Aliases for MZF1 Gene

Aliases for MZF1 Gene

  • Myeloid Zinc Finger 1 2 3 4 5
  • ZSCAN6 2 3 4
  • MZF-1 2 3 4
  • Zinc Finger Protein 42 (Myeloid-Specific Retinoic Acid-Responsive) 2 3
  • Zinc Finger And SCAN Domain-Containing Protein 6 3 4
  • MZF1B 2 3
  • ZNF42 3 4
  • Zinc Finger Protein 42 4
  • ZFP98 3
  • Zfp98 2
  • MZF1 5
  • MZF 4

External Ids for MZF1 Gene

Previous HGNC Symbols for MZF1 Gene

  • ZNF42

Previous GeneCards Identifiers for MZF1 Gene

  • GC19M063766
  • GC19M059073
  • GC19M055383
  • GC19M058562
  • GC19M058563
  • GC19M058577

Summaries for MZF1 Gene

GeneCards Summary for MZF1 Gene

MZF1 (Myeloid Zinc Finger 1) is a Protein Coding gene. Diseases associated with MZF1 include Inflammatory Bowel Disease 27 and Lung Squamous Cell Carcinoma. Among its related pathways are Ectoderm Differentiation. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is ZNF33B.

UniProtKB/Swiss-Prot Summary for MZF1 Gene

  • Binds to target promoter DNA and functions as transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development.

Gene Wiki entry for MZF1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MZF1 Gene

Genomics for MZF1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MZF1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MZF1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MZF1

Top Transcription factor binding sites by QIAGEN in the MZF1 gene promoter:
  • AML1a

Genomic Locations for MZF1 Gene

Genomic Locations for MZF1 Gene
chr19:58,561,917-58,574,478
(GRCh38/hg38)
Size:
12,562 bases
Orientation:
Minus strand
chr19:59,073,284-59,084,942
(GRCh37/hg19)
Size:
11,659 bases
Orientation:
Minus strand

Genomic View for MZF1 Gene

Genes around MZF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MZF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MZF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MZF1 Gene

Proteins for MZF1 Gene

  • Protein details for MZF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28698-MZF1_HUMAN
    Recommended name:
    Myeloid zinc finger 1
    Protein Accession:
    P28698
    Secondary Accessions:
    • M0QXU0
    • Q7Z729
    • Q96I71
    • Q9NRY0
    • Q9UBW2

    Protein attributes for MZF1 Gene

    Size:
    734 amino acids
    Molecular mass:
    82055 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for MZF1 Gene

    Alternative splice isoforms for MZF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MZF1 Gene

Post-translational modifications for MZF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MZF1

No data available for DME Specific Peptides for MZF1 Gene

Domains & Families for MZF1 Gene

Gene Families for MZF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MZF1 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • Transcriptional regulator SCAN
ProtoNet:

Suggested Antigen Peptide Sequences for MZF1 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 42 (MZF1_HUMAN)
  • MZF1 protein (Q7Z729_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P28698

UniProtKB/Swiss-Prot:

MZF1_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with MZF1: view

Function for MZF1 Gene

Molecular function for MZF1 Gene

UniProtKB/Swiss-Prot Function:
Binds to target promoter DNA and functions as transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development.
UniProtKB/Swiss-Prot Induction:
By retinoic acid.

Phenotypes From GWAS Catalog for MZF1 Gene

Gene Ontology (GO) - Molecular Function for MZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 15541732
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 7579328
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 7579328
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 7579328
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with MZF1: view
genes like me logo Genes that share phenotypes with MZF1: view

Animal Models for MZF1 Gene

MGI Knock Outs for MZF1:

Animal Model Products

CRISPR Products

miRNA for MZF1 Gene

miRTarBase miRNAs that target MZF1

Transcription Factor Targets for MZF1 Gene

Selected GeneGlobe predicted Target genes for MZF1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MZF1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for MZF1 Gene

Localization for MZF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MZF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MZF1 gene
Compartment Confidence
nucleus 5
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with MZF1: view

Pathways & Interactions for MZF1 Gene

PathCards logo

SuperPathways for MZF1 Gene

SuperPathway Contained pathways
1 Ectoderm Differentiation
genes like me logo Genes that share pathways with MZF1: view

Pathways by source for MZF1 Gene

1 BioSystems pathway for MZF1 Gene

SIGNOR curated interactions for MZF1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for MZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 7579328
GO:0006355 regulation of transcription, DNA-templated IEA,IDA 15541732
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 7579328
genes like me logo Genes that share ontologies with MZF1: view

Drugs & Compounds for MZF1 Gene

(1) Drugs for MZF1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for MZF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MZF1: view

Transcripts for MZF1 Gene

mRNA/cDNA for MZF1 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MZF1

Alternative Splicing Database (ASD) splice patterns (SP) for MZF1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: -
SP5: - - - - -
SP6:
SP7:

Relevant External Links for MZF1 Gene

GeneLoc Exon Structure for
MZF1

Expression for MZF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MZF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MZF1

SOURCE GeneReport for Unigene cluster for MZF1 Gene:

Hs.399810

mRNA Expression by UniProt/SwissProt for MZF1 Gene:

P28698-MZF1_HUMAN
Tissue specificity: Preferentially expressed in differentiating myeloid cells. Detected in osteoblasts.

Evidence on tissue expression from TISSUES for MZF1 Gene

  • Skin(4.5)
  • Bone marrow(4.4)
  • Nervous system(2.2)
  • Intestine(2.2)
  • Kidney(2.1)
  • Spleen(2.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with MZF1: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MZF1 Gene

Orthologs for MZF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MZF1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MZF1 30 31
  • 97.27 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MZF1 30 31
  • 83.42 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mzf1 30
  • 82.76 (n)
Mouse
(Mus musculus)
Mammalia Mzf1 30 17 31
  • 82.76 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MZF1 30 31
  • 82.15 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 36 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii -- 30
Species where no ortholog for MZF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MZF1 Gene

ENSEMBL:
Gene Tree for MZF1 (if available)
TreeFam:
Gene Tree for MZF1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MZF1: view image

Paralogs for MZF1 Gene

Paralogs for MZF1 Gene

(365) SIMAP similar genes for MZF1 Gene using alignment to 3 proteins:

  • MZF1_HUMAN
  • M0R1U5_HUMAN
  • M0R2C0_HUMAN
genes like me logo Genes that share paralogs with MZF1: view

Variants for MZF1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MZF1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
718323 Benign: not provided 58,563,402(-) A/C MISSENSE_VARIANT,INTRON_VARIANT
786362 Benign: not provided 58,563,488(-) T/C SYNONYMOUS_VARIANT,INTRON_VARIANT
rs2229255 - p.Arg441Pro
rs3752109 - p.Arg51His
rs3752110 - p.Arg103His

Additional dbSNP identifiers (rs#s) for MZF1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MZF1 Gene

Variant ID Type Subtype PubMed ID
dgv3687n100 CNV gain 25217958
dgv3688n100 CNV gain 25217958
nsv1057077 CNV gain 25217958
nsv1057206 CNV gain 25217958
nsv1114041 CNV deletion 24896259
nsv1160670 CNV deletion 26073780
nsv515731 CNV gain+loss 19592680
nsv828657 CNV gain 20364138
nsv952156 CNV deletion 24416366

Variation tolerance for MZF1 Gene

Residual Variation Intolerance Score: 96.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.55; 93.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MZF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MZF1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MZF1 Gene

Disorders for MZF1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MZF1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
inflammatory bowel disease 27
  • ibd27
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
- elite association - COSMIC cancer census association via MalaCards
Search MZF1 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with MZF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MZF1 Gene

Publications for MZF1 Gene

  1. A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells. (PMID: 1860835) Hromas R … Kaushansky K (The Journal of biological chemistry 1991) 2 3 4 23
  2. Crucial roles of MZF1 and Sp1 in the transcriptional regulation of the peptidylarginine deiminase type I gene (PADI1) in human keratinocytes. (PMID: 17851584) Dong S … Takahara H (The Journal of investigative dermatology 2008) 3 4 23
  3. Structure of the SCAN domain from the tumor suppressor protein MZF1. (PMID: 16950398) Peterson FC … Volkman BF (Journal of molecular biology 2006) 3 4 23
  4. Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N-cadherin promoter in osteoblasts. (PMID: 15541732) Le Mée S … Marie PJ (Experimental cell research 2005) 3 4 23
  5. Human myeloid zinc finger gene MZF produces multiple transcripts and encodes a SCAN box protein. (PMID: 10974541) Peterson MJ … Morris JF (Gene 2000) 3 4 23

Products for MZF1 Gene