Aliases for N4BP2L1 Gene

Aliases for N4BP2L1 Gene

  • NEDD4 Binding Protein 2 Like 1 2 3 5
  • NEDD4-Binding Protein 2-Like 1 3 4
  • Hypothetical Gene CG018 2 3
  • CG018 2 3
  • N4BP2L1 5
  • CG081 4

External Ids for N4BP2L1 Gene

Previous GeneCards Identifiers for N4BP2L1 Gene

  • GC13M031872
  • GC13M032974
  • GC13M013786
  • GC13M032410
  • GC13M032945
  • GC13M033050
  • GC13M032987
  • GC13M033281
  • GC13M032418
  • GC13M032626
  • GC13M032667
  • GC13M032755
  • GC13M032843

Summaries for N4BP2L1 Gene

GeneCards Summary for N4BP2L1 Gene

N4BP2L1 (NEDD4 Binding Protein 2 Like 1) is a Protein Coding gene. Diseases associated with N4BP2L1 include Inflammatory Leiomyosarcoma. Gene Ontology (GO) annotations related to this gene include kinase activity. An important paralog of this gene is N4BP2.

Additional gene information for N4BP2L1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for N4BP2L1 Gene

Genomics for N4BP2L1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for N4BP2L1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J032425 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +1.6 1647 5.1 HNRNPL GATAD2A PRDM10 ZNF629 TFE3 ZNF692 RCOR2 POLR2A BACH1 LARP7 N4BP2L1 ENSG00000212293 N4BP2L2 PDS5B ENSG00000270008 ZAR1L
GH13J032252 Promoter/Enhancer 1.2 Ensembl ENCODE 9.4 +175.0 174959 3.7 RNF2 GATAD2A ATF7 REST TFE3 SOX13 NFKBIZ RCOR2 GABPA RBFOX2 FRY-AS1 FRY N4BP2L1 lnc-ZAR1L-2 lnc-ZAR1L-3 BRCA2
GH13J032471 Enhancer 1 Ensembl ENCODE 11.2 -42.4 -42360 1.9 IKZF1 BACH1 PKNOX1 ZNF24 SOX6 TCF12 EP300 UBTF EGR1 CTBP1 N4BP2L2 N4BP2L1 ENSG00000212293 PDS5B ATP8A2P2 piR-32214-136 ENSG00000270008
GH13J032452 Enhancer 0.9 Ensembl ENCODE 11.9 -23.9 -23885 1.4 GATAD2A RCOR2 CEBPA SOX13 ZNF316 MAFF MAFK JUND MAFG CREM piR-32214-136 ATP8A2P2 N4BP2L1 ENSG00000212293 N4BP2L2 ENSG00000270008
GH13J032260 Enhancer 1 Ensembl ENCODE 9.4 +166.6 166632 6.8 GATAD2A IKZF1 JUND PKNOX1 RXRB SP1 DPF2 HDAC1 SOX6 EP300 lnc-ZAR1L-2 FRY-AS1 FRY N4BP2L1 lnc-FRY-1 BRCA2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around N4BP2L1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for N4BP2L1

Top Transcription factor binding sites by QIAGEN in the N4BP2L1 gene promoter:
  • aMEF-2
  • AREB6
  • ARP-1
  • CREB
  • deltaCREB
  • FOXO1
  • FOXO1a
  • Lmo2
  • MEF-2A
  • NF-1

Genomic Locations for N4BP2L1 Gene

Genomic Locations for N4BP2L1 Gene
28,894 bases
Minus strand
27,456 bases
Minus strand

Genomic View for N4BP2L1 Gene

Genes around N4BP2L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
N4BP2L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for N4BP2L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for N4BP2L1 Gene

Proteins for N4BP2L1 Gene

  • Protein details for N4BP2L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NEDD4-binding protein 2-like 1
    Protein Accession:
    Secondary Accessions:
    • A4QN21
    • Q5TBK0

    Protein attributes for N4BP2L1 Gene

    243 amino acids
    Molecular mass:
    28981 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for N4BP2L1 Gene


neXtProt entry for N4BP2L1 Gene

Post-translational modifications for N4BP2L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for N4BP2L1 Gene

Domains & Families for N4BP2L1 Gene

Gene Families for N4BP2L1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for N4BP2L1 Gene


Suggested Antigen Peptide Sequences for N4BP2L1 Gene

GenScript: Design optimal peptide antigens:
  • NEDD4-binding protein 2-like 1 (N42L1_HUMAN)
  • N4BP2L1 protein (Q8WTU5_HUMAN)
genes like me logo Genes that share domains with N4BP2L1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for N4BP2L1 Gene

