Aliases for MZT2B Gene

Aliases for MZT2B Gene

  • Mitotic Spindle Organizing Protein 2B 2 3 5
  • Mitotic-Spindle Organizing Protein Associated With A Ring Of Gamma-Tubulin 2B 2 3 4
  • MOZART2B 2 3 4
  • Family With Sequence Similarity 128, Member B 2 3
  • Mitotic-Spindle Organizing Protein 2B 3 4
  • FAM128B 3 4
  • FLJ14346 2
  • MZT2B 5

External Ids for MZT2B Gene

Previous HGNC Symbols for MZT2B Gene

  • FAM128B

Previous GeneCards Identifiers for MZT2B Gene

  • GC02P130941
  • GC02P123235

Summaries for MZT2B Gene

GeneCards Summary for MZT2B Gene

MZT2B (Mitotic Spindle Organizing Protein 2B) is a Protein Coding gene. An important paralog of this gene is MZT2A.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MZT2B Gene

Genomics for MZT2B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MZT2B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J130180 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +0.7 663 5.2 SP1 ZNF207 NCOR1 MYC IKZF1 ZNF592 POLR2A BRCA1 NFIC ZIC2 MZT2B SMPD4 lnc-MZT2B-5 lnc-TUBA3E-1 TUBA3E NOC2LP1 RAB6C-AS1
GH02J130130 Promoter 1.1 EPDnew Ensembl 250.2 -52.0 -52036 4.2 IKZF1 SAP130 THRB MLLT1 NFYC CTCF ARID4B ZNF512 MNT RNF2 POTEF MED15P9 lnc-MZT2B-1 MZT2B RAB6C-AS1 CCDC74B lnc-CCDC74B-1
GH02J130824 Enhancer 1.5 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.6 +644.8 644758 6.7 ZNF207 JUND ATF2 BRCA1 BCL11A CEBPB TRIM22 MAX EP300 IRF4 GPR148 ARHGEF4 ENSG00000233221 MZT2B CCDC74A HSALNG0018848 HSALNG0018847-002 AMER3
GH02J130157 Enhancer 0.9 Ensembl ENCODE 0.4 -23.6 -23557 1.6 SP1 ZNF600 ZIC2 TRIM22 EBF1 SMARCA5 PRDM10 BHLHE40 SUPT5H POLR2A HSALNG0018779 TUBA3E piR-43666 CCDC74B lnc-TUBA3E-1 MZT2B SMPD4
GH02J130185 Enhancer 0.4 Ensembl 0.7 +3.6 3564 0.2 ZBTB33 ZFHX2 ZNF121 TUBA3E MZT2B SMPD4 lnc-MZT2B-5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MZT2B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MZT2B

Genomic Locations for MZT2B Gene

Latest Assembly
8,993 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
8,466 bases
Plus strand

(GRCh37/hg19 by Ensembl)
8,993 bases
Plus strand

Genomic View for MZT2B Gene

Genes around MZT2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MZT2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MZT2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MZT2B Gene

Proteins for MZT2B Gene

  • Protein details for MZT2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitotic-spindle organizing protein 2B
    Protein Accession:
    Secondary Accessions:
    • Q96CG4

    Protein attributes for MZT2B Gene

    158 amino acids
    Molecular mass:
    16226 Da
    Quaternary structure:
    • Part of the gamma-tubulin complex. Interacts with TUBG1.

neXtProt entry for MZT2B Gene

Post-translational modifications for MZT2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MZT2B Gene

Domains & Families for MZT2B Gene

Gene Families for MZT2B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MZT2B Gene


Suggested Antigen Peptide Sequences for MZT2B Gene

GenScript: Design optimal peptide antigens:
  • Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B (MZT2B_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MOZART2 family.
  • Belongs to the MOZART2 family.
genes like me logo Genes that share domains with MZT2B: view

Function for MZT2B Gene

Gene Ontology (GO) - Molecular Function for MZT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20360068
genes like me logo Genes that share ontologies with MZT2B: view
genes like me logo Genes that share phenotypes with MZT2B: view

miRNA for MZT2B Gene

miRTarBase miRNAs that target MZT2B

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MZT2B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MZT2B Gene

Localization for MZT2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MZT2B Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MZT2B gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 4
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MZT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IBA,IDA 20360068
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA,IDA 20360068
genes like me logo Genes that share ontologies with MZT2B: view

Pathways & Interactions for MZT2B Gene

PathCards logo

SuperPathways for MZT2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MZT2B Gene


No data available for Pathways by source and SIGNOR curated interactions for MZT2B Gene

Drugs & Compounds for MZT2B Gene

No Compound Related Data Available

Transcripts for MZT2B Gene

mRNA/cDNA for MZT2B Gene

7 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MZT2B

Alternative Splicing Database (ASD) splice patterns (SP) for MZT2B Gene

No ASD Table

Relevant External Links for MZT2B Gene

GeneLoc Exon Structure for

Expression for MZT2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MZT2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MZT2B Gene

This gene is overexpressed in Bone (40.0) and Pancreas (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MZT2B Gene

Protein tissue co-expression partners for MZT2B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MZT2B

SOURCE GeneReport for Unigene cluster for MZT2B Gene:


Evidence on tissue expression from TISSUES for MZT2B Gene

  • Nervous system(4.6)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with MZT2B: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MZT2B Gene

Orthologs for MZT2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MZT2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MZT2B 29
  • 99.16 (n)
(Canis familiaris)
Mammalia -- 30
  • 94 (a)
MZT2B 29
  • 91.02 (n)
(Bos Taurus)
Mammalia LOC787548 29
  • 87.47 (n)
MZT2 30
  • 82 (a)
(Mus musculus)
Mammalia Mzt2 30
  • 70 (a)
(Monodelphis domestica)
Mammalia -- 30
  • 69 (a)
(Gallus gallus)
Aves -- 30
  • 54 (a)
(Anolis carolinensis)
Reptilia -- 30
  • 54 (a)
-- 30
  • 41 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mzt2b 29
  • 60.43 (n)
(Danio rerio)
Actinopterygii mzt2b 29 30
  • 59.06 (n)
Species where no ortholog for MZT2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MZT2B Gene

Gene Tree for MZT2B (if available)
Gene Tree for MZT2B (if available)
Evolutionary constrained regions (ECRs) for MZT2B: view image
Alliance of Genome Resources:
Additional Orthologs for MZT2B

Paralogs for MZT2B Gene

Paralogs for MZT2B Gene

(1) SIMAP similar genes for MZT2B Gene using alignment to 5 proteins:

  • B8ZZ87_HUMAN
  • H7BZ50_HUMAN
  • H7C173_HUMAN
  • H7C293_HUMAN Pseudogenes for MZT2B Gene

genes like me logo Genes that share paralogs with MZT2B: view

Variants for MZT2B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MZT2B Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs1043059 -- p.Ala118Val
rs1043152 -- p.Arg155Gln

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MZT2B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MZT2B Gene

Variant ID Type Subtype PubMed ID
dgv2032n106 OTHER inversion 24896259
dgv4073n100 CNV gain 25217958
dgv475n27 CNV gain 19166990
dgv7079n54 CNV loss 21841781
dgv7080n54 CNV gain 21841781
esv2751826 CNV gain 17911159
esv2759092 CNV gain+loss 17122850
esv2760631 CNV gain+loss 21179565
esv2763387 CNV loss 21179565
esv3584065 CNV loss 25503493
esv3592440 CNV loss 21293372
esv3592441 CNV gain 21293372
esv3893326 CNV gain 25118596
nsv1001337 CNV loss 25217958
nsv1004301 CNV loss 25217958
nsv1005664 CNV loss 25217958
nsv1008911 CNV gain 25217958
nsv1008970 CNV loss 25217958
nsv1072028 CNV deletion 25765185
nsv428403 CNV loss 18775914
nsv459274 CNV loss 19166990
nsv470485 CNV gain 18288195
nsv482053 CNV gain 20164927
nsv520559 CNV gain+loss 19592680
nsv583046 CNV loss 21841781
nsv583113 CNV gain 21841781
nsv7327 OTHER inversion 18451855
nsv818080 CNV gain 17921354
nsv821629 CNV loss 15273396
nsv834375 CNV loss 17160897
nsv961882 CNV duplication 23825009
nsv998333 CNV gain+loss 25217958

Variation tolerance for MZT2B Gene

Gene Damage Index Score: 1.97; 36.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MZT2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MZT2B Gene

Disorders for MZT2B Gene

Additional Disease Information for MZT2B

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for MZT2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MZT2B Gene

Publications for MZT2B Gene

  1. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins JR … Peters JM (Science (New York, N.Y.) 2010) 2 3 4
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
  3. Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions. (PMID: 32203420) Müller PM … Rocks O (Nature cell biology 2020) 3
  4. Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D. (PMID: 31980649) Kennedy SA … Kolch W (Nature communications 2020) 3
  5. RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease. (PMID: 29802200) Bishof I … Seyfried NT (The Journal of biological chemistry 2018) 3

Products for MZT2B Gene

Sources for MZT2B Gene