NAA15 Gene (Protein Coding)

N-Alpha-Acetyltransferase 15, NatA Auxiliary Subunit

GC04P139301
GIFtS:
40
N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided... See more...

Aliases for NAA15 Gene

Aliases for NAA15 Gene

  • N-Alpha-Acetyltransferase 15, NatA Auxiliary Subunit 2 3 4
  • N(Alpha)-Acetyltransferase 15, NatA Auxiliary Subunit 2 5
  • NMDA Receptor-Regulated Protein 1 3 4
  • N-Terminal Acetyltransferase 3 4
  • Gastric Cancer Antigen Ga19 3 4
  • NMDA Receptor Regulated 1 2 3
  • Protein Tubedown-1 3 4
  • TBDN100 3 4
  • NARG1 3 4
  • NATH 3 4
  • Transcriptional Coactivator Tubedown-100 3
  • Tubedown-1 3
  • Tbdn100 4
  • MRD50 3
  • NAT1P 3
  • Ga19 3
  • TBDN 3
  • GA19 4

External Ids for NAA15 Gene

Previous HGNC Symbols for NAA15 Gene

  • NARG1

Previous GeneCards Identifiers for NAA15 Gene

  • GC04P140222
  • GC04P135952

Summaries for NAA15 Gene

Entrez Gene Summary for NAA15 Gene

  • N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017]

GeneCards Summary for NAA15 Gene

NAA15 (N-Alpha-Acetyltransferase 15, NatA Auxiliary Subunit) is a Protein Coding gene. Diseases associated with NAA15 include Mental Retardation, Autosomal Dominant 50 and Ogden Syndrome. Among its related pathways are Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include N-acetyltransferase activity. An important paralog of this gene is NAA16.

UniProtKB/Swiss-Prot Summary for NAA15 Gene

  • Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.

Gene Wiki entry for NAA15 Gene

Additional gene information for NAA15 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NAA15 Gene

Genomics for NAA15 Gene

GeneHancer (GH) Regulatory Elements for NAA15 Gene

Promoters and enhancers for NAA15 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAA15 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NAA15

Genomic Locations for NAA15 Gene

Genomic Locations for NAA15 Gene
chr4:139,301,467-139,420,033
(GRCh38/hg38)
Size:
118,567 bases
Orientation:
Plus strand
chr4:140,222,609-140,341,187
(GRCh37/hg19)
Size:
118,579 bases
Orientation:
Plus strand

Genomic View for NAA15 Gene

Genes around NAA15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA15 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NAA15 Gene

Proteins for NAA15 Gene

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  • Protein details for NAA15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXJ9-NAA15_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 15, NatA auxiliary subunit
    Protein Accession:
    Q9BXJ9
    Secondary Accessions:
    • D3DNY6
    • Q52LG9
    • Q8IWH4
    • Q8NEV2
    • Q9H8P6

    Protein attributes for NAA15 Gene

    Size:
    866 amino acids
    Molecular mass:
    101272 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA10 or probably NAA11 and NAA15 (PubMed:15496142, PubMed:16638120). Interacts with XRCC6, NAA50 and XRCC5 (PubMed:12145306, PubMed:29754825, PubMed:16507339). Associates with HYPK when in a complex with NAA10 (PubMed:20154145, PubMed:29754825). Interaction with HYPK reduces the capacity to interact with NAA50 (PubMed:29754825).
    SequenceCaution:
    • Sequence=AAH39818.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NAA15 Gene

    Alternative splice isoforms for NAA15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA15 Gene

Protein Expression for NAA15 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NAA15 Gene

  • Cleaved by caspases during apoptosis, resulting in a stable 35 kDa fragment.
  • Ubiquitination at Lys34, Lys41, Lys262, Lys266, Lys286, Lys305, Lys312, Lys454, Lys496, Lys543, Lys659, Lys756, and Lys770
  • Modification sites at PhosphoSitePlus

Other Protein References for NAA15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NAA15 Gene

Domains & Families for NAA15 Gene

Gene Families for NAA15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NAA15 Gene

Blocks:
  • FIS bacterial regulatory protein HTH signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NAA15 Gene

GenScript: Design optimal peptide antigens:
  • Tbdn100 (NAA15_HUMAN)
  • NARG1 protein (Q58F05_HUMAN)
genes like me logo Genes that share domains with NAA15: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NAA15 Gene

Function for NAA15 Gene

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Molecular function for NAA15 Gene

UniProtKB/Swiss-Prot Function:
Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.

Phenotypes From GWAS Catalog for NAA15 Gene

Gene Ontology (GO) - Molecular Function for NAA15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0004596 contributes_to peptide alpha-N-acetyltransferase activity IBA 21873635
GO:0005515 protein binding IEA,IPI 12145306
GO:0016407 contributes_to acetyltransferase activity IDA 15496142
GO:0043022 contributes_to ribosome binding IDA 15496142
genes like me logo Genes that share ontologies with NAA15: view
genes like me logo Genes that share phenotypes with NAA15: view

Human Phenotype Ontology for NAA15 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

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No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA15 Gene

Localization for NAA15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA15 Gene

Cytoplasm. Nucleus. Note=Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAA15 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
cytoskeleton 2
golgi apparatus 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NAA15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 12140756
GO:0005667 transcription factor complex IDA 12145306
GO:0005737 cytoplasm IBA,IDA 12140756
GO:0005829 cytosol IDA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with NAA15: view

Pathways & Interactions for NAA15 Gene

PathCards logo

SuperPathways for NAA15 Gene

SuperPathway Contained pathways
1 Mesodermal Commitment Pathway
Endoderm Differentiation
.36
genes like me logo Genes that share pathways with NAA15: view

Pathways by source for NAA15 Gene

1 BioSystems pathway for NAA15 Gene

Gene Ontology (GO) - Biological Process for NAA15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006474 N-terminal protein amino acid acetylation IDA 15496142
GO:0007275 multicellular organism development IEA --
GO:0017196 N-terminal peptidyl-methionine acetylation IBA 21873635
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with NAA15: view

No data available for SIGNOR curated interactions for NAA15 Gene

Drugs & Compounds for NAA15 Gene

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(1) Additional Compounds for NAA15 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NAA15: view

Transcripts for NAA15 Gene

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mRNA/cDNA for NAA15 Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAA15 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
SP1: - -
SP2: - - -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:

ExUns: 20b ^ 21 ^ 22a · 22b ^ 23
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6: - -
SP7:
SP8:

Relevant External Links for NAA15 Gene

GeneLoc Exon Structure for
NAA15

Expression for NAA15 Gene

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  1. Primer
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NAA15 Gene

mRNA expression in normal human tissues for NAA15 Gene
mRNA expression by BioGPS for NAA15 GenemRNA expression by GTEx for NAA15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAA15 Gene

This gene is overexpressed in Lymph node (16.5) and Peripheral blood mononuclear cells (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAA15 Gene



Protein tissue co-expression partners for NAA15 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NAA15

SOURCE GeneReport for Unigene cluster for NAA15 Gene:

Hs.745047

mRNA Expression by UniProt/SwissProt for NAA15 Gene:

Q9BXJ9-NAA15_HUMAN
Tissue specificity: Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, urogenital system and upper gastrointestinal tract. Overexpressed in gastric cancer, in papillary thyroid carcinomas and in a Burkitt lymphoma cell line (Daudi). Specifically suppressed in abnormal proliferating blood vessels in eyes of patients with proliferative diabetic retinopathy.

Evidence on tissue expression from TISSUES for NAA15 Gene

  • Nervous system(4.6)
  • Heart(4.4)
  • Bone(4)
genes like me logo Genes that share expression patterns with NAA15: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAA15 Gene

Orthologs for NAA15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAA15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia NAA15 31 30
  • 99.85 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia NAA15 31
  • 97 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia NAA15 31 30
  • 96.04 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia NAA15 31 30
  • 95.92 (n)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 95 (a)
 OneToMany
-- 31
  • 82 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Naa15 17 31 30
  • 93.14 (n)
rat
(Rattus norvegicus)
 Mammalia Naa15 30
  • 92.52 (n)
chicken
(Gallus gallus)
 Aves NAA15 31 30
  • 85.67 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia NAA15 31
  • 96 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia naa15 30
  • 80.52 (n)
Str.7467 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.4200 30
zebrafish
(Danio rerio)
 Actinopterygii naa15b 31
  • 85 (a)
 OneToMany
naa15a 31 30
  • 69.75 (n)
 OneToMany
Dr.15380 30
fruit fly
(Drosophila melanogaster)
 Insecta Nat1 31
  • 51 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea hpo-29 31
  • 42 (a)
 OneToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes NAT1 31
  • 28 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.10581 31
  • 50 (a)
 OneToMany
Species where no ortholog for NAA15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAA15 Gene

ENSEMBL:
Gene Tree for NAA15 (if available)
TreeFam:
Gene Tree for NAA15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NAA15: view image

Paralogs for NAA15 Gene

Paralogs for NAA15 Gene

(10) SIMAP similar genes for NAA15 Gene using alignment to 2 proteins:

  • NAA15_HUMAN
  • D6RAP7_HUMAN
genes like me logo Genes that share paralogs with NAA15: view

Variants for NAA15 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NAA15 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
641161 Pathogenic: not provided 139,334,222(+) C/T NONSENSE
716110 Benign: not provided 139,370,401(+) C/T SYNONYMOUS_VARIANT
730948 Benign: not provided 139,378,814(+) T/C SYNONYMOUS_VARIANT
776020 Benign: not provided 139,349,481(+) A/G SYNONYMOUS_VARIANT
799117 Likely Benign: not provided 139,387,970(+) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for NAA15 Gene

Structural Variations from Database of Genomic Variants (DGV) for NAA15 Gene

Variant ID Type Subtype PubMed ID
dgv1532e212 CNV loss 25503493
dgv5409n100 CNV loss 25217958
dgv9292n54 CNV loss 21841781
dgv9293n54 CNV loss 21841781
dgv9294n54 CNV loss 21841781
dgv977e199 CNV deletion 23128226
esv2728426 CNV deletion 23290073
esv2762465 CNV loss 21179565
esv3564714 CNV deletion 23714750
esv3602437 CNV loss 21293372
nsv1023892 CNV gain 25217958
nsv1034429 CNV loss 25217958
nsv442922 CNV loss 18776908
nsv4529 CNV insertion 18451855
nsv478370 CNV novel sequence insertion 20440878
nsv514254 CNV loss 21397061
nsv595589 CNV loss 21841781
nsv595592 CNV loss 21841781
nsv822748 CNV loss 20364138
nsv830084 CNV loss 17160897

Variation tolerance for NAA15 Gene

Residual Variation Intolerance Score: 9.72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAA15 Gene

Human Gene Mutation Database (HGMD)
NAA15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAA15

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA15 Gene

Disorders for NAA15 Gene

MalaCards: The human disease database

(8) MalaCards diseases for NAA15 Gene - From: OMIM, ClinVar, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search NAA15 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NAA15_HUMAN
  • Mental retardation, autosomal dominant 50 (MRD50) [MIM:617787]: A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269 PubMed:28191889}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for NAA15

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NAA15: view

No data available for Genatlas for NAA15 Gene

Publications for NAA15 Gene

  1. NATH, a novel gene overexpressed in papillary thyroid carcinomas. (PMID: 12140756) Fluge Ø … Lillehaug JR (Oncogene 2002) 2 3 4 23 54
  2. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B … Sherman F (BMC proceedings 2009) 2 3 4 54
  3. Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans. (PMID: 19420222) Arnesen T … Gevaert K (Proceedings of the National Academy of Sciences of the United States of America 2009) 2 3 23 54
  4. Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase. (PMID: 16638120) Arnesen T … Lillehaug JR (BMC biochemistry 2006) 3 4 23 54
  5. Identification and characterization of the human ARD1-NATH protein acetyltransferase complex. (PMID: 15496142) Arnesen T … Lillehaug JR (The Biochemical journal 2005) 3 4 23 54

ExternalLinks

View latest publications for NAA15 gene in Mastermind

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