Aliases for NAALAD2 Gene
Aliases for NAALAD2 Gene
External Ids for NAALAD2 Gene
- HGNC: 14526
- Entrez Gene: 10003
- Ensembl: ENSG00000077616
- OMIM: 611636
- UniProtKB: Q9Y3Q0
Previous GeneCards Identifiers for NAALAD2 Gene
- GC11P092197
- GC11P091374
- GC11P090052
- GC11P089555
- GC11P089556
- GC11P089508
- GC11P089867
- GC11P085952
Summaries for NAALAD2 Gene
-
This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The representative member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which is a marker of prostatic carcinomas and is the first to be shown to possess NAALADase activity. NAALADase cleaves N-acetyl-L-aspartate-L-glutamate (NAAG), which is a neuropeptide expressed both in the central nervous systems and in the periphery and is thought to function as a neurotransmitter. The product of this gene is a type II integral membrane protein. Transient transfection of this gene confers both NAALADase and dipetidyl peptidase IV activities to mammalian cells. This gene is highly expressed in ovary and testis as well as within discrete brain areas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
GeneCards Summary for NAALAD2 Gene
NAALAD2 (N-Acetylated Alpha-Linked Acidic Dipeptidase 2) is a Protein Coding gene. Diseases associated with NAALAD2 include Colonic Benign Neoplasm. Among its related pathways are Viral mRNA Translation and Metabolism. Gene Ontology (GO) annotations related to this gene include peptidase activity and serine-type peptidase activity. An important paralog of this gene is FOLH1.
UniProtKB/Swiss-Prot for NAALAD2 Gene
-
Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivate the peptide neurotransmitter N-acetylaspartylglutamate.
Additional gene information for NAALAD2 Gene
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAALAD2 Gene
Genomics for NAALAD2 Gene
GeneHancer (GH) Regulatory Elements for NAALAD2 Gene
Promoters and enhancers for NAALAD2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11I090133 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE | 575.9 | +3.2 | 3227 | 2.1 | FOXA2 THRB ZNF48 ZNF335 GLIS2 RCOR1 SP3 SP5 ZBTB11 ELF1 | NAALAD2 TRIM49C GC11P090149 | |
| GH11I090220 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE | 5.7 | +90.9 | 90873 | 3.3 | ATF1 ARID4B SIN3A DMAP1 ZNF48 YY1 POLR2B GLIS2 ELK1 MXD4 | CHORDC1 ENSG00000280367 NAALAD2 GC11M090194 | |
| GH11I090204 | Enhancer | 0.6 | ENCODE | 5.9 | +73.5 | 73503 | 0.2 | CTCF PKNOX1 ZNF654 TRIM22 CEBPG REST RAD21 ZNF213 ZNF629 SMC3 | NAALAD2 GC11M090194 CHORDC1 ENSG00000280367 | |
| GH11I090746 | Enhancer | 0.2 | ENCODE | 4.9 | +615.6 | 615625 | 1.5 | NAALAD2 ENSG00000280430 GC11M090779 GC11M090778 DISC1FP1 | ||
| GH11I090159 | Enhancer | 0.3 | FANTOM5 | 2.3 | +28.6 | 28633 | 0.4 | NAALAD2 GC11P090149 GC11M090179 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around NAALAD2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for NAALAD2 Gene
Genomic Locations for NAALAD2 Gene
- chr11:90,131,515-90,199,743
- (GRCh38/hg38)
- Size:
- 68,229 bases
- Orientation:
- Plus strand
- chr11:89,864,683-89,926,062
- (GRCh37/hg19)
Genomic View for NAALAD2 Gene
Genes around NAALAD2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q14.3 by Ensembl
- 11q14.3 by Entrez Gene
- 11q14.3 by HGNC
NAALAD2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NAALAD2 Gene
Proteins for NAALAD2 Gene
-
Protein details for NAALAD2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y3Q0-NALD2_HUMAN
- Recommended name:
- N-acetylated-alpha-linked acidic dipeptidase 2
- Protein Accession:
- Q9Y3Q0
- B3KQR4
- Q4KKV4
- Q4VAM9
Protein attributes for NAALAD2 Gene
- Size:
- 740 amino acids
- Molecular mass:
- 83592 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Homodimer.
Three dimensional structures from OCA and Proteopedia for NAALAD2 Gene
Protein Expression for NAALAD2 Gene
Selected DME Specific Peptides for NAALAD2 Gene
- Q9Y3Q0:
-
- FYDPTFK
- EPDRYVILGGHRD
- IEGNYTLRVDCTPL
- ILYSDPADYF
- NDQLMLLER
- LERAFIDPLGLP
- SFDSLFSAV
Post-translational modifications for NAALAD2 Gene
- Glycosylation at isoforms=2111, isoforms=2143, isoforms=2185, isoforms=314, Asn449, isoforms=603, and isoforms=628
Other Protein References for NAALAD2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for NAALAD2 (NAALADase-2/NAALAD2)
- Novus Biologicals Antibodies for NAALAD2
- Invitrogen Antibodies for NAALAD2
- antibodies-online: Search results for 5 available NAALAD2 Antibodies ranked by validation data
- Compare Top NAALAD2 Antibodies
-
Quality Products:
- Search GeneTex for Antibodies for NAALAD2
Protein Products
- R&D Systems Proteins and Enzymes for NAALAD2 (NAALADase-2/NAALAD2)
-
OriGene Purified Proteins for NAALAD2
- Search Origene for MassSpec and Protein Over-expression Lysates for NAALAD2
- Origene Custom Protein Services for NAALAD2
- antibodies-online: Search results for 6 available NAALAD2 Proteins ranked by validation data
- Compare Top NAALAD2 Proteins
-
Quality Products:
- Search GeneTex for Proteins for NAALAD2
Assay Products
- antibodies-online: Search results for 2 available NAALAD2 Elisa Kits ranked by validation data
- Compare Top NAALAD2 Elisa Kits
-
Quality Products:
Domains & Families for NAALAD2 Gene
Gene Families for NAALAD2 Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for NAALAD2 Gene
Suggested Antigen Peptide Sequences for NAALAD2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y3Q0UniProtKB/Swiss-Prot:
NALD2_HUMAN :- The NAALADase activity is found in the central region, the dipeptidyl peptidase IV type activity in the C-terminal.
- Belongs to the peptidase M28 family. M28B subfamily.
- Domain:
-
- The NAALADase activity is found in the central region, the dipeptidyl peptidase IV type activity in the C-terminal.
- Family:
-
- Belongs to the peptidase M28 family. M28B subfamily.
Function for NAALAD2 Gene
Molecular function for NAALAD2 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by quisqualate.
- UniProtKB/Swiss-Prot Function:
- Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivate the peptide neurotransmitter N-acetylaspartylglutamate.
Enzyme Numbers (IUBMB) for NAALAD2 Gene
Phenotypes From GWAS Catalog for NAALAD2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004180 | carboxypeptidase activity | NAS | 10085079 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008236 | serine-type peptidase activity | NAS | 10085079 |
| GO:0008237 | metallopeptidase activity | IEA | -- |
| GO:0008239 | dipeptidyl-peptidase activity | NAS | 10085079 |
Phenotypes for NAALAD2 Gene
- GenomeRNAi human phenotypes for NAALAD2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for NAALAD2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for NAALAD2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NAALAD2 gene
- Search ViGene Biosciences for NAALAD2
CRISPR Products
-
OriGene CRISPR knockouts for NAALAD2
- genomics-online: gRNA clones - Search results for 79 available NAALAD2 gene related products
- Overview of 79 available NAALAD2 gene related products
- Applied Biological Materials CRISPR for NAALAD2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NAALAD2
- GenScript: Design CRISPR guide RNA sequences for NAALAD2
miRNA for NAALAD2 Gene
- miRTarBase miRNAs that target NAALAD2
miRNA Products
- Search ViGene Biosciences for NAALAD2
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for NAALAD2
- Browse OriGene Inhibitory RNA Products For NAALAD2
- genomics-online: shRNA clones - Search results for 79 available NAALAD2 gene related products
- Overview of 79 available NAALAD2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NAALAD2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NAALAD2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NAALAD2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NAALAD2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for NAALAD2
-
ViGene Biosciences adenoviral particle packaged cDNA for NAALAD2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for NAALAD2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NAALAD2 gene
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAALAD2 Gene
Localization for NAALAD2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NAALAD2 Gene
- Cell membrane; Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 3 |
| endoplasmic reticulum | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | NAS | 10085079 |
Pathways & Interactions for NAALAD2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Amino acid synthesis and interconversion (transamination) | ||
| 2 | Metabolism |
.37
|
|
| 3 | Viral mRNA Translation | ||
Pathways by source for NAALAD2 Gene
3 Reactome pathways for NAALAD2 Gene
Interacting Proteins for NAALAD2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | NAS | 10085079 |
