Aliases for MELTF Gene
External Ids for MELTF Gene
Previous HGNC Symbols for MELTF Gene
The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008]
GeneCards Summary for MELTF Gene
MELTF (Melanotransferrin) is a Protein Coding gene. Diseases associated with MELTF include Osteogenic Sarcoma and Melanotic Neuroectodermal Tumor. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. An important paralog of this gene is TF.
UniProtKB/Swiss-Prot Summary for MELTF Gene
Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.