External Ids for MYOCD Gene
Previous GeneCards Identifiers for MYOCD Gene
This gene encodes a nuclear protein, which is expressed in heart, aorta, and in smooth muscle cell-containing tissues. It functions as a transcriptional co-activator of serum response factor (SRF) and modulates expression of cardiac and smooth muscle-specific SRF-target genes, and thus may play a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
GeneCards Summary for MYOCD Gene
MYOCD (Myocardin) is a Protein Coding gene. Diseases associated with MYOCD include Megabladder, Congenital and Prune Belly Syndrome. Among its related pathways are SRF and miRs in Smooth Muscle Differentiation and Proliferation and HOP Signaling. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription coactivator activity. An important paralog of this gene is MRTFB.
UniProtKB/Swiss-Prot Summary for MYOCD Gene
Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity).