Aliases for NAA35 Gene

Aliases for NAA35 Gene

  • N-Alpha-Acetyltransferase 35, NatC Auxiliary Subunit 2 3 4
  • N(Alpha)-Acetyltransferase 35, NatC Auxiliary Subunit 2 5
  • Embryonic Growth-Associated Protein Homolog 3 4
  • Protein MAK10 Homolog 3 4
  • MAK10 3 4
  • EGAP 3 4
  • MAK10 Homolog, Amino-Acid N-Acetyltransferase Subunit (S. Cerevisiae) 2
  • MAK10 Homolog, Amino-Acid N-Acetyltransferase Subunit 3
  • Corneal Wound Healing-Related Protein 3
  • BA379P1.1 3
  • MAK10P 3

External Ids for NAA35 Gene

Previous HGNC Symbols for NAA35 Gene

  • MAK10

Previous GeneCards Identifiers for NAA35 Gene

  • GC09P088556
  • GC09P058381

Summaries for NAA35 Gene

GeneCards Summary for NAA35 Gene

NAA35 (N-Alpha-Acetyltransferase 35, NatC Auxiliary Subunit) is a Protein Coding gene. Diseases associated with NAA35 include Ogden Syndrome and Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome. Among its related pathways are Vesicle-mediated transport and Golgi-to-ER retrograde transport.

UniProtKB/Swiss-Prot Summary for NAA35 Gene

  • Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.

Additional gene information for NAA35 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NAA35 Gene

Genomics for NAA35 Gene

GeneHancer (GH) Regulatory Elements for NAA35 Gene

Promoters and enhancers for NAA35 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J085939 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.2 184 3.4 ZBTB40 ZNF217 ZSCAN5C NRF1 POLR2G SP1 NCOR1 PHF8 ZFX EP300 NAA35 lnc-GOLM1-4 GOLM1 ENSG00000165121 piR-50443-379 RF00017-7671
GH09J085881 Promoter 0.4 EPDnew 500.2 -59.9 -59898 0.1 GLIS1 piR-53338-135 NAA35 piR-51267-034 lnc-NAA35-6 RF00017-7671
GH09J086731 Enhancer 1.2 Ensembl ENCODE dbSUPER 29.4 +792.6 792617 5.1 ZSCAN5C JUND FOS ZNF639 ZNF10 ZIC2 KLF7 ZNF662 EP300 ATF2 HSALNG0072415 NAA35 GAS1RR ENSG00000165121 ENSG00000231741 GAS1 DAPK1 HSALNG0072414
GH09J084949 Enhancer 0.7 dbSUPER 30.2 -990.0 -990030 3.2 EP300 RBAK ZNF623 ZNF510 ZNF266 ZNF316 MAFF MAFK ZBTB11 ZNF426 HNRNPK NAA35 ENSG00000165121 ENSG00000235298 HSALNG0072321 piR-61945-505 NTRK2
GH09J085401 Enhancer 0.8 Ensembl 11.3 -538.7 -538741 1.2 ZSCAN5C JUND ZNF639 ZNF10 TRIM28 KLF7 ZEB1 OSR2 BCL11A WT1 ENSG00000231741 ENSG00000165121 NAA35 piR-55110-092 piR-60885-165 ENSG00000285634 LOC105376121
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAA35 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NAA35

Genomic Locations for NAA35 Gene

Genomic Locations for NAA35 Gene
chr9:85,941,142-86,025,462
(GRCh38/hg38)
Size:
84,321 bases
Orientation:
Plus strand
chr9:88,556,057-88,637,217
(GRCh37/hg19)
Size:
81,161 bases
Orientation:
Plus strand

Genomic View for NAA35 Gene

Genes around NAA35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA35 Gene

Proteins for NAA35 Gene

  • Protein details for NAA35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZE5-NAA35_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 35, NatC auxiliary subunit
    Protein Accession:
    Q5VZE5
    Secondary Accessions:
    • Q5VZE6
    • Q9H631
    • Q9H703

    Protein attributes for NAA35 Gene

    Size:
    725 amino acids
    Molecular mass:
    83639 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
    SequenceCaution:
    • Sequence=BAB15097.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAB15435.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NAA35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA35 Gene

Post-translational modifications for NAA35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NAA35 Gene

Domains & Families for NAA35 Gene

Gene Families for NAA35 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NAA35 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NAA35 Gene

GenScript: Design optimal peptide antigens:
  • Protein MAK10 homolog (NAA35_HUMAN)
  • cDNA FLJ31497 fis, clone NT2NE2005317, highly similar to Homo sapiens MAK10 homolog, amino-acid N-acetyltransferase subunit, (S. cerevisiae) (MAK10), mRNA (Q5VZE6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5VZE5

UniProtKB/Swiss-Prot:

NAA35_HUMAN :
  • Belongs to the MAK10 family.
Family:
  • Belongs to the MAK10 family.
genes like me logo Genes that share domains with NAA35: view

Function for NAA35 Gene

Molecular function for NAA35 Gene

UniProtKB/Swiss-Prot Function:
Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.

