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This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The representative member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which is a marker of prostatic carcinomas and is the first to be shown to possess NAALADase activity. NAALADase cleaves N-acetyl-L-aspartate-L-glutamate (NAAG), which is a... See more...
Aliases for NAALAD2 Gene
Aliases for NAALAD2 Gene
External Ids for NAALAD2 Gene
- HGNC: 14526
- Entrez Gene: 10003
- Ensembl: ENSG00000077616
- OMIM: 611636
- UniProtKB: Q9Y3Q0
Previous GeneCards Identifiers for NAALAD2 Gene
- GC11P092197
- GC11P091374
- GC11P090052
- GC11P089555
- GC11P089556
- GC11P089508
- GC11P089867
- GC11P085952
Summaries for NAALAD2 Gene
-
This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The representative member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which is a marker of prostatic carcinomas and is the first to be shown to possess NAALADase activity. NAALADase cleaves N-acetyl-L-aspartate-L-glutamate (NAAG), which is a neuropeptide expressed both in the central nervous systems and in the periphery and is thought to function as a neurotransmitter. The product of this gene is a type II integral membrane protein. Transient transfection of this gene confers both NAALADase and dipetidyl peptidase IV activities to mammalian cells. This gene is highly expressed in ovary and testis as well as within discrete brain areas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
GeneCards Summary for NAALAD2 Gene
NAALAD2 (N-Acetylated Alpha-Linked Acidic Dipeptidase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Amino acid synthesis and interconversion (transamination). Gene Ontology (GO) annotations related to this gene include peptidase activity and serine-type peptidase activity. An important paralog of this gene is FOLH1.
UniProtKB/Swiss-Prot Summary for NAALAD2 Gene
-
Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivates the peptide neurotransmitter N-acetylaspartylglutamate.
Additional gene information for NAALAD2 Gene
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NAALAD2 Gene
Genomics for NAALAD2 Gene
GeneHancer (GH) Regulatory Elements for NAALAD2 Gene
Promoters and enhancers for NAALAD2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11J090133 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE CraniofacialAtlas | 525.8 | +3.6 | 3627 | 2.9 | MYC POLR2G TEAD4 ZIC2 ZNF423 SAP30 HDAC2 POLR2A KMT2B SIN3A | NAALAD2 TRIM49C piR-39098-040 | |
| GH11J090132 | Enhancer | 0.2 | Ensembl | 500.7 | +0.6 | 586 | 0.2 | NAALAD2 piR-39098-040 | ||
| GH11J090220 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 5.7 | +90.8 | 90786 | 4.6 | ZBTB40 SIN3A NRF1 POLR2G PHF8 ZFX POLR2A ZBTB11 ZBTB26 SAP30 | CHORDC1 GU134617 ENSG00000280367 lnc-NAALAD2-3 lnc-TRIM49D1-2 NAALAD2 TRIM49C lnc-CHORDC1-1 | |
| GH11J090204 | Enhancer | 0.7 | Ensembl ENCODE | 5.9 | +73.9 | 73856 | 1.3 | CTCF REST RAD21 SMC3 CEBPG ZNF213 ZNF654 ZNF143 PKNOX1 ZNF629 | NAALAD2 lnc-CHORDC1-1 lnc-TRIM49D1-2 CHORDC1 | |
| GH11J090139 | Enhancer | 0.2 | Ensembl | 25.5 | +7.9 | 7886 | 0.4 | NAALAD2 CHORDC1 piR-39098-040 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NAALAD2 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NAALAD2
- Top Transcription factor binding sites by QIAGEN in the NAALAD2 gene promoter:
-
- CUTL1
- FOXD1
- FOXD3
- Meis-1
- Meis-1a
- Meis-1b
- NCX
- Pax-2
- Pax-2a
- Pax-2b
Genomic Locations for NAALAD2 Gene
Genomic Locations for NAALAD2 Gene
- chr11:90,131,515-90,199,743
- (GRCh38/hg38)
- Size:
- 68,229 bases
- Orientation:
- Plus strand
- chr11:89,864,683-89,926,062
- (GRCh37/hg19)
- Size:
- 61,380 bases
- Orientation:
- Plus strand
Genomic View for NAALAD2 Gene
Genes around NAALAD2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q14.3 by HGNC
- 11q14.3 by Entrez Gene
- 11q14.3 by Ensembl
NAALAD2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NAALAD2 Gene
Proteins for NAALAD2 Gene
-
Protein details for NAALAD2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y3Q0-NALD2_HUMAN
- Recommended name:
- N-acetylated-alpha-linked acidic dipeptidase 2
- Protein Accession:
- Q9Y3Q0
- B3KQR4
- Q4KKV4
- Q4VAM9
Protein attributes for NAALAD2 Gene
- Size:
- 740 amino acids
- Molecular mass:
- 83592 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Homodimer.
