Aliases for MYRFL Gene

Aliases for MYRFL Gene

  • Myelin Regulatory Factor Like 2 3 5
  • Myelin Regulatory Factor-Like Protein 3 4
  • C12orf15 3 4
  • C12orf28 3 4
  • Bcm1377 2 3
  • Chromosome 12 Open Reading Frame 15 2
  • Chromosome 12 Open Reading Frame 28 2
  • Myelin Regulatory Factor-Like 2
  • FLJ25056 2
  • MYRFL 5

External Ids for MYRFL Gene

Previous HGNC Symbols for MYRFL Gene

  • C12orf15
  • C12orf28

Previous GeneCards Identifiers for MYRFL Gene

  • GC12P070221

Summaries for MYRFL Gene

GeneCards Summary for MYRFL Gene

MYRFL (Myelin Regulatory Factor Like) is a Protein Coding gene. Diseases associated with MYRFL include Conduct Disorder. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is MYRF.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MYRFL Gene

Genomics for MYRFL Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MYRFL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J069824 Enhancer 0.3 ENCODE 600.7 +1.6 1563 2.6 ZNF316 MYRFL NONHSAG011651.2 RF00005-048 RAB3IP ENSG00000247131 ENSG00000258052 CNOT2
GH12J069738 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 22.5 -84.7 -84717 3.6 RNF2 CEBPG SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 RFX1 LEF1 ENSG00000247131 RAB3IP LOC101928002 MYRFL CPSF6 PRANCR BEST3 piR-56451-035 ENSG00000258052
GH12J069833 Enhancer 0.7 Ensembl ENCODE 27 +11.7 11652 5.7 FOXA1 PRDM1 SOX13 CEBPG SOX5 HLF ZNF644 MYRFL RAB3IP RF00005-048 NONHSAG011651.2 piR-36756-022 ENSG00000258052 CNOT2
GH12J069931 Enhancer 1.2 FANTOM5 Ensembl ENCODE CraniofacialAtlas 12.1 +109.6 109583 6.2 TEAD4 FOXA1 PKNOX1 CTBP1 ESRRA YY1 ZNF217 GATA3 POLR2A DPF2 MYRFL PRANCR piR-48799-027 lnc-BEST3-5 CNOT2
GH12J069907 Enhancer 0.7 Ensembl ENCODE 15.2 +83.2 83183 3.4 IKZF2 RUNX3 KLF4 CEBPG TBL1XR1 ATF2 JUN BHLHE40 IKZF1 lnc-BEST3-4 lnc-BEST3-5 MYRFL RAB3IP CNOT2 ENSG00000247131 PRANCR
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MYRFL on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MYRFL

Genomic Locations for MYRFL Gene

Genomic Locations for MYRFL Gene
134,580 bases
Plus strand
133,794 bases
Plus strand

Genomic View for MYRFL Gene

Genes around MYRFL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYRFL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYRFL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYRFL Gene

Proteins for MYRFL Gene

  • Protein details for MYRFL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myelin regulatory factor-like protein
    Protein Accession:

    Protein attributes for MYRFL Gene

    910 amino acids
    Molecular mass:
    101670 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB71571.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for MYRFL Gene

Post-translational modifications for MYRFL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYRFL Gene

Domains & Families for MYRFL Gene

Gene Families for MYRFL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MYRFL Gene

Suggested Antigen Peptide Sequences for MYRFL Gene

GenScript: Design optimal peptide antigens:
  • C12orf28 protein (B7ZL36_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MRF family.
  • Belongs to the MRF family.
genes like me logo Genes that share domains with MYRFL: view

Function for MYRFL Gene

Phenotypes From GWAS Catalog for MYRFL Gene

Gene Ontology (GO) - Molecular Function for MYRFL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA,IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
genes like me logo Genes that share ontologies with MYRFL: view
genes like me logo Genes that share phenotypes with MYRFL: view

Animal Models for MYRFL Gene

MGI Knock Outs for MYRFL:
  • Myrfl Myrfl<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYRFL

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MYRFL Gene

Localization for MYRFL Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYRFL Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYRFL gene
Compartment Confidence
nucleus 3
extracellular 2
plasma membrane 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MYRFL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MYRFL: view

Pathways & Interactions for MYRFL Gene

PathCards logo

SuperPathways for MYRFL Gene

No Data Available

Interacting Proteins for MYRFL Gene

Gene Ontology (GO) - Biological Process for MYRFL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045893 positive regulation of transcription, DNA-templated IBA 21873635
genes like me logo Genes that share ontologies with MYRFL: view

No data available for Pathways by source and SIGNOR curated interactions for MYRFL Gene

Drugs & Compounds for MYRFL Gene

No Compound Related Data Available

Transcripts for MYRFL Gene

mRNA/cDNA for MYRFL Gene

5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYRFL

Alternative Splicing Database (ASD) splice patterns (SP) for MYRFL Gene

No ASD Table

Relevant External Links for MYRFL Gene

GeneLoc Exon Structure for

Expression for MYRFL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MYRFL Gene

mRNA differential expression in normal tissues according to GTEx for MYRFL Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x18.8) and Testis (x4.2).

Protein differential expression in normal tissues from HIPED for MYRFL Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MYRFL Gene

Protein tissue co-expression partners for MYRFL Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MYRFL

SOURCE GeneReport for Unigene cluster for MYRFL Gene:


Evidence on tissue expression from TISSUES for MYRFL Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with MYRFL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYRFL Gene

Orthologs for MYRFL Gene

This gene was present in the common ancestor of animals.

Orthologs for MYRFL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MYRFL 30 31
  • 99.41 (n)
(Bos Taurus)
Mammalia MYRFL 30 31
  • 88.44 (n)
(Canis familiaris)
Mammalia MYRFL 30 31
  • 87.39 (n)
(Mus musculus)
Mammalia Myrfl 30 17 31
  • 84.05 (n)
(Rattus norvegicus)
Mammalia Myrfl 30
  • 80.61 (n)
(Monodelphis domestica)
Mammalia MYRFL 31
  • 19 (a)
(Ornithorhynchus anatinus)
Mammalia MYRFL 31
  • 12 (a)
(Gallus gallus)
Aves MYRFL 30 31
  • 70.63 (n)
(Anolis carolinensis)
Reptilia MYRFL 31
  • 13 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia myrfl 30
  • 66.28 (n)
(Danio rerio)
Actinopterygii LOC100329855 30
  • 57.91 (n)
  • 8 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta CG3328 31
  • 2 (a)
(Caenorhabditis elegans)
Secernentea pqn-47 30 31
  • 45.11 (n)
F21A10.2 31
  • 4 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 1 (a)
Species where no ortholog for MYRFL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MYRFL Gene

Gene Tree for MYRFL (if available)
Gene Tree for MYRFL (if available)
Evolutionary constrained regions (ECRs) for MYRFL: view image

Paralogs for MYRFL Gene

Paralogs for MYRFL Gene

(2) SIMAP similar genes for MYRFL Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MYRFL: view

Variants for MYRFL Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MYRFL Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs1555258490 Uncertain Significance: not provided 69,936,587(+) CAA/C FRAMESHIFT_VARIANT
rs10879065 - p.Leu845Met
rs11177991 - p.Ala753Ser
rs35051828 - p.Ser723Leu

Additional dbSNP identifiers (rs#s) for MYRFL Gene

Variation tolerance for MYRFL Gene

Gene Damage Index Score: 11.06; 92.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYRFL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MYRFL Gene

Disorders for MYRFL Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYRFL Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
conduct disorder
- elite association - COSMIC cancer census association via MalaCards
Search MYRFL in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with MYRFL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYRFL Gene

Publications for MYRFL Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Myrf guides target gene selection of transcription factor Sox10 during oligodendroglial development. (PMID: 31828317) Aprato J … Wegner M (Nucleic acids research 2020) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney RJ … Gill M (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3

Products for MYRFL Gene

Sources for MYRFL Gene