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NAA25 Gene(Protein Coding)

N(Alpha)-Acetyltransferase 25, NatB Auxiliary Subunit

GCID:
GC12M112026
GIFtS:
40
Genes Participants
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Aliases for NAA25 Gene

Aliases for NAA25 Gene

  • N(Alpha)-Acetyltransferase 25, NatB Auxiliary Subunit 2 3 5
  • N-Alpha-Acetyltransferase 25, NatB Auxiliary Subunit 3 4
  • N-Terminal Acetyltransferase B Complex Subunit NAA25 3 4
  • NatB Complex Subunit MDM20 3 4
  • C12orf30 3 4
  • MDM20 3 4
  • NAP1 3 4
  • Mitochondrial Distribution And Morphology Protein 20 4
  • N-Terminal Acetyltransferase B Complex Subunit MDM20 4
  • Mitochondrial Distribution And Morphology 20 3
  • Chromosome 12 Open Reading Frame 30 2
  • P120 4

External Ids for NAA25 Gene

Previous HGNC Symbols for NAA25 Gene

  • C12orf30

Previous GeneCards Identifiers for NAA25 Gene

  • GC12M112464
  • GC12M109477

Summaries for NAA25 Gene

Entrez Gene Summary for NAA25 Gene

  • This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010]

GeneCards Summary for NAA25 Gene

NAA25 (N(Alpha)-Acetyltransferase 25, NatB Auxiliary Subunit) is a Protein Coding gene. An important paralog of this gene is NAA16.

UniProtKB/Swiss-Prot for NAA25 Gene

  • Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression.

Additional gene information for NAA25 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA25 Gene

Genomics for NAA25 Gene

GeneHancer (GH) Regulatory Elements for NAA25 Gene

Promoters and enhancers for NAA25 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12J112106 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 600.7 +0.2 224 4.6 ELF3 ZFX MNT NKRF MLLT1 ZNF121 CEBPG POLR2A ZNF384 ZNF687 GC12P112109 NAA25 TMEM116 ADAM1A ENSG00000200688
GH12J112011 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11 +95.5 95459 4.3 SP1 CC2D1A ZFX ELF3 MNT CBFA2T2 NKRF POLR2A MLLT1 CEBPG TMEM116 ERP29 RPL6 MAPKAPK5 NAA25 HSPA8P14 TRAFD1 RPS2P41 GC12P112008 ENSG00000274227
GH12J112124 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.7 -19.2 -19246 7.2 ZNF652 SP1 ZFX NKRF POLR2A MLLT1 CEBPG GTF2F1 ZNF384 ZNF687 TRAFD1 TMEM116 MAPKAPK5 BRAP ADAM1A NAA25 ERP29 GC12P112151
GH12J113069 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.2 -961.2 -961211 4.1 SP1 ZKSCAN8 ZNF687 RELA CREM MLLT1 IKZF1 RXRA PRDM10 IKZF2 GC12P113070 RBM19 NAA25 ENSG00000201208 DDX54 RITA1 CFAP73 DTX1 PLBD2 SDSL
GH12J112327 Enhancer 0.7 Ensembl 18.7 -218.8 -218779 0.4 ZNF121 ZNF404 MZF1 ZNF680 ZNF560 KLF7 ZNF501 ZNF140 ZNF316 ZNF266 PCNPP1 ADAM1A MAPKAPK5 HSPA8P14 NAA25 RPL6 ATXN2-AS HECTD4 TPCN1 TRAFD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAA25 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NAA25 Gene

Genomic Locations for NAA25 Gene
chr12:112,026,689-112,109,022
(GRCh38/hg38)
Size:
82,334 bases
Orientation:
Minus strand
chr12:112,464,493-112,546,826
(GRCh37/hg19)
Size:
82,334 bases
Orientation:
Minus strand

Genomic View for NAA25 Gene

Genes around NAA25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA25 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NAA25 Gene

Proteins for NAA25 Gene

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  • Protein details for NAA25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14CX7-NAA25_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 25, NatB auxiliary subunit
    Protein Accession:
    Q14CX7
    Secondary Accessions:
    • A0JLU7
    • Q6MZH1
    • Q7Z4N6
    • Q9H911

    Protein attributes for NAA25 Gene

    Size:
    972 amino acids
    Molecular mass:
    112292 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.
    SequenceCaution:
    • Sequence=BAB14432.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAE46062.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NAA25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA25 Gene

Protein Expression for NAA25 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NAA25 Gene

  • Ubiquitination at posLast=742742
  • Modification sites at PhosphoSitePlus

Other Protein References for NAA25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NAA25 Gene

Domains & Families for NAA25 Gene

Gene Families for NAA25 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NAA25 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NAA25 Gene

GenScript: Design optimal peptide antigens:
  • p120 (NAA25_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14CX7

UniProtKB/Swiss-Prot:

NAA25_HUMAN :
  • Belongs to the MDM20/NAA25 family.
Family:
  • Belongs to the MDM20/NAA25 family.
genes like me logo Genes that share domains with NAA25: view

Function for NAA25 Gene

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  6. Cell Line

Molecular function for NAA25 Gene

UniProtKB/Swiss-Prot Function:
Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression.