Three dimensional structures from OCA and Proteopedia for NAALAD2 Gene
Protein Expression for NAALAD2 Gene
Selected DME Specific Peptides for NAALAD2 Gene
- Q9Y3Q0:
-
- FYDPTFK
- EPDRYVILGGHRD
- IEGNYTLRVDCTPL
- ILYSDPADYF
- NDQLMLLER
- LERAFIDPLGLP
- SFDSLFSAV
Post-translational modifications for NAALAD2 Gene
Other Protein References for NAALAD2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-NAALAD2 monoclonal antibody
- Creative Biolabs Mouse Anti-NAALAD2 Recombinant Antibody (CBWJN-1149)
- Novus Biologicals Antibodies for NAALAD2
- Invitrogen Antibodies for NAALAD2 (AFLGC-NAALAD2)
- antibodies-online: Show 5 available NAALAD2 Antibodies ranked by validation data
- Compare Top NAALAD2 Antibodies
-
Quality Products:
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for NAALAD2
- Origene Custom Protein Services for NAALAD2
- antibodies-online: Show 6 available NAALAD2 Proteins ranked by validation data
- Compare Top NAALAD2 Proteins
-
Quality Products:
Assay Products
- antibodies-online: Show 4 available NAALAD2 Elisa Kits ranked by validation data
- Compare Top NAALAD2 Elisa Kits
-
Quality Products:
Domains & Families for NAALAD2 Gene
Gene Families for NAALAD2 Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for NAALAD2 Gene
- Blocks:
-
- Protease-associated PA
- Transferrin receptor-like dimerisation domain
- Peptidase family M28
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for NAALAD2 Gene
- GenScript: Design optimal peptide antigens:
-
- N-acetylated-alpha-linked acidic dipeptidase II (NALD2_HUMAN)
- NAALAD2 protein (Q4G181_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y3Q0UniProtKB/Swiss-Prot:
NALD2_HUMAN :- The NAALADase activity is found in the central region, the dipeptidyl peptidase IV type activity in the C-terminal.
- Belongs to the peptidase M28 family. M28B subfamily.
- Domain:
-
- The NAALADase activity is found in the central region, the dipeptidyl peptidase IV type activity in the C-terminal.
- Family:
-
- Belongs to the peptidase M28 family. M28B subfamily.
Function for NAALAD2 Gene
Molecular function for NAALAD2 Gene
- UniProtKB/Swiss-Prot Function:
- Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivates the peptide neurotransmitter N-acetylaspartylglutamate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates.; EC=3.4.17.21;.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by quisqualate.
Enzyme Numbers (IUBMB) for NAALAD2 Gene
Phenotypes From GWAS Catalog for NAALAD2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004180 | carboxypeptidase activity | IBA,NAS | 10085079 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008236 | serine-type peptidase activity | NAS | 10085079 |
| GO:0008237 | metallopeptidase activity | IEA | -- |
| GO:0008239 | dipeptidyl-peptidase activity | NAS | 10085079 |
Phenotypes for NAALAD2 Gene
- GenomeRNAi human phenotypes for NAALAD2:
Animal Model Products
-
Taconic Biosciences Mouse Models for NAALAD2
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NAALAD2 - Select products 50% OFF >
- * NAALAD2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NAALAD2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NAALAD2
- genomics-online: gRNA clones - Search for available NAALAD2 gRNA products
- Overview of 58 available NAALAD2 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for NAALAD2
miRNA for NAALAD2 Gene
- miRTarBase miRNAs that target NAALAD2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NAALAD2
- Browse OriGene Inhibitory RNA Products For NAALAD2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAALAD2
- genomics-online: shRNA clones - Search for available NAALAD2 shRNA products
- Overview of 58 available NAALAD2 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for NAALAD2 - Select products 50% OFF >
- * NAALAD2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for NAALAD2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NAALAD2
Cell Line Products
-
Horizon Cell Lines for NAALAD2
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAALAD2 Gene
Localization for NAALAD2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NAALAD2 Gene
- Cell membrane; Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| nucleus | 3 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| golgi apparatus | 0 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | NAS | 10085079 |
Pathways & Interactions for NAALAD2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Amino acid synthesis and interconversion (transamination) | ||
| 2 | Metabolism |
.40
|
|
| 3 | Viral mRNA Translation | ||
Pathways by source for NAALAD2 Gene
3 Reactome pathways for NAALAD2 Gene
Interacting Proteins for NAALAD2 Gene
GPS-Prot Interaction Network for NAALAD2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | NAS | 10085079 |
| GO:0008152 | metabolic process | IEA | -- |
