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Aliases for MYOM3 Gene

Aliases for MYOM3 Gene

  • Myomesin 3 2 3 5
  • Myomesin Family, Member 3 2 3
  • Myomesin-3 3 4
  • Myomesin Family Member 3 4

External Ids for MYOM3 Gene

Previous GeneCards Identifiers for MYOM3 Gene

  • GC00U916990
  • GC01M024127
  • GC01M024255
  • GC01M024383
  • GC01M022635

Summaries for MYOM3 Gene

GeneCards Summary for MYOM3 Gene

MYOM3 (Myomesin 3) is a Protein Coding gene. Diseases associated with MYOM3 include Dilated Cardiomyopathy. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity. An important paralog of this gene is MYOM2.

UniProtKB/Swiss-Prot for MYOM3 Gene

  • May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle.

Additional gene information for MYOM3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYOM3 Gene

Genomics for MYOM3 Gene

GeneHancer (GH) Regulatory Elements for MYOM3 Gene

Promoters and enhancers for MYOM3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J024091 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 623.4 +9.7 9653 21.4 CTCF MNT MLLT1 ZNF121 GTF2F1 ZSCAN21 MAFK TFE3 SP7 PPARG MYOM3 SRRM1 LINC01355 SRSF10 ELOA IL22RA1 LOC105376864
GH01J024115 Enhancer 1.4 Ensembl ENCODE dbSUPER 14.9 -6.9 -6942 6.2 ELF3 ZNF121 CEBPG ZNF24 TFE3 SP1 PPARG HNF1A SP5 ZNF644 MYOM3 IL22RA1 ENSG00000232298 GRHL3 NCMAP IFNLR1 PNRC2 GC01P024142
GH01J024014 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +93.5 93469 10.6 ZNF652 ELF3 MNT POLR2A ZNF121 CEBPG RERE ZNF384 NFIB NCOA3 SRSF10 LINC01355 SRRM1 HNRNPR PNRC2 CNR2 ENSG00000230703 MYOM3 LOC105376863 ENSG00000225315
GH01J024149 Enhancer 1.1 FANTOM5 ENCODE 11.2 -39.2 -39200 3.8 CTCF ELF3 SP1 SP5 RAD21 SMARCA4 HMG20B RXRA DPF2 IKZF1 IFNLR1 GRHL3 MYOM3 ENSG00000232298 NCMAP IL22RA1 PNRC2 GC01P024177
GH01J024079 Enhancer 0.5 dbSUPER 18.1 +31.6 31649 2 SP1 RXRA ZNF768 HNF4A MAX ZMYM3 MYOM3 PNRC2 ENSG00000230703 LOC105376864 ENSG00000225315
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MYOM3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MYOM3 gene promoter:
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXO1
  • FOXO1a
  • Max1
  • MyoD
  • NF-1
  • Pax-4a
  • Pax-5
  • TGIF

Genomic Locations for MYOM3 Gene

Genomic Locations for MYOM3 Gene
chr1:24,056,035-24,112,175
(GRCh38/hg38)
Size:
56,141 bases
Orientation:
Minus strand
chr1:24,382,525-24,438,665
(GRCh37/hg19)
Size:
56,141 bases
Orientation:
Minus strand

Genomic View for MYOM3 Gene

Genes around MYOM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYOM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYOM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYOM3 Gene

Proteins for MYOM3 Gene

  • Protein details for MYOM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VTT5-MYOM3_HUMAN
    Recommended name:
    Myomesin-3
    Protein Accession:
    Q5VTT5
    Secondary Accessions:
    • A6NF75
    • Q5VTT6
    • Q6AWC0
    • Q6AWC1
    • Q6NXF9
    • Q6ZRG7
    • Q7Z3G9
    • Q8NA11
    • Q96C54

    Protein attributes for MYOM3 Gene

    Size:
    1437 amino acids
    Molecular mass:
    162189 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for MYOM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYOM3 Gene

Post-translational modifications for MYOM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYOM3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYOM3 Gene

Domains & Families for MYOM3 Gene

Suggested Antigen Peptide Sequences for MYOM3 Gene

GenScript: Design optimal peptide antigens:
  • Myomesin family member 3 (MYOM3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MYOM3: view

No data available for UniProtKB/Swiss-Prot for MYOM3 Gene

Function for MYOM3 Gene

Molecular function for MYOM3 Gene

UniProtKB/Swiss-Prot Function:
May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle.

Phenotypes From GWAS Catalog for MYOM3 Gene

Gene Ontology (GO) - Molecular Function for MYOM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008307 structural constituent of muscle IBA 21873635
GO:0042803 protein homodimerization activity ISS,IEA --
GO:0051015 actin filament binding IBA 21873635
GO:0051371 muscle alpha-actinin binding IBA 21873635
genes like me logo Genes that share ontologies with MYOM3: view
genes like me logo Genes that share phenotypes with MYOM3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MYOM3

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for MYOM3 - Now 50% OFF >
  • * MYOM3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * MYOM3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MYOM3 Gene

Localization for MYOM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYOM3 Gene

Cytoplasm, myofibril, sarcomere, M line.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYOM3 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MYOM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005865 striated muscle thin filament IBA 21873635
GO:0030017 sarcomere IBA 21873635
GO:0030018 Z disc IBA 21873635
GO:0031430 M band ISS,IBA --
genes like me logo Genes that share ontologies with MYOM3: view

