MYOG Gene (Protein Coding)

Myogenin

GC01M203083
GIFtS:
41
Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH) proteins. It is essential for the development of functional skeletal muscle. [provided by RefSeq, Jul 2008] See more...

Aliases for MYOG Gene

Aliases for MYOG Gene

  • Myogenin 2 3 4 5
  • Myogenic Factor 4 2 3 4
  • Class C Basic Helix-Loop-Helix Protein 3 3 4
  • BHLHc3 3 4
  • Myf-4 3 4
  • MYF4 3 4
  • Myogenin (Myogenic Factor 4) 2
  • BHLHC3 4

External Ids for MYOG Gene

Previous HGNC Symbols for MYOG Gene

  • MYF4

Previous GeneCards Identifiers for MYOG Gene

  • GC01M200735
  • GC01M198482
  • GC01M199518
  • GC01M200340
  • GC01M199783
  • GC01M201318
  • GC01M203052
  • GC01M174217

Summaries for MYOG Gene

Entrez Gene Summary for MYOG Gene

  • Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH) proteins. It is essential for the development of functional skeletal muscle. [provided by RefSeq, Jul 2008]

GeneCards Summary for MYOG Gene

MYOG (Myogenin) is a Protein Coding gene. Diseases associated with MYOG include Embryonal Rhabdomyosarcoma and Gallbladder Sarcoma. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Hypertrophy Model. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is MYF6.

UniProtKB/Swiss-Prot Summary for MYOG Gene

  • Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity).

Gene Wiki entry for MYOG Gene

Additional gene information for MYOG Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MYOG Gene

Genomics for MYOG Gene

GeneHancer (GH) Regulatory Elements for MYOG Gene

Promoters and enhancers for MYOG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MYOG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MYOG gene promoter:
  • AML1a
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • MyoD
  • p53

Genomic Locations for MYOG Gene

Genomic Locations for MYOG Gene
chr1:203,083,129-203,086,038
(GRCh38/hg38)
Size:
2,910 bases
Orientation:
Minus strand
chr1:203,052,257-203,055,377
(GRCh37/hg19)
Size:
3,121 bases
Orientation:
Minus strand

Genomic View for MYOG Gene

Genes around MYOG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYOG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYOG Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MYOG Gene

Proteins for MYOG Gene

Products:

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  • Protein details for MYOG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15173-MYOG_HUMAN
    Recommended name:
    Myogenin
    Protein Accession:
    P15173
    Secondary Accessions:
    • Q53XW6

    Protein attributes for MYOG Gene

    Size:
    224 amino acids
    Molecular mass:
    25037 Da
    Quaternary structure:
    • Homodimer and heterodimer with E12; heterodimerization enhances MYOG DNA-binding and transcriptional activities. Interacts with SMARCA4/BRG1/BAF190A. Interacts (via C-terminal region) with SSRP1 and SUPT16H; the interaction is indicative of an interaction with the FACT complex (By similarity). Interacts with CSRP3.

neXtProt entry for MYOG Gene

Post-translational modifications for MYOG Gene

  • Phosphorylated by CAMK2G on threonine and serine amino acids in a muscle activity-dependent manner. Phosphorylation of Thr-87 impairs both DNA-binding and trans-activation functions in contracting muscles (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYOG Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Biorbyt antibodies for MYOG

No data available for DME Specific Peptides for MYOG Gene

Domains & Families for MYOG Gene

Gene Families for MYOG Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MYOG Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MYOG Gene

GenScript: Design optimal peptide antigens:
  • Myogenic factor 4 (MYOG_HUMAN)
  • Myogenin (Q9HCA4_HUMAN)
genes like me logo Genes that share domains with MYOG: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MYOG Gene

Function for MYOG Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for MYOG Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity).
GENATLAS Biochemistry:
myogenic factor 4,transcription activator (myogenin),required for the differentiation of skeletal muscle

Phenotypes From GWAS Catalog for MYOG Gene

Gene Ontology (GO) - Molecular Function for MYOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISS --
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA,IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0000987 proximal promoter sequence-specific DNA binding IEA --
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific TAS,IEA 19783823
genes like me logo Genes that share ontologies with MYOG: view
genes like me logo Genes that share phenotypes with MYOG: view

Animal Models for MYOG Gene

MGI Knock Outs for MYOG:
  • Myog Myog<tm1Whk>
  • Myog Myog<tm1.1(cre/ERT2)Lepr>
  • Myog Myog<tm1Yin>

Animal Model Products

CRISPR Products

miRNA for MYOG Gene

miRTarBase miRNAs that target MYOG
Targeted motifs for MYOG Gene
HOMER Transcription Factor Regulatory Elements motif MYOG
  • Consensus sequence: AACAGCTG Submotif: canonical Cell Type: C2C12 GEO ID: GSE36024

Clone Products

  • Addgene plasmids for MYOG

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for MYOG Gene

Localization for MYOG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYOG Gene

Nucleus. Note=Recruited to late myogenic gene promoter regulatory sequences with SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin-remodeling and transcription initiation in developing embryos. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYOG gene
Compartment Confidence
nucleus 5
cytoskeleton 4
extracellular 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MYOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,ISS --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex ISS --
GO:0032993 protein-DNA complex IEA,ISS --
genes like me logo Genes that share ontologies with MYOG: view

Pathways & Interactions for MYOG Gene

genes like me logo Genes that share pathways with MYOG: view

SIGNOR curated interactions for MYOG Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MYOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007049 cell cycle IEA --
GO:0007275 multicellular organism development IEA --
GO:0007517 muscle organ development IEA --
genes like me logo Genes that share ontologies with MYOG: view

Drugs & Compounds for MYOG Gene

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  1. Drug

(16) Drugs for MYOG Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(15) Additional Compounds for MYOG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MYOG: view

Transcripts for MYOG Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MYOG Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for MYOG

Alternative Splicing Database (ASD) splice patterns (SP) for MYOG Gene

No ASD Table

Relevant External Links for MYOG Gene

GeneLoc Exon Structure for
MYOG
ECgene alternative splicing isoforms for
MYOG

Expression for MYOG Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYOG Gene

mRNA expression in normal human tissues for MYOG Gene
mRNA expression by BioGPS for MYOG GenemRNA expression by GTEx for MYOG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYOG Gene

This gene is overexpressed in Muscle - Skeletal (x49.4).

NURSA nuclear receptor signaling pathways regulating expression of MYOG Gene:

MYOG

SOURCE GeneReport for Unigene cluster for MYOG Gene:

Hs.2830

Evidence on tissue expression from TISSUES for MYOG Gene

  • Eye(4.8)
  • Muscle(4.8)
  • Liver(3.7)
  • Nervous system(3.7)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with MYOG: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYOG Gene

Orthologs for MYOG Gene

This gene was present in the common ancestor of animals.

Orthologs for MYOG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia MYOG 33
  • 96 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Myog 32
  • 90.77 (n)
mouse
(Mus musculus)
 Mammalia Myog 17 33 32
  • 90.62 (n)
cow
(Bos Taurus)
 Mammalia MYOG 33 32
  • 90.48 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia MYOG 33 32
  • 89.88 (n)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia MYOG 33
  • 79 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia MYOG 33
  • 74 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves MYOG 33 32
  • 74.44 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia MYOG 33
  • 60 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia myog 32
  • 60.76 (n)
Str.11193 32
zebrafish
(Danio rerio)
 Actinopterygii myog 33 32 32
  • 64.21 (n)
 OneToOne
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.11695 32
fruit fly
(Drosophila melanogaster)
 Insecta nau 33
  • 24 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea hlh-1 33
  • 24 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 33
  • 14 (a)
 OneToMany
Species where no ortholog for MYOG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYOG Gene

ENSEMBL:
Gene Tree for MYOG (if available)
TreeFam:
Gene Tree for MYOG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MYOG: view image

Paralogs for MYOG Gene

Paralogs for MYOG Gene

(4) SIMAP similar genes for MYOG Gene using alignment to 2 proteins:

  • MYOG_HUMAN
  • L8E8X4_HUMAN
genes like me logo Genes that share paralogs with MYOG: view

Variants for MYOG Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MYOG Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000969987 -- 203,083,154(-) T/C 3_prime_UTR_variant
rs1000978200 -- 203,082,691(-) G/A/C downstream_transcript_variant
rs1001283955 -- 203,083,130(-) T/C 3_prime_UTR_variant
rs1001634508 -- 203,085,895(-) G/C coding_sequence_variant, missense_variant
rs1001748892 -- 203,086,061(-) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MYOG Gene

Variant ID Type Subtype PubMed ID
nsv832370 CNV loss 17160897

Variation tolerance for MYOG Gene

Residual Variation Intolerance Score: 85.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYOG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYOG

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYOG Gene

Disorders for MYOG Gene

MalaCards: The human disease database

(26) MalaCards diseases for MYOG Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
embryonal rhabdomyosarcoma
  • botryoid rhabdomyosarcoma
gallbladder sarcoma
  • malignant mesenchymal tumor of gallbladder
rhabdomyosarcoma
muscle cancer
  • malignant neoplasm of muscle
leiomyosarcoma
  • leiomyosarcomas
- elite association - COSMIC cancer census association via MalaCards
Search MYOG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MYOG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MYOG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYOG Gene

Publications for MYOG Gene

  1. Human bHLH transcription factor gene myogenin (MYOG): genomic sequence and negative mutation analysis in patients with severe congenital myopathies. (PMID: 10329008) Tseng BS … Butler IJ (Genomics 1999) 2 3 23 56
  2. Transcription of the muscle regulatory gene Myf4 is regulated by serum components, peptide growth factors and signaling pathways involving G proteins. (PMID: 1659574) Salminen A … Arnold HH (The Journal of cell biology 1991) 3 4 23 56
  3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges LM … MrOS Research Group (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009) 3 43 56
  4. Opposing control of rhabdomyosarcoma growth and differentiation by myogenin and interleukin 4. (PMID: 19372547) Nanni P … Lollini PL (Molecular cancer therapeutics 2009) 3 23 56
  5. Decreased Jun-D and myogenin expression in muscle wasting of human cachexia. (PMID: 19470832) Ramamoorthy S … Buck M (American journal of physiology. Endocrinology and metabolism 2009) 3 23 56

ExternalLinks

View latest publications for MYOG gene in Mastermind

Products for MYOG Gene

  • Addgene plasmids for MYOG
  • Biorbyt antibodies for MYOG

Sources for MYOG Gene