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This gene encodes an enzyme that localizes to the Golgi apparatus, where it transfers an acetyl group to the N-terminus of free proteins. This enzyme acts on histones, and its activity is important for chromatin assembly and chromosome integrity. Alternative splicing and the use of alternative promoters results in multiple transcript variants. The upstream promoter is located in a differentially methylated region (DMR) and undergoes imprinting; transcript variants originating from this position are expressed from the maternal allele. [provided by RefSeq, Nov 2015]
NAA60 (N-Alpha-Acetyltransferase 60, NatF Catalytic Subunit) is a Protein Coding gene. Diseases associated with NAA60 include Ogden Syndrome and Scheuermann Disease. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and peptide alpha-N-acetyltransferase activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004402 | histone acetyltransferase activity | IBA | 21873635 |
GO:0004596 | peptide alpha-N-acetyltransferase activity | IBA,IDA | 21750686 |
GO:0008080 | N-acetyltransferase activity | IEA | -- |
GO:0010485 | H4 histone acetyltransferase activity | IDA | 21981917 |
GO:0016740 | transferase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | IBA,IDA | 21981917 |
GO:0005794 | Golgi apparatus | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006325 | chromatin organization | IEA | -- |
GO:0006334 | nucleosome assembly | IDA | 21981917 |
GO:0006474 | N-terminal protein amino acid acetylation | IDA | 25732826 |
GO:0007059 | chromosome segregation | ISS | -- |
GO:0008283 | cell proliferation | IMP | 21981917 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Coenzyme A | Investigational | Nutra | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
acetyl-coa |
|
72-89-9 |
|
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | ||||||||||||||||||
SP3: | |||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||
SP5: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
|
OneToMany | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
NAA60 30 |
|
||||
Mouse (Mus musculus) |
Mammalia | Naa60 30 17 31 |
|
OneToMany | |
Rat (Rattus norvegicus) |
Mammalia | Naa60 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Cow (Bos Taurus) |
Mammalia | NAA60 30 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | NAA60 30 |
|
||
-- 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | naa60 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | nat15 30 31 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005192 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Naa60 30 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | F30F8.10 30 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
780018 | Benign: not provided | 3,484,780(+) | C/G | MISSENSE_VARIANT | |
807967 | Uncertain Significance: not provided | 3,483,592(+) | G/A | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
871515 | Likely Benign: not provided | 3,482,528(+) | C/T | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
rs34464545 | - | p.His218Gln |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv324e201 | CNV | deletion | 23290073 |
dgv325e201 | CNV | deletion | 23290073 |
esv2665923 | CNV | deletion | 23128226 |
esv2750408 | CNV | deletion | 23290073 |
esv2750409 | CNV | deletion | 23290073 |
esv29492 | CNV | gain | 19812545 |
esv3553026 | CNV | deletion | 23714750 |
esv3637667 | CNV | gain | 21293372 |
esv3637668 | CNV | loss | 21293372 |
nsv1051957 | CNV | loss | 25217958 |
nsv1070738 | CNV | deletion | 25765185 |
nsv1148032 | CNV | deletion | 26484159 |
nsv1715 | CNV | deletion | 18451855 |
nsv512420 | CNV | loss | 21212237 |
nsv952908 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
ogden syndrome |
|
|
scheuermann disease |
|
|
temple syndrome |
|
|