Aliases for MYO19 Gene

Aliases for MYO19 Gene

  • Myosin XIX 2 3 5
  • Myosin Head Domain-Containing Protein 1 3 4
  • Myosin Head Domain Containing 1 2 3
  • Unconventional Myosin-XIX 3 4
  • MYOHD1 3 4

External Ids for MYO19 Gene

Previous HGNC Symbols for MYO19 Gene

  • MYOHD1

Previous GeneCards Identifiers for MYO19 Gene

  • GC17M031926
  • GC17M034851
  • GC17M030788

Summaries for MYO19 Gene

GeneCards Summary for MYO19 Gene

MYO19 (Myosin XIX) is a Protein Coding gene. Diseases associated with MYO19 include Hyperkalemic Periodic Paralysis. Gene Ontology (GO) annotations related to this gene include actin binding and motor activity. An important paralog of this gene is MYH13.

UniProtKB/Swiss-Prot Summary for MYO19 Gene

  • Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane (PubMed:19932026, PubMed:23568824, PubMed:25447992). Motor protein that moves towards the plus-end of actin filaments (By similarity). Required for mitochondrial inheritance during mitosis (PubMed:25447992). May be involved in mitochondrial transport or positioning (PubMed:23568824).

Additional gene information for MYO19 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MYO19 Gene

Genomics for MYO19 Gene

GeneHancer (GH) Regulatory Elements for MYO19 Gene

Promoters and enhancers for MYO19 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J036589 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 16.6 -53.3 -53311 14.1 ZBTB40 CTCF SIN3A MYC NRF1 POLR2G USF1 SP1 PHF8 ZFX DHRS11 MRM1 piR-56497-065 ZNHIT3 MYO19 CCL4L2 GGNBP2
GH17J036543 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 19.4 -2.6 -2566 5.6 EP300 HNRNPK ZBTB40 ZNF217 TCF12 SIN3A NRF1 POLR2G SP1 GTF2E2 GGNBP2 lnc-MYO19-1 ZNHIT3 MYO19 DHRS11 HE856173 lnc-GGNBP2-1
GH17J036532 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 19.2 +8.7 8700 3.7 HNRNPK ZBTB40 EP300 CTCF TCF12 SIN3A MYC POLR2G USF1 NCOR1 PIGW MYO19 lnc-TBC1D3F-8 lnc-MYO19-1
GH17J036485 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 19.3 +56.5 56534 2.6 ZBTB40 ZNF217 EP300 TCF12 SIN3A NRF1 POLR2G SP1 PHF8 ZNF639 ZNHIT3 LOC105371749 lnc-MYO19-2 piR-31974 MYO19 PIGW RNA5SP439
GH17J036482 Enhancer 1.2 FANTOM5 ENCODE 18.1 +60.4 60398 0.9 CTCF TCF12 MYC USF1 TEAD4 ZNF10 ZBTB10 ZBTB26 TARDBP REST SNHG30 MYO19 AP2B1 LOC105371749 lnc-MYO19-2 piR-35666-009
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MYO19 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MYO19

Top Transcription factor binding sites by QIAGEN in the MYO19 gene promoter:
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • Nkx2-5

Genomic Locations for MYO19 Gene

Genomic Locations for MYO19 Gene
chr17:36,495,633-36,543,435
(GRCh38/hg38)
Size:
47,803 bases
Orientation:
Minus strand
chr17:34,851,477-34,899,284
(GRCh37/hg19)
Size:
47,808 bases
Orientation:
Minus strand

Genomic View for MYO19 Gene

Genes around MYO19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO19 Gene

Proteins for MYO19 Gene

  • Protein details for MYO19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96H55-MYO19_HUMAN
    Recommended name:
    Unconventional myosin-XIX
    Protein Accession:
    Q96H55
    Secondary Accessions:
    • Q59GS4
    • Q9H5X2

    Protein attributes for MYO19 Gene

    Size:
    970 amino acids
    Molecular mass:
    109135 Da
    Quaternary structure:
    • Myosin is a hexamer of 2 heavy chains and 4 light chains: interacts with myosin light chains MYL9 and MYL12B.
    SequenceCaution:
    • Sequence=BAD92272.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MYO19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO19 Gene

Post-translational modifications for MYO19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYO19 Gene

Domains & Families for MYO19 Gene

Gene Families for MYO19 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MYO19 Gene

Blocks:
  • IQ calmodulin-binding region
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MYO19 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ61374, highly similar to Homo sapiens myosin head domain containing 1 (MYOHD1), transcript variant 3, mRNA (B4DSL5_HUMAN)
  • cDNA FLJ61691, highly similar to Homo sapiens myosin head domain containing 1 (MYOHD1), transcript variant 2, mRNA (B7Z1T7_HUMAN)
  • Myosin head domain-containing protein 1 (MYO19_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96H55

UniProtKB/Swiss-Prot:

MYO19_HUMAN :
  • The MyMOMA (MYO19-specific mitochondrial outer membrane-association) region mediates association with the mitochondrion outer membrane via electrostatic interaction.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Domain:
  • The MyMOMA (MYO19-specific mitochondrial outer membrane-association) region mediates association with the mitochondrion outer membrane via electrostatic interaction.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYO19: view

Function for MYO19 Gene

Molecular function for MYO19 Gene

UniProtKB/Swiss-Prot Function:
Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane (PubMed:19932026, PubMed:23568824, PubMed:25447992). Motor protein that moves towards the plus-end of actin filaments (By similarity). Required for mitochondrial inheritance during mitosis (PubMed:25447992). May be involved in mitochondrial transport or positioning (PubMed:23568824).

Phenotypes From GWAS Catalog for MYO19 Gene

Gene Ontology (GO) - Molecular Function for MYO19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA,IDA 23568824
GO:0005515 protein binding IEA --
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity IDA 23568824
genes like me logo Genes that share ontologies with MYO19: view
genes like me logo Genes that share phenotypes with MYO19: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYO19

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYO19 Gene

Localization for MYO19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO19 Gene

Mitochondrion outer membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYO19 gene
Compartment Confidence
mitochondrion 5
cytosol 5
cytoskeleton 4
nucleus 2
plasma membrane 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MYO19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IDA,IEA 23568824
GO:0005741 mitochondrial outer membrane IEA,IDA 27126804
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with MYO19: view

Pathways & Interactions for MYO19 Gene

PathCards logo

SuperPathways for MYO19 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MYO19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032465 regulation of cytokinesis IMP 25447992
GO:0034642 mitochondrion migration along actin filament IDA 19932026
GO:0090140 regulation of mitochondrial fission IMP 25447992
genes like me logo Genes that share ontologies with MYO19: view

No data available for Pathways by source and SIGNOR curated interactions for MYO19 Gene

Drugs & Compounds for MYO19 Gene

No Compound Related Data Available

Transcripts for MYO19 Gene

mRNA/cDNA for MYO19 Gene

4 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
27 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYO19

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYO19 Gene

No ASD Table

Relevant External Links for MYO19 Gene

GeneLoc Exon Structure for
MYO19

Expression for MYO19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MYO19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MYO19 Gene

This gene is overexpressed in Lung (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MYO19 Gene



Protein tissue co-expression partners for MYO19 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MYO19

SOURCE GeneReport for Unigene cluster for MYO19 Gene:

Hs.302051

mRNA Expression by UniProt/SwissProt for MYO19 Gene:

Q96H55-MYO19_HUMAN
Tissue specificity: Widely expressed in multiple tissues and cell lines.

Evidence on tissue expression from TISSUES for MYO19 Gene

  • Nervous system(4.6)
  • Lung(2)
genes like me logo Genes that share expression patterns with MYO19: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYO19 Gene

Orthologs for MYO19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYO19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYO19 30
  • 99.31 (n)
dog
(Canis familiaris)
Mammalia MYO19 30
  • 87.32 (n)
cow
(Bos Taurus)
Mammalia MYO19 30
  • 84.89 (n)
rat
(Rattus norvegicus)
Mammalia Myo19 30
  • 83.52 (n)
mouse
(Mus musculus)
Mammalia Myo19 17 30
  • 83.39 (n)
chicken
(Gallus gallus)
Aves MYO19 30
  • 62.94 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia myo19 30
  • 60.54 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC562279 30
  • 58.11 (n)
Species where no ortholog for MYO19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYO19 Gene

ENSEMBL:
Gene Tree for MYO19 (if available)
TreeFam:
Gene Tree for MYO19 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MYO19: view image

Paralogs for MYO19 Gene

(19) SIMAP similar genes for MYO19 Gene using alignment to 11 proteins:

  • MYO19_HUMAN
  • B4DSL5_HUMAN
  • K7EJW5_HUMAN
  • K7EMZ0_HUMAN
  • K7EP95_HUMAN
  • K7EQ57_HUMAN
  • K7EQI7_HUMAN
  • K7ERE8_HUMAN
  • K7ES03_HUMAN
  • L8E979_HUMAN
  • L8EB70_HUMAN
genes like me logo Genes that share paralogs with MYO19: view

Variants for MYO19 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MYO19 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs2306595 - p.Asn176Ser
rs7217346 - p.Leu475Ile
rs9890918 - p.Gln203His

Additional dbSNP identifiers (rs#s) for MYO19 Gene

Structural Variations from Database of Genomic Variants (DGV) for MYO19 Gene

Variant ID Type Subtype PubMed ID
dgv3154n100 CNV gain 25217958
dgv3155n100 CNV gain 25217958
dgv573e214 CNV gain 21293372
esv2763162 CNV gain 21179565
esv3640471 CNV gain 21293372
esv3640472 CNV gain 21293372
esv3640473 CNV gain 21293372
nsv457734 CNV gain 19166990
nsv469760 CNV loss 16826518
nsv469796 CNV gain+loss 16826518
nsv469853 CNV gain+loss 16826518
nsv471697 CNV gain 15918152
nsv516100 CNV gain+loss 19592680
nsv574909 CNV gain 21841781

Variation tolerance for MYO19 Gene

Residual Variation Intolerance Score: 85.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.68; 91.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYO19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYO19

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO19 Gene

Disorders for MYO19 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYO19 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hyperkalemic periodic paralysis
  • hypp
- elite association - COSMIC cancer census association via MalaCards
Search MYO19 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MYO19

genes like me logo Genes that share disorders with MYO19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYO19 Gene

Publications for MYO19 Gene

  1. Human Myo19 is a novel myosin that associates with mitochondria. (PMID: 19932026) Quintero OA … Cheney RE (Current biology : CB 2009) 2 3 4 54
  2. Positively charged residues within the MYO19 MyMOMA domain are essential for proper localization of MYO19 to the mitochondrial outer membrane. (PMID: 27126804) Hawthorne JL … Quintero OA (Cytoskeleton (Hoboken, N.J.) 2016) 3 4 54
  3. Myo19 is an outer mitochondrial membrane motor and effector of starvation-induced filopodia. (PMID: 26659663) Shneyer BI … Henn A (Journal of cell science 2016) 3 4 54
  4. Myo19 ensures symmetric partitioning of mitochondria and coupling of mitochondrial segregation to cell division. (PMID: 25447992) Rohn JL … Baum B (Current biology : CB 2014) 3 4 54
  5. Biochemical and bioinformatic analysis of the myosin-XIX motor domain. (PMID: 23568824) Adikes RC … Quintero OA (Cytoskeleton (Hoboken, N.J.) 2013) 3 4 54

Products for MYO19 Gene

Sources for MYO19 Gene