Aliases for MYRF Gene
External Ids for MYRF Gene
Previous HGNC Symbols for MYRF Gene
Previous GeneCards Identifiers for MYRF Gene
This gene encodes a transcription factor that is required for central nervous system myelination and may regulate oligodendrocyte differentiation. It is thought to act by increasing the expression of genes that effect myelin production but may also directly promote myelin gene expression. Loss of a similar gene in mouse models results in severe demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
GeneCards Summary for MYRF Gene
MYRF (Myelin Regulatory Factor) is a Protein Coding gene. Diseases associated with MYRF include Encephalitis/Encephalopathy, Mild, With Reversible Myelin Vacuolization and Cardiac-Urogenital Syndrome. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and peptidase activity. An important paralog of this gene is MYRFL.
UniProtKB/Swiss-Prot Summary for MYRF Gene
Myelin regulatory factor: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed:23966832).
Myelin regulatory factor, C-terminal: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage.
Myelin regulatory factor, N-terminal: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:23966832).