFtS:
40

Aliases for NAB1 Gene

Aliases for NAB1 Gene

  • NGFI-A Binding Protein 1 2 3 5
  • Transcriptional Regulatory Protein P54 3 4
  • NGFI-A-Binding Protein 1 3 4
  • EGR-1-Binding Protein 1 3 4
  • EGR1 Binding Protein 1 2 3
  • NGFI-A Binding Protein 1 (EGR1 Binding Protein 1) 2

External Ids for NAB1 Gene

Previous GeneCards Identifiers for NAB1 Gene

  • GC02P189718
  • GC02P190226
  • GC02P191477
  • GC02P191716
  • GC02P191339
  • GC02P191222
  • GC02P183373

Summaries for NAB1 Gene

GeneCards Summary for NAB1 Gene

NAB1 (NGFI-A Binding Protein 1) is a Protein Coding gene. Diseases associated with NAB1 include Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive and Charcot-Marie-Tooth Disease, Demyelinating, Type 1D. Among its related pathways are Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include transcription factor binding. An important paralog of this gene is NAB2.

UniProtKB/Swiss-Prot Summary for NAB1 Gene

  • Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2.

Gene Wiki entry for NAB1 Gene

Additional gene information for NAB1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NAB1 Gene

Genomics for NAB1 Gene

GeneHancer (GH) Regulatory Elements for NAB1 Gene

Promoters and enhancers for NAB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAB1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NAB1

Top Transcription factor binding sites by QIAGEN in the NAB1 gene promoter:
  • AML1a
  • ATF-2
  • c-Ets-1
  • CRE-BP1
  • CUTL1
  • HNF-3beta
  • HOXA5
  • LyF-1
  • Msx-1
  • Pax-4a

Genomic Locations for NAB1 Gene

Genomic Locations for NAB1 Gene
chr2:190,646,746-190,692,766
(GRCh38/hg38)
Size:
46,021 bases
Orientation:
Plus strand
chr2:191,511,472-191,557,492
(GRCh37/hg19)
Size:
46,021 bases
Orientation:
Plus strand

Genomic View for NAB1 Gene

Genes around NAB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAB1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NAB1 Gene

Proteins for NAB1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NAB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13506-NAB1_HUMAN
    Recommended name:
    NGFI-A-binding protein 1
    Protein Accession:
    Q13506
    Secondary Accessions:
    • O75383
    • O75384
    • Q6GTU1
    • Q9UEV1

    Protein attributes for NAB1 Gene

    Size:
    487 amino acids
    Molecular mass:
    54401 Da
    Quaternary structure:
    • Homomultimers may associate with EGR1 bound to DNA.

    Three dimensional structures from OCA and Proteopedia for NAB1 Gene

    Alternative splice isoforms for NAB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAB1 Gene

Protein Expression for NAB1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NAB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NAB1 Gene

Domains & Families for NAB1 Gene

Gene Families for NAB1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NAB1 Gene

Blocks:
  • Nab1, C-terminal
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NAB1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ61129, highly similar to NGFI-A-binding protein 1 (B4DKG1_HUMAN)
  • Transcriptional regulatory protein p54 (NAB1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13506

UniProtKB/Swiss-Prot:

NAB1_HUMAN :
  • The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization.
  • Belongs to the NAB family.
Domain:
  • The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization.
  • The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression.
Family:
  • Belongs to the NAB family.
genes like me logo Genes that share domains with NAB1: view

Function for NAB1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for NAB1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2.
GENATLAS Biochemistry:
NGFI-A (nerve growth factor induced clone A) binding protein 1 (EGR1 binding protein) also repressor of EGR2

Phenotypes From GWAS Catalog for NAB1 Gene

Gene Ontology (GO) - Molecular Function for NAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription coregulator activity IEA --
GO:0008134 transcription factor binding IEA --
GO:0140110 transcription regulator activity IEA --
genes like me logo Genes that share ontologies with NAB1: view
genes like me logo Genes that share phenotypes with NAB1: view

Animal Models for NAB1 Gene

MGI Knock Outs for NAB1:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NAB1 Gene

Localization for NAB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAB1 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAB1 gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,NAS 8668170
genes like me logo Genes that share ontologies with NAB1: view

Pathways & Interactions for NAB1 Gene

PathCards logo

SuperPathways for NAB1 Gene

genes like me logo Genes that share pathways with NAB1: view

Pathways by source for NAB1 Gene

1 BioSystems pathway for NAB1 Gene

Gene Ontology (GO) - Biological Process for NAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001958 endochondral ossification IEA --
GO:0006355 regulation of transcription, DNA-templated NAS,IEA 8668170
GO:0014037 Schwann cell differentiation IEA --
GO:0042552 myelination IEA --
GO:0045682 regulation of epidermis development IEA --
genes like me logo Genes that share ontologies with NAB1: view

No data available for SIGNOR curated interactions for NAB1 Gene

Drugs & Compounds for NAB1 Gene

Products:

  1. Drug

(1) Additional Compounds for NAB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NAB1: view

Transcripts for NAB1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for NAB1 Gene

5 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAB1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
SP1: - - -
SP2:
SP3: -
SP4: - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - -
SP8:
SP9: -
SP10: - - - - -

Relevant External Links for NAB1 Gene

GeneLoc Exon Structure for
NAB1

Expression for NAB1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NAB1 Gene

mRNA expression in normal human tissues for NAB1 Gene
mRNA expression by GTEx for NAB1 GenemRNA expression by BioGPS for NAB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAB1 Gene

This gene is overexpressed in Serum (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAB1 Gene



Protein tissue co-expression partners for NAB1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NAB1

SOURCE GeneReport for Unigene cluster for NAB1 Gene:

Hs.107474

mRNA Expression by UniProt/SwissProt for NAB1 Gene:

Q13506-NAB1_HUMAN
Tissue specificity: Isoform Short is found in myeloid leukemia cell line KG-1.

Evidence on tissue expression from TISSUES for NAB1 Gene

  • Nervous system(4.7)
  • Liver(4.3)
  • Pancreas(2.6)
  • Heart(2)
genes like me logo Genes that share expression patterns with NAB1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAB1 Gene

Orthologs for NAB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NAB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia NAB1 31 30
  • 99.59 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia NAB1 31 30
  • 92.2 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia NAB1 31
  • 92 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Nab1 17 31 30
  • 87.7 (n)
rat
(Rattus norvegicus)
 Mammalia Nab1 30
  • 87.6 (n)
dog
(Canis familiaris)
 Mammalia NAB1 31 30
  • 81.14 (n)
 OneToOne
chicken
(Gallus gallus)
 Aves NAB1 31 30
  • 78.33 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia NAB1 31
  • 72 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia nab1 30
  • 71.56 (n)
Str.19373 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.15920 30
zebrafish
(Danio rerio)
 Actinopterygii nab1b 31 30
  • 65.9 (n)
 OneToMany
nab1a 31
  • 51 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta nab 31
  • 22 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea mab-10 31
  • 20 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.6864 31
  • 34 (a)
 OneToMany
Cin.11359 30
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.11359 30
Species where no ortholog for NAB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAB1 Gene

ENSEMBL:
Gene Tree for NAB1 (if available)
TreeFam:
Gene Tree for NAB1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NAB1: view image

Paralogs for NAB1 Gene

Paralogs for NAB1 Gene

(1) SIMAP similar genes for NAB1 Gene using alignment to 10 proteins:

  • NAB1_HUMAN
  • B4DKG1_HUMAN
  • B8ZZS2_HUMAN
  • C9J3V0_HUMAN
  • C9JFF6_HUMAN
  • C9JID4_HUMAN
  • C9JJ42_HUMAN
  • C9JL92_HUMAN
  • F8W8J7_HUMAN
  • H0Y4C5_HUMAN

Pseudogenes.org Pseudogenes for NAB1 Gene

genes like me logo Genes that share paralogs with NAB1: view

Variants for NAB1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Additional dbSNP identifiers (rs#s) for NAB1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NAB1 Gene

Variant ID Type Subtype PubMed ID
dgv1200e212 CNV loss 25503493
esv3584252 CNV loss 25503493
nsv1072472 CNV deletion 25765185
nsv3082 CNV insertion 18451855
nsv834492 CNV gain 17160897

Variation tolerance for NAB1 Gene

Residual Variation Intolerance Score: 8.84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAB1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NAB1 Gene

Disorders for NAB1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NAB1 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search NAB1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NAB1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NAB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAB1 Gene

Publications for NAB1 Gene

  1. NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. (PMID: 8668170) Svaren J … Milbrandt J (Molecular and cellular biology 1996) 2 3 4 23 54
  2. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. (PMID: 21399635) Mells GF … Anderson CA (Nature genetics 2011) 3 41 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 54
  5. NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex. (PMID: 16574654) Srinivasan R … Svaren J (The Journal of biological chemistry 2006) 3 23 54

ExternalLinks

View latest publications for NAB1 gene in Mastermind

Products for NAB1 Gene

Sources for NAB1 Gene