Phenotypes From GWAS Catalog for NAA35 Gene

Gene Ontology (GO) - Molecular Function for NAA35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004596 peptide alpha-N-acetyltransferase activity IBA 21873635
GO:0005515 protein binding IPI 19398576
genes like me logo Genes that share ontologies with NAA35: view
genes like me logo Genes that share phenotypes with NAA35: view

Animal Model Products

CRISPR Products

miRNA for NAA35 Gene

miRTarBase miRNAs that target NAA35

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAA35

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA35 Gene

Localization for NAA35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA35 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAA35 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NAA35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005844 colocalizes_with polysome IDA 19398576
GO:0031417 NatC complex IBA,IDA 19398576
genes like me logo Genes that share ontologies with NAA35: view

Pathways & Interactions for NAA35 Gene

genes like me logo Genes that share pathways with NAA35: view

Gene Ontology (GO) - Biological Process for NAA35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006474 N-terminal protein amino acid acetylation IBA 21873635
GO:0017196 N-terminal peptidyl-methionine acetylation IEA --
GO:0043066 negative regulation of apoptotic process IMP 19398576
GO:0048659 smooth muscle cell proliferation ISS --
genes like me logo Genes that share ontologies with NAA35: view

No data available for SIGNOR curated interactions for NAA35 Gene

Drugs & Compounds for NAA35 Gene

No Compound Related Data Available

Transcripts for NAA35 Gene

mRNA/cDNA for NAA35 Gene

4 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAA35

Alternative Splicing Database (ASD) splice patterns (SP) for NAA35 Gene

No ASD Table

Relevant External Links for NAA35 Gene

GeneLoc Exon Structure for
NAA35

Expression for NAA35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NAA35 Gene

Protein differential expression in normal tissues from HIPED for NAA35 Gene

This gene is overexpressed in Breast (32.3), Urine (9.1), and Plasma (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAA35 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NAA35

SOURCE GeneReport for Unigene cluster for NAA35 Gene:

Hs.436098

Evidence on tissue expression from TISSUES for NAA35 Gene

  • Nervous system(4.3)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with NAA35: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAA35 Gene

Orthologs for NAA35 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAA35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAA35 31 30
  • 99.82 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NAA35 31
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAA35 31 30
  • 95.26 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NAA35 31 30
  • 94.57 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NAA35 31
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Naa35 17 31 30
  • 88.92 (n)
rat
(Rattus norvegicus)
Mammalia Naa35 30
  • 88.23 (n)
chicken
(Gallus gallus)
Aves NAA35 31 30
  • 84.6 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAA35 31
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia naa35 30
  • 79.59 (n)
Str.16347 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.19076 30
zebrafish
(Danio rerio)
Actinopterygii naa35 31 30
  • 75.51 (n)
OneToOne
wufb21g10 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005863 30
  • 51.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4065 31 30
  • 50.07 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T23B12.4 31 30
  • 44.93 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAK10 33
thale cress
(Arabidopsis thaliana)
eudicotyledons MAK10 30
  • 42.72 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 45 (a)
OneToOne
Cin.10400 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10400 30
Species where no ortholog for NAA35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAA35 Gene

ENSEMBL:
Gene Tree for NAA35 (if available)
TreeFam:
Gene Tree for NAA35 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NAA35: view image

Paralogs for NAA35 Gene

No data available for Paralogs for NAA35 Gene

Variants for NAA35 Gene

Additional dbSNP identifiers (rs#s) for NAA35 Gene

Structural Variations from Database of Genomic Variants (DGV) for NAA35 Gene

Variant ID Type Subtype PubMed ID
nsv475991 CNV novel sequence insertion 20440878
nsv519890 CNV loss 19592680
nsv831646 CNV loss 17160897

Variation tolerance for NAA35 Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAA35 Gene

Human Gene Mutation Database (HGMD)
NAA35
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAA35

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NAA35 Gene

Disorders for NAA35 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NAA35 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search NAA35 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NAA35

genes like me logo Genes that share disorders with NAA35: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAA35 Gene

Publications for NAA35 Gene

  1. Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization. (PMID: 19398576) Starheim KK … Arnesen T (Molecular and cellular biology 2009) 2 3 4 54
  2. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B … Sherman F (BMC proceedings 2009) 2 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. (PMID: 30575818) Tiemann K … Kani K (Oncogene 2019) 3 54
  5. Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function. (PMID: 29467282) Heidelberger JB … Beli P (EMBO reports 2018) 3 54

Products for NAA35 Gene

Sources for NAA35 Gene