Aliases for NAA40 Gene

Aliases for NAA40 Gene

  • N(Alpha)-Acetyltransferase 40, NatD Catalytic Subunit 2 3 5
  • N-Acetyltransferase 11 (GCN5-Related, Putative) 2 3
  • N-Alpha-Acetyltransferase 40 3 4
  • Protein Acetyltransferase 1 3 4
  • N-Alpha-Acetyltransferase D 3 4
  • N-Acetyltransferase 11 2 4
  • NAT11 3 4
  • PATT1 3 4
  • HNatD 3 4
  • NatD 3 4
  • N(Alpha)-Acetyltransferase 40, NatD Catalytic Subunit, Homolog (S. Cerevisiae) 2
  • N(Alpha)-Acetyltransferase 40, NatD Catalytic Subunit, Homolog 3
  • N-Alpha Acetyl Transferase 40 3
  • NatD Catalytic Subunit 3
  • EC 2.3.1.257 4

External Ids for NAA40 Gene

Previous HGNC Symbols for NAA40 Gene

  • NAT11

Previous GeneCards Identifiers for NAA40 Gene

  • GC11P063706
  • GC11P060036

Summaries for NAA40 Gene

GeneCards Summary for NAA40 Gene

NAA40 (N(Alpha)-Acetyltransferase 40, NatD Catalytic Subunit) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include N-acetyltransferase activity.

UniProtKB/Swiss-Prot Summary for NAA40 Gene

  • N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A (PubMed:21935442, PubMed:25619998). In contrast to other N-alpha-acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg-Gly sequence' (PubMed:21935442, PubMed:25619998). Acts as a negative regulator of apoptosis (PubMed:26666750). May play a role in hepatic lipid metabolism (By similarity).

Additional gene information for NAA40 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NAA40 Gene

Genomics for NAA40 Gene

GeneHancer (GH) Regulatory Elements for NAA40 Gene

Promoters and enhancers for NAA40 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J063937 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 750.6 -0.1 -60 2.8 SIN3A ZBTB40 SP1 CTCF SMARCE1 RBPJ POLR2A USF2 ATF1 CREB1 NAA40 lnc-RCOR2-2 SF1 KCNK4 RTN3 NRXN2 SLC22A6 PPP2R5B ENSG00000257086 FLRT1
GH11J063940 Promoter/Enhancer 0.7 Ensembl ENCODE 750.6 +1.9 1904 1.1 BCOR FEZF1 ZBTB33 NAA40 lnc-RCOR2-2 lnc-NAA40-1 RF00017-938
GH11J063837 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.2 -98.4 -98393 6.5 ZNF24 ZBTB40 CTCF FOXA1 RBPJ POLR2A USF2 HCFC1 CC2D1A ETV6 MARK2 SF1 KCNK4 SNHG1 RTN3 NRXN2 NAA40 RNU6-1306P PLCB3 SLC22A6
GH11J064183 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 9.8 +246.8 246842 5.2 E2F8 SIN3A ZBTB40 SP1 CTCF MLX RBPJ SMARCE1 POLR2A CEBPZ STIP1 lnc-STIP1-1 lnc-MACROD1-1 SF1 IMMP1LP1 KCNK4 PLCB3 TRPT1 ZFPL1 ENSG00000257086
GH11J064163 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 10 +226.5 226465 4 ZNF24 CTCF SIX5 FOXA1 RBPJ SMARCE1 POLR2A HDAC2 ZNF217 HCFC1 MACROD1 LOC105369339 lnc-STIP1-2 SF1 ZFPL1 PLCB3 TRPT1 ATG2A TRMT112 ENSG00000257086
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAA40 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NAA40 Gene

Genomic Locations for NAA40 Gene
chr11:63,938,959-63,957,319
(GRCh38/hg38)
Size:
18,361 bases
Orientation:
Plus strand
chr11:63,706,431-63,724,800
(GRCh37/hg19)
Size:
18,370 bases
Orientation:
Plus strand

Genomic View for NAA40 Gene

Genes around NAA40 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA40 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA40 Gene

Proteins for NAA40 Gene

  • Protein details for NAA40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UY6-NAA40_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 40
    Protein Accession:
    Q86UY6
    Secondary Accessions:
    • B4DR03
    • B4DU10
    • Q5HYL5
    • Q9H897

    Protein attributes for NAA40 Gene

    Size:
    237 amino acids
    Molecular mass:
    27194 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI46006.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NAA40 Gene

    Alternative splice isoforms for NAA40 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA40 Gene

Post-translational modifications for NAA40 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NAA40 Gene

Domains & Families for NAA40 Gene

Gene Families for NAA40 Gene

Protein Domains for NAA40 Gene

Suggested Antigen Peptide Sequences for NAA40 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58929 (B4DR03_HUMAN)
  • cDNA FLJ57593 (B4DU10_HUMAN)
  • N-alpha acetyl transferase 40 (F2YHM7_HUMAN)
  • N-acetyltransferase 11 (NAA40_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86UY6

UniProtKB/Swiss-Prot:

NAA40_HUMAN :
  • Belongs to the acetyltransferase family. NAA40 subfamily.
Family:
  • Belongs to the acetyltransferase family. NAA40 subfamily.
genes like me logo Genes that share domains with NAA40: view

Function for NAA40 Gene

Molecular function for NAA40 Gene

UniProtKB/Swiss-Prot Function:
N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A (PubMed:21935442, PubMed:25619998). In contrast to other N-alpha-acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg-Gly sequence' (PubMed:21935442, PubMed:25619998). Acts as a negative regulator of apoptosis (PubMed:26666750). May play a role in hepatic lipid metabolism (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + N-terminal L-seryl-[histone H4] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4]; Xref=Rhea:RHEA:50596, Rhea:RHEA-COMP:12740, Rhea:RHEA-COMP:12743, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64738, ChEBI:CHEBI:83690; EC=2.3.1.257; Evidence={ECO:0000269 PubMed:21935442, ECO:0000269 PubMed:25619998};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + N-terminal L-seryl-[histone H2A] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A]; Xref=Rhea:RHEA:50600, Rhea:RHEA-COMP:12742, Rhea:RHEA-COMP:12744, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64738, ChEBI:CHEBI:83690; EC=2.3.1.257; Evidence={ECO:0000269 PubMed:21935442, ECO:0000269 PubMed:25619998};.
UniProtKB/Swiss-Prot Induction:
Down-regulated in hepatocellular carcinoma tissues.

Enzyme Numbers (IUBMB) for NAA40 Gene

Gene Ontology (GO) - Molecular Function for NAA40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010485 H4 histone acetyltransferase activity IDA 25619998
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0043998 H2A histone acetyltransferase activity IDA 25619998
GO:1990189 peptide-serine-N-acetyltransferase activity IDA 25619998
genes like me logo Genes that share ontologies with NAA40: view
genes like me logo Genes that share phenotypes with NAA40: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NAA40

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAA40

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA40 Gene

Localization for NAA40 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA40 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAA40 gene
Compartment Confidence
nucleus 3
extracellular 2
cytosol 1
mitochondrion 0
peroxisome 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NAA40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NAA40: view

Pathways & Interactions for NAA40 Gene

PathCards logo

SuperPathways for NAA40 Gene

genes like me logo Genes that share pathways with NAA40: view

Pathways by source for NAA40 Gene

1 BioSystems pathway for NAA40 Gene

Gene Ontology (GO) - Biological Process for NAA40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006474 N-terminal protein amino acid acetylation IDA,IBA 25619998
GO:0006629 lipid metabolic process IEA --
GO:0043967 histone H4 acetylation IDA 25619998
GO:0043968 histone H2A acetylation IDA 25619998
GO:0061187 regulation of chromatin silencing at rDNA IBA 21873635
genes like me logo Genes that share ontologies with NAA40: view

No data available for SIGNOR curated interactions for NAA40 Gene

Drugs & Compounds for NAA40 Gene

No Compound Related Data Available

Transcripts for NAA40 Gene

mRNA/cDNA for NAA40 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAA40

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAA40 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - - - - -
SP2: - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - - - - -
SP6: - -
SP7:
SP8:

Relevant External Links for NAA40 Gene

GeneLoc Exon Structure for
NAA40
ECgene alternative splicing isoforms for
NAA40

Expression for NAA40 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAA40 Gene

Protein differential expression in normal tissues from HIPED for NAA40 Gene

This gene is overexpressed in Fetal heart (42.0) and Fetal testis (21.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAA40 Gene



Protein tissue co-expression partners for NAA40 Gene

NURSA nuclear receptor signaling pathways regulating expression of NAA40 Gene:

NAA40

SOURCE GeneReport for Unigene cluster for NAA40 Gene:

Hs.523753

mRNA Expression by UniProt/SwissProt for NAA40 Gene:

Q86UY6-NAA40_HUMAN
Tissue specificity: Widely expressed; with the highest expression level in liver and the lowest expression in brain (at protein level).

Evidence on tissue expression from TISSUES for NAA40 Gene

  • Thyroid gland(4.2)
  • Eye(4)
  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with NAA40: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAA40 Gene

Orthologs for NAA40 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAA40 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAA40 33 32
  • 99.72 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NAT11 33
  • 98 (a)
OneToOne
NAA40 32
  • 91.98 (n)
dog
(Canis familiaris)
Mammalia NAA40 33 32
  • 92.95 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Naa40 32
  • 91.7 (n)
mouse
(Mus musculus)
Mammalia Naa40 17 33 32
  • 91.42 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NAA40 33
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NAA40 33
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves NAA40 33 32
  • 80.57 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAA40 33
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia naa40 32
  • 73.87 (n)
Str.2069 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.16373 32
zebrafish
(Danio rerio)
Actinopterygii naa40 33 33 32
  • 75 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008428 32
  • 51.55 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7593 33 32
  • 49.18 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y38A10A.7 33 32
  • 44.79 (n)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G18335 32
  • 45.93 (n)
rice
(Oryza sativa)
Liliopsida Os05g0387800 32
  • 46.06 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 50 (a)
OneToOne
Species where no ortholog for NAA40 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAA40 Gene

ENSEMBL:
Gene Tree for NAA40 (if available)
TreeFam:
Gene Tree for NAA40 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NAA40: view image

Paralogs for NAA40 Gene

Pseudogenes.org Pseudogenes for NAA40 Gene

genes like me logo Genes that share paralogs with NAA40: view

No data available for Paralogs for NAA40 Gene

Variants for NAA40 Gene

Sequence variations from dbSNP and Humsavar for NAA40 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000363486 -- 63,949,568(+) T/C intron_variant
rs1000381586 -- 63,943,993(+) T/G intron_variant
rs1000387467 -- 63,949,845(+) C/T intron_variant
rs1000517014 -- 63,943,348(+) A/G intron_variant
rs1000566246 -- 63,939,312(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NAA40 Gene

Variant ID Type Subtype PubMed ID
nsv555180 CNV loss 21841781
nsv555181 CNV loss 21841781
nsv825941 CNV gain 20364138
nsv951010 CNV deletion 24416366

Variation tolerance for NAA40 Gene

Residual Variation Intolerance Score: 33.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAA40 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAA40

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA40 Gene

Disorders for NAA40 Gene

Additional Disease Information for NAA40

No disorders were found for NAA40 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAA40 Gene

Publications for NAA40 Gene

  1. The human N-alpha-acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4. (PMID: 21935442) Hole K … Arnesen T (PloS one 2011) 2 3 4 56
  2. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B … Sherman F (BMC proceedings 2009) 2 3 4 56
  3. Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway. (PMID: 26666750) Pavlou D … Kirmizis A (Apoptosis : an international journal on programmed cell death 2016) 3 4 56
  4. The molecular basis for histone H4- and H2A-specific amino-terminal acetylation by NatD. (PMID: 25619998) Magin RS … Marmorstein R (Structure (London, England : 1993) 2015) 3 4 56
  5. Structure of Patt1 human proapoptotic histone acetyltransferase. (PMID: 24248912) Jędrzejewski RP … Kaźmierkiewicz R (Journal of molecular modeling 2013) 3 4 56

Products for NAA40 Gene

Sources for NAA40 Gene