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Aliases for NAA16 Gene

Aliases for NAA16 Gene

  • N(Alpha)-Acetyltransferase 16, NatA Auxiliary Subunit 2 3 5
  • NMDA Receptor-Regulated 1-Like Protein 3 4
  • NARG1-Like Protein 3 4
  • NARG1L 3 4
  • N-Alpha-Acetyltransferase 16, NatA Auxiliary Subunit 3
  • NMDA Receptor Regulated 1-Like 2
  • NAT2 4

External Ids for NAA16 Gene

Previous HGNC Symbols for NAA16 Gene

  • NARG1L

Previous GeneCards Identifiers for NAA16 Gene

  • GC13P041885
  • GC13P022684

Summaries for NAA16 Gene

GeneCards Summary for NAA16 Gene

NAA16 (N(Alpha)-Acetyltransferase 16, NatA Auxiliary Subunit) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ribosome binding and peptide alpha-N-acetyltransferase activity. An important paralog of this gene is NAA15.

UniProtKB/Swiss-Prot for NAA16 Gene

  • Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity.

Additional gene information for NAA16 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA16 Gene

Genomics for NAA16 Gene

GeneHancer (GH) Regulatory Elements for NAA16 Gene

Promoters and enhancers for NAA16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I041310 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 572.9 +1.1 1063 3.5 PKNOX1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 IRF4 YY1 POLR2B ZNF213 NAA16 MTRF1 RNU6-57P
GH13I041056 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 20.5 -249.9 -249912 9.7 MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC WBP4 ELF1 TRE-TTC1-2 NAA16 TPTE2P5 MTRF1 RNU6-57P CYCSP34
GH13I040661 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 20.4 -646.2 -646190 7.2 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 IRF4 ZNF207 ZNF143 FOS FOXO1 PIR36841 NAA16 LINC00548 TPTE2P5 CYCSP34 SLC25A15 GC13P040667
GH13I042270 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 17.7 +962.6 962571 6.4 HDGF PKNOX1 CLOCK MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 AKAP11 NAA16 TNFSF11 DGKH GC13M042285
GH13I041456 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 17.8 +150.8 150794 10.9 HDGF ATF1 ARNT ZNF493 SIN3A IRF4 ZNF48 TCF12 ZNF766 GATA2 RGCC NAA16 TPTE2P5 GC13P041458 GC13P041459 LOC105370174
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NAA16 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NAA16 Gene

Genomic Locations for NAA16 Gene
chr13:41,311,205-41,377,030
(GRCh38/hg38)
Size:
65,826 bases
Orientation:
Plus strand
chr13:41,885,341-41,951,166
(GRCh37/hg19)

Genomic View for NAA16 Gene

Genes around NAA16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA16 Gene

Proteins for NAA16 Gene

  • Protein details for NAA16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6N069-NAA16_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 16, NatA auxiliary subunit
    Protein Accession:
    Q6N069
    Secondary Accessions:
    • B0QZ59
    • Q5VSP9
    • Q6P2D5
    • Q8N5J3
    • Q8N870

    Protein attributes for NAA16 Gene

    Size:
    864 amino acids
    Molecular mass:
    101462 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA10 and NAA16.

    Alternative splice isoforms for NAA16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA16 Gene

Post-translational modifications for NAA16 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NAA16 Gene

Domains & Families for NAA16 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NAA16: view

No data available for UniProtKB/Swiss-Prot for NAA16 Gene

Function for NAA16 Gene

Molecular function for NAA16 Gene

UniProtKB/Swiss-Prot Function:
Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity.

Phenotypes From GWAS Catalog for NAA16 Gene

Gene Ontology (GO) - Molecular Function for NAA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004596 contributes_to peptide alpha-N-acetyltransferase activity IDA 19480662
GO:0005515 protein binding IPI 19480662
GO:0016407 contributes_to acetyltransferase activity ISS --
GO:0043022 contributes_to ribosome binding ISS --
genes like me logo Genes that share ontologies with NAA16: view
genes like me logo Genes that share phenotypes with NAA16: view

Animal Model Products

miRNA for NAA16 Gene

miRTarBase miRNAs that target NAA16

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA16 Gene

Localization for NAA16 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAA16 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NAA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005667 transcription factor complex ISS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol IDA --
GO:0031415 NatA complex IDA 19480662
genes like me logo Genes that share ontologies with NAA16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NAA16 Gene

Pathways & Interactions for NAA16 Gene

SuperPathways for NAA16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006474 N-terminal protein amino acid acetylation ISS --
GO:0017196 N-terminal peptidyl-methionine acetylation IBA --
GO:0043066 negative regulation of apoptotic process IMP 19480662
GO:0045893 positive regulation of transcription, DNA-templated ISS --
GO:0050821 protein stabilization IMP 19480662
genes like me logo Genes that share ontologies with NAA16: view

No data available for Pathways by source and SIGNOR curated interactions for NAA16 Gene

Drugs & Compounds for NAA16 Gene

No Compound Related Data Available

Transcripts for NAA16 Gene

Unigene Clusters for NAA16 Gene

N(alpha)-acetyltransferase 16, NatA auxiliary subunit:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAA16 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14a · 14b · 14c
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6: - -
SP7: -
SP8:

Relevant External Links for NAA16 Gene

GeneLoc Exon Structure for
NAA16
ECgene alternative splicing isoforms for
NAA16

Expression for NAA16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAA16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAA16 Gene

This gene is overexpressed in Lymph node (21.3), Plasma (13.4), Heart (8.6), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAA16 Gene



Protein tissue co-expression partners for NAA16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAA16 Gene:

NAA16

SOURCE GeneReport for Unigene cluster for NAA16 Gene:

Hs.512914

Evidence on tissue expression from TISSUES for NAA16 Gene

  • Intestine(4.2)
  • Pancreas(4.2)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with NAA16: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAA16 Gene

Orthologs for NAA16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAA16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAA16 33 34
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia NAA16 33 34
  • 94.09 (n)
cow
(Bos Taurus)
Mammalia NAA16 34
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NAA16 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Naa16 33
  • 88.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NAA16 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Naa16 33 16 34
  • 87.58 (n)
chicken
(Gallus gallus)
Aves NAA16 33 34
  • 84.26 (n)
lizard
(Anolis carolinensis)
Reptilia NAA16 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia naa16 33
  • 76.16 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002284 33
  • 54.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta Nat1 33 34
  • 53.89 (n)
worm
(Caenorhabditis elegans)
Secernentea hpo-29 33 34
  • 51.53 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAT1 34 36
  • 29 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB2753 33
  • 53.35 (n)
rice
(Oryza sativa)
Liliopsida Os01g0617500 33
  • 52.52 (n)
Os.11466 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes naa15 33
  • 49.62 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10581 34
  • 49 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU11379 33
  • 45.46 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5282 33
Species where no ortholog for NAA16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for NAA16 Gene

ENSEMBL:
Gene Tree for NAA16 (if available)
TreeFam:
Gene Tree for NAA16 (if available)

Paralogs for NAA16 Gene

Paralogs for NAA16 Gene

(3) SIMAP similar genes for NAA16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NAA16: view

Variants for NAA16 Gene

Sequence variations from dbSNP and Humsavar for NAA16 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000027487 -- 41,349,193(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000059218 -- 41,326,428(+) A/C/G genic_upstream_transcript_variant, intron_variant
rs1000075493 -- 41,345,268(+) C/A genic_downstream_transcript_variant, intron_variant
rs1000104628 -- 41,332,891(+) A/G intron_variant
rs1000136118 -- 41,345,860(+) C/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NAA16 Gene

Variant ID Type Subtype PubMed ID
esv1009722 CNV deletion 20482838
esv1370240 CNV deletion 17803354
esv2073591 CNV deletion 18987734
esv2494010 CNV deletion 19546169
esv2498442 CNV insertion 19546169
esv2747303 CNV deletion 23290073
esv3305228 CNV mobile element insertion 20981092
esv3322672 CNV insertion 20981092
esv4789 CNV loss 18987735
nsv957451 CNV deletion 24416366

Variation tolerance for NAA16 Gene

Residual Variation Intolerance Score: 11.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.21; 69.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAA16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAA16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA16 Gene

Disorders for NAA16 Gene

Additional Disease Information for NAA16

No disorders were found for NAA16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAA16 Gene

Publications for NAA16 Gene

  1. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B … Sherman F (BMC proceedings 2009) 2 3 4 58
  2. A novel human NatA Nalpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1). (PMID: 19480662) Arnesen T … Lillehaug JR (BMC biochemistry 2009) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for NAA16 Gene

Sources for NAA16 Gene

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