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Aliases for NAA11 Gene

Aliases for NAA11 Gene

  • N(Alpha)-Acetyltransferase 11, NatA Catalytic Subunit 2 3 5
  • N-Terminal Acetyltransferase Complex ARD1 Subunit Homolog B 3 4
  • N-Alpha-Acetyltransferase 11 3 4
  • NatA Catalytic Subunit Naa11 3 4
  • ARD1B 3 4
  • HARD2 3 4
  • ARD2 3 4
  • =N-Terminal Acetyltransferase Complex ARD1 Subunit Homolog B 3
  • ARD1 Homolog B (S. Cerevisiae) 2
  • Human Arrest Defective 2 3
  • ARD1 Homolog B 3
  • EC 2.3.1.255 4

External Ids for NAA11 Gene

Previous HGNC Symbols for NAA11 Gene

  • ARD1B

Previous GeneCards Identifiers for NAA11 Gene

  • GC04M080237
  • GC04M075985

Summaries for NAA11 Gene

GeneCards Summary for NAA11 Gene

NAA11 (N(Alpha)-Acetyltransferase 11, NatA Catalytic Subunit) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and peptide alpha-N-acetyltransferase activity. An important paralog of this gene is NAA10.

UniProtKB/Swiss-Prot for NAA11 Gene

  • Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex.

Additional gene information for NAA11 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA11 Gene

Genomics for NAA11 Gene

GeneHancer (GH) Regulatory Elements for NAA11 Gene

Promoters and enhancers for NAA11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J079324 Promoter/Enhancer 1.2 EPDnew ENCODE 606.1 +0.4 402 1.8 ZFX GMEB1 ATF1 NR2C1 NRF1 POLR2A NR2C2 NFIC CREM FOXK2 NAA11 GC04P079267
GH04J079209 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 8.5 +114.9 114920 4.2 CC2D1A ZFX ZKSCAN8 CBFA2T2 ZNF148 MLLT1 CEBPG GTF2F1 CSDE1 TFE3 NAA11 GC04P079267 GC04M079034 LINC01088
GH04J079360 Enhancer 0.5 dbSUPER 17.5 -38.5 -38457 8 POLR2A ZNF316 MAFK EMSY NAA11 LOC105377300
GH04J079249 Enhancer 0.5 Ensembl 7.5 +75.6 75649 1.2 IKZF1 IKZF2 LARP7 ATF7 POLR2A NAA11 GC04P079267 GC04M079034 LINC01088
GH04J079216 Enhancer 0.3 Ensembl 8.8 +108.7 108749 1 ATF2 NAA11 GC04P079267 GC04M079034 LINC01088
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAA11 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NAA11 Gene

Genomic Locations for NAA11 Gene
chr4:79,225,694-79,326,050
(GRCh38/hg38)
Size:
100,357 bases
Orientation:
Minus strand
chr4:80,146,848-80,247,204
(GRCh37/hg19)
Size:
100,357 bases
Orientation:
Minus strand

Genomic View for NAA11 Gene

Genes around NAA11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA11 Gene

Proteins for NAA11 Gene

  • Protein details for NAA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSU3-NAA11_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 11
    Protein Accession:
    Q9BSU3
    Secondary Accessions:
    • Q66K19
    • Q6P479

    Protein attributes for NAA11 Gene

    Size:
    229 amino acids
    Molecular mass:
    25979 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA11 and NAA15 (Probable). Interacts with HIF1A.
    SequenceCaution:
    • Sequence=AAH04552.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH63623.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH80651.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NAA11 Gene

Post-translational modifications for NAA11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAA11 Gene

No data available for DME Specific Peptides for NAA11 Gene

Domains & Families for NAA11 Gene

Gene Families for NAA11 Gene

Protein Domains for NAA11 Gene

Suggested Antigen Peptide Sequences for NAA11 Gene

GenScript: Design optimal peptide antigens:
  • N-terminal acetyltransferase complex ARD1 subunit homolog B (NAA11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BSU3

UniProtKB/Swiss-Prot:

NAA11_HUMAN :
  • Belongs to the acetyltransferase family. ARD1 subfamily.
Family:
  • Belongs to the acetyltransferase family. ARD1 subfamily.
genes like me logo Genes that share domains with NAA11: view

Function for NAA11 Gene

Molecular function for NAA11 Gene

UniProtKB/Swiss-Prot Function:
Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + N-terminal glycyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein]; Xref=Rhea:RHEA:50496, Rhea:RHEA-COMP:12666, Rhea:RHEA-COMP:12700, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64723, ChEBI:CHEBI:133369; EC=2.3.1.255; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein]; Xref=Rhea:RHEA:50500, Rhea:RHEA-COMP:12701, Rhea:RHEA-COMP:12702, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64718, ChEBI:CHEBI:83683; EC=2.3.1.255; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein]; Xref=Rhea:RHEA:50504, Rhea:RHEA-COMP:12703, Rhea:RHEA-COMP:12704, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64738, ChEBI:CHEBI:83690; EC=2.3.1.255; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + N-terminal L-valyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein]; Xref=Rhea:RHEA:50508, Rhea:RHEA-COMP:12705, Rhea:RHEA-COMP:12706, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64741, ChEBI:CHEBI:133371; EC=2.3.1.255; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + N-terminal L-cysteinyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:50512, Rhea:RHEA-COMP:12707, Rhea:RHEA-COMP:12708, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:65250, ChEBI:CHEBI:133372; EC=2.3.1.255; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + N-terminal L-threonyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein]; Xref=Rhea:RHEA:50516, Rhea:RHEA-COMP:12709, Rhea:RHEA-COMP:12710, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64739, ChEBI:CHEBI:133375; EC=2.3.1.255; Evidence=. ;.

Enzyme Numbers (IUBMB) for NAA11 Gene

Phenotypes From GWAS Catalog for NAA11 Gene

Gene Ontology (GO) - Molecular Function for NAA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004596 peptide alpha-N-acetyltransferase activity IDA 16638120
GO:0005515 protein binding IPI 19480662
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:1990189 peptide-serine-N-acetyltransferase activity IBA 21873635
genes like me logo Genes that share ontologies with NAA11: view
genes like me logo Genes that share phenotypes with NAA11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NAA11

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for NAA11 - Now 50% OFF >
  • * NAA11 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NAA11 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NAA11 Gene

Localization for NAA11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA11 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAA11 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NAA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0031415 NatA complex IBA,IDA 16638120
genes like me logo Genes that share ontologies with NAA11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NAA11 Gene

Pathways & Interactions for NAA11 Gene

PathCards logo

SuperPathways for NAA11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006474 N-terminal protein amino acid acetylation IDA,IBA 16638120
GO:0017198 N-terminal peptidyl-serine acetylation IBA 21873635
GO:0018002 N-terminal peptidyl-glutamic acid acetylation IBA 21873635
genes like me logo Genes that share ontologies with NAA11: view

No data available for Pathways by source and SIGNOR curated interactions for NAA11 Gene

Drugs & Compounds for NAA11 Gene

(1) Drugs for NAA11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for NAA11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • AcCoA
  • Acetyl coenzyme A
  • S-Acetyl-CoA
  • S-Acetyl-coenzyme A
  • Ac-CoA
72-89-9
genes like me logo Genes that share compounds with NAA11: view

Transcripts for NAA11 Gene

mRNA/cDNA for NAA11 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for NAA11 Gene

N(alpha)-acetyltransferase 11, NatA catalytic subunit:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for NAA11 - Now 50% OFF >
  • * NAA11 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NAA11 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for NAA11 Gene

No ASD Table

Relevant External Links for NAA11 Gene

GeneLoc Exon Structure for
NAA11
ECgene alternative splicing isoforms for
NAA11

Expression for NAA11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAA11 Gene

mRNA differential expression in normal tissues according to GTEx for NAA11 Gene

This gene is overexpressed in Testis (x34.4).

Protein differential expression in normal tissues from HIPED for NAA11 Gene

This gene is overexpressed in Testis (42.4), Heart (17.9), and Ovary (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAA11 Gene



Protein tissue co-expression partners for NAA11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAA11 Gene:

NAA11

SOURCE GeneReport for Unigene cluster for NAA11 Gene:

Hs.676048

mRNA Expression by UniProt/SwissProt for NAA11 Gene:

Q9BSU3-NAA11_HUMAN
Tissue specificity: Present in several cell lines, with highest levels in MCF-7 cells (at protein level).

Evidence on tissue expression from TISSUES for NAA11 Gene

  • Skin(4.1)
genes like me logo Genes that share expression patterns with NAA11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAA11 Gene

Orthologs for NAA11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAA11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAA11 35 34
  • 99.42 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 89 (a)
OneToMany
cow
(Bos Taurus)
Mammalia NAA11 35 34
  • 87.92 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gm16286 35
  • 86 (a)
OneToMany
Naa11 17 35 34
  • 83.89 (n)
dog
(Canis familiaris)
Mammalia NAA11 35 34
  • 85.01 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Naa11 34
  • 83.81 (n)
zebrafish
(Danio rerio)
Actinopterygii naa10 35
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta vnc 35
  • 65 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K07H8.3 35
  • 66 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARD1 35 34
  • 57.4 (n)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR409W 34
  • 57.32 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E03367g 34
  • 55.85 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G13780 34
  • 65.54 (n)
rice
(Oryza sativa)
Liliopsida Os04g0635800 34
  • 62.69 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11133 35
  • 63 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes naa10 34
  • 62.12 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08944 34
  • 61.39 (n)
Species where no ortholog for NAA11 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NAA11 Gene

ENSEMBL:
Gene Tree for NAA11 (if available)
TreeFam:
Gene Tree for NAA11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NAA11: view image

Paralogs for NAA11 Gene

Paralogs for NAA11 Gene

(2) SIMAP similar genes for NAA11 Gene using alignment to 2 proteins:

  • NAA11_HUMAN
  • H0Y8T0_HUMAN
genes like me logo Genes that share paralogs with NAA11: view

Variants for NAA11 Gene

Sequence variations from dbSNP and Humsavar for NAA11 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000039454 -- 79,161,882(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000047267 -- 79,279,487(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000057777 -- 79,267,581(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000108203 -- 79,267,125(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000118580 -- 79,281,756(-) G/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NAA11 Gene

Variant ID Type Subtype PubMed ID
esv2727859 CNV deletion 23290073
nsv1006026 CNV loss 25217958
nsv999174 CNV loss 25217958

Variation tolerance for NAA11 Gene

Residual Variation Intolerance Score: 48.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAA11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAA11

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA11 Gene

Disorders for NAA11 Gene

Additional Disease Information for NAA11

No disorders were found for NAA11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAA11 Gene

Publications for NAA11 Gene

  1. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B … Sherman F (BMC proceedings 2009) 2 3 4 58
  2. Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase. (PMID: 16638120) Arnesen T … Lillehaug JR (BMC biochemistry 2006) 2 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 58

Products for NAA11 Gene

Sources for NAA11 Gene

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