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This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The representative member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which is a marker of prostatic carcinomas and is the first to be shown to possess NAALADase activity. NAALADase cleaves N-acetyl-L-aspartate-L-glutamate (NAAG), which is a neuropeptide expressed both in the central nervous systems and in the periphery and is thought to function as a neurotransmitter. The product of this gene is a type II integral membrane protein. Transient transfection of this gene confers both NAALADase and dipetidyl peptidase IV activities to mammalian cells. This gene is highly expressed in ovary and testis as well as within discrete brain areas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
NAALAD2 (N-Acetylated Alpha-Linked Acidic Dipeptidase 2) is a Protein Coding gene. Diseases associated with NAALAD2 include Fetal Erythroblastosis. Among its related pathways are Viral mRNA Translation and Amino acid synthesis and interconversion (transamination). Gene Ontology (GO) annotations related to this gene include peptidase activity and serine-type peptidase activity. An important paralog of this gene is FOLH1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003824 | catalytic activity | IEA | -- |
GO:0004180 | carboxypeptidase activity | IBA,NAS | 10085079 |
GO:0004181 | metallocarboxypeptidase activity | IEA | -- |
GO:0005515 | protein binding | IPI | 32296183 |
GO:0008233 | peptidase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | NAS | 10085079 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Amino acid synthesis and interconversion (transamination) | ||
2 | Metabolism |
.40
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|
3 | Viral mRNA Translation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006508 | proteolysis | NAS | 10085079 |
GO:0008152 | metabolic process | IEA | -- |
GO:0008652 | cellular amino acid biosynthetic process | TAS | -- |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: |
ExUns: | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 |
---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||
SP2: | |||||||||
SP3: | |||||||||
SP4: | - | - | - | - | |||||
SP5: | |||||||||
SP6: | |||||||||
SP7: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NAALAD2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NAALAD2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NAALAD2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Naalad2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Naalad2 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | NAALAD2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | NAALAD2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | NAALAD2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NAALAD2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | naalad2 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.15462 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | naalad2 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | R57.1 30 |
|
||
gcp-2.1 31 |
|
ManyToMany | |||
C35C5.2 32 |
|
|
|||
gcp-2.2 31 |
|
ManyToMany | |||
gcp-2.3 31 |
|
ManyToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | VPS70 31 33 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT5G19740 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os01g0740500 30 |
|
||
Os.18145 30 |
|
||||
Barley (Hordeum vulgare) |
Liliopsida | Hv.3035 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU06285 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPBC354.09c 30 |
|
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs10830430 | - |
p.Ile446Val |
|||
rs11018879 | - |
p.Val101Ile |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv687n106 | CNV | deletion | 24896259 |
esv1511526 | CNV | insertion | 17803354 |
esv2759849 | CNV | gain+loss | 17122850 |
esv3307873 | CNV | mobile element insertion | 20981092 |
esv3331098 | CNV | insertion | 20981092 |
esv3548126 | CNV | deletion | 23714750 |
esv3579841 | CNV | loss | 25503493 |
esv3579993 | CNV | gain | 25503493 |
esv3627188 | CNV | loss | 21293372 |
esv3892056 | CNV | gain+loss | 25118596 |
nsv1035213 | CNV | gain | 25217958 |
nsv1036092 | CNV | loss | 25217958 |
nsv1048042 | CNV | loss | 25217958 |
nsv1048624 | CNV | loss | 25217958 |
nsv1054560 | CNV | loss | 25217958 |
nsv1111059 | CNV | tandem duplication | 24896259 |
nsv1116681 | CNV | tandem duplication | 24896259 |
nsv1119422 | CNV | insertion | 24896259 |
nsv1138061 | CNV | deletion | 24896259 |
nsv468787 | CNV | loss | 19166990 |
nsv555830 | CNV | loss | 21841781 |
nsv555831 | CNV | loss | 21841781 |
nsv555832 | CNV | gain | 21841781 |
nsv555833 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
fetal erythroblastosis |
|
|