Aliases for MYO9B Gene
External Ids for MYO9B Gene
Previous HGNC Symbols for MYO9B Gene
Previous GeneCards Identifiers for MYO9B Gene
This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for MYO9B Gene
MYO9B (Myosin IXB) is a Protein Coding gene. Diseases associated with MYO9B include Celiac Disease 4 and Inflammatory Bowel Disease 6. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and GTPase activator activity. An important paralog of this gene is MYO9A.
UniProtKB/Swiss-Prot for MYO9B Gene
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:9490638, PubMed:26529257). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257).