This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010] See more...

Aliases for NAA25 Gene

Aliases for NAA25 Gene

  • N-Alpha-Acetyltransferase 25, NatB Auxiliary Subunit 2 3 4 5
  • N-Terminal Acetyltransferase B Complex Subunit NAA25 3 4
  • NatB Complex Subunit MDM20 3 4
  • C12orf30 3 4
  • MDM20 3 4
  • NAP1 3 4
  • N(Alpha)-Acetyltransferase 25, NatB Auxiliary Subunit 2
  • Mitochondrial Distribution And Morphology Protein 20 4
  • N-Terminal Acetyltransferase B Complex Subunit MDM20 4
  • Mitochondrial Distribution And Morphology 20 3
  • Chromosome 12 Open Reading Frame 30 2
  • FLJ13089 2
  • NAA25 5
  • P120 4

External Ids for NAA25 Gene

Previous HGNC Symbols for NAA25 Gene

  • C12orf30

Previous GeneCards Identifiers for NAA25 Gene

  • GC12M112464
  • GC12M109477

Summaries for NAA25 Gene

Entrez Gene Summary for NAA25 Gene

  • This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010]

GeneCards Summary for NAA25 Gene

NAA25 (N-Alpha-Acetyltransferase 25, NatB Auxiliary Subunit) is a Protein Coding gene. Diseases associated with NAA25 include Ogden Syndrome and Ectodermal Dysplasia 4, Hair/Nail Type. An important paralog of this gene is NAA16.

UniProtKB/Swiss-Prot Summary for NAA25 Gene

  • Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NAA25 Gene

Genomics for NAA25 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NAA25 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J112106 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +0.0 6 4.6 GATAD2A PRDM10 RFX1 IKZF1 POLR2A BACH1 FOXA1 LARP7 PRDM1 ZNF143 NAA25 lnc-HECTD4-2 lnc-TRAFD1-2 TMEM116 ADAM1A ERP29
GH12J112011 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11 +95.2 95241 4.3 RNF2 SP1 CREB1 GATAD2A PRDM10 ZNF629 REST TFE3 LEF1 IKZF1 TMEM116 ERP29 lnc-NAA25-5 RPL6 MAPKAPK5 HECTD4 ADAM1A NAA25 HSPA8P14 TRAFD1
GH12J112124 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -19.5 -19497 8.2 SP1 CREB1 ZNF629 IKZF1 ZNF692 POLR2A BACH1 FOS JUND FOXA1 TRAFD1 TMEM116 MAPKAPK5 ADAM1A NAA25 ERP29 MN309607 HECTD4
GH12J113069 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 13.2 -961.6 -961596 4.4 SP1 GATAD2A PRDM10 REST KDM1A STAT3 RELA RXRB IKZF2 RCOR1 RBM19 NAA25 ENSG00000201208 DDX54 RITA1 CFAP73 DTX1 PLBD2 SDSL piR-43104-010
GH12J112386 Enhancer 1 ENCODE 10.9 -278.4 -278430 1.1 CTCF PRDM10 ZNF629 LEF1 IKZF1 JUND ZNF143 REST RAD21 BRD9 HECTD4 ATXN2 ADAM1A NAA25 HSALNG0094111 RF00017-1280 PTPN11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAA25 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NAA25

Genomic Locations for NAA25 Gene

Genomic Locations for NAA25 Gene
chr12:112,026,689-112,108,804
(GRCh38/hg38)
Size:
82,116 bases
Orientation:
Minus strand
chr12:112,464,493-112,546,826
(GRCh37/hg19)
Size:
82,334 bases
Orientation:
Minus strand

Genomic View for NAA25 Gene

Genes around NAA25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA25 Gene

Proteins for NAA25 Gene

  • Protein details for NAA25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14CX7-NAA25_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 25, NatB auxiliary subunit
    Protein Accession:
    Q14CX7
    Secondary Accessions:
    • A0JLU7
    • Q6MZH1
    • Q7Z4N6
    • Q9H911

    Protein attributes for NAA25 Gene

    Size:
    972 amino acids
    Molecular mass:
    112292 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.
    SequenceCaution:
    • Sequence=BAB14432.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAE46062.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NAA25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA25 Gene

Post-translational modifications for NAA25 Gene

  • Ubiquitination at Lys742
  • Modification sites at PhosphoSitePlus

Other Protein References for NAA25 Gene

No data available for DME Specific Peptides for NAA25 Gene

Domains & Families for NAA25 Gene

Gene Families for NAA25 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NAA25 Gene

Suggested Antigen Peptide Sequences for NAA25 Gene

GenScript: Design optimal peptide antigens:
  • p120 (NAA25_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14CX7

UniProtKB/Swiss-Prot:

NAA25_HUMAN :
  • Belongs to the MDM20/NAA25 family.
Family:
  • Belongs to the MDM20/NAA25 family.
genes like me logo Genes that share domains with NAA25: view

Function for NAA25 Gene

Molecular function for NAA25 Gene

UniProtKB/Swiss-Prot Function:
Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression.

