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Aliases for MZT2B Gene

Aliases for MZT2B Gene

  • Mitotic Spindle Organizing Protein 2B 2 3 5
  • Mitotic-Spindle Organizing Protein Associated With A Ring Of Gamma-Tubulin 2B 2 3 4
  • Family With Sequence Similarity 128, Member B 2 3
  • MOZART2B 3 4
  • FAM128B 3 4
  • Mitotic-Spindle Organizing Protein 2B 3

External Ids for MZT2B Gene

Previous HGNC Symbols for MZT2B Gene

  • FAM128B

Previous GeneCards Identifiers for MZT2B Gene

  • GC02P130941
  • GC02P123235

Summaries for MZT2B Gene

GeneCards Summary for MZT2B Gene

MZT2B (Mitotic Spindle Organizing Protein 2B) is a Protein Coding gene. An important paralog of this gene is MZT2A.

Additional gene information for MZT2B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MZT2B Gene

Genomics for MZT2B Gene

GeneHancer (GH) Regulatory Elements for MZT2B Gene

Promoters and enhancers for MZT2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I130180 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.0 993 4.5 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 MZT2B SMPD4 TUBA3E NOC2LP1 RAB6C-AS1
GH02I130823 Enhancer 1.2 Ensembl ENCODE dbSUPER 4.6 +643.0 643043 1.9 HDGF BMI1 BATF IRF4 ZSCAN5C ZNF207 ZNF143 ATF7 ETV6 FOS GPR148 ARHGEF4 MZT2B CCDC74A CYCSP8 GC02P130572
GH02I130194 Enhancer 0.5 dbSUPER 0.4 +13.5 13534 0.4 MEIS2 NCOR1 NR2C1 CBFA2T3 CBFA2T2 KDM1A TUBA3E PLAC9P1 SMPD4 MZT2B
GH02I130195 Enhancer 0.5 dbSUPER 0.4 +14.3 14267 0.9 MEIS2 NCOR1 CBFA2T3 NR2C1 CBFA2T2 KDM1A TUBA3E SMPD4 MZT2B
GH02I130198 Promoter 0.5 EPDnew 0.4 +16.9 16915 0.1 TUBA3E SMPD4 MZT2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MZT2B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MZT2B Gene

Genomic Locations for MZT2B Gene
chr2:130,181,544-130,204,794
(GRCh38/hg38)
Size:
23,251 bases
Orientation:
Plus strand
chr2:130,939,310-130,948,302
(GRCh37/hg19)

Genomic View for MZT2B Gene

Genes around MZT2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MZT2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MZT2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MZT2B Gene

Proteins for MZT2B Gene

  • Protein details for MZT2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NZ67-MZT2B_HUMAN
    Recommended name:
    Mitotic-spindle organizing protein 2B
    Protein Accession:
    Q6NZ67
    Secondary Accessions:
    • Q96CG4

    Protein attributes for MZT2B Gene

    Size:
    158 amino acids
    Molecular mass:
    16226 Da
    Quaternary structure:
    • Part of the gamma-tubulin complex. Interacts with TUBG1.

neXtProt entry for MZT2B Gene

Post-translational modifications for MZT2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MZT2B Gene

Domains & Families for MZT2B Gene

Gene Families for MZT2B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MZT2B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MZT2B Gene

Graphical View of Domain Structure for InterPro Entry

Q6NZ67

UniProtKB/Swiss-Prot:

MZT2B_HUMAN :
  • Belongs to the MOZART2 family.
Family:
  • Belongs to the MOZART2 family.
genes like me logo Genes that share domains with MZT2B: view

Function for MZT2B Gene

Gene Ontology (GO) - Molecular Function for MZT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20360068
genes like me logo Genes that share ontologies with MZT2B: view

Phenotypes for MZT2B Gene

genes like me logo Genes that share phenotypes with MZT2B: view

miRNA for MZT2B Gene

miRTarBase miRNAs that target MZT2B

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MZT2B Gene

Localization for MZT2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MZT2B Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MZT2B gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MZT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 20360068
GO:0005815 microtubule organizing center IDA --
GO:0005819 spindle IEA,IDA 20360068
genes like me logo Genes that share ontologies with MZT2B: view

Pathways & Interactions for MZT2B Gene

SuperPathways for MZT2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MZT2B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MZT2B Gene

Drugs & Compounds for MZT2B Gene

No Compound Related Data Available

Transcripts for MZT2B Gene

Unigene Clusters for MZT2B Gene

Mitotic spindle organizing protein 2B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MZT2B Gene

No ASD Table

Relevant External Links for MZT2B Gene

GeneLoc Exon Structure for
MZT2B
ECgene alternative splicing isoforms for
MZT2B

Expression for MZT2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MZT2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MZT2B Gene

This gene is overexpressed in Bone (40.0) and Pancreas (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MZT2B Gene



Protein tissue co-expression partners for MZT2B Gene

NURSA nuclear receptor signaling pathways regulating expression of MZT2B Gene:

MZT2B

SOURCE GeneReport for Unigene cluster for MZT2B Gene:

Hs.469925

Evidence on tissue expression from TISSUES for MZT2B Gene

  • Nervous system(4.6)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with MZT2B: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MZT2B Gene

Orthologs for MZT2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MZT2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MZT2B 33
  • 99.16 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 94 (a)
OneToMany
MZT2B 33
  • 91.02 (n)
cow
(Bos Taurus)
Mammalia LOC787548 33
  • 87.47 (n)
MZT2 34
  • 82 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mzt2 34
  • 70 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 54 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 54 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mzt2b 33
  • 60.43 (n)
zebrafish
(Danio rerio)
Actinopterygii mzt2b 33 34
  • 59.06 (n)
Species where no ortholog for MZT2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MZT2B Gene

ENSEMBL:
Gene Tree for MZT2B (if available)
TreeFam:
Gene Tree for MZT2B (if available)

Paralogs for MZT2B Gene

Paralogs for MZT2B Gene

(1) SIMAP similar genes for MZT2B Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for MZT2B Gene

genes like me logo Genes that share paralogs with MZT2B: view

Variants for MZT2B Gene

Sequence variations from dbSNP and Humsavar for MZT2B Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs730882212 likely-pathogenic, Global developmental delay, Lissencephaly, Primary microcephaly, Seizures 130,194,199(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000136066 -- 130,180,891(+) G/T upstream_transcript_variant
rs1000227143 -- 130,193,270(+) A/T genic_downstream_transcript_variant, intron_variant
rs1000510490 -- 130,194,562(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000536099 -- 130,182,056(+) G/A/C 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MZT2B Gene

Variant ID Type Subtype PubMed ID
dgv2032n106 OTHER inversion 24896259
dgv4073n100 CNV gain 25217958
dgv475n27 CNV gain 19166990
dgv7079n54 CNV loss 21841781
dgv7080n54 CNV gain 21841781
esv2751826 CNV gain 17911159
esv2759092 CNV gain+loss 17122850
esv2760631 CNV gain+loss 21179565
esv2763387 CNV loss 21179565
esv3584065 CNV loss 25503493
esv3592440 CNV loss 21293372
esv3592441 CNV gain 21293372
esv3893326 CNV gain 25118596
nsv1001337 CNV loss 25217958
nsv1004301 CNV loss 25217958
nsv1005664 CNV loss 25217958
nsv1008911 CNV gain 25217958
nsv1008970 CNV loss 25217958
nsv1072028 CNV deletion 25765185
nsv428403 CNV loss 18775914
nsv459274 CNV loss 19166990
nsv470485 CNV gain 18288195
nsv482053 CNV gain 20164927
nsv520559 CNV gain+loss 19592680
nsv583046 CNV loss 21841781
nsv583113 CNV gain 21841781
nsv7327 OTHER inversion 18451855
nsv818080 CNV gain 17921354
nsv821629 CNV loss 15273396
nsv834375 CNV loss 17160897
nsv961882 CNV duplication 23825009
nsv998333 CNV gain+loss 25217958

Variation tolerance for MZT2B Gene

Gene Damage Index Score: 1.97; 36.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MZT2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MZT2B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MZT2B Gene

Disorders for MZT2B Gene

Additional Disease Information for MZT2B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MZT2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MZT2B Gene

Publications for MZT2B Gene

  1. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins JR … Peters JM (Science (New York, N.Y.) 2010) 2 3 4 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp JJ … Guthrie C (Nature structural & molecular biology 2015) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for MZT2B Gene

Sources for MZT2B Gene

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