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Aliases for MYO1D Gene

Aliases for MYO1D Gene

  • Myosin ID 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 108 2 3
  • Unconventional Myosin-Id 3
  • Myosin-I Gamma 3
  • PPP1R108 3
  • KIAA0727 4
  • Myr4 3

External Ids for MYO1D Gene

Previous GeneCards Identifiers for MYO1D Gene

  • GC17M030586
  • GC17M032854
  • GC17M030965
  • GC17M027844
  • GC17M030819
  • GC17M027005

Summaries for MYO1D Gene

GeneCards Summary for MYO1D Gene

MYO1D (Myosin ID) is a Protein Coding gene. Diseases associated with MYO1D include Visceral Heterotaxy. Among its related pathways are PAK Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include actin binding and calmodulin binding. An important paralog of this gene is MYO1G.

UniProtKB/Swiss-Prot for MYO1D Gene

  • Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).

Additional gene information for MYO1D Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO1D Gene

Genomics for MYO1D Gene

GeneHancer (GH) Regulatory Elements for MYO1D Gene

Promoters and enhancers for MYO1D Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I032875 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 555.3 -0.6 -626 4.5 PKNOX1 FOXA2 ARID4B SIN3A ZNF2 YY1 ZNF766 E2F8 ZNF207 ZNF143 MYO1D ENSG00000226377 GC17P032879 LOC102724715 TMEM98
GH17I032909 Enhancer 1.4 Ensembl ENCODE dbSUPER 18.8 -34.2 -34233 3.5 HDGF PKNOX1 SMAD1 ATF1 FOXA2 ARNT ARID4B ZNF280A POLR2B ZNF766 MYO1D TMEM98 ENSG00000226377 ENSG00000236377 GC17P032879
GH17I032348 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10 +526.5 526547 4.1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC MEF2D ZNF207 C17orf75 GC17M032350 GC17P032358 PIR54391 MIR632 SUZ12 UTP6 PSMD11 LRRC37B
GH17I032340 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10 +535.1 535107 2.2 ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC C17orf75 ZNF207 UTP6 SUZ12 RHBDL3 TMEM98 SH3GL1P1 PSMD11 MYO1D OOSP1P2
GH17I032827 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 13 +48.5 48527 3.2 HDGF PKNOX1 FOXA2 BATF IRF4 YY1 ZNF766 ZNF143 BCLAF1 IKZF2 ENSG00000201178 GC17M032831 GC17P032830 LOC101927198 MYO1D ENSG00000226377 TMEM98
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MYO1D on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MYO1D gene promoter:

Genomic Locations for MYO1D Gene

Genomic Locations for MYO1D Gene
384,656 bases
Minus strand

Genomic View for MYO1D Gene

Genes around MYO1D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO1D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO1D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO1D Gene

Proteins for MYO1D Gene

  • Protein details for MYO1D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Unconventional myosin-Id
    Protein Accession:
    Secondary Accessions:
    • A6H8V3
    • Q8NHP9

    Protein attributes for MYO1D Gene

    1006 amino acids
    Molecular mass:
    116202 Da
    Quaternary structure:
    • Binds calmodulin through its IQ motifs.
    • Sequence=BAA34447.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MYO1D Gene

Post-translational modifications for MYO1D Gene

  • Ubiquitination at isoforms=559, isoforms=767, and Lys811

No data available for DME Specific Peptides for MYO1D Gene

Domains & Families for MYO1D Gene

Gene Families for MYO1D Gene

Suggested Antigen Peptide Sequences for MYO1D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYO1D: view

Function for MYO1D Gene

Molecular function for MYO1D Gene

GENATLAS Biochemistry:
myosin ID,unconventional,apparently non filamentous,homologous to mouse Myo1f,expressed in cochlea
UniProtKB/Swiss-Prot Function:
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).

Phenotypes From GWAS Catalog for MYO1D Gene

Gene Ontology (GO) - Molecular Function for MYO1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000146 microfilament motor activity IEA --
GO:0000166 nucleotide binding IEA --
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0005516 calmodulin binding ISS --
genes like me logo Genes that share ontologies with MYO1D: view

Phenotypes for MYO1D Gene

genes like me logo Genes that share phenotypes with MYO1D: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYO1D Gene

Localization for MYO1D Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYO1D gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
endosome 5
cytoskeleton 4
nucleus 3
endoplasmic reticulum 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MYO1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome ISS --
GO:0005790 smooth endoplasmic reticulum IEA --
GO:0005829 cytosol IEA --
GO:0005903 brush border IEA,ISS --
GO:0016323 basolateral plasma membrane ISS,IEA --
genes like me logo Genes that share ontologies with MYO1D: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYO1D Gene

Pathways & Interactions for MYO1D Gene

genes like me logo Genes that share pathways with MYO1D: view

Gene Ontology (GO) - Biological Process for MYO1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0030900 forebrain development IEA --
GO:0051641 cellular localization IEA,ISS --
GO:0061502 early endosome to recycling endosome transport ISS --
genes like me logo Genes that share ontologies with MYO1D: view

No data available for SIGNOR curated interactions for MYO1D Gene

Drugs & Compounds for MYO1D Gene

No Compound Related Data Available

Transcripts for MYO1D Gene

Unigene Clusters for MYO1D Gene

Myosin ID:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYO1D Gene

No ASD Table

Relevant External Links for MYO1D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MYO1D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYO1D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYO1D Gene

This gene is overexpressed in Artery - Aorta (x7.7), Artery - Tibial (x5.5), and Artery - Coronary (x5.0).

Protein differential expression in normal tissues from HIPED for MYO1D Gene

This gene is overexpressed in Spinal cord (14.8) and Nasal epithelium (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYO1D Gene

Protein tissue co-expression partners for MYO1D Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MYO1D Gene:


SOURCE GeneReport for Unigene cluster for MYO1D Gene:


mRNA Expression by UniProt/SwissProt for MYO1D Gene:

Tissue specificity: Expressed in many tissues. Highest levels in brain, followed by lung and ovary; expression is lowest in spleen.

Evidence on tissue expression from TISSUES for MYO1D Gene

  • Nervous system(4.6)
  • Intestine(2.9)
  • Blood(2.5)
  • Pancreas(2.5)
  • Skin(2.3)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with MYO1D: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MYO1D Gene

Orthologs for MYO1D Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MYO1D Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MYO1D 34 33
  • 99.6 (n)
(Canis familiaris)
Mammalia MYO1D 33 34
  • 92.61 (n)
(Monodelphis domestica)
Mammalia MYO1D 34
  • 92 (a)
(Bos Taurus)
Mammalia MYO1D 33 34
  • 90.56 (n)
(Rattus norvegicus)
Mammalia Myo1d 33
  • 90.49 (n)
(Mus musculus)
Mammalia Myo1d 33 16 34
  • 90.46 (n)
(Ornithorhynchus anatinus)
Mammalia MYO1D 34
  • 88 (a)
(Gallus gallus)
Aves MYO1D 34 33
  • 78.51 (n)
(Anolis carolinensis)
Reptilia MYO1D 34
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia myo1d 33
  • 71.97 (n)
(Danio rerio)
Actinopterygii MYO1D 34
  • 81 (a)
si:ch211-94l19.4 33
  • 72.58 (n)
fruit fly
(Drosophila melanogaster)
Insecta Myo31DF 33 34
  • 55.64 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010160 33
  • 35.1 (n)
(Caenorhabditis elegans)
Secernentea hum-5 33 34
  • 55.05 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MYO3 34
  • 26 (a)
(Zea mays)
Liliopsida Zm.442 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 58 (a)
Species where no ortholog for MYO1D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYO1D Gene

Gene Tree for MYO1D (if available)
Gene Tree for MYO1D (if available)

Paralogs for MYO1D Gene

Variants for MYO1D Gene

Sequence variations from dbSNP and Humsavar for MYO1D Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000001783 -- 32,828,249(-) G/A intron_variant
rs1000017043 -- 32,847,485(-) G/A intron_variant
rs1000026813 -- 32,555,158(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000030841 -- 32,700,366(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000036109 -- 32,523,990(-) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MYO1D Gene

Variant ID Type Subtype PubMed ID
nsv833417 CNV gain 17160897
nsv833416 CNV gain 17160897
nsv833415 CNV gain 17160897
nsv519839 CNV loss 19592680
nsv510705 CNV deletion 20534489
nsv507839 OTHER sequence alteration 20534489
nsv472817 CNV novel sequence insertion 20440878
nsv1134640 CNV deletion 24896259
nsv1109070 CNV deletion 24896259
nsv1072729 CNV deletion 25765185
esv3892994 CNV gain 25118596
esv3640391 CNV loss 21293372
esv3640386 CNV loss 21293372
esv3640385 CNV loss 21293372
esv3640384 CNV loss 21293372
esv3582606 CNV loss 25503493
esv3554324 CNV deletion 23714750
esv3401653 CNV insertion 20981092
esv3388006 CNV insertion 20981092
esv3387354 CNV insertion 20981092
esv3379868 CNV insertion 20981092
esv3342524 CNV duplication 20981092
esv3306358 CNV mobile element insertion 20981092
esv2670976 CNV deletion 23128226
esv1340589 CNV insertion 17803354
dgv568e214 CNV gain 21293372

Variation tolerance for MYO1D Gene

Residual Variation Intolerance Score: 10.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.55; 55.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYO1D Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO1D Gene

Disorders for MYO1D Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYO1D Gene - From: DISEASES

Disorder Aliases PubMed IDs
visceral heterotaxy
  • heterotaxia
- elite association - COSMIC cancer census association via MalaCards
Search MYO1D in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MYO1D

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MYO1D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYO1D Gene

Publications for MYO1D Gene

  1. Genetic association of short sleep duration with hypertension incidence--a 6-year follow-up in the Korean genome and epidemiology study. (PMID: 22322875) Kim SJ … Shin C (Circulation journal : official journal of the Japanese Circulation Society 2012) 3 44 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Genome-wide association study of pancreatic cancer in Japanese population. (PMID: 20686608) Low SK … Sakamoto H (PloS one 2010) 3 44 58
  4. High density SNP association study of a major autism linkage region on chromosome 17. (PMID: 17376794) Stone JL … Nelson SF (Human molecular genetics 2007) 3 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for MYO1D Gene

Sources for MYO1D Gene

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