Myosins are molecular motors that use the energy from ATP hydrolysis to generate force on actin filaments. The protein encoded by this gene is an unconventional myosin that may be involved in the intracellular movement of membrane-enclosed compartments. There is evidence to suggest that mutations in this gene can result in hearing loss. [provided by RefSeq, Jan 2017] See more...

Aliases for MYO1F Gene

Aliases for MYO1F Gene

  • Myosin IF 2 3 5
  • Unconventional Myosin-If 3 4
  • Myosin-Ie 3 4
  • Myosin-ID 3

External Ids for MYO1F Gene

Previous GeneCards Identifiers for MYO1F Gene

  • GC19M008814
  • GC19M008480
  • GC19M008491
  • GC19M008241
  • GC19M008585

Summaries for MYO1F Gene

Entrez Gene Summary for MYO1F Gene

  • Myosins are molecular motors that use the energy from ATP hydrolysis to generate force on actin filaments. The protein encoded by this gene is an unconventional myosin that may be involved in the intracellular movement of membrane-enclosed compartments. There is evidence to suggest that mutations in this gene can result in hearing loss. [provided by RefSeq, Jan 2017]

GeneCards Summary for MYO1F Gene

MYO1F (Myosin IF) is a Protein Coding gene. Diseases associated with MYO1F include Deafness, Autosomal Recessive 15. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include actin binding and motor activity. An important paralog of this gene is MYO1E.

UniProtKB/Swiss-Prot Summary for MYO1F Gene

  • Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).

Gene Wiki entry for MYO1F Gene

Additional gene information for MYO1F Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MYO1F Gene

Genomics for MYO1F Gene

GeneHancer (GH) Regulatory Elements for MYO1F Gene

Promoters and enhancers for MYO1F Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J008566 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 543.1 +5.0 5049 11.3 SP1 GTF2E2 JUND FOS EP300 ZIC2 AFF1 HES1 TSC22D4 TOE1 MYO1F piR-57138-029 PRAM1 ENSG00000267986 ZNF558 XAB2 MARCHF2 RAB11B lnc-ADAMTS10-1
GH19J008578 Promoter/Enhancer 1 Ensembl ENCODE 500.7 -1.5 -1522 0.6 CTCF GABPA RAD21 CTBP1 TRIM22 EZH2 TEAD1 SMC3 YY1 POU2F2 MYO1F lnc-ADAMTS10-1 ENSG00000267986
GH19J008511 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 27.6 +62.2 62239 9.9 ZBTB40 EP300 SIN3A NRF1 POLR2G GTF2E2 PHF8 CTCF ZNF10 ZBTB5 ZNF414 lnc-HNRNPM-6 lnc-ZNF414-1 MYO1F ZNF177 ZNF317 PRAM1 ZNF699 ENSG00000267273 STXBP2
GH19J008524 Promoter/Enhancer 2 Ensembl ENCODE CraniofacialAtlas dbSUPER 20.4 +51.2 51218 2.9 EP300 CTCF NRF1 POLR2G NCOR1 RBAK ZNF639 POLR2A ZBTB10 CLOCK lnc-ZNF414-2 ELAVL1 HNRNPM ZNF558 ZNF699 ZNF414 ZNF266 ZNF317 ZNF559 XAB2
GH19J008639 Enhancer 1.1 FANTOM5 ENCODE 31.3 -62.8 -62823 1.7 EP300 TCF12 NCOR1 TCF7 SKI TEAD1 ZBTB26 RBM25 FOXA2 SIN3A MYO1F ADAMTS10 ACTL9 PRAM1 ENSG00000270614 FJ601684-213 LINC01862
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MYO1F on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MYO1F

Top Transcription factor binding sites by QIAGEN in the MYO1F gene promoter:
  • Bach2
  • FAC1
  • FOXJ2
  • FOXJ2 (long isoform)
  • GR
  • GR-alpha
  • HOXA5
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for MYO1F Gene

Genomic Locations for MYO1F Gene
chr19:8,520,778-8,577,577
(GRCh38/hg38)
Size:
56,800 bases
Orientation:
Minus strand
chr19:8,585,674-8,642,461
(GRCh37/hg19)
Size:
56,788 bases
Orientation:
Minus strand

Genomic View for MYO1F Gene

Genes around MYO1F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO1F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO1F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO1F Gene

Proteins for MYO1F Gene

  • Protein details for MYO1F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00160-MYO1F_HUMAN
    Recommended name:
    Unconventional myosin-If
    Protein Accession:
    O00160
    Secondary Accessions:
    • Q8WWN7

    Protein attributes for MYO1F Gene

    Size:
    1098 amino acids
    Molecular mass:
    124844 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MYO1F Gene

Post-translational modifications for MYO1F Gene

  • Ubiquitination at Lys170, Lys355, Lys673, and Lys905
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MYO1F Gene

Domains & Families for MYO1F Gene

Gene Families for MYO1F Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MYO1F Gene

Blocks:
  • SH3 domain signature
  • IQ calmodulin-binding region
  • Myosin tail 2
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MYO1F Gene

GenScript: Design optimal peptide antigens:
  • Myosin-Ie (MYO1F_HUMAN)
  • Myosin-ID (Q92827_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00160

UniProtKB/Swiss-Prot:

MYO1F_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYO1F: view

Function for MYO1F Gene

Molecular function for MYO1F Gene

UniProtKB/Swiss-Prot Function:
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).
GENATLAS Biochemistry:
myosin IF,unconventional,apparently non filamentous,homologous to mouse Myo1f,widely expressed,but not in the heart

Phenotypes From GWAS Catalog for MYO1F Gene

Gene Ontology (GO) - Molecular Function for MYO1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003779 actin binding NAS 9119401
GO:0005515 protein binding IEA --
GO:0005516 calmodulin binding IEA --
GO:0005524 ATP binding NAS 9119401
genes like me logo Genes that share ontologies with MYO1F: view
genes like me logo Genes that share phenotypes with MYO1F: view

Animal Models for MYO1F Gene

MGI Knock Outs for MYO1F:

Animal Model Products

CRISPR Products

miRNA for MYO1F Gene

miRTarBase miRNAs that target MYO1F

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYO1F Gene

Localization for MYO1F Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYO1F gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1
endosome 1

Gene Ontology (GO) - Cellular Components for MYO1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016459 myosin complex IEA --
GO:0016461 unconventional myosin complex NAS 9119401
genes like me logo Genes that share ontologies with MYO1F: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MYO1F Gene

Pathways & Interactions for MYO1F Gene

PathCards logo

SuperPathways for MYO1F Gene

SuperPathway Contained pathways
1 PAK Pathway
.56
.56
.36
2 Actin Nucleation by ARP-WASP Complex
.66
.35
3 RhoGDI Pathway
.33
.33
4 wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
.32
.31
5 Pathogenic Escherichia coli infection
genes like me logo Genes that share pathways with MYO1F: view

Pathways by source for MYO1F Gene

1 KEGG pathway for MYO1F Gene
2 GeneGo (Thomson Reuters) pathways for MYO1F Gene
  • Transport Clathrin-coated vesicle cycle
  • wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)
11 Qiagen pathways for MYO1F Gene
  • Actin Nucleation by ARP-WASP Complex
  • Antioxidant Action of Vitamin-C
  • Cellular Effects of Sildenafil
  • Epithelial Adherens Junctions
  • Epithelial Tight Junctions

Interacting Proteins for MYO1F Gene

;

Gene Ontology (GO) - Biological Process for MYO1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MYO1F: view

No data available for SIGNOR curated interactions for MYO1F Gene

Drugs & Compounds for MYO1F Gene

No Compound Related Data Available

Transcripts for MYO1F Gene

mRNA/cDNA for MYO1F Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYO1F Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - -
SP2:
SP3: -
SP4: -
SP5:
SP6: -
SP7:
SP8:
SP9:

ExUns: 19a · 19b · 19c ^ 20 ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for MYO1F Gene

GeneLoc Exon Structure for
MYO1F

Expression for MYO1F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MYO1F Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYO1F Gene

This gene is overexpressed in Whole Blood (x38.8).