| GO:0008152 | metabolic process | IEA | -- |
| GO:0008652 | cellular amino acid biosynthetic process | TAS | -- |
| GO:0042135 | neurotransmitter catabolic process | IEA | -- |
No data available for SIGNOR curated interactions for NAALAD2 Gene
Transcripts for NAALAD2 Gene
mRNA/cDNA for NAALAD2 Gene
- (6) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (52) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NAALAD2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for NAALAD2
- genomics-online: gRNA clones - Search results for 79 available NAALAD2 gene related products
- Overview of 79 available NAALAD2 gene related products
- Applied Biological Materials CRISPR for NAALAD2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NAALAD2
- GenScript: Design CRISPR guide RNA sequences for NAALAD2
miRNA Products
- Search ViGene Biosciences for NAALAD2
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for NAALAD2
- Browse OriGene Inhibitory RNA Products For NAALAD2
- genomics-online: shRNA clones - Search results for 79 available NAALAD2 gene related products
- Overview of 79 available NAALAD2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NAALAD2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NAALAD2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NAALAD2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NAALAD2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
| ExUns: | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | |||||||||
| SP3: | |||||||||
| SP4: | - | - | - | - | |||||
| SP5: | |||||||||
| SP6: | |||||||||
| SP7: |
Expression for NAALAD2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Heart (Cardiovascular System)
- Mature Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Mature Cardiac Fibroblasts Myocardium
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Testis (Reproductive System)
- Spermatid Seminiferous Tubules
-
Gonad
- Spermatid Seminiferous Tubules
- Trophoblast (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for NAALAD2 Gene
This gene is overexpressed in Pituitary (x6.1).
This gene is overexpressed in Fetal ovary (16.1), Ovary (14.3), Testis (11.1), Prostate (6.9), and Stomach (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAALAD2 Gene
NURSA nuclear receptor signaling pathways regulating expression of NAALAD2 Gene:
NAALAD2SOURCE GeneReport for Unigene cluster for NAALAD2 Gene:
Hs.503560mRNA Expression by UniProt/SwissProt for NAALAD2 Gene:
Q9Y3Q0-NALD2_HUMAN
Tissue specificity:
Highest expression in the testis. Also found in ovary and spleen. Weak expression in prostate, heart and placenta. In brain, expressed in striatum, parietal cortex and ventral striatum with lower levels in hippocampus, brain stem, putamen and superior colliculus.
Evidence on tissue expression from TISSUES for NAALAD2 Gene
- Heart(5)
Primer Products
-
OriGene qPCR primer pairs for NAALAD2
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NAALAD2 Gene
Orthologs for NAALAD2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NAALAD2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | NAALAD2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | NAALAD2 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Naalad2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Naalad2 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | NAALAD2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | NAALAD2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NAALAD2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | NAALAD2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | naalad2 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.15462 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | naalad2 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | R57.1 33 |
|
||
| gcp-2.1 34 |
|
ManyToMany | |||
| C35C5.2 35 |
|
|
|||
| gcp-2.2 34 |
|
ManyToMany | |||
| gcp-2.3 34 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | VPS70 34 36 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT5G19740 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os01g0740500 33 |
|
||
| Os.18145 33 |
|
||||
| barley (Hordeum vulgare) |
Liliopsida | Hv.3035 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU06285 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPBC354.09c 33 |
|
- Species where no ortholog for NAALAD2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for NAALAD2 Gene
(4) SIMAP similar genes for NAALAD2 Gene using alignment to 9 proteins:
Pseudogenes.org Pseudogenes for NAALAD2 Gene
Variants for NAALAD2 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000023553 | -- | 90,153,149(+) | T/A | intron_variant | |
| rs1000077237 | -- | 90,153,507(+) | C/T | intron_variant | |
| rs1000088064 | -- | 90,180,808(+) | A/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000125896 | -- | 90,158,549(+) | A/G | intron_variant | |
| rs1000166742 | -- | 90,192,411(+) | G/A | 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv555833 | CNV | loss | 21841781 |
| nsv555832 | CNV | gain | 21841781 |
| nsv555831 | CNV | loss | 21841781 |
| nsv555830 | CNV | loss | 21841781 |
| nsv468787 | CNV | loss | 19166990 |
| nsv1138061 | CNV | deletion | 24896259 |
| nsv1119422 | CNV | insertion | 24896259 |
| nsv1116681 | CNV | tandem duplication | 24896259 |
| nsv1111059 | CNV | tandem duplication | 24896259 |
| nsv1054560 | CNV | loss | 25217958 |
| nsv1048624 | CNV | loss | 25217958 |
| nsv1048042 | CNV | loss | 25217958 |
| nsv1036092 | CNV | loss | 25217958 |
| nsv1035213 | CNV | gain | 25217958 |
| esv3892056 | CNV | gain+loss | 25118596 |
| esv3627188 | CNV | loss | 21293372 |
| esv3579993 | CNV | gain | 25503493 |
| esv3579841 | CNV | loss | 25503493 |
| esv3548126 | CNV | deletion | 23714750 |
| esv3331098 | CNV | insertion | 20981092 |
| esv3307873 | CNV | mobile element insertion | 20981092 |
| esv2759849 | CNV | gain+loss | 17122850 |
| esv1511526 | CNV | insertion | 17803354 |
| dgv687n106 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.45;
85.71% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NAALAD2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NAALAD2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAALAD2 Gene
Disorders for NAALAD2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| colonic benign neoplasm |
|
|
Search NAALAD2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NAALAD2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for NAALAD2 Gene
Publications for NAALAD2 Gene
- Isolation and expression of novel human glutamate carboxypeptidases with N-acetylated alpha-linked acidic dipeptidase and dipeptidyl peptidase IV activity. (PMID: 10085079) Pangalos MN … Gordon RD (The Journal of biological chemistry 1999) 2 3 4 22 58
- Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. (PMID: 21738478) Okada Y … Kamatani N (PLoS genetics 2011) 3 44 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III. (PMID: 19678840) Hlouchova K … Lubkowski J (The FEBS journal 2009) 3 4 58
- Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
Products for NAALAD2 Gene
- R&D Systems Antibodies for NAALAD2 (NAALADase-2/NAALAD2)
- R&D Systems Proteins and Enzymes for NAALAD2 (NAALADase-2/NAALAD2)
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for NAALAD2
- Search Origene for MassSpec and Protein Over-expression Lysates for NAALAD2
- Origene Custom Protein Services for NAALAD2
- Origene shrna and RNAi products in human, mouse, rat for NAALAD2
- Browse OriGene Inhibitory RNA Products For NAALAD2
- OriGene qPCR primer pairs for NAALAD2
- OriGene CRISPR knockouts for NAALAD2
- OriGene ORF clones in human for NAALAD2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NAALAD2
- GenScript: Next-day shipping of latest version cDNA ORF clones for NAALAD2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for NAALAD2
- GenScript Custom Assay Services for NAALAD2
- GenScript Custom overexpressing Cell Line Services for NAALAD2
- GenScript: Design CRISPR guide RNA sequences for NAALAD2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for NAALAD2
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for NAALAD2
- Novus Biologicals lysates and proteins for NAALAD2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for NAALAD2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for NAALAD2
- VectorBuilder custom plasmid, inducible vectors for NAALAD2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NAALAD2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 5 available NAALAD2 Antibodies ranked by validation data
- Compare Top NAALAD2 Antibodies
- Quality Products:
- antibodies-online: Search results for 2 available NAALAD2 Elisa Kits ranked by validation data
- Compare Top NAALAD2 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 6 available NAALAD2 Proteins ranked by validation data
- Compare Top NAALAD2 Proteins
- Quality Products:
- Search GeneTex for Antibodies for NAALAD2
- Search GeneTex for Proteins for NAALAD2
- ViGene Biosciences adenoviral particle packaged cDNA for NAALAD2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for NAALAD2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for NAALAD2 gene
- Search ViGene Biosciences for NAALAD2
- Horizon Cell Lines for NAALAD2
- genomics-online: cdna clones - Search results for 79 available NAALAD2 gene related products
- Overview of 79 available NAALAD2 gene related products
- orf clones - Search results for 79 available NAALAD2 gene related products
- Overview of 79 available NAALAD2 gene related products
- genomics-online: gRNA clones - Search results for 79 available NAALAD2 gene related products
- Overview of 79 available NAALAD2 gene related products
- genomics-online: primer clones - Search results for 79 available NAALAD2 gene related products
- Overview of 79 available NAALAD2 gene related products
- genomics-online: shRNA clones - Search results for 79 available NAALAD2 gene related products
- Overview of 79 available NAALAD2 gene related products
Sources for NAALAD2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew