Free for academic non-profit institutions. Other users need a Commercial license
N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017]
NAA15 (N-Alpha-Acetyltransferase 15, NatA Auxiliary Subunit) is a Protein Coding gene. Diseases associated with NAA15 include Mental Retardation, Autosomal Dominant 50 and Ogden Syndrome. Among its related pathways are Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include N-acetyltransferase activity. An important paralog of this gene is NAA16.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0004596 | contributes_to peptide alpha-N-acetyltransferase activity | IBA | 21873635 |
GO:0005515 | protein binding | IEA,IPI | 12145306 |
GO:0016407 | contributes_to acetyltransferase activity | IDA | 15496142 |
GO:0043022 | contributes_to ribosome binding | IDA | 15496142 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 12140756 |
GO:0005667 | transcription factor complex | IDA | 12145306 |
GO:0005737 | cytoplasm | IBA,IDA | 12140756 |
GO:0005829 | cytosol | IDA | -- |
GO:0016020 | membrane | HDA | 19946888 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Mesodermal Commitment Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001525 | angiogenesis | IEA | -- |
GO:0006474 | N-terminal protein amino acid acetylation | IDA | 15496142 |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0017196 | N-terminal peptidyl-methionine acetylation | IBA | 21873635 |
GO:0030154 | cell differentiation | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: |
ExUns: | 20b | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 |
---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||
SP2: | |||||||||
SP3: | |||||||||
SP4: | |||||||||
SP5: | - | ||||||||
SP6: | - | - | |||||||
SP7: | |||||||||
SP8: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NAA15 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | NAA15 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NAA15 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NAA15 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | Naa15 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Naa15 30 |
|
||
Chicken (Gallus gallus) |
Aves | NAA15 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NAA15 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | naa15 30 |
|
||
Str.7467 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.4200 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | naa15b 31 |
|
OneToMany | |
naa15a 30 31 |
|
OneToMany | |||
Dr.15380 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Nat1 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | hpo-29 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NAT1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10581 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
641161 | Pathogenic: not provided | 139,334,222(+) | C/T | NONSENSE | |
716110 | Benign: not provided | 139,370,401(+) | C/T | SYNONYMOUS_VARIANT | |
730948 | Benign: not provided | 139,378,814(+) | T/C | SYNONYMOUS_VARIANT | |
776020 | Benign: not provided | 139,349,481(+) | A/G | SYNONYMOUS_VARIANT | |
799117 | Likely Benign: not provided | 139,387,970(+) | T/C | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1532e212 | CNV | loss | 25503493 |
dgv5409n100 | CNV | loss | 25217958 |
dgv9292n54 | CNV | loss | 21841781 |
dgv9293n54 | CNV | loss | 21841781 |
dgv9294n54 | CNV | loss | 21841781 |
dgv977e199 | CNV | deletion | 23128226 |
esv2728426 | CNV | deletion | 23290073 |
esv2762465 | CNV | loss | 21179565 |
esv3564714 | CNV | deletion | 23714750 |
esv3602437 | CNV | loss | 21293372 |
nsv1023892 | CNV | gain | 25217958 |
nsv1034429 | CNV | loss | 25217958 |
nsv442922 | CNV | loss | 18776908 |
nsv4529 | CNV | insertion | 18451855 |
nsv478370 | CNV | novel sequence insertion | 20440878 |
nsv514254 | CNV | loss | 21397061 |
nsv595589 | CNV | loss | 21841781 |
nsv595592 | CNV | loss | 21841781 |
nsv822748 | CNV | loss | 20364138 |
nsv830084 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
mental retardation, autosomal dominant 50 |
|
|
ogden syndrome |
|
|
transient bullous dermolysis of the newborn |
|
|
mental retardation, autosomal dominant 10 |
|
|
epidermolysis bullosa dystrophica |
|
|