N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major ... See more...

Aliases for NAA10 Gene

Aliases for NAA10 Gene

  • N-Alpha-Acetyltransferase 10, NatA Catalytic Subunit 2 3
  • N-Terminal Acetyltransferase Complex ARD1 Subunit Homolog A 3 4
  • N(Alpha)-Acetyltransferase 10, NatA Catalytic Subunit 2 5
  • N-Alpha-Acetyltransferase 10 3 4
  • NatA Catalytic Subunit Naa10 3 4
  • Arrest Defective Protein 1 2 3
  • ARD1A 3 4
  • HARD1 3 4
  • ARD1 3 4
  • TE2 3 4
  • ARD1 Homolog A, N-Acetyltransferase (S. Cerevisiae) 2
  • ARD1 Homolog, N-Acetyltransferase (S. Cerevisiae) 2
  • N-Acetyltransferase ARD1, Human Homolog Of 3
  • ARD1 Homolog A, N-Acetyltransferase 3
  • EC 2.3.1.255 4
  • DXS707 3
  • MCOPS1 3
  • ARD1P 3
  • OGDNS 3
  • NATD 3

External Ids for NAA10 Gene

Previous HGNC Symbols for NAA10 Gene

  • ARD1
  • ARD1A

Previous GeneCards Identifiers for NAA10 Gene

  • GC0XM153194
  • GC0XM141848

Summaries for NAA10 Gene

Entrez Gene Summary for NAA10 Gene

  • N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for NAA10 Gene

NAA10 (N-Alpha-Acetyltransferase 10, NatA Catalytic Subunit) is a Protein Coding gene. Diseases associated with NAA10 include Ogden Syndrome and Microphthalmia, Syndromic 1. Among its related pathways are DNA Damage and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and N-acetyltransferase activity. An important paralog of this gene is NAA11.

UniProtKB/Swiss-Prot Summary for NAA10 Gene

  • Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19826488, PubMed:19420222, PubMed:20145209, PubMed:27708256, PubMed:25489052, PubMed:29754825). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acetylates HIST1H4A (PubMed:29754825). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821).

Gene Wiki entry for NAA10 Gene

Additional gene information for NAA10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NAA10 Gene

Genomics for NAA10 Gene

GeneHancer (GH) Regulatory Elements for NAA10 Gene

Promoters and enhancers for NAA10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ153933 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.4 353 2.8 NRF1 SP1 ZFX POLR2A ZBTB11 ZNF423 GABPA ZBTB26 MYC CTBP1 ARHGAP4 NAA10 lnc-ARHGAP4-1 lnc-RENBP-1 TMEM187 ENSG00000261773 ENSG00000260081 RENBP
GH0XJ153930 Promoter 0.4 EPDnew 500.7 +4.4 4443 0.1 RBFOX2 NAA10 HCFC1-AS1 TMEM187 HCFC1 ARHGAP4 lnc-RENBP-1 RF00017-8804
GH0XJ153884 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl ENCODE 12.5 +49.0 49049 3 CTCF ZIC2 ZNF263 ZBTB26 KLF7 TOE1 MYC POLR2A EZH2 KLF9 L1CAM RENBP TMEM187 PDZD4 IDH3G SSR4 SRPK3 PLXNB3 NAA10 ARHGAP4
GH0XJ153888 Enhancer 0.5 Ensembl 12.5 +47.0 46953 0.4 ELF1 ZMYM3 BHLHE40 IKZF1 EBF1 RELB SKIL TMEM187 PDZD4 NAA10 ARHGAP4 RENBP ABCD1 BCAP31 ENSG00000232725 PLXNB3 L1CAM
GH0XJ153921 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 +9.1 9149 9.3 HNRNPK ZBTB40 EP300 CTCF NRF1 POLR2G USF1 SP1 PHF8 ZFX RF00017-8804 ARHGAP4 TMEM187 HCFC1-AS1 HCFC1 DKC1 lnc-NAA10-1 NAA10 lnc-RENBP-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAA10 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NAA10

Genomic Locations for NAA10 Gene

Genomic Locations for NAA10 Gene
chrX:153,929,225-153,935,154
(GRCh38/hg38)
Size:
5,930 bases
Orientation:
Minus strand
chrX:153,194,695-153,200,676
(GRCh37/hg19)
Size:
5,982 bases
Orientation:
Minus strand

Genomic View for NAA10 Gene

Genes around NAA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA10 Gene

Proteins for NAA10 Gene

  • Protein details for NAA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41227-NAA10_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 10
    Protein Accession:
    P41227
    Secondary Accessions:
    • A6NM98

    Protein attributes for NAA10 Gene

    Size:
    235 amino acids
    Molecular mass:
    26459 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA10 and NAA15 or NAA16 (PubMed:20154145). Interacts with HIF1A (via its ODD domain); the interaction increases HIF1A protein stability during normoxia, an down-regulates it when induced by hypoxia (PubMed:12464182). Interacts with NAA50 and with the ribosome (PubMed:16507339). Binds to MYLK (PubMed:19826488). Interacts with NAA15 (PubMed:15496142, PubMed:29754825). Associates with HYPK when in complex with NAA15 (PubMed:15496142, PubMed:29754825). Interacts with NAA16 (PubMed:19480662). Interacts (via its C-terminal domain) with TSC2, leading to its acetylation (PubMed:20145209). Interacts with IKBKB (PubMed:19716809). Interacts with HSPA1A and HSPA1B leading to its acetylation (PubMed:27708256).

    Three dimensional structures from OCA and Proteopedia for NAA10 Gene

    Alternative splice isoforms for NAA10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA10 Gene

Post-translational modifications for NAA10 Gene

Antibody Products

  • Abcam antibodies for NAA10
  • Santa Cruz Biotechnology (SCBT) Antibodies for NAA10

No data available for DME Specific Peptides for NAA10 Gene

Domains & Families for NAA10 Gene

Gene Families for NAA10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for NAA10 Gene

Blocks:
  • GCN5-related N-acetyltransferase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NAA10 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ78896, highly similar to N-terminal acetyltransferase complex ARD1 subunit homolog A (EC 2.3.1.88) (B7Z9N2_HUMAN)
  • N-terminal acetyltransferase complex ARD1 subunit homolog A (NAA10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P41227

UniProtKB/Swiss-Prot:

NAA10_HUMAN :
  • Belongs to the acetyltransferase family. ARD1 subfamily.
Family:
  • Belongs to the acetyltransferase family. ARD1 subfamily.
genes like me logo Genes that share domains with NAA10: view

Function for NAA10 Gene

Molecular function for NAA10 Gene

UniProtKB/Swiss-Prot Function:
Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19826488, PubMed:19420222, PubMed:20145209, PubMed:27708256, PubMed:25489052, PubMed:29754825). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acetylates HIST1H4A (PubMed:29754825). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + N-terminal glycyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein]; Xref=Rhea:RHEA:50496, Rhea:RHEA-COMP:12666, Rhea:RHEA-COMP:12700, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64723, ChEBI:CHEBI:133369; EC=2.3.1.255; Evidence={ECO:0000269 PubMed:15496142, ECO:0000269 PubMed:19420222, ECO:0000269 PubMed:25489052};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein]; Xref=Rhea:RHEA:50500, Rhea:RHEA-COMP:12701, Rhea:RHEA-COMP:12702, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64718, ChEBI:CHEBI:83683; EC=2.3.1.255; Evidence={ECO:0000269 PubMed:15496142, ECO:0000269 PubMed:19420222, ECO:0000269 PubMed:25489052};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein]; Xref=Rhea:RHEA:50504, Rhea:RHEA-COMP:12703, Rhea:RHEA-COMP:12704, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64738, ChEBI:CHEBI:83690; EC=2.3.1.255; Evidence={ECO:0000269 PubMed:15496142, ECO:0000269 PubMed:19420222, ECO:0000269 PubMed:25489052, ECO:0000269 PubMed:29754825};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + N-terminal L-valyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein]; Xref=Rhea:RHEA:50508, Rhea:RHEA-COMP:12705, Rhea:RHEA-COMP:12706, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64741, ChEBI:CHEBI:133371; EC=2.3.1.255; Evidence={ECO:0000269 PubMed:15496142, ECO:0000269 PubMed:19420222, ECO:0000269 PubMed:25489052};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + N-terminal L-cysteinyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:50512, Rhea:RHEA-COMP:12707, Rhea:RHEA-COMP:12708, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:65250, ChEBI:CHEBI:133372; EC=2.3.1.255; Evidence={ECO:0000269 PubMed:15496142, ECO:0000269 PubMed:19420222, ECO:0000269 PubMed:25489052};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + N-terminal L-threonyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein]; Xref=Rhea:RHEA:50516, Rhea:RHEA-COMP:12709, Rhea:RHEA-COMP:12710, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64739, ChEBI:CHEBI:133375; EC=2.3.1.255; Evidence={ECO:0000269 PubMed:15496142, ECO:0000269 PubMed:19420222, ECO:0000269 PubMed:25489052};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=27 uM for acetyl-CoA (at pH 8.0 and at 25 degrees Celsius) {ECO:0000269 PubMed:29754825}; KM=30 uM for histone H4 peptide (at pH 8.0 and at 25 degrees Celsius) {ECO:0000269 PubMed:29754825};

Enzyme Numbers (IUBMB) for NAA10 Gene

Phenotypes From GWAS Catalog for NAA10 Gene

Gene Ontology (GO) - Molecular Function for NAA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004596 contributes_to peptide alpha-N-acetyltransferase activity IDA 19480662
GO:0005515 protein binding IPI 15496142
GO:0008080 N-acetyltransferase activity IEA,TAS 7981673
GO:0016407 contributes_to acetyltransferase activity IDA 15496142
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with NAA10: view
genes like me logo Genes that share phenotypes with NAA10: view

Human Phenotype Ontology for NAA10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAA10

Clone Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for NAA10 Gene

Localization for NAA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA10 Gene

Cytoplasm. Nucleus. Note=Also present in the free cytosolic and cytoskeleton-bound polysomes. {ECO:0000269 PubMed:15496142}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAA10 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NAA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus IDA,TAS 15496142
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA,IEA 15496142
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with NAA10: view

Pathways & Interactions for NAA10 Gene

genes like me logo Genes that share pathways with NAA10: view

Pathways by source for NAA10 Gene

1 BioSystems pathway for NAA10 Gene
2 Cell Signaling Technology pathways for NAA10 Gene

Gene Ontology (GO) - Biological Process for NAA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006323 DNA packaging TAS 7981673
GO:0006473 protein acetylation IDA 27708256
GO:0006474 N-terminal protein amino acid acetylation IBA,IDA 15496142
GO:0006475 internal protein amino acid acetylation TAS 7981673
GO:0017198 N-terminal peptidyl-serine acetylation IBA 21873635
genes like me logo Genes that share ontologies with NAA10: view

No data available for SIGNOR curated interactions for NAA10 Gene

Drugs & Compounds for NAA10 Gene

(2) Drugs for NAA10 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for NAA10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • AcCoA
  • Acetyl coenzyme A
  • S-Acetyl-CoA
  • S-Acetyl-coenzyme A
  • Ac-CoA
72-89-9
genes like me logo Genes that share compounds with NAA10: view

Transcripts for NAA10 Gene

mRNA/cDNA for NAA10 Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAA10

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAA10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - -
SP6: - - - -
SP7: -
SP8:
SP9: - -
SP10: -

Relevant External Links for NAA10 Gene

GeneLoc Exon Structure for
NAA10

Expression for NAA10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NAA10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAA10 Gene

This gene is overexpressed in Breast (16.5), Nasal epithelium (7.7), and Bone marrow stromal cell (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAA10 Gene



Protein tissue co-expression partners for NAA10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NAA10

SOURCE GeneReport for Unigene cluster for NAA10 Gene:

Hs.433291

mRNA Expression by UniProt/SwissProt for NAA10 Gene:

P41227-NAA10_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for NAA10 Gene

  • Liver(4.4)
  • Lung(4.4)
  • Nervous system(3.6)
  • Muscle(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for NAA10 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • middle ear
  • mouth
  • neck
  • nose
  • outer ear
  • pharynx
  • skull
  • tooth
Thorax:
  • aorta
  • chest wall
  • clavicle
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • abdominal wall
  • intestine
  • kidney
  • large intestine
  • stomach
Pelvis:
  • anus
  • pelvis
  • penis
  • rectum
  • testicle
  • ureter
  • urethra
  • urinary bladder
  • vagina
Limb:
  • arm
  • digit
  • finger
  • foot
  • forearm
  • hand
  • humerus
  • lower limb
  • radius
  • shoulder
  • toe
  • ulna
  • upper limb
General:
  • blood
  • blood vessel
  • hair
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with NAA10: view

No data available for mRNA differential expression in normal tissues for NAA10 Gene

Orthologs for NAA10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAA10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAA10 31 30
  • 99.57 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 94 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Naa10 17 31 30
  • 91.85 (n)
cow
(Bos Taurus)
Mammalia NAA10 31 30
  • 91.26 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Naa10 30
  • 91.26 (n)
dog
(Canis familiaris)
Mammalia NAA10 31 30
  • 90.96 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NAA10 31
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAA10 31
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia naa10 30
  • 76.41 (n)
Str.2590 30
zebrafish
(Danio rerio)
Actinopterygii naa10 31 30
  • 74.69 (n)
OneToMany
wufc66b08 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9985 30
fruit fly
(Drosophila melanogaster)
Insecta vnc 31 30
  • 77.49 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005410 30
  • 71.46 (n)
worm
(Caenorhabditis elegans)
Secernentea K07H8.3 31 30
  • 64.47 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARD1 33 31
  • 43 (a)
soybean
(Glycine max)
eudicotyledons Gma.2977 30
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3014 30
wheat
(Triticum aestivum)
Liliopsida Ta.5608 30
barley
(Hordeum vulgare)
Liliopsida Hv.2338 30
rice
(Oryza sativa)
Liliopsida Os.10971 30
corn
(Zea mays)
Liliopsida Zm.2319 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11133 31
  • 63 (a)
OneToMany
Cin.631 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.631 30
Species where no ortholog for NAA10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NAA10 Gene

