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Aliases for MZT1 Gene

Aliases for MZT1 Gene

  • Mitotic Spindle Organizing Protein 1 2 3 5
  • Mitotic-Spindle Organizing Protein Associated With A Ring Of Gamma-Tubulin 1 2 3 4
  • C13orf37 3 4
  • MOZART1 3 4
  • Mitotic-Spindle Organizing Protein 1 3
  • Chromosome 13 Open Reading Frame 37 2

External Ids for MZT1 Gene

Previous HGNC Symbols for MZT1 Gene

  • C13orf37

Previous GeneCards Identifiers for MZT1 Gene

  • GC13M073283
  • GC13M053980
  • GC13M073288
  • GC13M073291
  • GC13M073297

Summaries for MZT1 Gene

GeneCards Summary for MZT1 Gene

MZT1 (Mitotic Spindle Organizing Protein 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MZT1 Gene

  • Required for gamma-tubulin complex recruitment to the centrosome.

Additional gene information for MZT1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MZT1 Gene

Genomics for MZT1 Gene

GeneHancer (GH) Regulatory Elements for MZT1 Gene

Promoters and enhancers for MZT1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I072726 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 558.8 -0.1 -143 3.2 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 BORA MZT1 DIS3 PIBF1
GH13I072661 Enhancer 0.4 UCNEbase 5.1 +66.4 66350 0.3 PIBF1 MZT1 RPL21P110 ENSG00000199282
GH13I072779 Enhancer 0.2 Ensembl 0.2 -51.6 -51601 0.4 PIBF1 DIS3 MZT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MZT1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MZT1 Gene

Genomic Locations for MZT1 Gene
19,444 bases
Minus strand

Genomic View for MZT1 Gene

Genes around MZT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MZT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MZT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MZT1 Gene

Proteins for MZT1 Gene

  • Protein details for MZT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitotic-spindle organizing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q5W0P5

    Protein attributes for MZT1 Gene

    82 amino acids
    Molecular mass:
    8479 Da
    Quaternary structure:
    • Part of the gamma-tubulin complex. Interacts with TUBG1.

neXtProt entry for MZT1 Gene

Post-translational modifications for MZT1 Gene

  • Ubiquitination at isoforms=65 and isoforms=75

Other Protein References for MZT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MZT1 Gene

Domains & Families for MZT1 Gene

Gene Families for MZT1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MZT1 Gene


Suggested Antigen Peptide Sequences for MZT1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MOZART1 family.
  • Belongs to the MOZART1 family.
genes like me logo Genes that share domains with MZT1: view

Function for MZT1 Gene

Molecular function for MZT1 Gene

UniProtKB/Swiss-Prot Function:
Required for gamma-tubulin complex recruitment to the centrosome.

Gene Ontology (GO) - Molecular Function for MZT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20360068
GO:0043015 gamma-tubulin binding IBA --
genes like me logo Genes that share ontologies with MZT1: view

Phenotypes for MZT1 Gene

GenomeRNAi human phenotypes for MZT1:
genes like me logo Genes that share phenotypes with MZT1: view

Clone Products

  • Addgene plasmids for MZT1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MZT1 Gene

Localization for MZT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MZT1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MZT1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 2
plasma membrane 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MZT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000923 equatorial microtubule organizing center IBA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 20360068
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IDA,IEA 20360068
genes like me logo Genes that share ontologies with MZT1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MZT1 Gene

Pathways & Interactions for MZT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MZT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033566 gamma-tubulin complex localization IMP 20360068
GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center IBA --
GO:0051417 NOT microtubule nucleation by spindle pole body IBA --
GO:0090307 mitotic spindle assembly IBA --
genes like me logo Genes that share ontologies with MZT1: view

No data available for Pathways by source and SIGNOR curated interactions for MZT1 Gene

Drugs & Compounds for MZT1 Gene

No Compound Related Data Available

Transcripts for MZT1 Gene

mRNA/cDNA for MZT1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(131) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MZT1 Gene

Mitotic spindle organizing protein 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for MZT1

Alternative Splicing Database (ASD) splice patterns (SP) for MZT1 Gene

No ASD Table

Relevant External Links for MZT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MZT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MZT1 Gene

mRNA differential expression in normal tissues according to GTEx for MZT1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x4.3) and Brain - Caudate (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for MZT1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.4), Fetal ovary (13.5), Colon (7.3), and Fetal Brain (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MZT1 Gene

Protein tissue co-expression partners for MZT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MZT1 Gene:


SOURCE GeneReport for Unigene cluster for MZT1 Gene:


Evidence on tissue expression from TISSUES for MZT1 Gene

  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with MZT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MZT1 Gene

Orthologs for MZT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MZT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MZT1 33 34
  • 99.59 (n)
(Bos Taurus)
Mammalia MZT1 33 34
  • 92.93 (n)
(Canis familiaris)
Mammalia MZT1 33 34
  • 92.93 (n)
(Mus musculus)
Mammalia Mzt1 33 16 34
  • 91.28 (n)
(Rattus norvegicus)
Mammalia Mzt1 33
  • 90.26 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 90 (a)
-- 34
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia MZT1 34
  • 86 (a)
(Gallus gallus)
Aves MZT1 33 34
  • 85.35 (n)
(Anolis carolinensis)
Reptilia MZT1 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mzt1 33
  • 77.27 (n)
(Danio rerio)
Actinopterygii LOC100333194 33
  • 71.72 (n)
MZT1 34
  • 55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 51 (a)
Species where no ortholog for MZT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MZT1 Gene

Gene Tree for MZT1 (if available)
Gene Tree for MZT1 (if available)

Paralogs for MZT1 Gene Pseudogenes for MZT1 Gene

genes like me logo Genes that share paralogs with MZT1: view

No data available for Paralogs for MZT1 Gene

Variants for MZT1 Gene

Sequence variations from dbSNP and Humsavar for MZT1 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000268547 -- 72,716,598(-) T/C intron_variant
rs1000326468 -- 72,708,874(-) T/C 3_prime_UTR_variant
rs1000368767 -- 72,729,530(-) C/T upstream_transcript_variant
rs1000543475 -- 72,710,952(-) A/G intron_variant
rs1000959611 -- 72,723,217(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MZT1 Gene

Variant ID Type Subtype PubMed ID
nsv826707 CNV loss 20364138
esv3632699 CNV loss 21293372
esv2747634 CNV deletion 23290073
esv2747633 CNV deletion 23290073
esv2667348 CNV deletion 23128226

Variation tolerance for MZT1 Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MZT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MZT1 Gene

Disorders for MZT1 Gene

Additional Disease Information for MZT1

No disorders were found for MZT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MZT1 Gene

Publications for MZT1 Gene

  1. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins JR … Peters JM (Science (New York, N.Y.) 2010) 2 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. NMR secondary structure and interactions of recombinant human MOZART1 protein, a component of the gamma-tubulin complex. (PMID: 28851027) Cukier CD … Gervais V (Protein science : a publication of the Protein Society 2017) 3 58
  4. MZT1 regulates microtubule nucleation by linking γTuRC assembly to adapter-mediated targeting and activation. (PMID: 27852835) Cota RR … Lüders J (Journal of cell science 2017) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for MZT1 Gene

  • Addgene plasmids for MZT1

Sources for MZT1 Gene

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