Aliases for MYO1E Gene
External Ids for MYO1E Gene
Previous GeneCards Identifiers for MYO1E Gene
This gene encodes a member of the nonmuscle class I myosins which are a subgroup of the unconventional myosin protein family. The unconventional myosin proteins function as actin-based molecular motors. Class I myosins are characterized by a head (motor) domain, a regulatory domain and a either a short or long tail domain. Among the class I myosins, this protein is distinguished by a long tail domain that is involved in crosslinking actin filaments. This protein localizes to the cytoplasm and may be involved in intracellular movement and membrane trafficking. Mutations in this gene are the cause of focal segmental glomerulosclerosis-6. This gene has been referred to as myosin IC in the literature but is distinct from the myosin IC gene located on chromosome 17. [provided by RefSeq, Jan 2012]
GeneCards Summary for MYO1E Gene
MYO1E (Myosin IE) is a Protein Coding gene. Diseases associated with MYO1E include Focal Segmental Glomerulosclerosis 6 and Genetic Steroid-Resistant Nephrotic Syndrome. Among its related pathways are Delta508-CFTR traffic / ER-to-Golgi in CF and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include calmodulin binding and phosphatidylinositol binding. An important paralog of this gene is MYO1F.
UniProtKB/Swiss-Prot Summary for MYO1E Gene
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14.