ENSEMBL:
Gene Tree for NAA10 (if available)
TreeFam:
Gene Tree for NAA10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NAA10: view image

Paralogs for NAA10 Gene

Paralogs for NAA10 Gene

(4) SIMAP similar genes for NAA10 Gene using alignment to 5 proteins:

  • NAA10_HUMAN
  • A8MWP7_HUMAN
  • C9JN83_HUMAN
  • C9JW55_HUMAN
  • F8W808_HUMAN
genes like me logo Genes that share paralogs with NAA10: view

Variants for NAA10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NAA10 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
617458 Likely Pathogenic: Microphthalmia syndromic 4 153,929,947(-) T/C THREE_PRIME_UTR_VARIANT
617462 Likely Pathogenic: Microphthalmia syndromic 4 153,929,948(-) T/C THREE_PRIME_UTR_VARIANT
617463 Likely Pathogenic: Microphthalmia syndromic 4 153,929,944(-) T/C THREE_PRIME_UTR_VARIANT
637034 Likely Pathogenic: N-terminal acetyltransferase deficiency 153,934,382(-) G/T MISSENSE_VARIANT
667507 Benign: not provided 153,930,976(-) C/A INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for NAA10 Gene

Structural Variations from Database of Genomic Variants (DGV) for NAA10 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV gain+loss 17666407
nsv1144325 CNV deletion 24896259
nsv469867 CNV loss 16826518

Variation tolerance for NAA10 Gene

Residual Variation Intolerance Score: 24.1% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAA10 Gene

Human Gene Mutation Database (HGMD)
NAA10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAA10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA10 Gene

Disorders for NAA10 Gene

MalaCards: The human disease database

(11) MalaCards diseases for NAA10 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search NAA10 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NAA10_HUMAN
  • N-terminal acetyltransferase deficiency (NATD) [MIM:300855]: An enzymatic deficiency resulting in postnatal growth failure with severe delays and dysmorphic features. It is clinically characterized by wrinkled forehead, prominent eyes, widely opened anterior and posterior fontanels, downsloping palpebral fissures, thickened lids, large ears, flared nares, hypoplastic alae, short columella, protruding upper lip, and microretrognathia. There are also delayed closing of fontanels and broad great toes. Skin is characterized by redundancy or laxity with minimal subcutaneous fat, cutaneous capillary malformations, and very fine hair and eyebrows. Death results from cardiogenic shock following arrhythmia. {ECO:0000269 PubMed:21700266, ECO:0000269 PubMed:25489052, ECO:0000269 PubMed:26522270, ECO:0000269 PubMed:31174490}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Microphthalmia, syndromic, 1 (MCOPS1) [MIM:309800]: A rare syndrome defined by the canonical features of unilateral or bilateral microphthalmia or anophthalmia and defects in the skeletal and genitourinary systems. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. Anomalies of the digits, teeth, and ears are hallmarks of MCOPS1. Intellectual disability ranges from mild to severe, with self-mutilating behaviors and seizures in severely affected MCOPS1 individuals. {ECO:0000269 PubMed:24431331}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for NAA10

genes like me logo Genes that share disorders with NAA10: view

No data available for Genatlas for NAA10 Gene

Publications for NAA10 Gene

  1. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B … Sherman F (BMC proceedings 2009) 2 3 4 54
  2. Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans. (PMID: 19420222) Arnesen T … Gevaert K (Proceedings of the National Academy of Sciences of the United States of America 2009) 2 3 4 54
  3. Identification and characterization of the human ARD1-NATH protein acetyltransferase complex. (PMID: 15496142) Arnesen T … Lillehaug JR (The Biochemical journal 2005) 3 4 23 54
  4. Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation. (PMID: 12464182) Jeong JW … Kim KW (Cell 2002) 3 4 23 54
  5. Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae. (PMID: 7981673) Tribioli C … Toniolo D (Human molecular genetics 1994) 2 3 4 54

Products for NAA10 Gene

  • Signalway ELISA kits for NAA10
  • Signalway Proteins for NAA10

Sources for NAA10 Gene