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This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010]
NAA25 (N-Alpha-Acetyltransferase 25, NatB Auxiliary Subunit) is a Protein Coding gene. Diseases associated with NAA25 include Ogden Syndrome and Ectodermal Dysplasia 4, Hair/Nail Type. An important paralog of this gene is NAA16.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004596 | contributes_to peptide alpha-N-acetyltransferase activity | IBA | 21873635 |
GO:0005515 | protein binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005794 | Golgi apparatus | IDA | -- |
GO:0005829 | cytosol | IDA | -- |
GO:0031416 | NatB complex | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0017196 | N-terminal peptidyl-methionine acetylation | IBA | 21873635 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: |
ExUns: | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 |
---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||
SP2: | - | ||||||||
SP3: | |||||||||
SP4: | |||||||||
SP5: | |||||||||
SP6: | |||||||||
SP7: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NAA25 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NAA25 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NAA25 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | Naa25 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Naa25 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | NAA25 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | NAA25 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NAA25 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | naa25 30 |
|
||
Str.1475 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.7595 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | naa25 30 31 |
|
OneToOne | |
Dr.14297 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | psidin 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | NAA25_ANOGA 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | cra-1 30 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MDM20 33 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | naa25 30 |
|
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
765613 | Likely Benign: not provided | 112,053,591(-) | G/A | SYNONYMOUS_VARIANT | |
787176 | Likely Benign: not provided | 112,043,707(-) | C/T | MISSENSE_VARIANT | |
793601 | Likely Benign: not provided | 112,033,384(-) | G/A | INTRON_VARIANT | |
VAR_035872 | A breast cancer sample | p.Ser789Arg | |||
rs12231744 | - | p.Lys876Arg |
Disorder | Aliases | PubMed IDs |
---|---|---|
ogden syndrome |
|
|
ectodermal dysplasia 4, hair/nail type |
|
|