Aliases for MYPN Gene
External Ids for MYPN Gene
Previous GeneCards Identifiers for MYPN Gene
Striated muscle in vertebrates comprises large proteins which must be organized properly to contract efficiently. Z-lines in striated muscle are a sign of this organization, representing the ends of actin thin filaments, titin, nebulin or nebulette and accessory proteins required for structure and function. This gene encodes a protein which interacts with nebulin in skeletal muscle or nebulette in cardiac muscle and alpha-actinin. In addition, this gene product can interact with a protein with the I-band indicating it has a regulatory as well as structural function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
GeneCards Summary for MYPN Gene
MYPN (Myopalladin) is a Protein Coding gene. Diseases associated with MYPN include Cardiomyopathy, Dilated, 1Kk and Nemaline Myopathy 11, Autosomal Recessive. Among its related pathways are Focal Adhesion. Gene Ontology (GO) annotations related to this gene include actin binding and cytoskeletal protein binding. An important paralog of this gene is PALLD.
UniProtKB/Swiss-Prot Summary for MYPN Gene
Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines.