Aliases for MYO18A Gene
External Ids for MYO18A Gene
Previous GeneCards Identifiers for MYO18A Gene
The protein encoded by this gene can bind GOLPH3, linking the Golgi to the cytoskeleton and influencing Golgi membrane trafficking. The encoded protein is also part of a complex that assembles lamellar actomyosin bundles and may be required for cell migration. [provided by RefSeq, Oct 2016]
GeneCards Summary for MYO18A Gene
MYO18A (Myosin XVIIIA) is a Protein Coding gene. Diseases associated with MYO18A include Atypical Chronic Myeloid Leukemia and 8P11 Myeloproliferative Syndrome. Among its related pathways are HIV Life Cycle and Signaling by FGFR2 in disease. Gene Ontology (GO) annotations related to this gene include actin filament binding. An important paralog of this gene is MYO18B.
UniProtKB/Swiss-Prot Summary for MYO18A Gene
May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939).