Function for N4BP2L1 Gene

Phenotypes From GWAS Catalog for N4BP2L1 Gene

genes like me logo Genes that share phenotypes with N4BP2L1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for N4BP2L1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for N4BP2L1 Gene

Localization for N4BP2L1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for N4BP2L1 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for N4BP2L1 Gene

Pathways & Interactions for N4BP2L1 Gene

PathCards logo

SuperPathways for N4BP2L1 Gene

No Data Available

Interacting Proteins for N4BP2L1 Gene

Gene Ontology (GO) - Biological Process for N4BP2L1 Gene


No data available for Pathways by source and SIGNOR curated interactions for N4BP2L1 Gene

Drugs & Compounds for N4BP2L1 Gene

No Compound Related Data Available

Transcripts for N4BP2L1 Gene

mRNA/cDNA for N4BP2L1 Gene

16 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for N4BP2L1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for N4BP2L1 Gene

No ASD Table

Relevant External Links for N4BP2L1 Gene

GeneLoc Exon Structure for

Expression for N4BP2L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for N4BP2L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for N4BP2L1 Gene

This gene is overexpressed in Liver (24.7), CD8 Tcells (20.4), Blymphocyte (15.6), and NK cells (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for N4BP2L1 Gene

Protein tissue co-expression partners for N4BP2L1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for N4BP2L1

SOURCE GeneReport for Unigene cluster for N4BP2L1 Gene:


Evidence on tissue expression from TISSUES for N4BP2L1 Gene

  • Nervous system(3.6)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with N4BP2L1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for N4BP2L1 Gene

Orthologs for N4BP2L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for N4BP2L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia N4BP2L1 30 31
  • 98.22 (n)
(Canis familiaris)
Mammalia N4BP2L1 30 31
  • 89.81 (n)
(Mus musculus)
Mammalia N4bp2l1 30 17 31
  • 83.61 (n)
(Rattus norvegicus)
Mammalia N4bp2l1 30
  • 82.91 (n)
(Monodelphis domestica)
Mammalia N4BP2L1 31
  • 78 (a)
(Bos Taurus)
Mammalia N4BP2L1 31
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia N4BP2L1 31
  • 7 (a)
(Gallus gallus)
Aves N4BP2L1 30 31
  • 73.48 (n)
(Anolis carolinensis)
Reptilia N4BP2L1 31
  • 59 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia n4bp2l1 30
  • 75 (n)
(Danio rerio)
Actinopterygii N4BP2L1 31
  • 19 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta CG7139 31
  • 7 (a)
Species where no ortholog for N4BP2L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for N4BP2L1 Gene

Gene Tree for N4BP2L1 (if available)
Gene Tree for N4BP2L1 (if available)
Evolutionary constrained regions (ECRs) for N4BP2L1: view image

Paralogs for N4BP2L1 Gene

Paralogs for N4BP2L1 Gene

(3) SIMAP similar genes for N4BP2L1 Gene using alignment to 5 proteins:

  • N42L1_HUMAN
  • H0Y2Y5_HUMAN
  • U3KQ14_HUMAN
genes like me logo Genes that share paralogs with N4BP2L1: view

Variants for N4BP2L1 Gene

Additional dbSNP identifiers (rs#s) for N4BP2L1 Gene

Structural Variations from Database of Genomic Variants (DGV) for N4BP2L1 Gene

Variant ID Type Subtype PubMed ID
nsv1070164 CNV deletion 25765185
nsv832576 CNV gain 17160897
nsv976257 CNV duplication 23825009

Variation tolerance for N4BP2L1 Gene

Residual Variation Intolerance Score: 30.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for N4BP2L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for N4BP2L1 Gene

Disorders for N4BP2L1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for N4BP2L1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
inflammatory leiomyosarcoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for N4BP2L1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with N4BP2L1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for N4BP2L1 Gene

Publications for N4BP2L1 Gene

  1. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 41
  2. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 41
  3. Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13. (PMID: 8812419) Couch FJ … Simard J (Genomics 1996) 2 3
  4. NEDD 4 binding protein 2-like 1 promotes cancer cell invasion in oral squamous cell carcinoma. (PMID: 27184799) Sasahira T … Kuniyasu H (Virchows Archiv : an international journal of pathology 2016) 3
  5. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (PMID: 23535729) Michailidou K … Easton DF (Nature genetics 2013) 3

Products for N4BP2L1 Gene

  • Signalway ELISA kits for N4BP2L1

Sources for N4BP2L1 Gene