NAT5 is a component of N-acetyltransferase complex B (NatB). Human NatB performs cotranslational N(alpha)-terminal acetylation of methionine residues when they are followed by asparagine (Starheim et al., 2008 [PubMed 18570629]).[supplied by OMIM, Apr 2009] See more...

Aliases for NAA20 Gene

Aliases for NAA20 Gene

  • N-Alpha-Acetyltransferase 20, NatB Catalytic Subunit 2 3
  • N-Acetyltransferase 5, ARD1 Subunit (Arrest-Defective 1, S. Cerevisiae, Homolog) 2 3
  • N-Terminal Acetyltransferase B Complex Catalytic Subunit NAA20 3 4
  • N-Terminal Acetyltransferase B Complex Catalytic Subunit NAT5 3 4
  • N(Alpha)-Acetyltransferase 20, NatB Catalytic Subunit 2 5
  • N-Acetyltransferase 5 (ARD1 Homolog, S. Cerevisiae) 2 3
  • N-Acetyltransferase 5 (GCN5-Related, Putative) 2 3
  • Methionine N-Acetyltransferase 3 4
  • N-Alpha-Acetyltransferase 20 3 4
  • NatB Complex Subunit NAT5 3 4
  • NatB Catalytic Subunit 3 4
  • N-Acetyltransferase 5 2 4
  • NAT5 3 4
  • N-Terminal Acetyltransferase Complex ARD1 Subunit 3
  • N-Acetyltransferase 3 Homolog (S. Cerevisiae) 2
  • N-Acetyltransferase 3 Homolog 3
  • EC 2.3.1.254 4
  • DJ1002M8.1 3
  • NAT3P 3
  • NAT5P 3
  • NAT3 3

External Ids for NAA20 Gene

Previous HGNC Symbols for NAA20 Gene

  • NAT5

Summaries for NAA20 Gene

Entrez Gene Summary for NAA20 Gene

  • NAT5 is a component of N-acetyltransferase complex B (NatB). Human NatB performs cotranslational N(alpha)-terminal acetylation of methionine residues when they are followed by asparagine (Starheim et al., 2008 [PubMed 18570629]).[supplied by OMIM, Apr 2009]

GeneCards Summary for NAA20 Gene

NAA20 (N-Alpha-Acetyltransferase 20, NatB Catalytic Subunit) is a Protein Coding gene. Diseases associated with NAA20 include Ogden Syndrome and Eastern Equine Encephalitis. Among its related pathways are Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and peptide alpha-N-acetyltransferase activity. An important paralog of this gene is NAA11.

UniProtKB/Swiss-Prot Summary for NAA20 Gene

  • Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.

Gene Wiki entry for NAA20 Gene

Additional gene information for NAA20 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NAA20 Gene

Genomics for NAA20 Gene

GeneHancer (GH) Regulatory Elements for NAA20 Gene

Promoters and enhancers for NAA20 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J020016 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +1.2 1155 4.1 EP300 HNRNPK ZBTB40 ZNF217 CTCF SIN3A TCF12 MYC POLR2G PHF8 NAA20 CFAP61 LOC105372553
GH20J020051 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.4 +35.1 35110 2.8 FOXK2 ZBTB40 ZNF217 EP300 SIN3A NRF1 TCF12 POLR2G NCOR1 PHF8 CFAP61 CRNKL1 NAA20 LOC105372553
GH20J019884 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 -129.4 -129442 7.6 TCF12 POLR2G NCOR1 FOS TCF7 TRIM28 TGIF2 SKI TEAD1 ZBTB26 RIN2 NAA20 RPL12P12 piR-52294-075 HSALNG0129028
GH20J019933 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 11.6 -81.5 -81475 4.9 ZNF217 EP300 RFX1 CHD1 CTBP1 SIN3A TCF12 CREB1 FOXA2 ZNF592 RIN2 NAA20 piR-52294-075 HSALNG0129028
GH20J019917 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 11.3 -97.7 -97749 4.6 EP300 SP1 NCOR1 KDM6A TCF7 MEF2C ZBTB25 TGIF2 SKI TEAD1 RIN2 NAA20 piR-52294-075 HSALNG0129028
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAA20 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NAA20

Genomic Locations for NAA20 Gene

Genomic Locations for NAA20 Gene
chr20:20,017,290-20,033,655
(GRCh38/hg38)
Size:
16,366 bases
Orientation:
Plus strand
chr20:19,997,760-20,014,299
(GRCh37/hg19)
Size:
16,540 bases
Orientation:
Plus strand

Genomic View for NAA20 Gene

Genes around NAA20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA20 Gene

Proteins for NAA20 Gene

  • Protein details for NAA20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61599-NAA20_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 20
    Protein Accession:
    P61599
    Secondary Accessions:
    • A6NHA3
    • B2R4G4
    • Q5TFT7
    • Q9D7H8
    • Q9H0Y4
    • Q9NQH6
    • Q9Y6D2

    Protein attributes for NAA20 Gene

    Size:
    178 amino acids
    Molecular mass:
    20368 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.
    SequenceCaution:
    • Sequence=BG548527; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for NAA20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA20 Gene

Post-translational modifications for NAA20 Gene

  • Ubiquitination at Lys124
  • Modification sites at PhosphoSitePlus

Other Protein References for NAA20 Gene

No data available for DME Specific Peptides for NAA20 Gene

Domains & Families for NAA20 Gene

Gene Families for NAA20 Gene

Protein Domains for NAA20 Gene

Suggested Antigen Peptide Sequences for NAA20 Gene

GenScript: Design optimal peptide antigens:
  • N-terminal acetyltransferase B complex catalytic subunit NAT5 (NAA20_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P61599

UniProtKB/Swiss-Prot:

NAA20_HUMAN :
  • Belongs to the acetyltransferase family. ARD1 subfamily.
Family:
  • Belongs to the acetyltransferase family. ARD1 subfamily.
genes like me logo Genes that share domains with NAA20: view

Function for NAA20 Gene

Molecular function for NAA20 Gene

UniProtKB/Swiss-Prot Function:
Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein]; Xref=Rhea:RHEA:50484, Rhea:RHEA-COMP:12694, Rhea:RHEA-COMP:12695, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:133356, ChEBI:CHEBI:133358; EC=2.3.1.254; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein]; Xref=Rhea:RHEA:50492, Rhea:RHEA-COMP:12698, Rhea:RHEA-COMP:12699, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:133361, ChEBI:CHEBI:133362; EC=2.3.1.254; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein]; Xref=Rhea:RHEA:50480, Rhea:RHEA-COMP:12692, Rhea:RHEA-COMP:12693, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:133045, ChEBI:CHEBI:133063; EC=2.3.1.254; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein]; Xref=Rhea:RHEA:50488, Rhea:RHEA-COMP:12696, Rhea:RHEA-COMP:12697, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:133359, ChEBI:CHEBI:133360; EC=2.3.1.254; Evidence=. ;.

Enzyme Numbers (IUBMB) for NAA20 Gene

Phenotypes From GWAS Catalog for NAA20 Gene

Gene Ontology (GO) - Molecular Function for NAA20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004596 peptide alpha-N-acetyltransferase activity IBA 21873635
GO:0008080 N-acetyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with NAA20: view
genes like me logo Genes that share phenotypes with NAA20: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NAA20

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAA20

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA20 Gene

Localization for NAA20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA20 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAA20 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NAA20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus IEA,IDA 25732826
GO:0005737 cytoplasm IDA,IEA 25732826
GO:0005829 cytosol IDA --
GO:0031416 NatB complex IBA 21873635
genes like me logo Genes that share ontologies with NAA20: view

Pathways & Interactions for NAA20 Gene

PathCards logo

SuperPathways for NAA20 Gene

genes like me logo Genes that share pathways with NAA20: view

Pathways by source for NAA20 Gene

1 BioSystems pathway for NAA20 Gene

Gene Ontology (GO) - Biological Process for NAA20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017196 N-terminal peptidyl-methionine acetylation IBA 21873635
genes like me logo Genes that share ontologies with NAA20: view

No data available for SIGNOR curated interactions for NAA20 Gene

Drugs & Compounds for NAA20 Gene

(1) Drugs for NAA20 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for NAA20 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • AcCoA
  • Acetyl coenzyme A
  • S-Acetyl-CoA
  • S-Acetyl-coenzyme A
  • Ac-CoA
72-89-9
genes like me logo Genes that share compounds with NAA20: view

Transcripts for NAA20 Gene

mRNA/cDNA for NAA20 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAA20

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAA20 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -
SP3: - -
SP4:

Relevant External Links for NAA20 Gene

GeneLoc Exon Structure for
NAA20

Expression for NAA20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NAA20 Gene

Protein differential expression in normal tissues from HIPED for NAA20 Gene

This gene is overexpressed in Breast (21.8) and Peripheral blood mononuclear cells (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAA20 Gene



Protein tissue co-expression partners for NAA20 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NAA20

SOURCE GeneReport for Unigene cluster for NAA20 Gene:

Hs.368783

Evidence on tissue expression from TISSUES for NAA20 Gene

  • Nervous system(4.7)
  • Pancreas(4.6)
  • Lung(4.3)
  • Muscle(2.3)
genes like me logo Genes that share expression patterns with NAA20: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAA20 Gene

Orthologs for NAA20 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAA20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAA20 31 30
  • 99.63 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NAA20 31
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAA20 31 30
  • 91.76 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NAA20 31 30
  • 91.39 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Naa20 30
  • 91.2 (n)
mouse
(Mus musculus)
Mammalia Naa20 17 31 30
  • 91.01 (n)
chicken
(Gallus gallus)
Aves NAA20 31 30
  • 81.65 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAA20 31
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia naa20 30
  • 81.65 (n)
MGC76078 30
zebrafish
(Danio rerio)
Actinopterygii naa20 31 30
  • 79.59 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14222 31 30
  • 68.02 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001878 30
  • 66.86 (n)
worm
(Caenorhabditis elegans)
Secernentea Y97E10AL.3 31 30
  • 60.31 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAT3 33 31 30
  • 52.68 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B11275g 30
  • 51.46 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR038C 30
  • 49.41 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G03150 30
  • 60.62 (n)
rice
(Oryza sativa)
Liliopsida Os03g0699400 30
  • 61.21 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 64 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU01276 30
  • 56.16 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes naa20 30
  • 55.56 (n)
Species where no ortholog for NAA20 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAA20 Gene

ENSEMBL:
Gene Tree for NAA20 (if available)
TreeFam:
Gene Tree for NAA20 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NAA20: view image

Paralogs for NAA20 Gene

Paralogs for NAA20 Gene

(1) SIMAP similar genes for NAA20 Gene using alignment to 2 proteins:

  • NAA20_HUMAN
  • A8MZB2_HUMAN

Pseudogenes.org Pseudogenes for NAA20 Gene

genes like me logo Genes that share paralogs with NAA20: view

Variants for NAA20 Gene

Additional dbSNP identifiers (rs#s) for NAA20 Gene

Structural Variations from Database of Genomic Variants (DGV) for NAA20 Gene

Variant ID Type Subtype PubMed ID
esv2665704 CNV deletion 23128226
esv3645467 CNV loss 21293372
nsv179610 CNV deletion 16902084

Variation tolerance for NAA20 Gene

Residual Variation Intolerance Score: 45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAA20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAA20

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NAA20 Gene

Disorders for NAA20 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NAA20 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ogden syndrome
  • ogdns
eastern equine encephalitis
  • eee
- elite association - COSMIC cancer census association via MalaCards
Search NAA20 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NAA20

genes like me logo Genes that share disorders with NAA20: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAA20 Gene

Publications for NAA20 Gene

  1. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B … Sherman F (BMC proceedings 2009) 2 3 4 54
  2. Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression. (PMID: 18570629) Starheim KK … Lillehaug JR (The Biochemical journal 2008) 2 3 4 54
  3. An organellar nα-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity. (PMID: 25732826) Aksnes H … Arnesen T (Cell reports 2015) 3 4 54
  4. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 2 3 54
  5. Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation. (PMID: 19716809) Kuo HP … Hung MC (Biochemical and biophysical research communications 2009) 3 23 54

Products for NAA20 Gene

Sources for NAA20 Gene