Aliases for N6AMT1 Gene
External Ids for N6AMT1 Gene
Previous HGNC Symbols for N6AMT1 Gene
Previous GeneCards Identifiers for N6AMT1 Gene
This gene encodes an N(6)-adenine-specific DNA methyltransferase. The encoded enzyme may be involved in the methylation of release factor I during translation termination. This enzyme is also involved in converting the arsenic metabolite monomethylarsonous acid to the less toxic dimethylarsonic acid. Alternative splicing pf this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jul 2014]
GeneCards Summary for N6AMT1 Gene
N6AMT1 (N-6 Adenine-Specific DNA Methyltransferase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and protein methyltransferase activity.
UniProtKB/Swiss-Prot for N6AMT1 Gene
Heterodimeric methyltransferase that catalyzes N5-methylation of ETF1 on Gln-185, using S-adenosyl L-methionine as methyl donor. ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May play a role in the modulation of arsenic-induced toxicity. May be involved in the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid.