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Aliases for MYRFL Gene

Aliases for MYRFL Gene

  • Myelin Regulatory Factor Like 2 3
  • Myelin Regulatory Factor-Like 2 5
  • C12orf15 3 4
  • C12orf28 3 4
  • Myelin Regulatory Factor-Like Protein 3
  • Chromosome 12 Open Reading Frame 15 2
  • Chromosome 12 Open Reading Frame 28 2
  • Bcm1377 3

External Ids for MYRFL Gene

Previous HGNC Symbols for MYRFL Gene

  • C12orf15
  • C12orf28

Previous GeneCards Identifiers for MYRFL Gene

  • GC12P070221

Summaries for MYRFL Gene

GeneCards Summary for MYRFL Gene

MYRFL (Myelin Regulatory Factor Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is MYRF.

Additional gene information for MYRFL Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYRFL Gene

Genomics for MYRFL Gene

GeneHancer (GH) Regulatory Elements for MYRFL Gene

Promoters and enhancers for MYRFL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J069824 Enhancer 0.3 ENCODE 650.7 +1.5 1512 2.6 ZNF316 MYRFL RAB3IP LOC101928002 ENSG00000258052 ENSG00000257241
GH12J069738 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 22.5 -85.1 -85115 2.5 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 KLF13 SP3 SP5 REST LOC101928002 RAB3IP MYRFL CPSF6 ENSG00000258052
GH12J069833 Enhancer 0.5 ENCODE 27 +11.6 11601 5.7 MITF SOX5 SOX13 HLF ZNF644 PRDM1 MYRFL RAB3IP ENSG00000258052 ENSG00000257241
GH12J069986 Enhancer 1.2 FANTOM5 Ensembl ENCODE 8.3 +163.8 163804 2.7 PKNOX1 ZSCAN4 ZNF143 FOS RCOR1 KLF13 CEBPB ZNF398 ZEB2 ELF1 CCT2 MYRFL RAB3IP ENSG00000257241 LOC100125409
GH12J069935 Enhancer 0.8 FANTOM5 ENCODE 12.1 +111.7 111727 1.5 SMARCE1 CTCF ESRRA DPF2 REST SP1 ZNF217 CTBP1 JUND GATA3 MYRFL ENSG00000257241
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MYRFL on UCSC Golden Path with GeneCards custom track

Genomic Locations for MYRFL Gene

Genomic Locations for MYRFL Gene
134,529 bases
Plus strand
133,794 bases
Plus strand

Genomic View for MYRFL Gene

Genes around MYRFL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYRFL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYRFL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYRFL Gene

Proteins for MYRFL Gene

  • Protein details for MYRFL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myelin regulatory factor-like protein
    Protein Accession:

    Protein attributes for MYRFL Gene

    910 amino acids
    Molecular mass:
    101670 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB71571.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for MYRFL Gene

Post-translational modifications for MYRFL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYRFL Gene

Domains & Families for MYRFL Gene

Gene Families for MYRFL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for MYRFL Gene

Suggested Antigen Peptide Sequences for MYRFL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MRF family.
  • Belongs to the MRF family.
genes like me logo Genes that share domains with MYRFL: view

Function for MYRFL Gene

Phenotypes From GWAS Catalog for MYRFL Gene

Gene Ontology (GO) - Molecular Function for MYRFL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0043565 sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with MYRFL: view
genes like me logo Genes that share phenotypes with MYRFL: view

Animal Models for MYRFL Gene

MGI Knock Outs for MYRFL:
  • Myrfl Myrfl<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYRFL

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MYRFL Gene

Localization for MYRFL Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYRFL Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYRFL gene
Compartment Confidence
extracellular 3
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MYRFL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MYRFL: view

Pathways & Interactions for MYRFL Gene

SuperPathways for MYRFL Gene

No Data Available

Interacting Proteins for MYRFL Gene

Gene Ontology (GO) - Biological Process for MYRFL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045893 positive regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with MYRFL: view

No data available for Pathways by source and SIGNOR curated interactions for MYRFL Gene

Drugs & Compounds for MYRFL Gene

No Compound Related Data Available

Transcripts for MYRFL Gene

mRNA/cDNA for MYRFL Gene

(13) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYRFL Gene

Myelin regulatory factor-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYRFL

Alternative Splicing Database (ASD) splice patterns (SP) for MYRFL Gene

No ASD Table

Relevant External Links for MYRFL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MYRFL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYRFL Gene

mRNA differential expression in normal tissues according to GTEx for MYRFL Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x18.8) and Testis (x4.2).

Protein differential expression in normal tissues from HIPED for MYRFL Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MYRFL Gene

Protein tissue co-expression partners for MYRFL Gene

NURSA nuclear receptor signaling pathways regulating expression of MYRFL Gene:


SOURCE GeneReport for Unigene cluster for MYRFL Gene:


Evidence on tissue expression from TISSUES for MYRFL Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with MYRFL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYRFL Gene

Orthologs for MYRFL Gene

This gene was present in the common ancestor of animals.

Orthologs for MYRFL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MYRFL 34 33
  • 99.41 (n)
(Bos Taurus)
Mammalia MYRFL 34 33
  • 88.44 (n)
(Canis familiaris)
Mammalia MYRFL 34 33
  • 87.39 (n)
(Mus musculus)
Mammalia Myrfl 16 34 33
  • 84.05 (n)
(Rattus norvegicus)
Mammalia Myrfl 33
  • 80.61 (n)
(Monodelphis domestica)
Mammalia MYRFL 34
  • 19 (a)
(Ornithorhynchus anatinus)
Mammalia MYRFL 34
  • 12 (a)
(Gallus gallus)
Aves MYRFL 34 33
  • 70.63 (n)
(Anolis carolinensis)
Reptilia MYRFL 34
  • 13 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia myrfl 33
  • 66.28 (n)
(Danio rerio)
Actinopterygii LOC100329855 33
  • 57.91 (n)
  • 8 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3328 34
  • 2 (a)
(Caenorhabditis elegans)
Secernentea pqn-47 34 33
  • 45.11 (n)
F21A10.2 34
  • 4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 1 (a)
Species where no ortholog for MYRFL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYRFL Gene

Gene Tree for MYRFL (if available)
Gene Tree for MYRFL (if available)
Evolutionary constrained regions (ECRs) for MYRFL: view image

Paralogs for MYRFL Gene

Paralogs for MYRFL Gene

(2) SIMAP similar genes for MYRFL Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MYRFL: view

Variants for MYRFL Gene

Sequence variations from dbSNP and Humsavar for MYRFL Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000106434 -- 69,945,677(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000125489 -- 69,854,151(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000130571 -- 69,955,654(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000178131 -- 69,905,218(+) A/G intron_variant
rs1000185599 -- 69,915,452(+) A/G intron_variant

Variation tolerance for MYRFL Gene

Gene Damage Index Score: 11.06; 92.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYRFL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MYRFL Gene

Disorders for MYRFL Gene

Additional Disease Information for MYRFL

No disorders were found for MYRFL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYRFL Gene

Publications for MYRFL Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney RJ … Gill M (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 58
  4. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for MYRFL Gene

Sources for MYRFL Gene

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