Phenotypes From GWAS Catalog for NAA25 Gene

Gene Ontology (GO) - Molecular Function for NAA25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004596 contributes_to peptide alpha-N-acetyltransferase activity IBA 21873635
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with NAA25: view
genes like me logo Genes that share phenotypes with NAA25: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAA25

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA25 Gene

Localization for NAA25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA25 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAA25 gene
Compartment Confidence
cytosol 5
golgi apparatus 4
nucleus 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NAA25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA --
GO:0031416 NatB complex IBA 21873635
genes like me logo Genes that share ontologies with NAA25: view

Pathways & Interactions for NAA25 Gene

PathCards logo

SuperPathways for NAA25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAA25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017196 N-terminal peptidyl-methionine acetylation IBA 21873635
genes like me logo Genes that share ontologies with NAA25: view

No data available for Pathways by source and SIGNOR curated interactions for NAA25 Gene

Drugs & Compounds for NAA25 Gene

No Compound Related Data Available

Transcripts for NAA25 Gene

mRNA/cDNA for NAA25 Gene

1 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAA25

Alternative Splicing Database (ASD) splice patterns (SP) for NAA25 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - -
SP2: - - - -
SP3: -
SP4: -
SP5:
SP6: - -
SP7:

ExUns: 22 ^ 23 ^ 24a · 24b ^ 25
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for NAA25 Gene

GeneLoc Exon Structure for
NAA25

Expression for NAA25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NAA25 Gene

Protein differential expression in normal tissues from HIPED for NAA25 Gene

This gene is overexpressed in Lymph node (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAA25 Gene



Protein tissue co-expression partners for NAA25 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NAA25

SOURCE GeneReport for Unigene cluster for NAA25 Gene:

Hs.530941

Evidence on tissue expression from TISSUES for NAA25 Gene

  • Eye(4.3)
  • Nervous system(3.5)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with NAA25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAA25 Gene

Orthologs for NAA25 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAA25 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NAA25 30 31
  • 99.73 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NAA25 30 31
  • 94.55 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NAA25 30 31
  • 94.17 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 89 (a)
OneToMany
-- 31
  • 86 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Naa25 30 17 31
  • 87.11 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Naa25 30
  • 86.62 (n)
Oppossum
(Monodelphis domestica)
Mammalia NAA25 31
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NAA25 30 31
  • 79.39 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NAA25 31
  • 80 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia naa25 30
  • 72.23 (n)
Str.1475 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.7595 30
Zebrafish
(Danio rerio)
Actinopterygii naa25 30 31
  • 66.77 (n)
OneToOne
Dr.14297 30
Fruit Fly
(Drosophila melanogaster)
Insecta psidin 30 31
  • 47.28 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta NAA25_ANOGA 30
  • 46.85 (n)
Worm
(Caenorhabditis elegans)
Secernentea cra-1 30 31
  • 43.8 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MDM20 33
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 42 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes naa25 30
  • 40.82 (n)
Species where no ortholog for NAA25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for NAA25 Gene

ENSEMBL:
Gene Tree for NAA25 (if available)
TreeFam:
Gene Tree for NAA25 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NAA25: view image

Paralogs for NAA25 Gene

Paralogs for NAA25 Gene

(3) SIMAP similar genes for NAA25 Gene using alignment to 4 proteins:

  • NAA25_HUMAN
  • F8VSB9_HUMAN
  • F8W0N5_HUMAN
  • H0YHR9_HUMAN
genes like me logo Genes that share paralogs with NAA25: view

Variants for NAA25 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NAA25 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
765613 Likely Benign: not provided 112,053,591(-) G/A SYNONYMOUS_VARIANT
787176 Likely Benign: not provided 112,043,707(-) C/T MISSENSE_VARIANT
793601 Likely Benign: not provided 112,033,384(-) G/A INTRON_VARIANT
VAR_035872 A breast cancer sample p.Ser789Arg
rs12231744 - p.Lys876Arg

Additional dbSNP identifiers (rs#s) for NAA25 Gene

Structural Variations from Database of Genomic Variants (DGV) for NAA25 Gene

Variant ID Type Subtype PubMed ID
nsv483114 CNV gain 15286789
nsv52789 CNV deletion 16902084

Variation tolerance for NAA25 Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.84; 89.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAA25 Gene

Human Gene Mutation Database (HGMD)
NAA25
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAA25

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA25 Gene

Disorders for NAA25 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NAA25 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ogden syndrome
  • ogdns
ectodermal dysplasia 4, hair/nail type
  • ectd4
- elite association - COSMIC cancer census association via MalaCards
Search NAA25 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NAA25

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with NAA25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAA25 Gene

Publications for NAA25 Gene

  1. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B … Sherman F (BMC proceedings 2009) 2 3 4
  2. Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression. (PMID: 18570629) Starheim KK … Lillehaug JR (The Biochemical journal 2008) 2 3 4
  3. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 2 3
  4. A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. (PMID: 21437268) McKay JD … Brennan P (PLoS genetics 2011) 3 41
  5. Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. (PMID: 18978792) Cooper JD … Todd JA (Nature genetics 2008) 3 41

Products for NAA25 Gene

Sources for NAA25 Gene