Pathways & Interactions for MYOM3 Gene

PathCards logo

SuperPathways for MYOM3 Gene

No Data Available

Interacting Proteins for MYOM3 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
https://version11.string-db.org/api/image/network?species=9606&limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000363557%0d9606.ENSP00000216181%0d9606.ENSP00000226207%0d9606.ENSP00000245503%0d9606.ENSP00000255381%0d9606.ENSP00000255416%0d
Selected Interacting proteins: ENSP00000363557 Q5VTT5-MYOM3_HUMAN for MYOM3 Gene via STRING IID UniProtKB

Gene Ontology (GO) - Biological Process for MYOM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction IBA 21873635
GO:0030240 skeletal muscle thin filament assembly IBA 21873635
GO:0030241 skeletal muscle myosin thick filament assembly IBA 21873635
GO:0045214 sarcomere organization IBA 21873635
GO:0048739 cardiac muscle fiber development IBA 21873635
genes like me logo Genes that share ontologies with MYOM3: view

No data available for Pathways by source and SIGNOR curated interactions for MYOM3 Gene

Drugs & Compounds for MYOM3 Gene

No Compound Related Data Available

Transcripts for MYOM3 Gene

mRNA/cDNA for MYOM3 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(59) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for MYOM3 Gene

Myomesin 3:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for MYOM3 - Now 50% OFF >
  • * MYOM3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * MYOM3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for MYOM3 Gene

No ASD Table

Relevant External Links for MYOM3 Gene

GeneLoc Exon Structure for
MYOM3
ECgene alternative splicing isoforms for
MYOM3

Expression for MYOM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYOM3 Gene

mRNA differential expression in normal tissues according to GTEx for MYOM3 Gene

This gene is overexpressed in Muscle - Skeletal (x23.2), Heart - Left Ventricle (x17.1), and Heart - Atrial Appendage (x8.7).

Protein differential expression in normal tissues from HIPED for MYOM3 Gene

This gene is overexpressed in Heart (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MYOM3 Gene



Protein tissue co-expression partners for MYOM3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MYOM3 Gene:

MYOM3

SOURCE GeneReport for Unigene cluster for MYOM3 Gene:

Hs.523413

Evidence on tissue expression from TISSUES for MYOM3 Gene

  • Muscle(4.6)
  • Intestine(4.2)
  • Nervous system(4.1)
  • Heart(3.5)
genes like me logo Genes that share expression patterns with MYOM3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYOM3 Gene

Orthologs for MYOM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MYOM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYOM3 35 34
  • 98.93 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MYOM3 35 34
  • 87.48 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MYOM3 35 34
  • 86.01 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Myom3 17 35 34
  • 83.37 (n)
rat
(Rattus norvegicus)
Mammalia Myom3 34
  • 82.83 (n)
oppossum
(Monodelphis domestica)
Mammalia MYOM3 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYOM3 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYOM3 35 34
  • 63.47 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYOM3 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myom3 34
  • 58.08 (n)
zebrafish
(Danio rerio)
Actinopterygii myom3 35 34
  • 54.3 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14964 35
  • 11 (a)
ManyToMany
sls 35
  • 2 (a)
ManyToMany
Species where no ortholog for MYOM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYOM3 Gene

ENSEMBL:
Gene Tree for MYOM3 (if available)
TreeFam:
Gene Tree for MYOM3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MYOM3: view image

Paralogs for MYOM3 Gene

(3) SIMAP similar genes for MYOM3 Gene using alignment to 3 proteins:

  • MYOM3_HUMAN
  • A6NI63_HUMAN
  • A6NIU4_HUMAN
genes like me logo Genes that share paralogs with MYOM3: view

Variants for MYOM3 Gene

Sequence variations from dbSNP and Humsavar for MYOM3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000022567 -- 24,113,097(-) G/A upstream_transcript_variant
rs1000031554 -- 24,100,729(-) A/G intron_variant
rs1000120884 -- 24,103,222(-) C/T intron_variant
rs1000215079 -- 24,100,909(-) A/G intron_variant
rs1000272353 -- 24,110,523(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MYOM3 Gene

Variant ID Type Subtype PubMed ID
dgv61n106 CNV deletion 24896259
esv1250620 CNV deletion 17803354
esv1968924 CNV deletion 18987734
esv2609872 CNV deletion 19546169
esv2745430 CNV deletion 23290073
esv2853014 CNV deletion 24192839
esv3558788 CNV deletion 23714750
esv5851 CNV loss 19470904
esv989974 CNV deletion 20482838
nsv472633 CNV novel sequence insertion 20440878
nsv475436 CNV novel sequence insertion 20440878
nsv822054 CNV loss 20364138

Variation tolerance for MYOM3 Gene

Residual Variation Intolerance Score: 99.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 26.68; 99.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYOM3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYOM3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYOM3 Gene

Disorders for MYOM3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYOM3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
dilated cardiomyopathy
  • cardiomyopathy, familial idiopathic
- elite association - COSMIC cancer census association via MalaCards
Search MYOM3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MYOM3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MYOM3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYOM3 Gene

Publications for MYOM3 Gene

  1. Myomesin 3, a novel structural component of the M-band in striated muscle. (PMID: 18177667) Schoenauer R … Agarkova I (Journal of molecular biology 2008) 2 3 23 58
  2. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 45 58
  3. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D … Psaty BM (Arteriosclerosis, thrombosis, and vascular biology 2008) 3 45 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3 58

Products for MYOM3 Gene

Sources for MYOM3 Gene

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