This gene encodes a member of the N-acetyltransferase family. N-acetyltransferases modify proteins by transferring acetyl groups from acetyl CoA to the N-termini of protein substrates. The encoded protein is a cytoplasmic N-acetyltransferase with a substrate specificity for proteins with an N-terminal methionine. This gene is located in the tumor suppressor gene region on chrom... See more...

Aliases for NAA80 Gene

Aliases for NAA80 Gene

  • N-Alpha-Acetyltransferase 80, NatH Catalytic Subunit 2 3
  • N(Alpha)-Acetyltransferase 80, NatH Catalytic Subunit 2 5
  • N-Alpha-Acetyltransferase 80 3 4
  • N-Acetyltransferase 6 2 4
  • Protein Fusion-2 3 4
  • HsNAAA80 3 4
  • NAT6 3 4
  • FUS2 3 4
  • N-Acetyltransferase 6 (GCN5-Related) 3
  • Protein Fus-2 4
  • EC 2.3.1.- 4
  • FUS-2 3

External Ids for NAA80 Gene

Previous HGNC Symbols for NAA80 Gene

  • NAT6

Summaries for NAA80 Gene

Entrez Gene Summary for NAA80 Gene

  • This gene encodes a member of the N-acetyltransferase family. N-acetyltransferases modify proteins by transferring acetyl groups from acetyl CoA to the N-termini of protein substrates. The encoded protein is a cytoplasmic N-acetyltransferase with a substrate specificity for proteins with an N-terminal methionine. This gene is located in the tumor suppressor gene region on chromosome 3p21.3 and the encoded protein may play a role in cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed. This gene overlaps and is on the same strand as hyaluronoglucosaminidase 3, and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]

GeneCards Summary for NAA80 Gene

NAA80 (N-Alpha-Acetyltransferase 80, NatH Catalytic Subunit) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for NAA80 Gene

  • N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively) (PubMed:30028079, PubMed:29581253). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation (PubMed:29581253). In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu (PubMed:30028079, PubMed:29581253). In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp (PubMed:10644992, PubMed:29581307). May act as a tumor suppressor (PubMed:10644992).

Additional gene information for NAA80 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NAA80 Gene

Genomics for NAA80 Gene

GeneHancer (GH) Regulatory Elements for NAA80 Gene

Promoters and enhancers for NAA80 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAA80 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NAA80

Genomic Locations for NAA80 Gene

Genomic Locations for NAA80 Gene
chr3:50,296,402-50,299,421
(GRCh38/hg38)
Size:
3,020 bases
Orientation:
Minus strand
chr3:50,333,833-50,336,852
(GRCh37/hg19)
Size:
3,020 bases
Orientation:
Minus strand

Genomic View for NAA80 Gene

Genes around NAA80 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA80 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA80 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA80 Gene

Proteins for NAA80 Gene

  • Protein details for NAA80 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93015-NAA80_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 80
    Protein Accession:
    Q93015
    Secondary Accessions:
    • Q93014

    Protein attributes for NAA80 Gene

    Size:
    286 amino acids
    Molecular mass:
    31445 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NAA80 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA80 Gene

Post-translational modifications for NAA80 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NAA80 Gene

Domains & Families for NAA80 Gene

Gene Families for NAA80 Gene

Protein Domains for NAA80 Gene

Blocks:
  • GCN5-related N-acetyltransferase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NAA80 Gene

GenScript: Design optimal peptide antigens:
  • Protein fusion-2 (NAT6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q93015

UniProtKB/Swiss-Prot:

NAA80_HUMAN :
  • Belongs to the acetyltransferase family.
Family:
  • Belongs to the acetyltransferase family.
genes like me logo Genes that share domains with NAA80: view

Function for NAA80 Gene

Molecular function for NAA80 Gene

UniProtKB/Swiss-Prot Function:
N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively) (PubMed:30028079, PubMed:29581253). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation (PubMed:29581253). In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu (PubMed:30028079, PubMed:29581253). In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp (PubMed:10644992, PubMed:29581307). May act as a tumor suppressor (PubMed:10644992).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein] = CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein]; Xref=Rhea:RHEA:57328, Rhea:RHEA-COMP:14863, Rhea:RHEA-COMP:14864, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:141602, ChEBI:CHEBI:141604; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein] = CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein]; Xref=Rhea:RHEA:57324, Rhea:RHEA-COMP:14865, Rhea:RHEA-COMP:14866, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:141603, ChEBI:CHEBI:141606; Evidence=. ;.

