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The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. [provided by RefSeq, Jul 2008] See more...
Aliases for MYT1 Gene
Aliases for MYT1 Gene
External Ids for MYT1 Gene
- HGNC: 7622
- Entrez Gene: 4661
- Ensembl: ENSG00000196132
- OMIM: 600379
- UniProtKB: Q01538
Previous HGNC Symbols for MYT1 Gene
- PLPB1
Previous GeneCards Identifiers for MYT1 Gene
- GC20P062673
- GC20P063475
- GC20P063522
- GC20P062253
- GC20P062266
- GC20P062795
- GC20P059521
- GC20P062796
- GC20P064151
- GC20P064185
- GC20P064208
- GC20P064213
- GC20P064258
- GC20P064154
Summaries for MYT1 Gene
-
The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. [provided by RefSeq, Jul 2008]
GeneCards Summary for MYT1 Gene
MYT1 (Myelin Transcription Factor 1) is a Protein Coding gene. Diseases associated with MYT1 include Periventricular Leukomalacia. Among its related pathways are AKT Siganaling Pathway and MECP2 and Associated Rett Syndrome. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and enhancer sequence-specific DNA binding. An important paralog of this gene is MYT1L.
UniProtKB/Swiss-Prot Summary for MYT1 Gene
-
Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.
Additional gene information for MYT1 Gene
- HGNC(7622)
- Entrez Gene(4661)
- Ensembl(ENSG00000196132)
- OMIM(600379)
- UniProtKB(Q01538)
- Open Targets Platform(ENSG00000196132)
- Search for MYT1 at DataMed
- Search for MYT1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MYT1 Gene
Genomics for MYT1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MYT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MYT1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MYT1
- Top Transcription factor binding sites by QIAGEN in the MYT1 gene promoter:
-
- C/EBPalpha
- Chx10
- CREB
- deltaCREB
- FOXI1
- HFH-3
- HNF-3beta
- MyoD
- POU2F1
- POU2F1a
Genomic Locations for MYT1 Gene
Genomic Locations for MYT1 Gene
- chr20:64,102,394-64,242,253
- (GRCh38/hg38)
- Size:
- 139,860 bases
- Orientation:
- Plus strand
- chr20:62,783,144-62,873,606
- (GRCh37/hg19)
- Size:
- 90,463 bases
- Orientation:
- Plus strand
Genomic View for MYT1 Gene
Genes around MYT1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.33 by HGNC
- 20q13.33 by Entrez Gene
- 20q13.33 by Ensembl
MYT1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MYT1 Gene
Proteins for MYT1 Gene
-
Protein details for MYT1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q01538-MYT1_HUMAN
- Recommended name:
- Myelin transcription factor 1
- Protein Accession:
- Q01538
- E1P5H0
- F5H7M8
- O94922
- Q7Z5W2
- Q9UPV2
Protein attributes for MYT1 Gene
- Size:
- 1121 amino acids
- Molecular mass:
- 122329 Da
- Quaternary structure:
-
- Interacts with STEAP3.
- SequenceCaution:
-
- Sequence=BAA74858.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for MYT1 Gene
Post-translational modifications for MYT1 Gene
Other Protein References for MYT1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-MYT1 (aa 586-685) polyclonal antibody
- Creative Biolabs Recombinant Mouse Anti-Human MYT1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for MYT1
- Novus Biologicals Antibodies for MYT1
-
Abcam antibodies for MYT1
- Invitrogen Antibodies for MYT1 (AFLGC-MYT1)
-
Biorbyt antibodies for MYT1
-
Boster Bio Antibodies for MYT1
-
Santa Cruz Biotechnology (SCBT) Antibodies for MYT1
- Sino Biological Antibodies for MYT1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MYT1
- Origene Custom Protein Services for MYT1
-
Signalway Proteins for MYT1
-
Abcam proteins for MYT1
Assay Products
- antibodies-online: Show 5 available MYT1 Elisa Kits ranked by validation data
- Compare Top MYT1 Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for MYT1
No data available for DME Specific Peptides for MYT1 Gene
Domains & Families for MYT1 Gene
Gene Families for MYT1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for MYT1 Gene
- InterPro:
- Blocks:
-
- Myelin transcription factor 1
- ProtoNet:
Suggested Antigen Peptide Sequences for MYT1 Gene
- GenScript: Design optimal peptide antigens:
-
- Proteolipid protein-binding protein (MYT1_HUMAN)
- MYT1 protein (Q7Z5W2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q01538UniProtKB/Swiss-Prot:
MYT1_HUMAN :- Contains 7 zinc fingers of the C2HC class arranged in two widely separated clusters. These two domains of DNA binding can function independently and recognize the same DNA sequence.
- Belongs to the MYT1 family.
- Domain:
-
- Contains 7 zinc fingers of the C2HC class arranged in two widely separated clusters. These two domains of DNA binding can function independently and recognize the same DNA sequence.
- Family:
-
- Belongs to the MYT1 family.
Function for MYT1 Gene
Molecular function for MYT1 Gene
- UniProtKB/Swiss-Prot Function:
- Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.
Phenotypes From GWAS Catalog for MYT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA-binding transcription factor activity | IEA,NAS | 1280325 |
| GO:0008270 | zinc ion binding | IEA,NAS | 1280325 |
Phenotypes for MYT1 Gene
- MGI mutant phenotypes for MYT1:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for MYT1:
-
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased viability ratio
- Decreased viability
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Increased nuclear migration speed
- Decreased viability in esophageal squamous lineage; decreased viability in glioblastoma multiforme (GBM) lineage
Animal Models for MYT1 Gene
- MGI Knock Outs for MYT1:
-
- Myt1 Myt1<tm1.1Ggu>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MYT1 - Select products 50% OFF >
- * MYT1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MYT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MYT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MYT1
miRNA for MYT1 Gene
- miRTarBase miRNAs that target MYT1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MYT1
- Browse OriGene Inhibitory RNA Products For MYT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYT1
Clone Products
- Applied Biological Materials (abm): Clones for MYT1 - Select products 50% OFF >
- * MYT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MYT1
- Addgene plasmids for MYT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MYT1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYT1 Gene
Localization for MYT1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MYT1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endosome | 1 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IEA,NAS | 1280325 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for MYT1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | AKT Siganaling Pathway | ||
| 2 | MAPK Erk Pathway |
.32
|
|
| 3 | Cyclins and Cell Cycle Regulation |
Cyclins and Cell Cycle Regulation
.67
|
|
| 4 | Mitotic Roles of Polo Like Kinases |
Mitotic Roles of Polo Like Kinases
-
|
|
| 5 | Mitotic G1-G1/S phases | ||
Pathways by source for MYT1 Gene
2 Sino Biological pathways for MYT1 Gene
3 BioSystems pathways for MYT1 Gene
2 Qiagen pathways for MYT1 Gene
- Cyclins and Cell Cycle Regulation
- Mitotic Roles of Polo Like Kinases
1 GeneTex pathway for MYT1 Gene
Interacting Proteins for MYT1 Gene
GPS-Prot Interaction Network for MYT1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IEA,NAS | 1280325 |
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007399 | nervous system development | IEA | -- |
| GO:0030154 | cell differentiation | IEA | -- |
No data available for SIGNOR curated interactions for MYT1 Gene
Transcripts for MYT1 Gene
mRNA/cDNA for MYT1 Gene
- 1 REFSEQ mRNAs :
- 5 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000328439 5557 nts (view in UCSC)
- ENST00000360149 2059 nts (view in UCSC)
- ENST00000536311 5614 nts (view in UCSC)
- ENST00000610671 624 nts (view in UCSC)
- ENST00000622439 2140 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MYT1 - Select products 50% OFF >
- * MYT1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MYT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MYT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MYT1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MYT1
- Browse OriGene Inhibitory RNA Products For MYT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYT1
Clone Products
- Applied Biological Materials (abm): Clones for MYT1 - Select products 50% OFF >
- * MYT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MYT1
- Addgene plasmids for MYT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MYT1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | · | 22c | · | 22d | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: |
| ExUns: | 22e | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26a | · | 26b | · | 26c | ^ | 27 | ^ | 28a | · | 28b | ^ | 29 | ^ | 30a | · | 30b | · | 30c | · | 30d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||
| SP8: | - | - | |||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||
| SP10: | - | - | |||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||
| SP12: | - | ||||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||||
| SP15: | - | - | |||||||||||||||||||||||||||||
| SP16: |
Relevant External Links for MYT1 Gene
- GeneLoc Exon Structure for
- MYT1
Expression for MYT1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Pancreas (Endocrine System)
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
- Endocrine Progenitor Cells Ventral Pancreatic Bud
-
Epithelial Cells
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
- Endocrine Progenitor Cells Ventral Pancreatic Bud
-
Brain (Nervous System)
- Oligodendrocyte Precursor Cells Motor Neural Progenitor Domain
- Cerebellum
-
Blood (Hematopoietic System)
- Erythroblasts Hematopoietic Bone Marrow
-
Neural Tube (Nervous System)
- Oligodendrocyte Precursor Cells Motor Neural Progenitor Domain
- Eye (Sensory Organs)
mRNA differential expression in normal tissues according to GTEx for MYT1 Gene
This gene is overexpressed in Brain - Cerebellar Hemisphere (x14.9) and Brain - Cerebellum (x13.9).
This gene is overexpressed in Retina (35.0), Platelet (19.2), and NK cells (12.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MYT1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MYT1
SOURCE GeneReport for Unigene cluster for MYT1 Gene:
Hs.279562mRNA Expression by UniProt/SwissProt for MYT1 Gene:
Q01538-MYT1_HUMAN
Tissue specificity:
Mostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes.
Evidence on tissue expression from TISSUES for MYT1 Gene
- Nervous system(4.6)
Primer Products
-
OriGene qPCR primer pairs for MYT1
-
OriGene qPCR primer pairs and template standards for MYT1
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MYT1 Gene
Orthologs for MYT1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MYT1 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MYT1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MYT1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Myt1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Myt1 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MYT1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MYT1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MYT1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MYT1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100490628 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC397982 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | myt1a 30 31 |
|
OneToMany | |
| myt1b 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG43689 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | ztf-11 31 |
|
OneToMany | |
| Soybean (Glycine max) |
eudicotyledons | Gma.17722 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.8435 30 |
|
- Species where no ortholog for MYT1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MYT1 Gene
- ENSEMBL:
- Gene Tree for MYT1 (if available)
- TreeFam:
- Gene Tree for MYT1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MYT1: view image
Paralogs for MYT1 Gene
Variants for MYT1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MYT1 Gene
| SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 714389 | Likely Benign: not provided | 64,208,061(+) | G/A | MISSENSE_VARIANT | |
| 714902 | Benign: not provided | 64,227,888(+) | C/T | SYNONYMOUS_VARIANT | |
| 715432 | Benign: not provided | 64,232,248(+) | C/T | SYNONYMOUS_VARIANT | |
| 717277 | Likely Benign: not provided | 64,205,787(+) | C/T | SYNONYMOUS_VARIANT | |
| 717969 | Benign: not provided | 64,213,639(+) | G/T | SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
20.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.52;
55.49% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MYT1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYT1 Gene
Disorders for MYT1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| periventricular leukomalacia |
|
Search MYT1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MYT1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MYT1 Gene
Publications for MYT1 Gene
- Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells. (PMID: 14962745) Nielsen JA … Armstrong RC (Molecular and cellular neurosciences 2004) 3 4 23
- Expression of myelin transcription factor I (MyTI), a "zinc-finger" DNA-binding protein, in developing oligodendrocytes. (PMID: 8530187) Armstrong RC … Hudson LD (Glia 1995) 3 4 23
- Novel member of the zinc finger superfamily: A C2-HC finger that recognizes a glia-specific gene. (PMID: 1280325) Kim JG … Hudson LD (Molecular and cellular biology 1992) 2 3 4
- Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PMID: 18950845) Vega A … Carracedo A (Gynecologic oncology 2009) 3 41
- Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS. (PMID: 17330875) Vana AC … Armstrong RC (Glia 2007) 3 23
ExternalLinks
Products for MYT1 Gene
- Custom Antibody ServicesOriGene Antibodies for MYT1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MYT1
- Origene Custom Protein Services for MYT1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MYT1
- Browse OriGene Inhibitory RNA Products For MYT1
- OriGene qPCR primer pairs for MYT1
- OriGene qPCR primer pairs and template standards for MYT1
- OriGene CRISPR knockouts for MYT1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MYT1
- Sino Biological Human cDNA Clone for MYT1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for MYT1
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MYT1
- Novus Biologicals proteins and lysates for MYT1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for MYT1
- Abcam proteins for MYT1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for MYT1 (AFLGC-MYT1)
- VectorBuilder Custom and pre-made DNA vectors for MYT1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MYT1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MYT1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for MYT1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MYT1
- Addgene plasmids for MYT1
- antibodies-online: Show 60 available MYT1 Antibodies ranked by validation data
- Compare Top MYT1 Antibodies
- antibodies-online: Show 5 available MYT1 Elisa Kits ranked by validation data
- Compare Top MYT1 Elisa Kits
- Quality Products:
- antibodies-online: Show 12 available MYT1 Proteins ranked by validation data
- Compare Top MYT1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for MYT1
- Search Santa Cruz Biotechnology (SCBT) for MYT1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MYT1
- Horizon Cell Lines for MYT1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MYT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MYT1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MYT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYT1
- Boster Bio Antibodies for MYT1
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for MYT1
Sources for MYT1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB