Aliases for NAAA Gene
External Ids for NAAA Gene
Previous HGNC Symbols for NAAA Gene
Previous GeneCards Identifiers for NAAA Gene
This gene encodes an N-acylethanolamine-hydrolyzing enzyme which is highly similar to acid ceramidase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for NAAA Gene
NAAA (N-Acylethanolamine Acid Amidase) is a Protein Coding gene. Diseases associated with NAAA include Bleeding Disorder, Platelet-Type, 12 and Thymus Small Cell Carcinoma. Among its related pathways are Neurotransmitter Release Cycle and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include transcription factor binding and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds. An important paralog of this gene is ASAH1.
UniProtKB/Swiss-Prot Summary for NAAA Gene
Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine (PubMed:15655246, PubMed:17980170, PubMed:18793752, PubMed:30301806). Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine (PubMed:15655246).