Enzyme Numbers (IUBMB) for NAA80 Gene

Phenotypes From GWAS Catalog for NAA80 Gene

Gene Ontology (GO) - Molecular Function for NAA80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004596 peptide alpha-N-acetyltransferase activity IDA 29581253
GO:0008080 N-acetyltransferase activity IDA,IBA 10644992
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:1905502 acetyl-CoA binding IDA,IBA 10644992
genes like me logo Genes that share ontologies with NAA80: view
genes like me logo Genes that share phenotypes with NAA80: view

miRNA for NAA80 Gene

miRTarBase miRNAs that target NAA80

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA80 Gene

Localization for NAA80 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA80 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAA80 gene
Compartment Confidence
cytosol 5
nucleus 1

Gene Ontology (GO) - Cellular Components for NAA80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IBA 10644992
GO:0005829 cytosol IDA,IEA 29581253
genes like me logo Genes that share ontologies with NAA80: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NAA80 Gene

Pathways & Interactions for NAA80 Gene

PathCards logo

SuperPathways for NAA80 Gene

No Data Available

Interacting Proteins for NAA80 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000346927 Q93015-NAA80_HUMAN for NAA80 Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for NAA80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006473 protein acetylation IDA,IBA 10644992
GO:0008064 regulation of actin polymerization or depolymerization IMP 29581253
GO:0017190 N-terminal peptidyl-aspartic acid acetylation IDA 29581253
GO:0018002 N-terminal peptidyl-glutamic acid acetylation IDA 29581253
GO:0030047 actin modification IDA 29581253
genes like me logo Genes that share ontologies with NAA80: view

No data available for Pathways by source and SIGNOR curated interactions for NAA80 Gene

Drugs & Compounds for NAA80 Gene

(1) Additional Compounds for NAA80 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-Hydroxyphenylacetyl-CoA
  • [(2R,3R,4R,5R)-5-(6-Aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-3-[2-[2-[2-(4-hydroxyphenyl)acetyl]sulfanylethylcarbamoyl]ethylcarbamoyl]-2,2-dimethyl-propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid
117411-05-9
genes like me logo Genes that share compounds with NAA80: view

Transcripts for NAA80 Gene

mRNA/cDNA for NAA80 Gene

3 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAA80 Gene

No ASD Table

Relevant External Links for NAA80 Gene

GeneLoc Exon Structure for
NAA80

Expression for NAA80 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NAA80

mRNA Expression by UniProt/SwissProt for NAA80 Gene:

Q93015-NAA80_HUMAN
Tissue specificity: Strongly expressed in heart and skeletal muscle, followed by brain and pancreas, with weak expression in kidney, liver, and lung and no expression in placenta.

Evidence on tissue expression from TISSUES for NAA80 Gene

  • Pancreas(4.2)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAA80 Gene

Orthologs for NAA80 Gene

This gene was present in the common ancestor of animals.

Orthologs for NAA80 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAT6 31 30
  • 99.03 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NAT6 30
  • 86.27 (n)
rat
(Rattus norvegicus)
Mammalia LOC100910872 30
  • 83.22 (n)
mouse
(Mus musculus)
Mammalia Nat6 31 30
  • 81.14 (n)
OneToOne
Naa80 17
cow
(Bos Taurus)
Mammalia NAT6 31
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NAT6 31
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NAT6 31
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAT6 31
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC101886319 30
  • 52.69 (n)
NAT6 31
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8481 31
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C56G2.15 31
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 33 (a)
OneToOne
Species where no ortholog for NAA80 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NAA80 Gene

ENSEMBL:
Gene Tree for NAA80 (if available)
TreeFam:
Gene Tree for NAA80 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NAA80: view image

Paralogs for NAA80 Gene

No data available for Paralogs for NAA80 Gene

Variants for NAA80 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NAA80 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs200439690 Non-small cell lung cancer cell lines p.Thr207Ser
VAR_014224 Non-small cell lung cancer cell lines p.Arg145Ser

Additional dbSNP identifiers (rs#s) for NAA80 Gene

Structural Variations from Database of Genomic Variants (DGV) for NAA80 Gene

Variant ID Type Subtype PubMed ID
dgv8316n54 CNV loss 21841781
dgv8317n54 CNV loss 21841781
esv2759148 CNV loss 17122850
nsv3813 CNV deletion 18451855
nsv460531 CNV loss 19166990
nsv470561 CNV loss 18288195
nsv523560 CNV loss 19592680
nsv523662 CNV loss 19592680
nsv590255 CNV loss 21841781
nsv834692 CNV loss 17160897
nsv834693 CNV loss 17160897
nsv954855 CNV deletion 24416366

Variation tolerance for NAA80 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.20; 69.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAA80 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAA80

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA80 Gene

Disorders for NAA80 Gene

Additional Disease Information for NAA80

No disorders were found for NAA80 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAA80 Gene

Publications for NAA80 Gene

  1. NAA80 is actin's N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility. (PMID: 29581253) Drazic A … Arnesen T (Proceedings of the National Academy of Sciences of the United States of America 2018) 2 3 4 54
  2. Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80. (PMID: 29581307) Goris M … Arnesen T (Proceedings of the National Academy of Sciences of the United States of America 2018) 2 3 4 54
  3. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium. (PMID: 11085536) Lerman MI … Minna JD (Cancer research 2000) 2 3 4 54
  4. The putative tumour suppressor Fus-2 is an N-acetyltransferase. (PMID: 10644992) Zegerman P … Kouzarides T (Oncogene 2000) 3 4 23 54
  5. NAT6 acetylates the N-terminus of different forms of actin. (PMID: 30028079) Wiame E … Van Schaftingen E (The FEBS journal 2018) 3 4 54

Products for NAA80 Gene

Sources for NAA80 Gene