This gene encodes an N-acylethanolamine-hydrolyzing enzyme which is highly similar to acid ceramidase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] See more...

Aliases for NAAA Gene

Aliases for NAAA Gene

  • N-Acylethanolamine Acid Amidase 2 3 5
  • N-Acylethanolamine-Hydrolyzing Acid Amidase 3 4
  • Acid Ceramidase-Like Protein 3 4
  • ASAH-Like Protein 3 4
  • ASAHL 3 4
  • PLT 3 4
  • N-Acylsphingosine Amidohydrolase (Acid Ceramidase)-Like 2
  • N-Acylsphingosine Amidohydrolase-Like 4
  • EC 3.5.1.60 4
  • NAAA 5

External Ids for NAAA Gene

Previous HGNC Symbols for NAAA Gene

  • ASAHL

Previous GeneCards Identifiers for NAAA Gene

  • GC04M077050
  • GC04M076831
  • GC04M072584

Summaries for NAAA Gene

Entrez Gene Summary for NAAA Gene

  • This gene encodes an N-acylethanolamine-hydrolyzing enzyme which is highly similar to acid ceramidase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for NAAA Gene

NAAA (N-Acylethanolamine Acid Amidase) is a Protein Coding gene. Diseases associated with NAAA include Bleeding Disorder, Platelet-Type, 12 and Thymus Small Cell Carcinoma. Among its related pathways are Neurotransmitter Release Cycle and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include transcription factor binding and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds. An important paralog of this gene is ASAH1.

UniProtKB/Swiss-Prot Summary for NAAA Gene

  • Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine (PubMed:15655246, PubMed:17980170, PubMed:18793752, PubMed:30301806). Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine (PubMed:15655246).

Gene Wiki entry for NAAA Gene

Additional gene information for NAAA Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NAAA Gene

Genomics for NAAA Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NAAA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J075939 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 664.2 +0.4 412 2.8 PRDM10 CTCF ZNF692 PRDM1 RBFOX2 PKNOX1 PATZ1 POLR2A ZNF501 HDAC1 NAAA RF00017-4335 lnc-SDAD1-2 piR-56647 PPEF2 SCARB2 ART3 lnc-SDAD1-1 SDAD1
GH04J075989 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 24.5 -49.2 -49188 2.8 SP1 CREB1 GATAD2A TEAD4 PRDM10 REST ZNF629 TFE3 SIX5 KDM1A SDAD1 lnc-SDAD1-3-002 NAAA SCARB2 ART3 SDAD1-AS1
GH04J076059 Enhancer 1.3 FANTOM5 Ensembl ENCODE 29.5 -119.6 -119588 4.8 GATAD2A ZNF512 LEF1 JUND GABPA RELA PKNOX1 RXRB NR2C1 IKZF2 ART3 CXCL10 CXCL9 NAAA CXCL11 NUP54 SDAD1 SDAD1-AS1 KR153194-147 piR-58297-350
GH04J075901 Promoter/Enhancer 1.1 FANTOM5 Ensembl ENCODE 30.9 +39.3 39301 0.6 ZNF316 MAFG CEBPG MAFK SPI1 ZNF384 EBF1 CEBPB SMARCE1 MAFF PPEF2 lnc-PPEF2-1 NAAA CXCL10 CXCL9 CXCL11 THAP6 RCHY1 lnc-NAAA-2 G3BP2
GH04J076011 Promoter/Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas 25.7 -71.3 -71271 2.5 RELA TCF12 IKZF2 SP1 EED NRF1 ZNF766 DPF2 RELB GATAD2B ART3 NAAA NUP54 CXCL10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAAA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NAAA

Top Transcription factor binding sites by QIAGEN in the NAAA gene promoter:
  • FOXJ2
  • FOXJ2 (long isoform)
  • POU2F1
  • POU2F1a
  • PPAR-gamma1
  • PPAR-gamma2
  • Sp1
  • TBP

Genomic Locations for NAAA Gene

Genomic Locations for NAAA Gene
chr4:75,910,655-75,941,013
(GRCh38/hg38)
Size:
30,359 bases
Orientation:
Minus strand
chr4:76,831,808-76,862,204
(GRCh37/hg19)
Size:
30,397 bases
Orientation:
Minus strand

Genomic View for NAAA Gene

Genes around NAAA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAAA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAAA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAAA Gene

Proteins for NAAA Gene

  • Protein details for NAAA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02083-NAAA_HUMAN
    Recommended name:
    N-acylethanolamine-hydrolyzing acid amidase
    Protein Accession:
    Q02083
    Secondary Accessions:
    • Q5KTF2
    • Q96EY2
    • Q9BRA8

    Protein attributes for NAAA Gene

    Size:
    359 amino acids
    Molecular mass:
    40066 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit, produced by autocatalytic cleavage.

    Three dimensional structures from OCA and Proteopedia for NAAA Gene

    Alternative splice isoforms for NAAA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAAA Gene

Post-translational modifications for NAAA Gene

  • N-glycosylated (PubMed:17980170, PubMed:18793752, PubMed:30301806). Tunicamycin treatment causes a reduction in specific activity against N-palmitoylethanolamine.
  • A disulfide bond is seen in the crystal structure of the human protein, but the Cys residues are not conserved in rodents.
  • Autoproteolytic cleavage at pH 4.5 gives rise to the alpha and beta subunit (PubMed:15655246, PubMed:22040171, PubMed:17980170, PubMed:18793752, PubMed:30301806). Cleavage gives rise to a conformation change that activates the enzyme (PubMed:17980170, PubMed:18793752, PubMed:30301806, PubMed:22040171). The same catalytic Cys residue mediates the autoproteolytic cleavage and subsequent hydrolysis of lipid substrates (PubMed:17980170, PubMed:18793752) (Probable).
  • Glycosylation at Asn37, Asn107, Asn309, and Asn333
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

No data available for DME Specific Peptides for NAAA Gene

Domains & Families for NAAA Gene

Gene Families for NAAA Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NAAA Gene

InterPro:
Blocks:
  • Choloylglycine hydrolase
ProtoNet:

Suggested Antigen Peptide Sequences for NAAA Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54891, highly similar to N-acylethanolamine-hydrolyzing acid amidase (EC 3.5.1.-) (B4DVL2_HUMAN)
  • N-acylsphingosine amidohydrolase-like (NAAA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q02083

UniProtKB/Swiss-Prot:

NAAA_HUMAN :
  • Belongs to the acid ceramidase family.
Family:
  • Belongs to the acid ceramidase family.
genes like me logo Genes that share domains with NAAA: view

Function for NAAA Gene

Molecular function for NAAA Gene

UniProtKB/Swiss-Prot Function:
Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine (PubMed:15655246, PubMed:17980170, PubMed:18793752, PubMed:30301806). Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine (PubMed:15655246).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-hexadecanoylethanolamine = ethanolamine + hexadecanoate; Xref=Rhea:RHEA:45064, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:57603, ChEBI:CHEBI:71464; Evidence={ECO:0000269|PubMed:15655246, ECO:0000269|PubMed:17980170, ECO:0000269|PubMed:18793752, ECO:0000269|PubMed:22040171, ECO:0000269|PubMed:30301806};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-(long-chain fatty acyl)ethanolamine = a long-chain fatty acid + ethanolamine; Xref=Rhea:RHEA:17505, ChEBI:CHEBI:15377, ChEBI:CHEBI:15897, ChEBI:CHEBI:57560, ChEBI:CHEBI:57603; EC=3.5.1.60; Evidence={ECO:0000269|PubMed:15655246, ECO:0000269|PubMed:17980170, ECO:0000269|PubMed:18793752, ECO:0000269|PubMed:22040171, ECO:0000269|PubMed:30301806};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=97 uM for N-palmitoylethanolamine {ECO:0000269|PubMed:15655246}; KM=21 uM for N-palmitoylethanolamine {ECO:0000269|PubMed:22040171}; Vmax=5.4 nmol/min/ug enzyme with N-palmitoylethanolamine as substrate {ECO:0000269|PubMed:22040171}; pH dependence: Optimum pH is 4.5 with N-palmitoylethanolamine as substrate. {ECO:0000269|PubMed:15655246, ECO:0000269|PubMed:18793752};
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by DTT and Nonidet P-40.

Enzyme Numbers (IUBMB) for NAAA Gene

Phenotypes From GWAS Catalog for NAAA Gene

Gene Ontology (GO) - Molecular Function for NAAA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008134 transcription factor binding IPI 21106534
GO:0016787 hydrolase activity IEA --
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IBA,IDA 17980170
GO:0017064 fatty acid amide hydrolase activity IDA 15655246
GO:0047412 N-(long-chain-acyl)ethanolamine deacylase activity IEA --
genes like me logo Genes that share ontologies with NAAA: view
genes like me logo Genes that share phenotypes with NAAA: view

Animal Models for NAAA Gene

MGI Knock Outs for NAAA:
  • Naaa Naaa<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAAA

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NAAA Gene

Localization for NAAA Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAAA Gene

Lysosome. Membrane. Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAAA gene
Compartment Confidence
extracellular 5
lysosome 5
cytosol 3
plasma membrane 2
cytoskeleton 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
mitochondrion 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NAAA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10610717
GO:0005764 lysosome IDA 15655246
GO:0016020 membrane IEA --
GO:0019898 extrinsic component of membrane IDA 30301806
GO:0043202 lysosomal lumen TAS --
genes like me logo Genes that share ontologies with NAAA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NAAA Gene

Pathways & Interactions for NAAA Gene

genes like me logo Genes that share pathways with NAAA: view

Pathways by source for NAAA Gene

UniProtKB/Swiss-Prot Q02083-NAAA_HUMAN

  • Pathway: Lipid metabolism; fatty acid metabolism.

Gene Ontology (GO) - Biological Process for NAAA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0007269 neurotransmitter secretion TAS --
GO:0016042 lipid catabolic process IEA --
GO:0070291 N-acylethanolamine metabolic process IDA 15655246
genes like me logo Genes that share ontologies with NAAA: view

No data available for SIGNOR curated interactions for NAAA Gene

Drugs & Compounds for NAAA Gene

(5) Drugs for NAAA Gene - From: DrugBank, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cannabidiol Approved, Investigational Pharma Agonist, Partial agonist, Antagonist, Channel blocker, Activator, Target, inhibitor 0
Medical Cannabis Experimental, Investigational Pharma Target, inhibitor 0
Nabiximols Investigational Pharma Target, inhibitor 59
CCP Pharma Inhibitor, Inhibition 0

(1) Additional Compounds for NAAA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NAAA: view

Transcripts for NAAA Gene

mRNA/cDNA for NAAA Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAAA

Alternative Splicing Database (ASD) splice patterns (SP) for NAAA Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: -
SP6: - - -
SP7:

Relevant External Links for NAAA Gene

GeneLoc Exon Structure for
NAAA

Expression for NAAA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NAAA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAAA Gene

This gene is overexpressed in Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for NAAA Gene

This gene is overexpressed in Spleen (18.2) and Tlymphocyte (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAAA Gene



Protein tissue co-expression partners for NAAA Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NAAA

SOURCE GeneReport for Unigene cluster for NAAA Gene:

Hs.437365

mRNA Expression by UniProt/SwissProt for NAAA Gene:

Q02083-NAAA_HUMAN
Tissue specificity: Expressed in numerous tissues, with highest levels in liver and kidney, followed by pancreas.

Evidence on tissue expression from TISSUES for NAAA Gene

  • Liver(4.6)
  • Muscle(4.5)
  • Blood(3.3)
  • Nervous system(3)
  • Spleen(2.9)
  • Bone marrow(2.8)
  • Lymph node(2.8)
  • Kidney(2.7)
  • Intestine(2.6)
  • Heart(2.6)
  • Skin(2.5)
  • Thyroid gland(2.2)
  • Lung(2.2)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with NAAA: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NAAA Gene

Orthologs for NAAA Gene

This gene was present in the common ancestor of animals.