| GO:0008652 | cellular amino acid biosynthetic process | TAS | -- |
| GO:0042135 | neurotransmitter catabolic process | IEA | -- |
No data available for SIGNOR curated interactions for NAALAD2 Gene
Transcripts for NAALAD2 Gene
mRNA/cDNA for NAALAD2 Gene
- 2 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000321955 3035 bps (ENST00000321955.8)
- ENST00000375944 1149 bps (ENST00000375944.7)
- ENST00000524501 2922 bps (ENST00000524501.1)
- ENST00000525171 1613 bps (ENST00000525171.5)
- ENST00000525497 730 bps (ENST00000525497.5)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NAALAD2 - Select products 50% OFF >
- * NAALAD2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NAALAD2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NAALAD2
- genomics-online: gRNA clones - Search for available NAALAD2 gRNA products
- Overview of 58 available NAALAD2 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for NAALAD2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NAALAD2
- Browse OriGene Inhibitory RNA Products For NAALAD2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAALAD2
- genomics-online: shRNA clones - Search for available NAALAD2 shRNA products
- Overview of 58 available NAALAD2 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for NAALAD2 - Select products 50% OFF >
- * NAALAD2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for NAALAD2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NAALAD2
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
| ExUns: | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | |||||||||
| SP3: | |||||||||
| SP4: | - | - | - | - | |||||
| SP5: | |||||||||
| SP6: | |||||||||
| SP7: |
Relevant External Links for NAALAD2 Gene
- GeneLoc Exon Structure for
- NAALAD2
Expression for NAALAD2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Heart (Cardiovascular System)
- Mature Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Mature Cardiac Fibroblasts Myocardium
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Testis (Reproductive System)
- Spermatid Seminiferous Tubules
-
Gonad
- Spermatid Seminiferous Tubules
- Trophoblast (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for NAALAD2 Gene
This gene is overexpressed in Pituitary (x6.1).
This gene is overexpressed in Fetal ovary (16.1), Ovary (14.3), Testis (11.1), Prostate (6.9), and Stomach (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAALAD2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NAALAD2
SOURCE GeneReport for Unigene cluster for NAALAD2 Gene:
Hs.503560mRNA Expression by UniProt/SwissProt for NAALAD2 Gene:
Q9Y3Q0-NALD2_HUMAN
Tissue specificity:
Highest expression in the testis. Also found in ovary and spleen. Weak expression in prostate, heart and placenta. In brain, expressed in striatum, parietal cortex and ventral striatum with lower levels in hippocampus, brain stem, putamen and superior colliculus.
Evidence on tissue expression from TISSUES for NAALAD2 Gene
- Heart(5)
Primer Products
-
OriGene qPCR primer pairs for NAALAD2
- genomics-online: primer clones - Search for available NAALAD2 Primer products
- Overview of 58 available NAALAD2 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NAALAD2 Gene
Orthologs for NAALAD2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NAALAD2 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | NAALAD2 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | NAALAD2 31 30 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Naalad2 30 |
|
||
| mouse (Mus musculus) |
Mammalia | Naalad2 17 31 30 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | NAALAD2 31 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | NAALAD2 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NAALAD2 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | NAALAD2 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | naalad2 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.15462 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | naalad2 31 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | R57.1 30 |
|
||
| gcp-2.1 31 |
|
ManyToMany | |||
| C35C5.2 32 |
|
|
|||
| gcp-2.2 31 |
|
ManyToMany | |||
| gcp-2.3 31 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | VPS70 33 31 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT5G19740 30 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os01g0740500 30 |
|
||
| Os.18145 30 |
|
||||
| barley (Hordeum vulgare) |
Liliopsida | Hv.3035 30 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU06285 30 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPBC354.09c 30 |
|
- Species where no ortholog for NAALAD2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for NAALAD2 Gene
- ENSEMBL:
- Gene Tree for NAALAD2 (if available)
- TreeFam:
- Gene Tree for NAALAD2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NAALAD2: view image