Protein differential expression in normal tissues from HIPED for MYO1F Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.9), Cervix (14.5), Tlymphocyte (9.4), NK cells (8.3), and Monocytes (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MYO1F Gene



Protein tissue co-expression partners for MYO1F Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MYO1F

SOURCE GeneReport for Unigene cluster for MYO1F Gene:

Hs.465818

Evidence on tissue expression from TISSUES for MYO1F Gene

  • Blood(4.5)
  • Spleen(4.3)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with MYO1F: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYO1F Gene

Orthologs for MYO1F Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYO1F Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYO1F 31 30
  • 96.03 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MYO1F 31 30
  • 89.69 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MYO1F 31 30
  • 89.4 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYO1F 31
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myo1f 17 31 30
  • 86.25 (n)
rat
(Rattus norvegicus)
Mammalia Myo1f 30
  • 86.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MYO1F 31
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYO1F 31 30
  • 79.49 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYO1F 31
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myo1f 30
  • 70.02 (n)
zebrafish
(Danio rerio)
Actinopterygii myo1f 31 30
  • 71.21 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3889 30
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL306C 30
  • 51.54 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MYO5 30
  • 46.89 (n)
MYO3 31
  • 33 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12562g 30
  • 46.8 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02111 30
  • 52.29 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes myo1 30
  • 46.6 (n)
Species where no ortholog for MYO1F was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYO1F Gene

ENSEMBL:
Gene Tree for MYO1F (if available)
TreeFam:
Gene Tree for MYO1F (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MYO1F: view image

Paralogs for MYO1F Gene

(35) SIMAP similar genes for MYO1F Gene using alignment to 6 proteins:

  • MYO1F_HUMAN
  • M0QXE0_HUMAN
  • M0QXU2_HUMAN
  • M0QXU5_HUMAN
  • M0QY89_HUMAN
  • Q92827_HUMAN
genes like me logo Genes that share paralogs with MYO1F: view

Variants for MYO1F Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MYO1F Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
668255 Likely Benign: not provided 8,522,532(-) C/T MISSENSE_VARIANT
668425 Likely Benign: not provided 8,544,288(-) G/T INTRON_VARIANT
668705 Likely Benign: not provided 8,522,409(-) T/G MISSENSE_VARIANT
676337 Benign: not provided 8,544,317(-) T/C MISSENSE_VARIANT
678701 Benign: not provided 8,544,375(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for MYO1F Gene

Structural Variations from Database of Genomic Variants (DGV) for MYO1F Gene

Variant ID Type Subtype PubMed ID
dgv137n111 CNV deletion 26073780
dgv396n27 CNV loss 19166990
dgv6258n54 CNV loss 21841781
esv2661355 CNV deletion 23128226
esv2718125 CNV deletion 23290073
esv2718126 CNV deletion 23290073
esv2762024 CNV gain 21179565
esv3363685 CNV insertion 20981092
esv3643618 CNV gain 21293372
esv3643619 CNV gain 21293372
nsv1127648 CNV deletion 24896259
nsv1138665 CNV deletion 24896259
nsv1143908 CNV deletion 24896259
nsv458350 CNV loss 19166990
nsv528946 CNV loss 19592680
nsv578559 CNV loss 21841781
nsv953966 CNV deletion 24416366

Variation tolerance for MYO1F Gene

Residual Variation Intolerance Score: 9.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYO1F Gene

Human Gene Mutation Database (HGMD)
MYO1F
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYO1F

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO1F Gene

Disorders for MYO1F Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYO1F Gene - From: DISEASES

Disorder Aliases PubMed IDs
deafness, autosomal recessive 15
  • dfnb15
- elite association - COSMIC cancer census association via MalaCards
Search MYO1F in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MYO1F_HUMAN
  • Note=Defects in MYO1F has been found in a patient with a form of non-syndromic sensorineural hearing loss. {ECO:0000269 PubMed:22938506}.

Additional Disease Information for MYO1F

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MYO1F: view

No data available for Genatlas for MYO1F Gene

Publications for MYO1F Gene

  1. Cloning of the genes encoding two murine and human cochlear unconventional type I myosins. (PMID: 9119401) Crozet F … Petit C (Genomics 1997) 2 3 4 54
  2. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H … Hirschhorn JN (Nature 2010) 3 41 54
  3. Are MYO1C and MYO1F associated with hearing loss? (PMID: 19027848) Zadro C … Carella M (Biochimica et biophysica acta 2009) 3 41 54
  4. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 41 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for MYO1F Gene

Sources for MYO1F Gene