Orthologs for NAAA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NAAA 30 31
  • 97.3 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NAAA 30
  • 87 (n)
Cow
(Bos Taurus)
Mammalia NAAA 30 31
  • 84.37 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Naaa 30 17 31
  • 82.52 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Naaa 30
  • 81 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia NAAA 31
  • 79 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 65 (a)
OneToMany
-- 31
  • 48 (a)
OneToMany
Chicken
(Gallus gallus)
Aves NAAA 30 31
  • 69.33 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NAAA 31
  • 66 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia naaa 30
  • 64.08 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9847 30
Worm
(Caenorhabditis elegans)
Secernentea Y55D5A.3 30 31
  • 46.88 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 34 (a)
OneToOne
Species where no ortholog for NAAA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for NAAA Gene

ENSEMBL:
Gene Tree for NAAA (if available)
TreeFam:
Gene Tree for NAAA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NAAA: view image

Paralogs for NAAA Gene

Paralogs for NAAA Gene

(1) SIMAP similar genes for NAAA Gene using alignment to 5 proteins:

  • NAAA_HUMAN
  • B4DVL2_HUMAN
  • D6R9S9_HUMAN
  • H0Y988_HUMAN
  • R4GNC0_HUMAN
genes like me logo Genes that share paralogs with NAAA: view

Variants for NAAA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NAAA Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
717150 Likely Benign: not provided 75,940,132(-) G/A SYNONYMOUS_VARIANT
727829 Likely Benign: not provided 75,940,151(-) T/C MISSENSE_VARIANT
749140 Likely Benign: not provided 75,925,738(-) G/A SYNONYMOUS_VARIANT
785096 Benign: not provided 75,921,004(-) C/T SYNONYMOUS_VARIANT
785097 Benign: not provided 75,921,130(-) G/A INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for NAAA Gene

Structural Variations from Database of Genomic Variants (DGV) for NAAA Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER inversion 18451855
nsv822621 CNV loss 20364138

Variation tolerance for NAAA Gene

Residual Variation Intolerance Score: 73.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.45; 71.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAAA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAAA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAAA Gene

Disorders for NAAA Gene

MalaCards: The human disease database

(11) MalaCards diseases for NAAA Gene - From: DISEASES

Disorder Aliases PubMed IDs
bleeding disorder, platelet-type, 12
  • bdplt12
thymus small cell carcinoma
  • small cell carcinoma of the thymus
benign mastocytoma
subleukemic leukemia
  • aleukemic leukemia cutis
acquired thrombocytopenia
  • secondary thrombocytopenia
- elite association - COSMIC cancer census association via MalaCards
Search NAAA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NAAA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with NAAA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAAA Gene

Publications for NAAA Gene

  1. Molecular cloning and characterization of a human cDNA and gene encoding a novel acid ceramidase-like protein. (PMID: 10610717) Hong SB … Schuchman EH (Genomics 1999) 2 3 4 23
  2. Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa. (PMID: 19014633) Müller TD … Hinney A (Child and adolescent psychiatry and mental health 2008) 3 23 41
  3. Proteolytic activation and glycosylation of N-acylethanolamine-hydrolyzing acid amidase, a lysosomal enzyme involved in the endocannabinoid metabolism. (PMID: 17980170) Zhao LY … Ueda N (Biochimica et biophysica acta 2007) 3 4 23
  4. Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase. (PMID: 15655246) Tsuboi K … Ueda N (The Journal of biological chemistry 2005) 3 4 23
  5. A human endogenous long terminal repeat provides a polyadenylation signal to a novel, alternatively spliced transcript in normal placenta. (PMID: 1446826) Goodchild NL … Mager DL (Gene 1992) 2 3 4

Products for NAAA Gene

  • Signalway ELISA kits for NAAA
  • Signalway Proteins for NAAA

Sources for NAAA Gene