Paralogs for NAALAD2 Gene
(4) SIMAP similar genes for NAALAD2 Gene using alignment to 9 proteins:
- NALD2_HUMAN
- E9PII2_HUMAN
- E9PJ53_HUMAN
- E9PJV2_HUMAN
- E9PKX5_HUMAN
- J3KNJ3_HUMAN
- L8EAF7_HUMAN
- Q4G181_HUMAN
- Q4KKV4_HUMAN
Pseudogenes.org Pseudogenes for NAALAD2 Gene
Variants for NAALAD2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NAALAD2 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs10830430 | - | p.Ile446Val | |||
| rs11018879 | - | p.Val101Ile |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv687n106 | CNV | deletion | 24896259 |
| esv1511526 | CNV | insertion | 17803354 |
| esv2759849 | CNV | gain+loss | 17122850 |
| esv3307873 | CNV | mobile element insertion | 20981092 |
| esv3331098 | CNV | insertion | 20981092 |
| esv3548126 | CNV | deletion | 23714750 |
| esv3579841 | CNV | loss | 25503493 |
| esv3579993 | CNV | gain | 25503493 |
| esv3627188 | CNV | loss | 21293372 |
| esv3892056 | CNV | gain+loss | 25118596 |
| nsv1035213 | CNV | gain | 25217958 |
| nsv1036092 | CNV | loss | 25217958 |
| nsv1048042 | CNV | loss | 25217958 |
| nsv1048624 | CNV | loss | 25217958 |
| nsv1054560 | CNV | loss | 25217958 |
| nsv1111059 | CNV | tandem duplication | 24896259 |
| nsv1116681 | CNV | tandem duplication | 24896259 |
| nsv1119422 | CNV | insertion | 24896259 |
| nsv1138061 | CNV | deletion | 24896259 |
| nsv468787 | CNV | loss | 19166990 |
| nsv555830 | CNV | loss | 21841781 |
| nsv555831 | CNV | loss | 21841781 |
| nsv555832 | CNV | gain | 21841781 |
| nsv555833 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.45;
85.71% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NAALAD2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NAALAD2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAALAD2 Gene
Disorders for NAALAD2 Gene
Additional Disease Information for NAALAD2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for NAALAD2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAALAD2 Gene
Publications for NAALAD2 Gene
- Isolation and expression of novel human glutamate carboxypeptidases with N-acetylated alpha-linked acidic dipeptidase and dipeptidyl peptidase IV activity. (PMID: 10085079) Pangalos MN … Gordon RD (The Journal of biological chemistry 1999) 2 3 4 23 54
- Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. (PMID: 21738478) Okada Y … Kamatani N (PLoS genetics 2011) 3 41 54
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
- Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III. (PMID: 19678840) Hlouchova K … Lubkowski J (The FEBS journal 2009) 3 4 54
- Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 54
ExternalLinks
Products for NAALAD2 Gene
- View all 2 R&D Systems NAALAD2 (NAALADase-2/NAALAD2) Products
- View all R&D Systems NAALAD2 (NAALADase-2/NAALAD2) Proteins and Enzymes
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- Learn more about R&D Systems custom NAALAD2 antibody, protein, and immunoassay development services
- Browse OriGene Antibodies
- Custom Antibody Services
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- Search Origene for MassSpec and Protein Over-expression Lysates for NAALAD2
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for NAALAD2
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- OriGene CRISPR knockouts for NAALAD2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Sino Biological Human cDNA Clone for NAALAD2
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for NAALAD2
- Novus Biologicals proteins and lysates for NAALAD2
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- Taconic Biosciences Mouse Models for NAALAD2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for NAALAD2 (AFLGC-NAALAD2)
- VectorBuilder Custom and pre-made DNA vectors for NAALAD2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for NAALAD2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for NAALAD2 (ie. knockout, knockin, CRISPRa, CRISPRi)
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- VectorBuilder Stable cell line generation for NAALAD2
- antibodies-online: Show 5 available NAALAD2 Antibodies ranked by validation data
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- antibodies-online: Show 6 available NAALAD2 Proteins ranked by validation data
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- Horizon Cell Lines for NAALAD2
- genomics-online: cdna clones - Search for available NAALAD2 CDNA products
- Overview of 58 available NAALAD2 gene related products
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- genomics-online: shRNA clones - Search for available NAALAD2 shRNA products
- Overview of 58 available NAALAD2 gene related products
- Browse GeneCopoeia Cell Lines
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Sources for NAALAD2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource
- (179) Signalway Antibody