MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010] See more...

Aliases for MYO1G Gene

Aliases for MYO1G Gene

  • Myosin IG 2 3 5
  • Minor Histocompatibility Antigen HA-2 2 3
  • Unconventional Myosin-Ig 3 4
  • HA2 3 4
  • Myosin-Ig 3
  • HLA-HA2 3
  • MYO1G 5
  • MHAG 3
  • HA-2 2

External Ids for MYO1G Gene

Previous GeneCards Identifiers for MYO1G Gene

  • GC07M044648
  • GC07M044708
  • GC07M044743
  • GC07M044742
  • GC07M044775
  • GC07M044968
  • GC07M045003

Summaries for MYO1G Gene

Entrez Gene Summary for MYO1G Gene

  • MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010]

GeneCards Summary for MYO1G Gene

MYO1G (Myosin IG) is a Protein Coding gene. Diseases associated with MYO1G include Laurence-Moon Syndrome. Among its related pathways are Delta508-CFTR traffic / ER-to-Golgi in CF and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include actin binding and motor activity. An important paralog of this gene is MYO1D.

UniProtKB/Swiss-Prot Summary for MYO1G Gene

  • Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis.
  • [Minor histocompatibility antigen HA-2]: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MYO1G Gene

Genomics for MYO1G Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MYO1G Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MYO1G on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MYO1G

Top Transcription factor binding sites by QIAGEN in the MYO1G gene promoter:
  • AREB6
  • Brachyury
  • C/EBPbeta
  • E47
  • GCNF
  • GCNF-1
  • GCNF-2
  • MyoD
  • Sp1
  • YY1

Genomic Locations for MYO1G Gene

Latest Assembly
chr7:44,962,662-44,979,105
(GRCh38/hg38)
Size:
16,444 bases
Orientation:
Minus strand

Previous Assembly
chr7:45,002,261-45,018,614
(GRCh37/hg19 by Entrez Gene)
Size:
16,354 bases
Orientation:
Minus strand

chr7:45,002,261-45,018,697
(GRCh37/hg19 by Ensembl)
Size:
16,437 bases
Orientation:
Minus strand

Genomic View for MYO1G Gene

Genes around MYO1G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO1G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO1G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO1G Gene

Proteins for MYO1G Gene

  • Protein details for MYO1G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B0I1T2-MYO1G_HUMAN
    Recommended name:
    Unconventional myosin-Ig
    Protein Accession:
    B0I1T2
    Secondary Accessions:
    • Q8TEI9
    • Q8TES2
    • Q96BE2
    • Q96RI5
    • Q96RI6

    Protein attributes for MYO1G Gene

    Size:
    1018 amino acids
    Molecular mass:
    116442 Da
    Quaternary structure:
    • Interacts with calmodulin; via its IQ motifs.
    SequenceCaution:
    • Sequence=BAB84876.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for MYO1G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO1G Gene

Post-translational modifications for MYO1G Gene

  • Ubiquitination at Lys87, Lys140, Lys164, Lys188, Lys214, Lys341, Lys357, Lys507, Lys518, Lys544, Lys571, Lys594, Lys690, Lys815, Lys863, and Lys898
  • Modification sites at PhosphoSitePlus

Other Protein References for MYO1G Gene

No data available for DME Specific Peptides for MYO1G Gene

Domains & Families for MYO1G Gene

Gene Families for MYO1G Gene

Suggested Antigen Peptide Sequences for MYO1G Gene

GenScript: Design optimal peptide antigens:
  • Myosin-Ig (MYO1G_HUMAN)
  • FLJ00293 protein (Q6ZNK5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

B0I1T2

UniProtKB/Swiss-Prot:

MYO1G_HUMAN :
  • The myosin tail domain mediates binding to phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P2), phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) and binds to membranous compartments. It is required for recruitment to Fc-gamma receptor (Fc-gamma-R) phagocytic cups.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Domain:
  • The myosin tail domain mediates binding to phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P2), phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) and binds to membranous compartments. It is required for recruitment to Fc-gamma receptor (Fc-gamma-R) phagocytic cups.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYO1G: view

Function for MYO1G Gene

Molecular function for MYO1G Gene

UniProtKB/Swiss-Prot Function:
Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis.
UniProtKB/Swiss-Prot Function:
[Minor histocompatibility antigen HA-2]: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201.

Phenotypes From GWAS Catalog for MYO1G Gene

Gene Ontology (GO) - Molecular Function for MYO1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000146 microfilament motor activity IBA 21873635
GO:0000166 nucleotide binding IEA --
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with MYO1G: view
genes like me logo Genes that share phenotypes with MYO1G: view

Animal Models for MYO1G Gene

MGI Knock Outs for MYO1G:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYO1G

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MYO1G Gene

Localization for MYO1G Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO1G Gene

Cell membrane. Peripheral membrane protein. Cell projection, phagocytic cup. Note=Recruited to Fc-gamma receptor (Fc-gamma-R) phagocytic cup. In T-cells, transiently accumulates in discrete areas at the plasma membrane of migrating cells or when membranes are deformed (By similarity). Localization at the membrane is not highly dependent on phosphatidylinositol 4,5-bisphosphate levels. Released from the membrane in the presence of ATP. May be enriched in peripheral processes, such as microvilli or ruffles. {ECO:0000250 UniProtKB:Q5SUA5, ECO:0000269 PubMed:20071333}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYO1G gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 4
cytosol 3
nucleus 2
golgi apparatus 2
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MYO1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001891 phagocytic cup ISS --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA 21873635
GO:0005886 plasma membrane IBA,IDA 19968988
GO:0005902 microvillus IEA,IBA 21873635
genes like me logo Genes that share ontologies with MYO1G: view

Pathways & Interactions for MYO1G Gene

PathCards logo

SuperPathways for MYO1G Gene

SuperPathway Contained pathways
1 PAK Pathway
.56
.56
.36
2 Actin Nucleation by ARP-WASP Complex
.66
.35
3 RhoGDI Pathway
.33
.33
4 Delta508-CFTR traffic / ER-to-Golgi in CF
.32
.31
5 Salmonella infection (KEGG)
genes like me logo Genes that share pathways with MYO1G: view

Pathways by source for MYO1G Gene

1 KEGG pathway for MYO1G Gene
2 GeneGo (Thomson Reuters) pathways for MYO1G Gene
  • Transport Clathrin-coated vesicle cycle
  • wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)
11 Qiagen pathways for MYO1G Gene
  • Actin Nucleation by ARP-WASP Complex
  • Antioxidant Action of Vitamin-C
  • Cellular Effects of Sildenafil
  • Epithelial Adherens Junctions
  • Epithelial Tight Junctions

Gene Ontology (GO) - Biological Process for MYO1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002456 T cell mediated immunity IEA,ISS --
GO:0006887 exocytosis IEA --
GO:0006909 phagocytosis IEA --
genes like me logo Genes that share ontologies with MYO1G: view

No data available for SIGNOR curated interactions for MYO1G Gene

Drugs & Compounds for MYO1G Gene

No Compound Related Data Available

Transcripts for MYO1G Gene

mRNA/cDNA for MYO1G Gene

1 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYO1G

Alternative Splicing Database (ASD) splice patterns (SP) for MYO1G Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - - -
SP2: - - - - - -
SP3: - -
SP4: - - - -
SP5: - -
SP6: - - -
SP7: - -

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -

Relevant External Links for MYO1G Gene

GeneLoc Exon Structure for
MYO1G

Expression for MYO1G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MYO1G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYO1G Gene

This gene is overexpressed in Whole Blood (x21.9).

Protein differential expression in normal tissues from HIPED for MYO1G Gene

This gene is overexpressed in Tlymphocyte (24.2), Peripheral blood mononuclear cells (13.7), and CD8 Tcells (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MYO1G Gene



Protein tissue co-expression partners for MYO1G Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MYO1G

SOURCE GeneReport for Unigene cluster for MYO1G Gene:

Hs.37617

mRNA Expression by UniProt/SwissProt for MYO1G Gene:

B0I1T2-MYO1G_HUMAN
Tissue specificity: Specifically expressed in hematopoietic cells.

Evidence on tissue expression from TISSUES for MYO1G Gene

  • Spleen(4.5)
  • Bone marrow(2.5)
  • Lymph node(2.4)
  • Blood(2.4)
genes like me logo Genes that share expression patterns with MYO1G: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MYO1G Gene

Orthologs for MYO1G Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYO1G Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MYO1G 29 30
  • 99.51 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MYO1G 30
  • 91 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia MYO1G 29 30
  • 88.45 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Myo1g 29 16 30
  • 86.23 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Myo1g 29
  • 85.57 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 82 (a)
OneToMany
-- 30
  • 72 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia MYO1G 30
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MYO1G 29 30
  • 73.51 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MYO1G 30
  • 69 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-92c9.3 29
  • 63.39 (n)
MYO1G 30
  • 62 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Myo31DF 30
  • 49 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea hum-5 30
  • 46 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MYO3 30
  • 25 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 52 (a)
OneToMany
Species where no ortholog for MYO1G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for MYO1G Gene

ENSEMBL:
Gene Tree for MYO1G (if available)
TreeFam:
Gene Tree for MYO1G (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MYO1G: view image
Alliance of Genome Resources:
Additional Orthologs for MYO1G

Paralogs for MYO1G Gene

(27) SIMAP similar genes for MYO1G Gene using alignment to 4 proteins:

  • MYO1G_HUMAN
  • F8WAS7_HUMAN
  • F8WEW9_HUMAN
  • Q6ZNK5_HUMAN
genes like me logo Genes that share paralogs with MYO1G: view

Variants for MYO1G Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MYO1G Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs2107737 -- p.Arg798Gln
rs3735485 -- p.Met489Thr
rs61739531 -- p.Val49Met
rs7792760 -- p.Gln861Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MYO1G Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MYO1G Gene

Variant ID Type Subtype PubMed ID
esv3369216 CNV duplication 20981092
nsv606828 CNV gain 21841781
nsv830985 CNV loss 17160897

Variation tolerance for MYO1G Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.67; 82.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYO1G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYO1G
Leiden Open Variation Database (LOVD)
MYO1G

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO1G Gene

Disorders for MYO1G Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYO1G Gene - From: COP

Disorder Aliases PubMed IDs
laurence-moon syndrome
  • lnms
- elite association - COSMIC cancer census association via MalaCards
Search MYO1G in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MYO1G

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MYO1G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYO1G Gene

Publications for MYO1G Gene

  1. Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain (Myo1PH). (PMID: 20071333) Patino-Lopez G … Shaw S (The Journal of biological chemistry 2010) 3 4
  2. Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogeneic hematopoietic cell transplantation. (PMID: 20353833) Larsen ME … Vindelov L (Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2010) 3 40
  3. Myosin 1G (Myo1G) is a haematopoietic specific myosin that localises to the plasma membrane and regulates cell elasticity. (PMID: 19968988) Olety B … Bähler M (FEBS letters 2010) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4

Products for MYO1G Gene

Sources for MYO1G Gene