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Aliases for N4BP2 Gene

Aliases for N4BP2 Gene

  • NEDD4 Binding Protein 2 2 3 5
  • BCL-3-Binding Protein 3 4
  • B3BP 3 4
  • NEDD4-Binding Protein 2 3
  • BCL-3 Binding Protein 2
  • EC 3.-.-.- 4
  • KIAA1413 4

External Ids for N4BP2 Gene

Previous GeneCards Identifiers for N4BP2 Gene

  • GC04P040068
  • GC04P040266
  • GC04P039893
  • GC04P039996
  • GC04P039972
  • GC04P039897
  • GC04P039734
  • GC04P039775
  • GC04P039381

Summaries for N4BP2 Gene

Entrez Gene Summary for N4BP2 Gene

  • This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

GeneCards Summary for N4BP2 Gene

N4BP2 (NEDD4 Binding Protein 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include endonuclease activity and ATP-dependent polydeoxyribonucleotide 5-hydroxyl-kinase activity. An important paralog of this gene is N4BP2L2.

UniProtKB/Swiss-Prot for N4BP2 Gene

  • Has 5-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination.

Additional gene information for N4BP2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for N4BP2 Gene

Genomics for N4BP2 Gene

GeneHancer (GH) Regulatory Elements for N4BP2 Gene

Promoters and enhancers for N4BP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I040054 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 567.1 +0.5 458 4.6 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D GLIS1 N4BP2 LOC344967 PDS5A ENSG00000250568 RHOH
GH04I040189 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 25.8 +143.9 143927 22 HDGF PKNOX1 FOXA2 SMAD1 ARNT SIN3A IRF4 YY1 POLR2B ZNF766 RHOH PDS5A N4BP2 RFC1 RBM47 LOC344967 ENSG00000250568 CHRNA9 ENSG00000250906 UGDH-AS1
GH04I040237 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 21.6 +182.8 182785 3.1 HDGF PKNOX1 SMAD1 ARNT POLR2B ZNF766 FOS SP3 REST ZNF592 N4BP2 PDS5A RFC1 RHOH LOC344967 CHRNA9 ENSG00000250906 ZBTB12BP RBM47 GC04P040236
GH04I040298 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 21.6 +249.4 249398 15.1 HDGF PKNOX1 FOXA2 SMAD1 SIN3A ZNF2 IRF4 ZNF207 ZNF143 JUNB LINC02265 N4BP2 PDS5A ZBTB12BP RHOH CHRNA9 LOC344967 RFC1 RBM47 ENSG00000250338
GH04I039695 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 12.9 -357.8 -357788 5.3 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B UBE2K RPL9 PDS5A ZBTB12BP N4BP2 RFC1 RBM47 GC04M039712 ENSG00000252975
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around N4BP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the N4BP2 gene promoter:

Genomic Locations for N4BP2 Gene

Genomic Locations for N4BP2 Gene
129,587 bases
Plus strand

Genomic View for N4BP2 Gene

Genes around N4BP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
N4BP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for N4BP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for N4BP2 Gene

Proteins for N4BP2 Gene

  • Protein details for N4BP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NEDD4-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • A0AVR3
    • Q9NVK2
    • Q9P2D4

    Protein attributes for N4BP2 Gene

    1770 amino acids
    Molecular mass:
    198801 Da
    Quaternary structure:
    • Binds NEDD4 (By similarity). Binds BCL3 and CREBBP.

    Three dimensional structures from OCA and Proteopedia for N4BP2 Gene

    Alternative splice isoforms for N4BP2 Gene


neXtProt entry for N4BP2 Gene

Post-translational modifications for N4BP2 Gene

  • Ubiquitinated; this targets the protein for degradation by the proteasome.
  • Ubiquitination at isoforms=220, isoforms=2414, isoforms=2453, Lys1160, Lys1247, isoforms=21440, and Lys1459
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for N4BP2 Gene

Domains & Families for N4BP2 Gene

Gene Families for N4BP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for N4BP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • The Smr domain has nicking endonuclease activity, but no significant double strand cleavage or exonuclease activity.
  • The Smr domain has nicking endonuclease activity, but no significant double strand cleavage or exonuclease activity.
genes like me logo Genes that share domains with N4BP2: view

Function for N4BP2 Gene

Molecular function for N4BP2 Gene

UniProtKB/Swiss-Prot Function:
Has 5-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination.

Enzyme Numbers (IUBMB) for N4BP2 Gene

Phenotypes From GWAS Catalog for N4BP2 Gene

Gene Ontology (GO) - Molecular Function for N4BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004519 endonuclease activity IDA 12730195
GO:0005515 protein binding IPI 12730195
GO:0005524 ATP binding IDA 12730195
GO:0016787 hydrolase activity IEA --
GO:0046404 ATP-dependent polydeoxyribonucleotide 5-hydroxyl-kinase activity IDA 12730195
genes like me logo Genes that share ontologies with N4BP2: view
genes like me logo Genes that share phenotypes with N4BP2: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for N4BP2 Gene

Localization for N4BP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for N4BP2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for N4BP2 gene
Compartment Confidence
nucleus 4
cytosol 4
plasma membrane 2
cytoskeleton 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for N4BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with N4BP2: view

Pathways & Interactions for N4BP2 Gene

SuperPathways for N4BP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for N4BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016310 phosphorylation IEA --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with N4BP2: view

No data available for Pathways by source and SIGNOR curated interactions for N4BP2 Gene

Drugs & Compounds for N4BP2 Gene

No Compound Related Data Available

Transcripts for N4BP2 Gene

Unigene Clusters for N4BP2 Gene

NEDD4 binding protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for N4BP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20
SP1: - -
SP3: -
SP6: - - -

Relevant External Links for N4BP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for N4BP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for N4BP2 Gene

Protein differential expression in normal tissues from HIPED for N4BP2 Gene

This gene is overexpressed in Liver, secretome (20.2), Colon muscle (17.2), Plasma (15.0), and Serum (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for N4BP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of N4BP2 Gene:


SOURCE GeneReport for Unigene cluster for N4BP2 Gene:


Evidence on tissue expression from TISSUES for N4BP2 Gene

  • Lung(4.2)
  • Nervous system(4.2)
  • Blood(4)
genes like me logo Genes that share expression patterns with N4BP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for N4BP2 Gene

Orthologs for N4BP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for N4BP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia N4BP2 33 34
  • 99.66 (n)
(Canis familiaris)
Mammalia N4BP2 33 34
  • 88.4 (n)
(Bos Taurus)
Mammalia N4BP2 33 34
  • 86.97 (n)
(Rattus norvegicus)
Mammalia N4bp2 33
  • 79.31 (n)
(Mus musculus)
Mammalia N4bp2 33 16 34
  • 78.58 (n)
(Ornithorhynchus anatinus)
Mammalia N4BP2 34
  • 44 (a)
(Gallus gallus)
Aves N4BP2 33 34
  • 58.37 (n)
(Anolis carolinensis)
Reptilia N4BP2 34
  • 35 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3753 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.20151 33
(Danio rerio)
Actinopterygii n4bp2 34
  • 29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7139 34
  • 20 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
Species where no ortholog for N4BP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for N4BP2 Gene

Gene Tree for N4BP2 (if available)
Gene Tree for N4BP2 (if available)

Paralogs for N4BP2 Gene

Paralogs for N4BP2 Gene

(2) SIMAP similar genes for N4BP2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with N4BP2: view

Variants for N4BP2 Gene

Sequence variations from dbSNP and Humsavar for N4BP2 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
VAR_035474 A breast cancer sample p.Pro283Ala
rs10000000 -- 40,087,276(+) A/T genic_upstream_transcript_variant, intron_variant
rs1000008879 -- 40,094,660(+) A/C/G genic_upstream_transcript_variant, intron_variant
rs1000018253 -- 40,087,304(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000065117 -- 40,070,934(+) C/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for N4BP2 Gene

Variant ID Type Subtype PubMed ID
dgv5194n100 CNV gain 25217958
esv29217 CNV loss 19812545
esv3575688 CNV gain 25503493
esv3600300 CNV loss 21293372
nsv1010235 CNV gain 25217958
nsv1012387 CNV gain 25217958
nsv461341 CNV gain 19166990
nsv472749 CNV novel sequence insertion 20440878
nsv594032 CNV gain 21841781
nsv594033 CNV gain 21841781
nsv594044 CNV gain 21841781
nsv594050 CNV loss 21841781

Variation tolerance for N4BP2 Gene

Residual Variation Intolerance Score: 90.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.86; 89.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for N4BP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for N4BP2 Gene

Disorders for N4BP2 Gene

Additional Disease Information for N4BP2

No disorders were found for N4BP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for N4BP2 Gene

Publications for N4BP2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. Haplotype of gene Nedd4 binding protein 2 associated with sporadic nasopharyngeal carcinoma in the Southern Chinese population. (PMID: 17626640) Zheng MZ … Zeng YX (Journal of translational medicine 2007) 3 22 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination. (PMID: 12730195) Watanabe N … Fujita T (The Journal of biological chemistry 2003) 3 4 58
  5. Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase. (PMID: 11717310) Murillas R … Kuehn MR (The Journal of biological chemistry 2002) 2 3 58

Products for N4BP2 Gene

Sources for N4BP2 Gene

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