Aliases for MYPOP Gene

Aliases for MYPOP Gene

  • Myb Related Transcription Factor, Partner Of Profilin 2 3 5
  • P42 Myb-Related Transcription Factor, Partner Of Profilin 2 3
  • Myb-Related Transcription Factor, Partner Of Profilin 3 4
  • Myb-Related Protein P42POP 3 4
  • P42pop 2 3
  • Partner Of Profilin 4
  • P42POP 4
  • MYPOP 5

External Ids for MYPOP Gene

Previous GeneCards Identifiers for MYPOP Gene

  • GC19M051086
  • GC19M046393
  • GC19M042822

Summaries for MYPOP Gene

GeneCards Summary for MYPOP Gene

MYPOP (Myb Related Transcription Factor, Partner Of Profilin) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding.

UniProtKB/Swiss-Prot Summary for MYPOP Gene

  • Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity).

Additional gene information for MYPOP Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MYPOP Gene

Genomics for MYPOP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MYPOP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MYPOP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MYPOP

Top Transcription factor binding sites by QIAGEN in the MYPOP gene promoter:
  • Bach2
  • E47
  • FOXO4
  • GATA-1
  • HOXA5
  • Ik-2
  • Lmo2
  • MZF-1
  • Tal-1
  • XBP-1

Genomic Locations for MYPOP Gene

Genomic Locations for MYPOP Gene
chr19:45,890,020-45,902,619
(GRCh38/hg38)
Size:
12,600 bases
Orientation:
Minus strand
chr19:46,393,278-46,405,862
(GRCh37/hg19)
Size:
12,585 bases
Orientation:
Minus strand

Genomic View for MYPOP Gene

Genes around MYPOP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYPOP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYPOP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYPOP Gene

Proteins for MYPOP Gene

  • Protein details for MYPOP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VE0-MYPOP_HUMAN
    Recommended name:
    Myb-related transcription factor, partner of profilin
    Protein Accession:
    Q86VE0

    Protein attributes for MYPOP Gene

    Size:
    399 amino acids
    Molecular mass:
    42508 Da
    Quaternary structure:
    • Interacts with PFN1. Homodimer and heterodimer with PFN1 (By similarity).

neXtProt entry for MYPOP Gene

Post-translational modifications for MYPOP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYPOP Gene

No data available for DME Specific Peptides for MYPOP Gene

Domains & Families for MYPOP Gene

Gene Families for MYPOP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MYPOP Gene

Suggested Antigen Peptide Sequences for MYPOP Gene

GenScript: Design optimal peptide antigens:
  • Partner of profilin (MYPOP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86VE0

UniProtKB/Swiss-Prot:

MYPOP_HUMAN :
  • The proline-rich region is required for PFN1 interaction.
Domain:
  • The proline-rich region is required for PFN1 interaction.
genes like me logo Genes that share domains with MYPOP: view

Function for MYPOP Gene

Molecular function for MYPOP Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity).

Phenotypes From GWAS Catalog for MYPOP Gene

Gene Ontology (GO) - Molecular Function for MYPOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA,IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with MYPOP: view
genes like me logo Genes that share phenotypes with MYPOP: view

Animal Model Products

CRISPR Products

miRNA for MYPOP Gene

miRTarBase miRNAs that target MYPOP

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYPOP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYPOP Gene

Localization for MYPOP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYPOP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYPOP gene
Compartment Confidence
nucleus 4
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MYPOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with MYPOP: view

Pathways & Interactions for MYPOP Gene

PathCards logo

SuperPathways for MYPOP Gene

No Data Available

Gene Ontology (GO) - Biological Process for MYPOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with MYPOP: view

No data available for Pathways by source and SIGNOR curated interactions for MYPOP Gene

Drugs & Compounds for MYPOP Gene

No Compound Related Data Available

Transcripts for MYPOP Gene

mRNA/cDNA for MYPOP Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYPOP

Alternative Splicing Database (ASD) splice patterns (SP) for MYPOP Gene

No ASD Table

Relevant External Links for MYPOP Gene

GeneLoc Exon Structure for
MYPOP

Expression for MYPOP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MYPOP Gene

Protein differential expression in normal tissues from HIPED for MYPOP Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MYPOP Gene



Protein tissue co-expression partners for MYPOP Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MYPOP

SOURCE GeneReport for Unigene cluster for MYPOP Gene:

Hs.515478

Evidence on tissue expression from TISSUES for MYPOP Gene

  • Blood(4.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with MYPOP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYPOP Gene

Orthologs for MYPOP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYPOP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MYPOP 30 31
  • 98.21 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MYPOP 30 31
  • 86.6 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MYPOP 30 31
  • 86.48 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mypop 30
  • 83.33 (n)
Mouse
(Mus musculus)
Mammalia Mypop 30 17 31
  • 82.71 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MYPOP 31
  • 64 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MYPOP 31
  • 47 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398691 30
Species where no ortholog for MYPOP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MYPOP Gene

ENSEMBL:
Gene Tree for MYPOP (if available)
TreeFam:
Gene Tree for MYPOP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MYPOP: view image

Paralogs for MYPOP Gene

No data available for Paralogs for MYPOP Gene

Variants for MYPOP Gene

Additional dbSNP identifiers (rs#s) for MYPOP Gene

Structural Variations from Database of Genomic Variants (DGV) for MYPOP Gene

Variant ID Type Subtype PubMed ID
nsv1071539 CNV deletion 25765185
nsv2507 CNV insertion 18451855
nsv510770 CNV deletion 20534489

Variation tolerance for MYPOP Gene

Gene Damage Index Score: 2.87; 48.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYPOP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYPOP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MYPOP Gene

Disorders for MYPOP Gene

No disorders were found for MYPOP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYPOP Gene

Publications for MYPOP Gene

  1. Profilin regulates the activity of p42POP, a novel Myb-related transcription factor. (PMID: 15615774) Lederer M … Rothkegel M (Journal of cell science 2005) 2 3
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. (PMID: 30804502) Nakamura K … Groth A (Nature cell biology 2019) 3
  4. The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. (PMID: 26687479) Oliviero G … Cagney G (Scientific reports 2015) 3
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4

Products for MYPOP Gene

Sources for MYPOP Gene