NAA38 Gene (Protein Coding)

N-Alpha-Acetyltransferase 38, NatC Auxiliary Subunit

GC17M007856
GIFtS:
32
See more...

Aliases for NAA38 Gene

Aliases for NAA38 Gene

  • N-Alpha-Acetyltransferase 38, NatC Auxiliary Subunit 2 3 4 5
  • PFAAP2 2 3 4
  • Phosphonoformate Immuno-Associated Protein 2 3 4
  • LSM Domain-Containing Protein 1 3 4
  • LSM Domain Containing 1 2 3
  • LSMD1 3 4
  • MAK31 3 4
  • N(Alpha)-Acetyltransferase 38, NatC Auxiliary Subunit 2
  • MGC14151 2
  • NAA38 5

External Ids for NAA38 Gene

Previous HGNC Symbols for NAA38 Gene

  • LSMD1

Previous GeneCards Identifiers for NAA38 Gene

  • GC07P117824
  • GC07P112190
  • GC17M007763

Summaries for NAA38 Gene

GeneCards Summary for NAA38 Gene

NAA38 (N-Alpha-Acetyltransferase 38, NatC Auxiliary Subunit) is a Protein Coding gene. Among its related pathways are Retrograde transport at the Trans-Golgi-Network and Golgi-to-ER retrograde transport.

UniProtKB/Swiss-Prot Summary for NAA38 Gene

  • Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.

Additional gene information for NAA38 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NAA38 Gene

Genomics for NAA38 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for NAA38 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAA38 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NAA38

Genomic Locations for NAA38 Gene

Genomic Locations for NAA38 Gene
chr17:7,856,681-7,885,420
(GRCh38/hg38)
Size:
28,740 bases
Orientation:
Minus strand
chr17:7,760,003-7,788,556
(GRCh37/hg19)
Size:
28,554 bases
Orientation:
Minus strand

Genomic View for NAA38 Gene

Genes around NAA38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA38 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NAA38 Gene

Proteins for NAA38 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NAA38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRA0-LSMD1_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 38, NatC auxiliary subunit
    Protein Accession:
    Q9BRA0
    Secondary Accessions:
    • Q8N4M0

    Protein attributes for NAA38 Gene

    Size:
    125 amino acids
    Molecular mass:
    13514 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.

    Alternative splice isoforms for NAA38 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA38 Gene

Protein Expression for NAA38 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NAA38 Gene

  • Ubiquitination at Lys51 and Lys86
  • Modification sites at PhosphoSitePlus

Other Protein References for NAA38 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NAA38 Gene

Domains & Families for NAA38 Gene

Gene Families for NAA38 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NAA38 Gene

InterPro:
Blocks:
  • Small nuclear ribonucleoprotein (Sm protein)
  • Like-Sm ribonucleoprotein-related, core
ProtoNet:

Suggested Antigen Peptide Sequences for NAA38 Gene

GenScript: Design optimal peptide antigens:
  • Phosphonoformate immuno-associated protein 2 (LSMD1_HUMAN)
  • U6 snRNA-associated Sm-like protein LSm8 (NAA38_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BRA0

UniProtKB/Swiss-Prot:

LSMD1_HUMAN :
  • Belongs to the snRNP Sm proteins family.
Family:
  • Belongs to the snRNP Sm proteins family.
genes like me logo Genes that share domains with NAA38: view

Function for NAA38 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for NAA38 Gene

UniProtKB/Swiss-Prot Function:
Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.

Phenotypes From GWAS Catalog for NAA38 Gene

Gene Ontology (GO) - Molecular Function for NAA38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NAA38: view
genes like me logo Genes that share phenotypes with NAA38: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAA38

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NAA38 Gene

Localization for NAA38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA38 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAA38 gene
Compartment Confidence
nucleus 5
extracellular 2
mitochondrion 1
golgi apparatus 1
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NAA38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 19398576
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 19398576
GO:0005844 colocalizes_with polysome IDA 19398576
GO:0031417 NatC complex IEA,IDA 19398576
genes like me logo Genes that share ontologies with NAA38: view

Pathways & Interactions for NAA38 Gene

genes like me logo Genes that share pathways with NAA38: view

Gene Ontology (GO) - Biological Process for NAA38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043066 negative regulation of apoptotic process IMP 19398576
genes like me logo Genes that share ontologies with NAA38: view

No data available for SIGNOR curated interactions for NAA38 Gene

Drugs & Compounds for NAA38 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for NAA38 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for NAA38 Gene

4 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAA38

Alternative Splicing Database (ASD) splice patterns (SP) for NAA38 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3
SP1: -
SP2:
SP3: -

Relevant External Links for NAA38 Gene

GeneLoc Exon Structure for
NAA38

Expression for NAA38 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NAA38 Gene

mRNA expression in normal human tissues for NAA38 Gene
mRNA expression by BioGPS for NAA38 GenemRNA expression by GTEx for NAA38 Gene

Protein differential expression in normal tissues from HIPED for NAA38 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.9) and Nasal epithelium (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAA38 Gene



Protein tissue co-expression partners for NAA38 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NAA38

Evidence on tissue expression from TISSUES for NAA38 Gene

  • Pancreas(4.3)
  • Liver(4.2)
  • Muscle(2.3)
genes like me logo Genes that share expression patterns with NAA38: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAA38 Gene

Orthologs for NAA38 Gene

This gene was present in the common ancestor of animals.

Orthologs for NAA38 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia NAA38 30
  • 99.42 (n)
LSMD1 31
  • 98 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia NAA38 30
  • 88.69 (n)
LSMD1 31
  • 77 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia NAA38 30
  • 87.67 (n)
LSMD1 31
  • 40 (a)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Naa38 30
  • 83.67 (n)
Mouse
(Mus musculus)
 Mammalia Naa38 30 17
  • 83.33 (n)
Lsmd1 31
  • 76 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia LSMD1 31
  • 71 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves LSMD1 30 31
  • 76.07 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia LSMD1 31
  • 66 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia naa38 30
  • 71.87 (n)
Str.17236 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.6876 30
Zebrafish
(Danio rerio)
 Actinopterygii naa38 30
  • 66.27 (n)
lsmd1 31
  • 64 (a)
 OneToOne
wufj33f12 30
Fruit Fly
(Drosophila melanogaster)
 Insecta CG31950 31
  • 33 (a)
 OneToOne
Species where no ortholog for NAA38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NAA38 Gene

ENSEMBL:
Gene Tree for NAA38 (if available)
TreeFam:
Gene Tree for NAA38 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NAA38: view image

Paralogs for NAA38 Gene

(4) SIMAP similar genes for NAA38 Gene using alignment to 6 proteins:

  • LSMD1_HUMAN
  • C9JIZ0_HUMAN
  • C9JNV3_HUMAN
  • F2Z2Y6_HUMAN
  • I3L3Z2_HUMAN
  • I3L4V0_HUMAN
genes like me logo Genes that share paralogs with NAA38: view

No data available for Paralogs for NAA38 Gene

Variants for NAA38 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NAA38 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
769908 Benign: not provided 7,885,064(-) G/GCCGCCGCCC INFRAME_INSERTION,INTRON_VARIANT
771021 Benign: not provided 7,885,046(-) G/GCCA INFRAME_INSERTION,INTRON_VARIANT
808218 Likely Benign: not provided 7,857,256(-) C/T NONSENSE,INTRON_VARIANT
871294 Uncertain Significance: not provided 7,885,021(-) T/G MISSENSE_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for NAA38 Gene

Structural Variations from Database of Genomic Variants (DGV) for NAA38 Gene

Variant ID Type Subtype PubMed ID
dgv510n67 CNV gain 20364138
nsv1070804 CNV deletion 25765185
nsv833351 CNV loss 17160897

Variation tolerance for NAA38 Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAA38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAA38

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA38 Gene

Disorders for NAA38 Gene

Additional Disease Information for NAA38

Genetic Association Database
(GAD)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for NAA38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAA38 Gene

Publications for NAA38 Gene

  1. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B … Sherman F (BMC proceedings 2009) 2 3 4
  2. Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization. (PMID: 19398576) Starheim KK … Arnesen T (Molecular and cellular biology 2009) 2 3 4
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3

ExternalLinks

View latest publications for NAA38 gene in Mastermind

Products for NAA38 Gene

  • Signalway Proteins for NAA38

Sources for NAA38 Gene