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Aliases for MAPK11 Gene

Aliases for MAPK11 Gene

  • Mitogen-Activated Protein Kinase 11 2 3 5
  • Mitogen-Activated Protein Kinase P38 Beta 3 4
  • MAP Kinase P38 Beta 3 4
  • MAP Kinase 11 3 4
  • EC 2.7.11.24 4 56
  • PRKM11 3 4
  • SAPK2B 3 4
  • SAPK2 3 4
  • P38-2 3 4
  • P38B 3 4
  • Mitogen-Activated Protein Kinase P38-2 3
  • Stress-Activated Protein Kinase-2b 3
  • Stress-Activated Protein Kinase 2b 4
  • Stress-Activated Protein Kinase-2 3
  • EC 2.7.11 56
  • P38BETA2 3
  • P38Beta 3
  • MAPK 11 4

External Ids for MAPK11 Gene

Previous HGNC Symbols for MAPK11 Gene

  • PRKM11

Previous GeneCards Identifiers for MAPK11 Gene

  • GC22M047253
  • GC22M048884
  • GC22M048874
  • GC22M049004
  • GC22M049044
  • GC22M050702
  • GC22M033599

Summaries for MAPK11 Gene

Entrez Gene Summary for MAPK11 Gene

  • This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for MAPK11 Gene

MAPK11 (Mitogen-Activated Protein Kinase 11) is a Protein Coding gene. Among its related pathways are RET signaling and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK14.

UniProtKB/Swiss-Prot for MAPK11 Gene

  • Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on Ser-10 (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment.

Tocris Summary for MAPK11 Gene

  • MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of cellular functions.

Gene Wiki entry for MAPK11 Gene

Additional gene information for MAPK11 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK11 Gene

Genomics for MAPK11 Gene

GeneHancer (GH) Regulatory Elements for MAPK11 Gene

Promoters and enhancers for MAPK11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I050269 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.2 160 1.9 ARID4B SIN3A ZNF48 GLIS2 ZNF143 RUNX3 SP3 NFYC NCOA1 MXD4 MAPK11 ENSG00000273253 MAPK12 PPP6R2 SELENOO
GH22I050271 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 559.2 -1.1 -1076 0.3 RB1 ARID4B SIN3A BMI1 ZNF143 SP3 SP5 REST ZNF148 SREBF1 MAPK11 DENND6B MAPK8IP2 SHANK3 PPP6R2 MOV10L1 MLC1 SBF1 ACR PIR50517
GH22I050272 Enhancer 0.7 dbSUPER 555.9 -1.9 -1900 1.2 CTCF KLF1 MXI1 MAZ SP3 RFX1 ZNF10 SIN3A BMI1 ZIC2 MAPK11 MAPK12 PIR50517
GH22I050188 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.1 +79.7 79688 5.6 HDGF PKNOX1 ATF1 SIN3A ZNF2 IRF4 ZNF766 GLIS2 ZNF143 KLF7 TRABD ENSG00000273188 TUBGCP6 MAPK12 HDAC10 BRD1 ENSG00000273253 MAPK11 PLXNB2 MLC1
GH22I049957 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.2 +307.7 307710 11.7 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 PIM3 MIR6821 RABL2B MAPK11 DENND6B MAPK8IP2 ENSG00000273253 IL17REL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAPK11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAPK11 gene promoter:

Genomic Locations for MAPK11 Gene

Genomic Locations for MAPK11 Gene
chr22:50,263,713-50,270,767
(GRCh38/hg38)
Size:
7,055 bases
Orientation:
Minus strand
chr22:50,702,142-50,709,196
(GRCh37/hg19)

Genomic View for MAPK11 Gene

Genes around MAPK11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK11 Gene

Proteins for MAPK11 Gene

  • Protein details for MAPK11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15759-MK11_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 11
    Protein Accession:
    Q15759
    Secondary Accessions:
    • A8K730
    • B0LPG1
    • B7Z630
    • E7ETQ1
    • L7RT27
    • O00284
    • O15472
    • Q2XNF2

    Protein attributes for MAPK11 Gene

    Size:
    364 amino acids
    Molecular mass:
    41357 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with HDAC3 and DUSP16.

    Three dimensional structures from OCA and Proteopedia for MAPK11 Gene

    Alternative splice isoforms for MAPK11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK11 Gene

Selected DME Specific Peptides for MAPK11 Gene

Q15759:
  • YVATRWYR
  • QTVDIWSVGCIMAE
  • GLKYIHSA
  • ILDFGLA
  • HSAGIIHRDLKPSN
  • KKLSRPFQ
  • LKYIHSA
  • QLLRGLKY
  • AVNEDCEL
  • YRAPEIML
  • LMGADLNNIVKCQ
  • DIWSVGCI
  • HENVIGLLD
  • LDFGLAR
  • LLDVFTP
  • VGSGAYG
  • TRWYRAPE
  • FYRQELNKT

Post-translational modifications for MAPK11 Gene

  • Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6, which activates the enzyme.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPK11 Gene

Domains & Families for MAPK11 Gene

Gene Families for MAPK11 Gene

Suggested Antigen Peptide Sequences for MAPK11 Gene

Graphical View of Domain Structure for InterPro Entry

Q15759

UniProtKB/Swiss-Prot:

MK11_HUMAN :
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Domain:
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK11: view

Function for MAPK11 Gene

Molecular function for MAPK11 Gene

GENATLAS Biochemistry:
mitogen-activated protein kinase 11
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on threonine and tyrosine by MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6. MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 induced by environmental stress. HDAC3 interacts directly and selectively with MAPK11 to repress ATF2 transcriptional activity, and regulate TNF gene expression in LPS-stimulated cells. Inhibited by SB203580 and pyridinyl-imidazole related compounds.
UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on Ser-10 (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment.

Enzyme Numbers (IUBMB) for MAPK11 Gene

Phenotypes From GWAS Catalog for MAPK11 Gene

Gene Ontology (GO) - Molecular Function for MAPK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004707 MAP kinase activity IDA,TAS 8663524
GO:0005515 protein binding IPI 17254968
genes like me logo Genes that share ontologies with MAPK11: view
genes like me logo Genes that share phenotypes with MAPK11: view

Animal Models for MAPK11 Gene

MGI Knock Outs for MAPK11:

Animal Model Products

miRNA for MAPK11 Gene

miRTarBase miRNAs that target MAPK11

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPK11 Gene

Localization for MAPK11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK11 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPK11 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 3
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MAPK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAPK11: view

Pathways & Interactions for MAPK11 Gene

SuperPathways for MAPK11 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 IL-2 Pathway
3 4-1BB Pathway
4 RET signaling
5 Toll-like receptor signaling pathway
genes like me logo Genes that share pathways with MAPK11: view

Pathways by source for MAPK11 Gene

SIGNOR curated interactions for MAPK11 Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for MAPK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0000187 activation of MAPK activity TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with MAPK11: view

Drugs & Compounds for MAPK11 Gene

(30) Drugs for MAPK11 Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
regorafenib Approved Pharma Target, inhibitor Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Pirfenidone Approved, Investigational Pharma inhibitor TGF-β production inhibitor, Antifibrotic agent; regulates cytokine levels in vivo 65
Stivarga Approved February 2013/ Approved September 2012 Pharma 0
Magnesium Approved Nutra 0
KC706 Investigational Pharma Target, inhibitor 0

(5) Additional Compounds for MAPK11 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(3) Tocris Compounds for MAPK11 Gene

Compound Action Cas Number
CMPD-1 Selective inhibitor of p38alpha-mediated MK2a phosphorylation; also tubulin polymerization inhibitor 41179-33-3
SKF 86002 dihydrochloride p38 MAPK inhibitor; anti-inflammatory agent 116339-68-5
TAK 715 Potent p38 MAPK inhibitor; anti-inflammatory 303162-79-0

(10) ApexBio Compounds for MAPK11 Gene

Compound Action Cas Number
BIRB 796 (Doramapimod) P38 MAPK inhibitor,cell permeable and highly selective 285983-48-4
Losmapimod 585543-15-3
LY2228820 P38 MAP kinase inhibitor 862507-23-1
PH-797804 P38 MAP kinase inhibitor, potent and selective 586379-66-0
SB 203580 P38 MAP kinase inhibitor 152121-47-6
SB202190 (FHPI) P38 MAPK inhibitor 152121-30-7
Skepinone-L P38-MAPK inhibitor,potent and selective 1221485-83-1
TAK-715 p38 MAPK inhibitor 303162-79-0
VX-702 P38α MAPK inhibitor,highly selective and ATP-competitive 479543-46-9
VX-745 P38α inhibitor,highly potent and selective 209410-46-8
genes like me logo Genes that share compounds with MAPK11: view

Drug Products

Transcripts for MAPK11 Gene

Unigene Clusters for MAPK11 Gene

Mitogen-activated protein kinase 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14
SP1: - - - - -
SP2: - - -
SP3: -
SP4:
SP5: - - -
SP6:

Relevant External Links for MAPK11 Gene

GeneLoc Exon Structure for
MAPK11
ECgene alternative splicing isoforms for
MAPK11

Expression for MAPK11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAPK11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAPK11 Gene

This gene is overexpressed in Retina (67.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAPK11 Gene



Protein tissue co-expression partners for MAPK11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAPK11 Gene:

MAPK11

SOURCE GeneReport for Unigene cluster for MAPK11 Gene:

Hs.57732

mRNA Expression by UniProt/SwissProt for MAPK11 Gene:

Q15759-MK11_HUMAN
Tissue specificity: Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for MAPK11 Gene

  • Nervous system(4.4)
  • Heart(2)
genes like me logo Genes that share expression patterns with MAPK11: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK11 Gene

Orthologs for MAPK11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAPK11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAPK11 34 33
  • 90.98 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MAPK11 33
  • 90.27 (n)
mouse
(Mus musculus)
Mammalia Mapk11 16 34 33
  • 88.83 (n)
rat
(Rattus norvegicus)
Mammalia Mapk11 33
  • 88.64 (n)
oppossum
(Monodelphis domestica)
Mammalia MAPK11 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPK11 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAPK11 34 33
  • 71.04 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPK11 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk11 33
  • 69.53 (n)
zebrafish
(Danio rerio)
Actinopterygii mapk11 34 33
  • 71.04 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta p38b 35 34
  • 67 (a)
Mpk2 35 34
  • 65 (a)
p38c 35 34
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea pmk-1 35 34
  • 64 (a)
pmk-2 34
  • 48 (a)
ManyToMany
pmk-3 35
  • 41 (a)
F09C12.2 35
  • 38 (a)
Y51B9A.9 35
  • 33 (a)
C49C3.10b 35
  • 29 (a)
C49C3.10a 35
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HOG1 34
  • 39 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons MPK10 33
  • 52.02 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 65 (a)
OneToMany
Species where no ortholog for MAPK11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPK11 Gene

ENSEMBL:
Gene Tree for MAPK11 (if available)
TreeFam:
Gene Tree for MAPK11 (if available)

Paralogs for MAPK11 Gene

Variants for MAPK11 Gene

Sequence variations from dbSNP and Humsavar for MAPK11 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
VAR_042264 A lung neuroendocrine carcinoma sample p.Ala221Val
rs1000047257 -- 50,269,722(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000207883 -- 50,271,851(-) G/C/T upstream_transcript_variant
rs1000261988 -- 50,271,600(-) G/A upstream_transcript_variant
rs1000266306 -- 50,268,620(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MAPK11 Gene

Variant ID Type Subtype PubMed ID
dgv781n67 CNV gain 20364138
dgv782n67 CNV gain 20364138
esv2724762 CNV deletion 23290073
nsv1066496 CNV loss 25217958
nsv1143040 CNV tandem duplication 24896259
nsv471223 CNV loss 18288195
nsv474782 CNV novel sequence insertion 20440878
nsv475003 CNV novel sequence insertion 20440878
nsv475390 CNV novel sequence insertion 20440878
nsv955199 CNV deletion 24416366

Variation tolerance for MAPK11 Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.25; 40.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAPK11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPK11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK11 Gene

Disorders for MAPK11 Gene

Additional Disease Information for MAPK11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MAPK11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAPK11 Gene

Publications for MAPK11 Gene

  1. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. (PMID: 9218798) Goedert M … Cohen P (The EMBO journal 1997) 2 3 4 22 58
  2. The three-dimensional structure of MAP kinase p38beta: different features of the ATP-binding site in p38beta compared with p38alpha. (PMID: 19622861) Patel SB … Scapin G (Acta crystallographica. Section D, Biological crystallography 2009) 3 4 22 58
  3. Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors. (PMID: 10330143) Yang SH … Sharrocks AD (Molecular and cellular biology 1999) 3 4 22 58
  4. Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. (PMID: 9207191) Kumar S … Young PR (Biochemical and biophysical research communications 1997) 3 4 22 58
  5. p38-2, a novel mitogen-activated protein kinase with distinct properties. (PMID: 9235954) Stein B … Barbosa MS (The Journal of biological chemistry 1997) 3 4 22 58

Products for MAPK11 Gene

Sources for MAPK11 Gene

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