Phenotypes From GWAS Catalog for NAA25 Gene

Gene Ontology (GO) - Molecular Function for NAA25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004596 contributes_to peptide alpha-N-acetyltransferase activity IBA 21873635
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with NAA25: view
genes like me logo Genes that share phenotypes with NAA25: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAA25

Clone Products

  • Applied Biological Materials (abm): Clones for NAA25 - Now 50% OFF >
  • * NAA25 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NAA25 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA25 Gene

Localization for NAA25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA25 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAA25 gene
Compartment Confidence
cytosol 5
golgi apparatus 4
nucleus 3
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NAA25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA --
GO:0031416 NatB complex IBA 21873635
genes like me logo Genes that share ontologies with NAA25: view

Pathways & Interactions for NAA25 Gene

GeneAnalytics - gene set analysis. Cells, Diseases, Pathways, Function and Compounds, relevant to your gene set. Powered by GeneCards
PathCards logo

SuperPathways for NAA25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAA25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017196 N-terminal peptidyl-methionine acetylation IBA 21873635
genes like me logo Genes that share ontologies with NAA25: view

No data available for Pathways by source and SIGNOR curated interactions for NAA25 Gene

Drugs & Compounds for NAA25 Gene

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  1. Drug
GeneAnalytics - gene set analysis. Cells, Diseases, Pathways, Function and Compounds, relevant to your gene set. Powered by GeneCards
No Compound Related Data Available

Transcripts for NAA25 Gene

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mRNA/cDNA for NAA25 Gene

(1) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(218) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for NAA25 Gene

N(alpha)-acetyltransferase 25, NatB auxiliary subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAA25

Clone Products

  • Applied Biological Materials (abm): Clones for NAA25 - Now 50% OFF >
  • * NAA25 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NAA25 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for NAA25 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - -
SP2: - - - -
SP3: -
SP4: -
SP5:
SP6: - -
SP7:

ExUns: 22 ^ 23 ^ 24a · 24b ^ 25
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for NAA25 Gene

GeneLoc Exon Structure for
NAA25
ECgene alternative splicing isoforms for
NAA25

Expression for NAA25 Gene

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  1. Primer
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GeneAnalytics - gene set analysis. Cells, Diseases, Pathways, Function and Compounds, relevant to your gene set. Powered by GeneCards

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAA25 Gene

mRNA expression in normal human tissues for NAA25 Gene
mRNA expression by BioGPS for NAA25 GenemRNA expression by GTEx for NAA25 Gene

Protein differential expression in normal tissues from HIPED for NAA25 Gene

This gene is overexpressed in Lymph node (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAA25 Gene



Protein tissue co-expression partners for NAA25 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAA25 Gene:

NAA25

SOURCE GeneReport for Unigene cluster for NAA25 Gene:

Hs.530941

Evidence on tissue expression from TISSUES for NAA25 Gene

  • Eye(4.3)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with NAA25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAA25 Gene

Orthologs for NAA25 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAA25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia NAA25 35 34
  • 99.73 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia NAA25 35 34
  • 94.55 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia NAA25 35 34
  • 94.17 (n)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 89 (a)
 OneToMany
-- 35
  • 86 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Naa25 17 35 34
  • 87.11 (n)
rat
(Rattus norvegicus)
 Mammalia Naa25 34
  • 86.62 (n)
oppossum
(Monodelphis domestica)
 Mammalia NAA25 35
  • 77 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves NAA25 35 34
  • 79.39 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia NAA25 35
  • 80 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia naa25 34
  • 72.23 (n)
Str.1475 34
African clawed frog
(Xenopus laevis)
 Amphibia Xl.7595 34
zebrafish
(Danio rerio)
 Actinopterygii naa25 35 34
  • 66.77 (n)
 OneToOne
Dr.14297 34
fruit fly
(Drosophila melanogaster)
 Insecta psidin 35 34
  • 47.28 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta NAA25_ANOGA 34
  • 46.85 (n)
worm
(Caenorhabditis elegans)
 Secernentea cra-1 35 34
  • 43.8 (n)
 OneToOne
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes MDM20 37
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 42 (a)
 OneToOne
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes naa25 34
  • 40.82 (n)
Species where no ortholog for NAA25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAA25 Gene

ENSEMBL:
Gene Tree for NAA25 (if available)
TreeFam:
Gene Tree for NAA25 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NAA25: view image

Paralogs for NAA25 Gene

Paralogs for NAA25 Gene

(3) SIMAP similar genes for NAA25 Gene using alignment to 4 proteins:

  • NAA25_HUMAN
  • F8VSB9_HUMAN
  • F8W0N5_HUMAN
  • H0YHR9_HUMAN
genes like me logo Genes that share paralogs with NAA25: view

Variants for NAA25 Gene

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Sequence variations from dbSNP and Humsavar for NAA25 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
VAR_035872 A breast cancer sample p.Ser789Arg
rs1000021466 -- 112,091,081(-) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000082646 -- 112,057,405(-) C/T intron_variant
rs1000097342 -- 112,084,529(-) G/A intron_variant
rs1000135391 -- 112,097,380(-) G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NAA25 Gene

Variant ID Type Subtype PubMed ID
nsv483114 CNV gain 15286789
nsv52789 CNV deletion 16902084

Variation tolerance for NAA25 Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.84; 89.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAA25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAA25
Human Gene Mutation Database (HGMD)
NAA25

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA25 Gene

Disorders for NAA25 Gene

Additional Disease Information for NAA25

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NAA25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAA25 Gene

Publications for NAA25 Gene

  1. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B … Sherman F (BMC proceedings 2009) 2 3 4 58
  2. Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression. (PMID: 18570629) Starheim KK … Lillehaug JR (The Biochemical journal 2008) 2 3 4 58
  3. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 2 3 58
  4. A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. (PMID: 21437268) McKay JD … Brennan P (PLoS genetics 2011) 3 45 58
  5. Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. (PMID: 18978792) Cooper JD … Todd JA (Nature genetics 2008) 3 45 58

ExternalLinks

View latest publications for NAA25 gene in Mastermind

Products for NAA25 Gene

Sources for NAA25 Gene

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