External Ids for MYO7B Gene
Previous GeneCards Identifiers for MYO7B Gene
The protein encoded by this gene is found in brush border microvilli of epithelial cells in the intestines and kidneys. The encoded protein is involved in linking protocadherins to the actin cytoskeleton and is essential for proper microvilli function. This protein aids in the accumulation of intermicrovillar adhesion components such as harmonin and ANKS4B, and this accumulation is necessary for normal brush border action. [provided by RefSeq, Jan 2017]
GeneCards Summary for MYO7B Gene
MYO7B (Myosin VIIB) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include actin binding and motor activity. An important paralog of this gene is MYO7A.
UniProtKB/Swiss-Prot for MYO7B Gene
Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. May link the complex to the actin core bundle of microvilli (Probable).