Aliases for NAA16 Gene

Aliases for NAA16 Gene

  • N-Alpha-Acetyltransferase 16, NatA Auxiliary Subunit 2 3 4 5
  • NMDA Receptor-Regulated 1-Like Protein 3 4
  • NARG1-Like Protein 3 4
  • NARG1L 3 4
  • N(Alpha)-Acetyltransferase 16, NatA Auxiliary Subunit 2
  • NMDA Receptor Regulated 1-Like 2
  • FLJ22054 2
  • MGC40612 2
  • PRO2435 2
  • NAA16 5
  • NAT2 4

External Ids for NAA16 Gene

Previous HGNC Symbols for NAA16 Gene

  • NARG1L

Previous GeneCards Identifiers for NAA16 Gene

  • GC13P041885
  • GC13P022684

Summaries for NAA16 Gene

GeneCards Summary for NAA16 Gene

NAA16 (N-Alpha-Acetyltransferase 16, NatA Auxiliary Subunit) is a Protein Coding gene. Diseases associated with NAA16 include Ogden Syndrome and Thyroid Gland Anaplastic Carcinoma. Gene Ontology (GO) annotations related to this gene include ribosome binding and peptide alpha-N-acetyltransferase activity. An important paralog of this gene is NAA15.

UniProtKB/Swiss-Prot Summary for NAA16 Gene

  • Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity.

Additional gene information for NAA16 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NAA16 Gene

Genomics for NAA16 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NAA16 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAA16 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NAA16

Genomic Locations for NAA16 Gene

Genomic Locations for NAA16 Gene
chr13:41,311,239-41,377,031
(GRCh38/hg38)
Size:
65,793 bases
Orientation:
Plus strand
chr13:41,885,341-41,951,166
(GRCh37/hg19)
Size:
65,826 bases
Orientation:
Plus strand

Genomic View for NAA16 Gene

Genes around NAA16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA16 Gene

Proteins for NAA16 Gene

  • Protein details for NAA16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6N069-NAA16_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 16, NatA auxiliary subunit
    Protein Accession:
    Q6N069
    Secondary Accessions:
    • B0QZ59
    • Q5VSP9
    • Q6P2D5
    • Q8N5J3
    • Q8N870

    Protein attributes for NAA16 Gene

    Size:
    864 amino acids
    Molecular mass:
    101462 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA10 and NAA16.

    Alternative splice isoforms for NAA16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA16 Gene

Post-translational modifications for NAA16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NAA16 Gene

Domains & Families for NAA16 Gene

Protein Domains for NAA16 Gene

Suggested Antigen Peptide Sequences for NAA16 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ77538, highly similar to Homo sapiens NMDA receptor regulated 1-like (NARG1L), transcript variant 1, mRNA (A4FU51_HUMAN)
  • NMDA receptor-regulated 1-like protein (NAA16_HUMAN)
  • NARG1L protein (Q8N352_HUMAN)
  • NARG1L protein (Q96AH6_HUMAN)
genes like me logo Genes that share domains with NAA16: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NAA16 Gene

Function for NAA16 Gene

Molecular function for NAA16 Gene

UniProtKB/Swiss-Prot Function:
Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity.

Phenotypes From GWAS Catalog for NAA16 Gene

Gene Ontology (GO) - Molecular Function for NAA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004596 contributes_to peptide alpha-N-acetyltransferase activity IBA 21873635
GO:0005515 protein binding IPI 19480662
GO:0016407 contributes_to acetyltransferase activity ISS --
GO:0043022 contributes_to ribosome binding ISS --
genes like me logo Genes that share ontologies with NAA16: view
genes like me logo Genes that share phenotypes with NAA16: view

Animal Model Products

CRISPR Products

miRNA for NAA16 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAA16

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA16 Gene

Localization for NAA16 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAA16 gene
Compartment Confidence
cytosol 5
extracellular 4
nucleus 4
plasma membrane 1
cytoskeleton 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NAA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005667 transcription factor complex ISS --
GO:0005737 cytoplasm IBA,ISS --
GO:0005829 cytosol IDA --
GO:0031415 NatA complex IBA,IDA 19480662
genes like me logo Genes that share ontologies with NAA16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NAA16 Gene

Pathways & Interactions for NAA16 Gene

PathCards logo

SuperPathways for NAA16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006474 N-terminal protein amino acid acetylation ISS --
GO:0017196 N-terminal peptidyl-methionine acetylation IBA 21873635
GO:0043066 negative regulation of apoptotic process IMP 19480662
GO:0045893 positive regulation of transcription, DNA-templated ISS --
GO:0050821 protein stabilization IMP 19480662
genes like me logo Genes that share ontologies with NAA16: view

No data available for Pathways by source and SIGNOR curated interactions for NAA16 Gene

Drugs & Compounds for NAA16 Gene

No Compound Related Data Available

Transcripts for NAA16 Gene

mRNA/cDNA for NAA16 Gene

3 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAA16

Alternative Splicing Database (ASD) splice patterns (SP) for NAA16 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14a · 14b · 14c
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6: - -
SP7: -
SP8:

Relevant External Links for NAA16 Gene

GeneLoc Exon Structure for
NAA16

Expression for NAA16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NAA16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAA16 Gene

This gene is overexpressed in Lymph node (21.3), Plasma (13.4), Heart (8.6), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAA16 Gene



Protein tissue co-expression partners for NAA16 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NAA16

SOURCE GeneReport for Unigene cluster for NAA16 Gene:

Hs.512914

Evidence on tissue expression from TISSUES for NAA16 Gene

  • Pancreas(4.2)
  • Intestine(4.2)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with NAA16: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAA16 Gene

Orthologs for NAA16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAA16 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NAA16 30 31
  • 99.54 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NAA16 30 31
  • 94.09 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NAA16 31
  • 93 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NAA16 31
  • 89 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Naa16 30
  • 88.12 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia NAA16 31
  • 88 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Naa16 30 17 31
  • 87.58 (n)
OneToOne
Chicken
(Gallus gallus)
Aves NAA16 30 31
  • 84.26 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NAA16 31
  • 88 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia naa16 30
  • 76.16 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002284 30
  • 54.98 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Nat1 30 31
  • 53.89 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea hpo-29 30 31
  • 51.53 (n)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAT1 31 33
  • 29 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons EMB2753 30
  • 53.35 (n)
Rice
(Oryza sativa)
Liliopsida Os01g0617500 30
  • 52.52 (n)
Os.11466 30
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes naa15 30
  • 49.62 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10581 31
  • 49 (a)
OneToMany
Bread mold
(Neurospora crassa)
Ascomycetes NCU11379 30
  • 45.46 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.5282 30
Species where no ortholog for NAA16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for NAA16 Gene

ENSEMBL:
Gene Tree for NAA16 (if available)
TreeFam:
Gene Tree for NAA16 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NAA16: view image

Paralogs for NAA16 Gene

Paralogs for NAA16 Gene

(3) SIMAP similar genes for NAA16 Gene using alignment to 1 proteins:

  • NAA16_HUMAN
genes like me logo Genes that share paralogs with NAA16: view

Variants for NAA16 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NAA16 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
rs17062054 - p.Glu344Gly

Additional dbSNP identifiers (rs#s) for NAA16 Gene

Structural Variations from Database of Genomic Variants (DGV) for NAA16 Gene

Variant ID Type Subtype PubMed ID
esv1009722 CNV deletion 20482838
esv1370240 CNV deletion 17803354
esv2073591 CNV deletion 18987734
esv2494010 CNV deletion 19546169
esv2498442 CNV insertion 19546169
esv2747303 CNV deletion 23290073
esv3305228 CNV mobile element insertion 20981092
esv3322672 CNV insertion 20981092
esv4789 CNV loss 18987735
nsv957451 CNV deletion 24416366

Variation tolerance for NAA16 Gene

Residual Variation Intolerance Score: 11.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.21; 69.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAA16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAA16

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA16 Gene

Disorders for NAA16 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NAA16 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ogden syndrome
  • ogdns
thyroid gland anaplastic carcinoma
  • anaplastic thyroid carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search NAA16 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with NAA16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAA16 Gene

Publications for NAA16 Gene

  1. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B … Sherman F (BMC proceedings 2009) 2 3 4
  2. A novel human NatA Nalpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1). (PMID: 19480662) Arnesen T … Lillehaug JR (BMC biochemistry 2009) 2 3 4
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for NAA16 Gene

Sources for NAA16 Gene