Aliases for NAA25 Gene
Aliases for NAA25 Gene
External Ids for NAA25 Gene
- HGNC: 25783
- Entrez Gene: 80018
- Ensembl: ENSG00000111300
- OMIM: 612755
- UniProtKB: Q14CX7
Previous HGNC Symbols for NAA25 Gene
- C12orf30
Previous GeneCards Identifiers for NAA25 Gene
- GC12M112464
- GC12M109477
Summaries for NAA25 Gene
-
This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010]
GeneCards Summary for NAA25 Gene
NAA25 (N(Alpha)-Acetyltransferase 25, NatB Auxiliary Subunit) is a Protein Coding gene. Diseases associated with NAA25 include Type 1 Diabetes Mellitus 2.
UniProtKB/Swiss-Prot for NAA25 Gene
-
Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression.
Additional gene information for NAA25 Gene
- Monarch Initiative
- Search for NAA25 at DataMed
- Search for NAA25 at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA25 Gene
Genomics for NAA25 Gene
GeneHancer (GH) Regulatory Elements for NAA25 Gene
Promoters and enhancers for NAA25 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around NAA25 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for NAA25 Gene
Genomic Locations for NAA25 Gene
- chr12:112,026,689-112,109,022
- (GRCh38/hg38)
- Size:
- 82,334 bases
- Orientation:
- Minus strand
- chr12:112,464,493-112,546,826
- (GRCh37/hg19)
Genomic View for NAA25 Gene
Genes around NAA25 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.13 by Ensembl
- 12q24.13 by Entrez Gene
- 12q24.13 by HGNC
NAA25 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NAA25 Gene
Proteins for NAA25 Gene
-
Protein details for NAA25 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14CX7-NAA25_HUMAN
- Recommended name:
- N-alpha-acetyltransferase 25, NatB auxiliary subunit
- Protein Accession:
- Q14CX7
- A0JLU7
- Q6MZH1
- Q7Z4N6
- Q9H911
Protein attributes for NAA25 Gene
- Size:
- 972 amino acids
- Molecular mass:
- 112292 Da
- Quaternary structure:
-
- Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.
- SequenceCaution:
-
- Sequence=BAB14432.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAE46062.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for NAA25 Gene
Post-translational modifications for NAA25 Gene
Other Protein References for NAA25 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for NAA25
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-
Abcam antibodies for NAA25
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Protein Products
-
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- Search Origene for MassSpec and Protein Over-expression Lysates for NAA25
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-
Abcam proteins for NAA25
Assay Products
No data available for DME Specific Peptides for NAA25 Gene
Domains & Families for NAA25 Gene
Gene Families for NAA25 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for NAA25 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for NAA25 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q14CX7- Family:
-
- Belongs to the MDM20/NAA25 family.
Function for NAA25 Gene
Molecular function for NAA25 Gene
- UniProtKB/Swiss-Prot Function:
- Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression.
Phenotypes From GWAS Catalog for NAA25 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004596 | contributes_to peptide alpha-N-acetyltransferase activity | IBA | -- |
Phenotypes for NAA25 Gene
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-
-
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miRNA for NAA25 Gene
- miRTarBase miRNAs that target NAA25
-
- hsa-let-7b-5p (MIRT005228)
- hsa-mir-16-5p (MIRT005259)
- hsa-mir-155-5p (MIRT020629)
- hsa-mir-30b-5p (MIRT023442)
- hsa-mir-92a-3p (MIRT049287)
- hsa-mir-6513-5p (MIRT472646)
- hsa-mir-887-5p (MIRT472647)
- hsa-mir-3913-5p (MIRT472648)
- hsa-mir-3122 (MIRT472649)
- hsa-mir-450a-1-3p (MIRT472650)
- hsa-mir-6809-3p (MIRT472651)
- hsa-mir-4753-3p (MIRT472652)
- hsa-mir-6716-5p (MIRT472653)
- hsa-mir-3140-3p (MIRT472654)
- hsa-mir-1236-3p (MIRT472655)
- hsa-mir-6515-3p (MIRT472656)
- hsa-mir-5002-5p (MIRT472657)
- hsa-mir-5571-5p (MIRT472658)
- hsa-mir-3908 (MIRT472659)
- hsa-mir-4506 (MIRT472660)
- hsa-mir-424-5p (MIRT472661)
- hsa-mir-497-5p (MIRT472662)
- hsa-mir-6838-5p (MIRT472663)
- hsa-mir-15b-5p (MIRT472664)
- hsa-mir-15a-5p (MIRT472665)
- hsa-mir-195-5p (MIRT472666)
- hsa-mir-552-5p (MIRT506471)
- hsa-mir-5011-5p (MIRT506472)
- hsa-mir-1277-5p (MIRT506473)
- hsa-mir-3924 (MIRT510033)
- hsa-mir-190a-3p (MIRT510034)
- hsa-mir-223-5p (MIRT510035)
- hsa-mir-511-3p (MIRT510036)
- hsa-mir-6507-5p (MIRT522376)
- hsa-mir-6516-3p (MIRT556007)
miRNA Products
- Search ViGene Biosciences for NAA25
Inhibitory RNA Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available NAA25 gene related products
- orf clones - Search results for available NAA25 gene related products
- Applied Biological Materials Clones for NAA25
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for NAA25 gene
-
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA25 Gene
Localization for NAA25 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NAA25 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| golgi apparatus | 5 |
| nucleus | 3 |
| cytoskeleton | 1 |
- Cytosol (3)
- Golgi apparatus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005794 | Golgi apparatus | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0031416 | NatB complex | IBA | -- |
Pathways & Interactions for NAA25 Gene
No Data Available
Interacting Proteins for NAA25 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0017196 | N-terminal peptidyl-methionine acetylation | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for NAA25 Gene
Transcripts for NAA25 Gene
mRNA/cDNA for NAA25 Gene
- (4) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (218) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NAA25 Gene
CRISPR Products
-
OriGene CRISPR knockouts for NAA25
- genomics-online: gRNA clones - Search results for available NAA25 gene related products
- Applied Biological Materials CRISPR for NAA25
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NAA25
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miRNA Products
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Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for NAA25
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- genomics-online: shRNA clones - Search results for available NAA25 gene related products
-
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Clone Products
- VectorBuilder custom plasmid, inducible vectors for NAA25
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NAA25
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available NAA25 gene related products
- orf clones - Search results for available NAA25 gene related products
- Applied Biological Materials Clones for NAA25
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
| ExUns: | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||
| SP2: | - | ||||||||
| SP3: | |||||||||
| SP4: | |||||||||
| SP5: | |||||||||
| SP6: | |||||||||
| SP7: |
Expression for NAA25 Gene
This gene is overexpressed in Lymph node (9.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAA25 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of NAA25 Gene:
NAA25SOURCE GeneReport for Unigene cluster for NAA25 Gene:
Hs.530941Evidence on tissue expression from TISSUES for NAA25 Gene
- Eye(4.3)
- Nervous system(3.1)
Primer Products
-
OriGene qPCR primer pairs for NAA25
-
OriGene qPCR primer pairs and template standards for NAA25
- genomics-online: primer clones - Search results for available NAA25 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAA25 Gene
Orthologs for NAA25 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NAA25 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | NAA25 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | NAA25 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Naa25 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Naa25 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | NAA25 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NAA25 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | NAA25 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | naa25 33 |
|
||
| Str.1475 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.7595 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | naa25 33 34 |
|
||
| Dr.14297 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | psidin 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | NAA25_ANOGA 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | cra-1 33 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MDM20 36 |
|
|
|
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | naa25 33 |
|
- Species where no ortholog for NAA25 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for NAA25 Gene
(3) SIMAP similar genes for NAA25 Gene using alignment to 4 proteins:
No data available for Paralogs for NAA25 Gene
Variants for NAA25 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_035872 | A breast cancer sample | p.Ser789Arg | |||
| rs1000021466 | -- | 112,091,081(-) | A/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000082646 | -- | 112,057,405(-) | C/T | intron_variant | |
| rs1000097342 | -- | 112,084,529(-) | G/A | intron_variant | |
| rs1000135391 | -- | 112,097,380(-) | G/T | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.84;
89.63% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NAA25 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA25 Gene
Disorders for NAA25 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| type 1 diabetes mellitus 2 |
|
|
Search NAA25 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NAA25
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for NAA25 Gene
Publications for NAA25 Gene
- A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B … Sherman F (BMC proceedings 2009) 2 3 4 58
- Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression. (PMID: 18570629) Starheim KK … Lillehaug JR (The Biochemical journal 2008) 2 3 4 58
- N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 2 3 58
- A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. (PMID: 21437268) McKay JD … Brennan P (PLoS genetics 2011) 3 44 58
- Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. (PMID: 18978792) Cooper JD … Todd JA (Nature genetics 2008) 3 44 58
Products for NAA25 Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for NAA25
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 25 available CTNND1 Antibodies ranked by validation data
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Sources for NAA25 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
